Shared Resources Job Openings

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Analytic Developer/QC Associate III is responsible for Quality Control (QC) cGMP testing activities in support of Human Gene Therapy Phase I/II clinical trials.  

This position will primarily focus on performing transfer, qualification, and validation of analytical test methods using FDA and ICH guidelines. In addition, the position will perform testing as needed in support of the Cell Processing and Biologics Production facilities (CPF and BPF). Cross-training on multiple assays will be required for this position as well as in laboratory quality systems.

Responsibilities

• Lead and participate in analytical method transfer/qualification/validation activities
• Participate in commissioning of laboratory instrumentation
• Perform cGMP in-process, lot release, and stability testing of raw materials, intermediates, drug substance, drug product, and human gene therapy products
• Review assays performed by peers
• Perform deviation and out of specification (OOS) investigations
• Write SOPs and test methods
• Perform general laboratory activities in accordance to SOPs and laboratory quality systems

Qualifications

MINIMUM QUALIFICATIONS:

• Bachelor’s or master’s degree in a life sciences field with 5+ years (3+ years MS), preferably with a background in biologics and/or cellular therapeutics
• Knowledge of regulatory guidance documents/information for Analytical Procedures and Method Validation
• Experience with ELISA, qPCR, gel electrophoresis, and HPLC methods
• Good written and oral communication. Good presentation skills
• Detail oriented, organized, proactive and self-motivated
• Possess strong communication and teamwork skills
• Ability to analyze data, assess/evaluate trends and make recommendations for improvement
• Experience with typical Quality Systems (ex. Document Control, Deviations, CAPA, Change Control, etc.)

PREFERRED QUALIFICATIONS:

• Knowledge of cGMP requirements for Phase I/II clinical trials
• Familiarity with Chemistry. Manufacturing, and Controls (CMC) information for Investigational New Drug Applications
• Experience with flow cytometry
• Experience with microbial-based assays
• Knowledge of aseptic and cell culture techniques   

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.  #ZR

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Quality Control laboratory performs in-process and release testing in support of Human Gene Therapy Phase I/II clinical research studies. We are looking for a dynamic, skilled, and detail-oriented Analytic Developer/Quality Control Associate III to join our team. The position will perform routine cell-based potency assays, as well as microbial safety assays utilizing ELISA, microscopy, and qPCR techniques. In addition, the position will be required to follow and maintain laboratory quality systems in our GMP environment. Eventually, the position may also be required to train on flow cytometry-based methods.

Responsibilities

• Perform in-process, lot release, and stability cGMP testing of raw materials and human gene therapy products
• Review assays performed by peers
• Write SOPs and test methods
• Perform deviation and out of specification (OOS) investigations
• Maintain laboratory cell lines
• Participate in environmental monitoring activities
• Maintain equipment
• Perform general activities in accordance with SOPs and laboratory quality systems

Qualifications

MINIMUM QUALIFICATIONS:

• Bachelor’s degree in a life sciences field (Biology, Chemistry, or related scientific major) with 5+ years (3+ years MS), preferably with a background in biologics and/or cellular therapeutics
• 5 years of experience in a laboratory setting or equivalent
• Hands-on experience with microtiter cell-based assays
• Experience with aseptic and cell culture techniques
• Experience with typical GMP Quality Systems (ex. Document Control, Deviations, CAPA, Change Control, etc.)
• Good written and oral communication skills
• Strong communication and writing skills with demonstrated ability to work in a dynamic team environment
• Physical requirements: must have the abiliy to life a minimum of 25 pounds, the ability to stand of extended periods.
   

PREFERRED QUALIFICATIONS:

• Experience with cytotoxicity, bacterial endotoxin, and qPCR testing
• Experience with Environmental Monitoring (EM) programs  

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Equipment Preparer Lead is responsible for assisting the Housing Systems Processing Supervisor in the oversight of the quality of work in the cage wash facility. Process the facilities’ soiled animal housing equipment and prepare for use. The incumbent works following established procedures in performing daily responsibilities. The Equipment Preparer Lead position reports directly to the Supervisor -Husbandry Systems Operations. This position is under supervision with no responsibility for supervision others.  Uses discretion and judgement in carrying out tasks.  

Essential Role Classification: 

The Equipment Preparer Lead is classified as essential personnel and, as such, is required to work with a minimal number of absences and during all Center closures except in the event of a major disaster when access to animal housing and use facilities is prohibited by governmental emergency personnel.   

Responsibilities

Housing Equipment Preparation: Oversees and prepares items for the equipment washers, including removal of soiled bedding, sorting of items into similar batches, soaking designated items and scrubbing items that are especially soiled. Be proficient at scheduling and preparing orders of animal caging and rodent drinking water for the animal technicians. 
 

Personnel and training: Train Comparative Medicine Staff in equipment preparation procedures.  Document training and performance level.  Assign duties to preparation staff, set priorities, plan schedules, and ensure sanitation and safety procedures are in compliance with established procedures and regulations. 
 

Equipment Operations: Be proficient at ensuring that clean equipment has been processed correctly and shows no sign of residual waste material or other types of contamination. Be proficient at notifying the Supervisor of any malfunctioning machinery or damaged equipment. Be proficient in operation of equipment washers, autoclaves and automatic water filling systems including preparing the acidification solution for the water filing stations under supervision.
 

Sanitation Operations: Delegate and participate in performing housekeeping duties such as sweeping, mopping, garbage removal, and equipment washing in animal housing areas and surrounding premises. Be proficient in appropriate sanitation procedures and perform collection of materials for quality testing.  
 

Research Support: Be proficient at preparing and providing special equipment orders. 
 

Perform other duties as assigned

Qualifications

MINIMUM QUALIFICATIONS:

• High school diploma or equivalent.
• Ability to lift and move 50 lbs on a regular basis and sustained physical activities such as bending, balancing, stooping, reaching, and remain standing for long periods of time.
• Ability to wear Personal Protective Equipment including scrubs, gloves, shoe covers, gowns, ear plugs / muffs, face mask, and eye protection.
• Maintenance of a valid Washington State Driver’s License and good driving record.  

