Multiple myeloma researchers discovered that pairing CAR T-cell therapy with a compound that made tumor cells more easily detected by those souped-up immune cells was both safe and effective, offering hope to patients of this notoriously evasive cancer.
In cases where leukemia patients’ cancer cells evolved to evade a previously effective form of immunotherapy, Fred Hutch researchers found that a specialized T cell receptor could help modified immune cells adapt and continue to recognize tumor cells as they change.
Patients recovering from bone marrow transplants are especially susceptible to a common virus that would give most people a mild cold. Our researchers are studying whether laboratory-manufactured copies of naturally occurring antibodies could give these patients an added layer of defense.
Vaccines offer a way to train patients’ immune system to detect and eliminate cancer. Now Fred Hutch researchers are showing some success in developing unconventional vaccines that use T cells to train the rest of the immune system to make more efficient antibodies.