 
PREFERRED QUALIFICATIONS:

• Janitorial, santization, production line or animal husbandry experience.
• Lead experience. 

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Bioinformatician II provides specialized consulting and data analysis services to researchers at the Fred Hutch and across the wider Fred Hutch/UW Cancer Consortium. This position requires the ability to work independently, manage multiple overlapping data analysis projects, and communicate effectively with faculty, post-doctoral fellows, and research staff on a wide range of topics in biology, analysis of next-generation sequencing data, sound experimental design, and data science.

Responsibilities

The Bioinformatician II reports to the Associate Director of the Bioinformatics Shared Resource and will work with Fred Hutch scientists to refine computational research questions, develop analytical processes applied to large genomic datasets, and provide timely results and documentation for processes used.

Job Duties

• Perform quality control and end-to-end analysis of large sequence datasets from diverse workflows
• Consult with researchers to refine research questions and to develop sound experimental designs
• Identify best-practice bioinformatics tools and strategies to meet the needs of proposed projects
• Provide figures and written sections describing methods and results for manuscripts, presentations, and grant applications
• Partner with researchers who are developing novel assays to design appropriate processing and analysis workflows
• Collaborate with colleagues in the Genomics Shared Resource and the Hutch Data Core to ensure the integrity and consistency of primary data, track experimental methods and metadata, define standardized analysis pipelines, and provide training and support as users analyze and interpret results

Qualifications

• MS or PhD in bioinformatics, computational biology, genetics, or related field
• At least three years’ professional experience with computational analysis of complex sequence-based data sets including some of these assays: whole exome sequencing; targeted amplicon sequencing; somatic variant calling; bulk RNA-seq expression ; single-cell expression and immune repertoire profiling; CUT&RUN; ChIP-seq; ATAC-seq; or CRISPR/Cas9 knockout screens
• Demonstrated fluency in R or Python 3, ideally both
• Proficiency with Linux/Unix shell scripting (e.g., bash)
• Strong organizational skills, including the ability to manage and prioritize multiple competing tasks
• Excellent written and verbal communication skills

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Master Scheduler will report directly to the Director of Therapeutic Products Program (TPP) Manufacturing.  This individual will work semi-autonomously to plan and prepare the daily and weekly production schedules required for the manufacture of cell therapies in the Cell Processing Facility (CPF).  This will include analyzing production schedules and overall manufacturing capacity to determine the optimal work schedule to ensure timely production of therapeutic products.  Energetic and enthusiastic and dedicated to life-saving research, the needed  skills and expertise for this position require developing and maintaining production planning tools and the master production schedules to ensure the efficient utilization of resources to meet the needs of the patients.

The Master Scheduler works independently and as part of the CPF Management team.  They will interface with manufacturing, principal investigators and external collaborators including, but not limited to, the Cell Therapy Laboratory (CTL) and Apheresis Unit.  Strong interpersonal and communication skills, along with a focused attention to detail, are required to ensure successful planning.

Responsibilities

May perform some or all of the following responsibilities:

• Ensure weekly and daily production schedules comply with the CPF production plan and expected patient infusion dates.
• Attend meetings as planning coordinator, representing the CPF.
• Work with MFG managers and supervisors to ensure technician training level matches assigned tasks.
• Maintain and communicate manufacturing scheduling requirements and changes with manufacturing management and associates, principal investigators, clinical nurses, QA, QC, CTL and Apheresis on a routine basis.
• Develop and maintain strong working relationships with customer groups to ensure proactive assessment of operations to support clinical needs.
• Serve as primary point of contact for all manufacturing scheduling-related issues.
• Develop, compile, and report production metrics to area management on a monthly, quarterly and annual basis.
• Be able to analyze data and evaluate capacity limitations so that the Production Schedule can be optimized.
• Drive projects for the implementation of improved scheduling tools and workflows to successful completion.

Qualifications

• Bachelor's degree.
• 3-5 years of experience in a manufacturing environment (preferably in a Cell Therapy, Pharmaceutical or BioPharmaceutical discipline).  Experience with operations scheduling is preferred.
• Must be proficient in Microsoft Office (Excel, Word, PowerPoint) . Knowledge and experience with SharePoint is preferred.
• Strong organizational and interpersonal skills required.
• Must have strong initiative, attention to detail,  problem solving and follow through.
• Must have strong customer service skills and excellent communication skills to effectively work with all levels of staff, both internally and externally.
• Willingness to learn additional departmental computer and software technologies.
• Ability to work independently on multiple projects and communicate status of projects to key decision makers on a proactive basis.
• Familiarity with requirements of GMP clinical production environments preferred.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

This position, reporting to the Manufacturing Manager, is responsible for leading the cGMP manufacturing team in the production of cellular and gene therapies in support of clinical research studies.  This position oversees a team of professional associates responsible for the cGMP manufacture of cell and gene therapies within the Cell Processing Facility (CPF).  The position addresses operational and routine challenges as they arise for Phase I/II manufacturing. Knowledge of cell culture and aseptic operations is essential. Demonstrated leadership and communication skills along with a strong working knowledge of the regulatory compliance requirements for the production of cell and gene therapies used in clinical studies are essential.

Responsibilities

• Provides guidance when deviations arise from approved policies and procedures. Investigate and write deviation reports and develop CAPA.
• Oversees and participates in cell processing operations such as cell selection/depletion, expansion, stimulation, transduction, cryopreservation, and patient infusion preparation, following cGMP manufacturing guidelines for clinical products.
• Ensures completion of daily and weekly manufacturing schedules by production associates to achieve all production deliverables.
• Assists in the maintenance of the production schedule to meet customer and business goals.
• Ensures that the facility and all production equipment, such as single-use bioreactors, incubators, centrifuges, cell sorting/selection equipment, and controlled-rate freezers, is working properly and is appropriately maintained per quality standards.
• Works closely with cross-functional teams and production staff to troubleshoot operational processing and equipment problems.
• Evaluates current practices and operations and drive implementation of changes to improve performance.
• Responsible for training, coaching, and mentoring lab technicians and associates on production functions and all compliance requirements per policies, procedures, and quality systems.
• Participates in interviewing and hiring staff.
• Develops goals for direct reports on an annual basis and routinely monitor progress against those objectives. Conducts annual performance reviews of direct reports.
• Works with manufacturing and technical staff to create, revise, and edit SOPs, batch records and raw material and product specifications as needed.
• Reviews and approves various GMP documentation in a timely fashion.
• Communicates status of operations, safety, maintenance or process issues in a timely manner to Area Management.

Qualifications

Minimum Qualifications

• Bachelor’s degree and 2-4 years of experience in a cell therapy/biologic production environment, or equivalent.
• Direct experience in aseptic processing techniques performed in a biosafety cabinet.
• Experience maintaining cell cultures.
• Solid understanding of cGMP requirements for clinical manufacturing.
• Ability to create and revise manufacturing documentation such as batch records, SOPs, deviation reports, and change controls.
• Ability to work with limited supervision in a fast-paced, dynamic, and highly regulated production environment.
• Excellent communication skills, both oral and written.
• Must have excellent communications skills, both verbal and written, within a diverse team environment.
• Ability to accurately and reproducibly perform arithmetic calculations including fractions, decimals, percentages, scientific notation, and basic algebraic and geometric calculations.
• Computer skills (MS Office).
• Must be able to wear clean room attire, surgical masks, and all required Personal Protective Equipment (PPE).
• Must have the ability to stand and to work in a biosafety cabinet for long periods.
• This position may require operation on a non-standard shift structure, for example, Sunday-Wednesday. Shifts are 4 days/week, 10 hours/day with some occasional weekend and holiday work.
• Meets physical requirements of the job, as follows: can lift a minimum of 25 pounds and the ability to bend, reach, stretch, and climb ladders.
• Ability to work non-standard shifts and occasional weekend days.

Preferred Qualifications

• Understanding of, and experience with, cell therapy/gene therapy clinical manufacturing.
• Experience actively managing direct reports.
• Experience with investigation methodologies, such as root cause analysis.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Working under the direction of the Sr. Administrative Director of Therapeutic Products Program (TPP) Operations, the Director of TPP Ops Manufacturing will define the overall strategy of the core MFG group, with oversight of both the Biologics and Cell Processing Facilities (BPF and CPF).  These diverse teams are responsible for the manufacture of cGMP clinical products for both internal and external clients.  The TPP MFG Director will provide direct technical and managerial leadership to the MFG groups. The responsibilities of primary importance are to ensure the successful and time-sensitive GMP manufacture and release of clinical products, promoting a culture of quality and compliance, and achieving continuous improvement. The position will involve managing manufacturing operations and the supervision of approximately 25 manufacturing staff. The successful applicant will interact on a daily basis with clinical trial sponsors, QA/QC, Process Development, Process Engineering, research scientists, product management, and members of Fred Hutch faculty and administration.

The BPF performs development and cGMP manufacturing production utilizing technologies ranging from small-scale fermentation to mid-scale (130L) mammalian cell culture, protein purification and fill finish operations. The manufactured products include, but are not limited to, monoclonal antibodies, fusion proteins, viral vectors, and plasmids.

The CPF performs development and cGMP manufacturing production activities for cell therapy clinical trials involving the selection, genetic modification, and ex-vivo expansion of stem cells, T-cells, and B-cells.

Responsibilities

Specific responsibilities include:

• Provide leadership for the MFG departments including hiring of manufacturing staff and providing mentorship and staff development
• Foster a culture of excellence in building high performing teams
• Ensure all staff maintain appropriate completion of required training
• As a member of the TPP Leadership Team, contribute to strategic planning in the development of TPP goals and objectives, and work with the other directors in providing leadership to the department
• Lead the improvement and implementation of all cGMP procedures and policies related to manufacturing operations
• Ensure effective and efficient completion of compliance deliverables, such as deviation initiation, investigation, CAPA development and CAPA closure
• Representing manufacturing in participation and response to audits and inspections
• Ensure planning and utilization of plant capacity meets the needs for the expected deliverables. Analyze and evaluate the effectiveness of manufacturing methods, costs and results
• Use of strong communication and teamwork skills to build high performing teams
• Demonstrate outstanding technical acumen, operational understanding and cGMP compliance for clinical products
• Ensure the design, implementation and effectiveness of operations systems and processes that facilitate safe, accurate and timely product delivery
• As owner of the production facilities, utilities and equipment, ensure appropriate maintenance and operation
• Provide oversight to the GMP Materials Control function
• Ensure appropriate manufacturing execution readiness preparations, to set teams up for success
• Deliver results by meeting production schedules, improving process outputs, and improving operational efficiency and compliance.  Maintain a high level of quality and safety standards

Qualifications

MINIMUM QUALIFICATIONS:

• Bachelor's degree in Biology, Chemistry, or related Science field. Adequate experience in lieu of degree is acceptable
• Hands on leader with minimum of 10 years supervisory experience and 7-10 years’ experience in leading and driving biologics and/or cell therapy manufacturing is required
• Strong understanding of aseptic techniques, cell culture/cell expansion processing
• Has a thorough understanding of cGMP requirements for clinical manufacturing, adept in the utilization of GMP systems
• Experience as a manufacturing production facility owner
• Demonstrated leadership skills and experience in personnel management
• Excellent problem solving, analytical and project management skills
• Ability to lead deviation response and root cause investigations, familiarity of FMEA methodology
• Strong capability in guiding complex projects to effective and timely completion
• Excellent communication skills, both oral and written. Writes and presents effectively
• Strong customer service skills to interface effectively with internal and external clients
• Ability to evaluate technical data and efficiently collaborate on, review and approve documents
• Must be able to wear appropriate clean room attire and have the ability to wear surgical masks and all Personal Protective Equipment (PPE)
• Evening and/or weekend work may occasionally be required based on project need

PREFERRED QUALIFICATIONS:

• An MS or PhD degree in Immunology or related field
• Experience with cell therapy processing operations and equipment
• Experience running multi-product clinical biologics manufacturing operations

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Reporting to the Sr. Director of Therapuetics Products Program (TPP), the TPP Process Development (PD) group supports cell processing and manufacturing activities for early-stage cell therapy clinical trials, and performs technology advancement and development around selection, transduction, and ex-vivo expansion parameters of stem cells, T-cells, and B-cells.  PD works closely with internal Fred Hutch investigators and external collaborators to establish production processes for early phase clinical trials. Long term objectives are to develop efficient, cost-effective, and scalable processes so that these lifesaving therapies can be brought to patients in need.

The Process Development Director will provide technical and managerial leadership to the TPP Process Development group as well as serve as a technical and scientific resource for the entire TPP organization.  The position will ensure that development activities are well aligned with manufacturing needs, experiments are appropriately designed, and that results are effectively communicated to key stakeholders.  The successful applicant will interact on a daily basis with clinical trial sponsors, Process Engineering, Manufacturing, Product Management, QA/QC, research scientists, and senior Fred Hutch faculty and administration. 

Responsibilities

Specific responsibilities will include:

• Provide technical expertise for the PD department in the design and analysis of experiments and in presenting resultant data to groups inside and outside of the department in a succinct, well-organized and coherent manner.
• Ensure the appropriate management and maintenance of the PD laboratory facility and its equipment.
• Provide senior leadership for the PD department including hiring and management of staff and providing mentorship and staff development
• As a member of the TPP Leadership team, contribute to strategic planning in the development of TPP goals and objectives, and work with the other directors in providing leadership to the department.
• Partner with investigators in the development of processes that will meet their clinical requirements and address constraints associated with larger-scale manufacturing.
• Coordinate with Product Management and project sponsors to define the scope of development projects, including cost estimates and timelines.
• Partner with GMP Process Engineering and manufacturing staff to ensure appropriate transfer of needed processes and analytical information for successful clinical material production
• Use strong communication and teamwork skills to build relationships with all stakeholders (e.g., faculty, research staff, GMP manufacturing, QA/QC etc.)
• Provide input to the department annual operating budgets
• Identify opportunities for process improvements and champion their successful implementation.
• Publication of novel process improvements, meeting abstracts and/or talks, as appropriate.

Qualifications

MINIMUM QUALIFICATIONS:

• Ph.D. in immunology, bioengineering, cellular biology, or related field
• One or more years of GMP or GMP-related (e.g., process transfer, MFG audit response) experience
• 7+ years of research experience in immunology, cell biology or related field that would support process development role
• Experience as a personnel manager who has led/developed high performing teams.
• Experience with design of experiment (DOE) fundamentals and resultant data analysis (e.g. JMP)
• Experience with primary cells (e.g., T cells, B cells, stem cells, etc) and their isolation from primary sources, such as tissue and apheresis.
• Familiarity with cell culture media development and optimization of cell culture processes and operating conditions
• Familiarity with cell processing equipment such as Miltenyi CliniMACs or Prodigy, LOVO, cell counters, etc.
• Knowledge of analytical methods to characterize processes including cell-based assays, flow cytometry, and proteomic/genomic methods.
• Familiar with the resolution of issues associated with process scale-up and transfer into a GMP manufacturing environment
• Ability to perform short- and long-term project planning in terms of the generation of scope of work documents and project plans, resource demands, timelines, and budget forecasting
• Ability to prioritize multiple tasks, work under various timeline pressures, and drive tasks to completion
• Strong collaboration, team-building, communication and organizational skills required.

PREFERRED QUALIFICATIONS:

• 10+ years' experience in process development and supporting GMP cell culture based manufacturing operations. The ideal candidate will have experience in cell therapy applications with T-cells and stem cells; however, recognizing that this is a nascent field the candidate may have transferable skills from other biologics fields
• Strong expertise in CAR-T cell therapy development and optimization
• Experience working with adherent and suspension cell cultures in various flask, GRex and bioreactor systems (fed-batch/perfusion; fixed/disposable)
• Experience with single use bioreactor systems and associated in-process analytical equipment.
• Analytics method development and transfer.
• Knowledge of retroviral or lentiviral vectors and transductions processes/systems.
• Experience with cell culture associated unit operations such as tangential flow filtration for cell harvest/concentration, centrifugation, and cryopreservation/thaw recovery.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Director, Cellular Imaging will oversee the Fred Hutch Cellular Imaging Core Facility and will be responsible for all aspect of the core functions, including providing outstanding imaging services, education and support to Fred Hutch investigators, scientific collaborations, strategic planning, acquisition, and implementation of new technologies. The resource overall mission is to provide access to equipment and expertise to assist investigators in applying sophisticated light microscopy techniques. In addition, the director will consult with the faculty advisory committee (FAC) members on a regular basis and keep faculty updated on technical and operational objectives.

Scope of Responsibilities

The Director of the Cellular Imaging Shared Resource is a team leader who possesses a broad-based knowledge of light microscopy technologies and applications.  This person works under the guidance of the Senior Director of Molecular and Cellular Scientific Resources, along with input from the FAC, to assist in setting the direction, overall operation, and administration of the shared resource. In addition to operational responsibilities, other activities include providing technical development efforts to advance imaging support to the Fred Hutch research community. More specifically, the director assesses current and future needs, evaluates new technologies and their potential benefits for research at the Center, obtains funding for the purchase of needed instruments, hardware and software, trains end-users, assists with the utilization of all available technologies, provides specialized services, and disseminates and promotes the use of imaging and quantitative image analysis techniques through demonstrations, workshops, and seminars.

Responsibilities

Leadership

• Create and maintain a team environment that strives toward excellence and that elevates the facility’s status as the premier scientific imaging core
• Hire, train, and mentor a highly skilled technical team
• Work with SR leadership and faculty advisors to develop a strategic vision for the core and create a roadmap to meet key objectives
• Maintain an environment that is agile and responsive to change
• Be proactive in identifying problems (and opportunities) and providing actionable solutions
• Build and maintain scientific, academic, and commercial partnerships

Research & Collaborative Development

• Identify, consult, and develop areas of collaboration for the core facility with faculty and industrial partners. Work with investigators to develop innovative applications for imaging technologies, assists and collaborate in experimental design.
• Identify equipment grant opportunities and develop/submit grant to acquire new technology/instrumentation for the core.
• Keep current in the field by maintaining contacts with colleagues, attending conferences and training sessions. 

Service and Support

• Engage and maintain positive working relationship with users of the core facility.
• Work with researchers to determine and guide appropriate imaging strategies for specific experiments and/or research projects.
• Communicate effectively about the services/resources available within and outside the institution to increase user base.
• Effectively address potential researcher concerns – including determining the cause of the problem; selecting and explaining the best solution to solve the problem; expediting correction or adjustment; following up to ensure resolution.
• Work with Morphometrics/Image Analyst to determine instrumentation and/or imaging limitations that need to be considered for image analysis development.
• Help researchers obtain preliminary data for grants using existing imaging technologies and/or image analysis software.
• Provide support letters for investigator research grant applications. 

Education & Training

• Develop and maintain a microscopy training program that utilizes existing expertise and provides users with a solid foundation for microscope utilization and troubleshooting.
• Conduct demo/workshops demonstrating capabilities of existing imaging equipment and analysis software.
• Conduct demo/workshops demonstrating novel technology in partnership with industry.
• Appropriate guidance and education for individual users to meet their research needs.

Operations

• Oversee daily operation of the laboratory. Delegate and oversee staff assignments.
• Work with Research Administration – Shared Resource to project and develop annual resource budget. Operate and maintain the core facility budget. Manage operating budgets including the development of financial projections and business cases. Evaluate workflow and service levels, develop policies and procedures to optimize workflow and deliver high quality service. Maintain cost effectiveness.
• Generate reporting metrics on facility deliverables and service levels to advise FAC.
• Supervise and ensure the accuracy, completeness and timeliness of record keeping including schedules, instrument log books, records of user activity, personnel and staff time, supply inventories, purchase orders, equipment use and maintenance, metric reporting and monthly billing.
• Development and monitoring of an effective staffing and retention strategy to include the hiring of employees, providing mentoring and professional development opportunities for direct reports, collaborate with human resources business partners to meet the talent management goals. Provide support and guidance to team members regarding Fred Hutch policies and procedures, organizational programs, and personnel issues.
•  

Qualifications

MINIMUM QUALIFICATIONS:

• Must have the knowledge and skills typically acquired through the completion of a PhD in Biophysics, Molecular Biology, Genetics or related field, with a minimum of 5 years of related experience.
• Demonstrated expertise in advanced imaging techniques e.g., confocal and two photon microscopy, light sheet, super-resolution imaging (STED and SIM), FRET, and fluorescence lifetime measurements microscopy technologies.
• Demonstrated ability to integrate multiple types of research approaches and hands-on experience with assembling and implementing advancing imaging systems.
• Strong organizational skills, attention to detail and accuracy and the ability to work in a team environment are essential.
• The individual will have excellent communication skills for interfacing with expert and non-expert users, as well as lay audiences.
• Proven customer service and end user support experience.

PREFERRED QUALIFICATIONS:

• Experience running a state-of-the-art microscopy core facility
• Peer-reviewed publications with a focus on advanced microscopy
• Grant writing experience (e.g., NIH S10 Shared Instrumentation Grant)

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.  

This position, reporting to the GMP Materials Supervisor, is responsible for maintaining inventory in support of clinical trials for the Therapeutic Products Program. This position manages the cGMP workflow for raw materials used to produce cellular and gene therapies in support of clinical research studies.

Responsibilities

• Follow and maintain the workflows of manufacturing Materials Control such as receipt and inspection, identification, quarantine, release, storage, and issuance of GMP materials used in production.
• Support monitoring of inventory, ordering, and handling of supplies needed for operations.
• Follow Standard Operating Procedures (SOPs) and complete required documentation such as on logbooks and forms.
• Perform timely and accurate transactions in the business inventory control systems.
• Maintain the storage areas in an organized and sanitary environment.
• Ensure material location status and quantity are accurate.
• Conduct cycle counts, resolve inventory discrepancy issues.
• Administrate final product shipping/distribution to our customers.
• Identify issues, work collaboratively with the team to problem solve and implement changes.
• Identify deviations from approved policies and procedures. Document deviations, assist in the investigations, and assist in the development of CAPA.
• Evaluate current practices and operations and contribute to changes to improve performance.
• Lead by example and take responsibility in the support of safety and cGMP compliance.
• Ensures that equipment used for raw material storage, such as fridges and freezers, are working properly and is appropriately maintained per quality standards.
• Work with manufacturing and technical staff to create, revise, and edit materials-related SOPs and product specifications as needed.

Qualifications

•  1-2 years of experience in Materials Control within regulated environment, such as cell therapy or biologics product, aerospace, or equivalent.
• High School diploma or equivalent. 
• Ability to work with limited supervision in a fast-paced, dynamic, and highly regulated environment.
• Must have strong communications skills, both verbal and written, within a diverse team environment.
• Basic computer skills (MS Office).
• Must be able to wear clean room attire, surgical masks, and all required Personal Protective Equipment (PPE).
• Shifts are 4 days/week, 10 hours/day with some occasional weekend and holiday work.
• Meets physical requirements of the job, as follows: can lift a minimum of 25 pounds and the ability to bend, reach, stretch, and climb ladders.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Flow Cytometry Specialist I-II will work as a member of a team to support the cytometry needs of the scientific community.  The incumbent works under the general supervision of the Flow Cytometry Director and works independently in performing daily responsibilities according to established procedures.

Responsibilities

Flow Cytometry Specialist I

• Perform all aspects of instrumentation support including instrument maintenance, start up, calibration, quality control, and troubleshooting. (20% effort)
• Assist clients with the setup of their experiments. (20% effort)
• Follow established SOPs (Standard Operating Procedures) to ensure high quality, reproducible results for the facility’s client base.  (20% effort)
• Assist clients in a GLP and GMP environments.  (10% effort)
• Train clients in the proper operation of the instrumentation.  (15% effort)
• Perform other duties as required.  (15% effort)

Flow Cytometry Specialist II

• Perform all aspects of instrumentation support including instrument maintenance, start up, calibration, quality control, and troubleshooting.  (20% effort)
• Independently assist clients with the setup of their experiments.  (20% effort)
• Assist clients in GLP, GMP, and BL2/3 environments.  (15% effort)
• Maintain accurate department records including instrument use logs, materials used, supply inventories, capital equipment lists, equipment maintenance lists, department purchases and accounting records.  (15% effort)
• Provide researchers advice in panel design and experimental troubleshooting.  (15% effort)
• Perform other duties as required.  (15% effort)

Qualifications

Flow Cytometry Specialist I

• Bachelor's degree in a physical or biological science or equivalent experience.
• Familiarity with or experience in optical systems, instrument analysis, computers, or molecular and cell biology strongly desired.
• 6-month experience in flow cytometry or lab utilizing flow cytometry desired.

Flow Cytometry Specialist II

• Bachelor's degree in a physical or biological science or equivalent experience and 3 years related experience.
• Familiarity with or experience in optical systems, instrument analysis, computers, or molecular and cell biology strongly desired.
• Must have 1+ year(s) experience working with flow cytometry either as a researcher using instrumentation or in a core facility/service roll.
• Demonstrated skill in working with electronics and machinery.
• Working knowledge of FlowJo software.
• Strong interpersonal and communication skills. 

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Genomics Specialist II will work as part of a team to provide Genomics services to the Center's diverse research community.  The incumbent will work under the direct supervision of the Genomics Resource Supervisor and will support day-to-day operation of the facility.  

Responsibilities

• Provide technical expertise to support all services pertaining to NextGen sequencing.
• Maintain a deep understanding of the technologies used in the Resource, and provide advice and support to researchers on troubleshooting issues.
• Implement new methodologies and services to support existing NextGen services.
• Have a mastery of molecular biology techniques pertaining to genomics-based technologies and be able to explain them to others.
• Efficiently manage projects by organizing and multi-tasking.
• Maintain a highly professional demeanor with researchers and associates.
• Maintain accurate documentation of laboratory activities.

Qualifications

• Bachelor degree in Molecular Biology, Genetics or related field.
• Must have the knowledge and skill-base typically acquired through the completion of an undergraduate degree in Molecular Biology, Genetics, or related field.
• Minimum of 5 years of professional laboratory experience.
• Other skills should include working knowledge of genomics-based instrumentation and techniques, as well has experience handling RNA.
• Strong interpersonal and organizational skills are essential.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Glassware Technician I cleans and sterilizes glassware for use in Center laboratories.

The incumbent works under the supervision of the Glassware supervisor or designated lead technicians. Adherence to departmental standard operating procedures in performing daily responsibilities is essential in preventing contamination of glassware which could have a detrimental effect on research. Non-routine decisions are referred to supervisor or designated lead technicians.

Responsibilities

• Process laboratory glassware according to established standard operating procedures and in accordance with specific laboratory instructions. These duties include:
  
  • Preparation of glassware for machine or hand washing.
  • Washing and drying of glassware using appropriate methodologies.
  • Preparation of glassware for dry heat or steam sterilization; i.e., bagging, wrapping.
  • Inspection of glassware at key points to ensure cleanliness.
  • Labeling of glassware, as required.
  • Review all carts prior to distribution to ensure accuracy of return.
• Perform designated quality assurance tests and keep timely and accurate records in log books according to established departmental procedures. Departmental testing occurs at all levels of facility operation.
• Assist with the validation of established standard operating procedures related to all phases of departmental operations.
• Sterilize liquids in accordance with established procedures. Develop knowledge to advise laboratory personnel on appropriate liquid sterilization methods and temperatures.
• Maintain departmental log books, i.e., breakage, maintenance, etc., according to established standard operating procedures.
• Learn and perform all duties in accordance with established departmental safety procedures and standards.
• Learn and operate all equipment within the facility according to manufacturer specifications. The latter includes glasswashers, dryers, dry heat sterilizers and autoclaves.
• Develop knowledge of all glassware and sterilization procedures, including manufacturing specifications/tolerance levels of various types of glassware. Advise laboratories of appropriate glassware processing methods.
• Clean and maintain laboratory and facility autoclaves, completing the appropriate documentation.
• Perform other duties as assigned.
• Clean and maintain the autoclave prior to beginning daily operation and as required throughout the day. Report all equipment problems to the supervisor.

Qualifications

• High school graduation or GED.
• Minimum of six months of glassware experience.
• Ability to work independently as well as part of a team.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.  #ZR

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures for the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

We are seeking multiple energetic, responsible interns to join our team, Office of Translational Research (OTR). STTR creates environments which enable researchers and clinicians to accelerate scientific discovery, translate it into cures and research advances which significantly improve patient outcomes and quality of life. We do this by focusing on three key areas:

Build seamless infrastructure to optimize and speed translational research
Strengthening tumor-specific translational research programs, and
Strengthening partnerships between Seattle-area and regional translational research institutions.
 

We are recruiting a Marketing/Communications intern to support STTR team members with development and implementation of outreach and communication strategies related to our infrastructure tools like:

Oncoscape
Specimen & Data Acquisition Network (SAN)
Seattle Translational Tumor Research
Specimen Data Management Tool

The goal of this internship is to increase awareness and use of all OTR offerings, across our over 500 clinical and research members. The work includes activities such as: one-on-one meetings with investigators, creation of “personas” (categories of users), outreach plans, and training and promotional materials.  We are looking for full-time interns, 40 hours per week, through August 12th, 2022.

Responsibilities

• Support the OTR team with developing communication strategies and implementing outreach goals
• Develop tools and methods for collecting data such as web-based surveys, and user experience questionnaires
• Conduct user interviews (current and/or potential), and follow up as needed
• Create graphical representations of user data
• Build a resource database
• Design physical and electronic outreach and training materials
• Create and edit content for outreach and information sharing on team websites
• Monitor and manage social media platforms, managing content and followers for outreach
• Event coordination support for research meetings and community events
• Participate in weekly team meetings and other group meetings as needed

Qualifications

Minimum Qualifications

• Pursuing a bachelor’s degree in Life Sciences, Communications/Marketing, Information Science, or similar program
• Event coordination support for research meetings and community events
• Effective communication skills
• Organized individual with attention to detail
• Enthusiastic about speeding research
• Self-starter
• Can manage multiple projects with competing deadlines

Preferred Qualifications

• Knowledge of genetics and biology
• Experience with social media platforms (Twitter, Facebook, user communities)
• Experience working with one of the following programs is highly desired: Adobe Photoshop, Adobe Experience Manager, YouTube, Smartsheet or comparable programs
• Experience with Microsoft Excel and/or Microsoft Access
• Experience with analytical tools

A cover letter stating your interest is highly recommended

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Fred Hutch Therapeutics Products Program (TPP) encompasses two, distinct, clinical manufacturing facilities in support of Phase I/II clinical trials. Trials consist of both internal, faculty-driven protocols as well as external partnerships with peer institutions and industry partners.

The Quality Assurance Associate III is responsible for creating, developing, monitoring, and managing quality systems that support receipt, processing, testing and release for products manufactured by Therapeutic Products Program (TPP).  A person in this position works on complex problems requiring data analysis and the ability to perform an in-depth evaluation of regulations and policies in selecting methods and techniques for obtaining results. Tasks are typically carried out with no instruction on routine work and may provide guidance to other junior personnel. The Quality Assurance Associate III has additional responsibilities in leading project efforts and management of quality systems.

Responsibilities

• Supports the cGMP cell therapy and biologics manufacturing operations as the responsible person for Quality systems
• Performs the batch record reviews, product release and associated deviation records.  Perform the review and investigation on the deviation records to meet the quality compliance requirements.
• Provide Quality Assurance oversight throughout the end-to-end production operations assuring current GMP compliance requirements
• Supports self-auditing program to assure continual compliance with FACT standards and clinical regulatory requirements
• Ensures that the change management related to manufacturing methods are evaluated and implemented to meet GMP requirements and internal standards
• Review and approve procedures, master batch records, and other QA controlled documentation, and associated document change requests.
• Partner with functional areas to resolve product quality impacting investigations and own CAPA related to area of responsibility.
• Manage the Deviation/CAPA process to ensure issues are identified and appropriate corrective and preventative measures have been designed and completed in a timely manner
• Provide QA support for validations including reviewing protocols and reports
• Participate and support internal and external audits
• Provide support in review of specification and test methods
• Embody lean principles and methods while fostering a continuous improvement mindset

Qualifications

• Bachelor of Science degree required in a scientific discipline including pharmaceutical, biologics, or related field
• 5-8 years of cellular or biological manufacturing experience including quality assurance responsibilities or an equal combination of education and working experience
• Working knowledge of cGMP regulation
• Detail oriented team player with effective organization and execution skills
• Strong communication and writing skills with demonstrated ability to work as an individual contributor and in a dynamic team environment
• Must have the ability to stand for long periods
• Must be able to don and wear appropriate clean room attire and have the ability to wear all required Personal Protective Equipment (PPE)

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The goal of the Translational Research Model Services (TRMS) core is to provide access to immune deficient murine and specialized technical services for preclinical studies by investigators. The TRMS core maintains production colonies of immune compromised mice, and conducts a full range of xenografting, monitoring, imaging and tissue sampling services. The TRMS core is seeking a Research Technician I-II.

Responsibilities

Main responsibilities of the Research Technician will include murine husbandry and colony maintenance, including monitoring health and breeding status, weaning pups, maintaining electronic breeding records, and transferring for projects. Additionally, the Research Technician performs various technical services, such as injections, blood draws, and tissue harvests. The Research Technician will also assist in maintaining a core database, billing and other administrative duties.

Qualifications

MINIMUM QUALIFICATIONS:

• BA/BS in scientific field
• A minimum of one year of experience handling mice.
• Basic computer skills (Microsoft Office)
• Be well organized, maintain good records, and display excellent communication skills
• Must be able to work in a fast-paced environment

PREFERRED QUALIFICATIONS:

• Two or more years of experience handling mice
• Experience with technical procedures, such as injections and blood draws
• AALAS certification at ALAT level or higher

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.  #ZR

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

The Comparative Medicine Transporter Technician position assumes responsibility for transporting materials, people, and animals between various local locations as well as completing small and large animal husbandry duties, custodial care, supply distribution, and inventory duties for the department. This position is under supervision of the Animal Facility Managers. Knowledge of and adherence to department procedures and animal handling guidelines are essential.

The Transporter Technician is classified as essential personnel and, as such, is required to work with minimal amount of absences and during all Center closures except in the event of a major disaster when access to animal housing and use facilities is prohibited by governmental emergency personnel.

Responsibilities

PRIMARY JOB DUTIES

• Drive animals, personnel, equipment and supplies to and from Fred Hutch locations to other local locations (e.g. vivariums, storage, airport or other local facilities) to maximize operational efficiencies and effective use of care days. Maintain an understanding of differing destination site requirements and regulations.
• Promote interdepartmental communication and collaboration to ensure timely and accurate movement of animals between locations. Learn and develop familiarity with electronic communication systems used to schedule transport.
• Coordinate and collaborate with facility management and research staff to identify animals for transport. Help prepare animals for transport including but not limited to removal/return to appropriate cages and/or holding racks.
• Ensure paperwork accompanying animals on transport is complete and compliant with internal and external transport requirements.
• Coordinate vehicle availability and maintenance needs.
• Assist as necessary in transport and receipt of animals from external vendor sources.
• Learn to and become proficient in Personnel Protective Equipment policies and procedures throughout the animal facilities
• Maintain an understanding of effective and safe animal handling and disease management principles. Demonstrate safe and appropriate animal handling.
• Learn to and become proficient in effectively communicating with research staff through verbal, written, or electronic means. 

SECONDARY JOB DUTIES

• Provide care for all small animal species in accordance with standard operating procedures, providing feed and fresh water to animals and changing animal housing when necessary.
• Learn to evaluate animals’ general health, report abnormalities to the small animal veterinary technicians or veterinarian for veterinary evaluation. Learn to perform preventive animal health care duties and administer treatments as prescribed.
• Provide care for canines in accordance with standard operating procedures including cleaning and sanitizing canine enclosures, feeding animals (standardized and prescribed diets), assuring that animals have fresh water at all times, transferring animals to clean caging, performing complete housekeeping duties in animal housing areas and surrounding premises, performing laundry cleaning services, and bathing, and socializing of the canines.
• Preform housekeeping duties such as sweeping, mopping, garbage removal, and equipment washing in animal housing areas and surrounding premises.
• Maintain accurate records of animal identification, veterinary treatments, animal census, facility housekeeping, and room parameters (e.g. daily temperature high and low).
• Learn to and become proficient in appropriately mixing and use of all cleaning solutions according to established SOPs and/or manufacturers’ instructions.
• Learn to and become proficient in material management inventory control, notifying the supervisor or designated technicians of items that need to be ordered.
• Attend and participate in assigned training classes, and become familiar with, and learn to utilize web based DVMax and eSirius systems for record keeping and other uses.
• Work on call, weekend, evening, or holiday shifts as needed or as assigned.
• Perform other duties as assigned.

Qualifications

• High school diploma or equivalent
• Maintenance of a valid Washington State Driver’s License and good driving record
• Good verbal and written communication skills
• Ability to follow written and verbal instructions that are presented in English
• Ability to lift and move 50 lbs on a regular basis and sustained physical activities such as bending, balancing, stooping, reaching, and remain standing for long periods of time
• Ability to wear Personal Protective Equipment including scrubs, disposable coveralls, gloves, shoe covers, gowns, ear plugs / muffs, face mask, and eye protection
• Science and animal husbandry background including prior experience or education in animal care preferred

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.  #ZR

Overview

Fred Hutchinson Cancer Center is an independent, nonprofit, unified adult cancer care and research center that is clinically integrated with UW Medicine, a world leader in clinical care, research and learning. The first National Cancer Institute-designated cancer center in the Pacific Northwest, Fred Hutch’s global leadership in bone marrow transplantation, HIV/AIDS prevention, immunotherapy, and COVID-19 vaccines has confirmed our reputation as one of the world’s leading cancer, infectious disease and biomedical research centers. Based in Seattle, Fred Hutch operates eight clinical care sites that provide medical oncology, infusion, radiation, proton therapy, and related services, and network affiliations with hospitals in five states. Together, our fully integrated research and clinical care teams seek to discover new cures to the world’s deadliest diseases and make life beyond cancer a reality.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion. 

JOB SUMMARY

The pathologist will participate in our missions of pathology diagnostic service, research collaboration, and education. The Veterinary Pathologist works with other pathologists, faculty, post-doctoral students, and staff members to provide diagnostic and research support in scientific programs that involve experimental manipulations of laboratory animals for various clinical and fundamental studies in cancer and infectious disease biology and therapeutics. Additionally, the veterinary pathologist may interpret human based studies. The Veterinary Pathologists also work with the Comparative Medicine Director to maintain and improve services offered within the resource. The Veterinary Pathologist reports directly to the Director of Translational Pathology.

Responsibilities

The Veterinary Pathologist provides support and training for all relevant pathology cases as well as to help develop new pathology-inclusive initiatives for Comparative Medicine and Experimental Histopathology.

PRIMARY JOB DUTIES

• Characterize and write summary reports regarding experimentally induced and natural occurring diseases in laboratory mice, rats, dogs, and occasional other research animal species used in the Center’s scientific programs.
• Collaborate with the Center’s research investigators in planning and performing studies of non-human subjects.
• Utilize clinical, gross, microscopic, cytological, clinicopathological, imaging data, and basic molecular techniques, including in situ hybridization during review of pathology cases in order to make comprehensive assessments.
• Collaborate with the Center’s scientists to comprehensively assess the pathobiology of genetically engineered mouse models, including different methods of phenotypic expression.
• Assist in preclinical development and safety evaluation of new therapeutic compounds
• Advise regarding the microbiological monitoring program for the Center’s laboratory rodent colonies, including relevant laboratory test platforms run in-house.
• Provide training in the appropriate methods of systemic gross necropsy evaluation and tissue collection for pathology cases.
• Assist in the writing of grant applications and other narratives for purchase of new equipment, development of new pathology-inclusive initiatives, and summary progress reports of funded projects.
• Serve as a member of the Center veterinary team regarding diagnosis, treatment and prevention of spontaneous diseases in animals.
• Assist the Director of Translational Pathology with project-specific tasks to maintain the quality of the resource and the cost-effectiveness of facility operations.
• Work with Shared Resources administrative personnel to establish fee schedules and policies for internal and external users.
• Review and annotate digital scanned slides for TMA production.
• Assist Experimental Histopathology technical staff in IHC and ISH validation and interpretation.
• Collaborate with center scientists on the design and interpretation of multiplex digital images (IHC and/or ISH).
• Keep current in the field by maintaining contacts with colleagues, attending conferences, attending training sessions, and advancing the knowledge base to meet the research needs of the Center’s scientific programs involving animals.
• Perform other responsibilities as required or as assigned by the Director.
• It is anticipated that 20% time will be devoted to professional improvement including research, conference attendance, manuscript preparation, Continuing Education requirement maintenance and committee service among others.

Qualifications

• Possess a DVM or equivalent degree from a veterinary college.
• Have 1-3 years’ experience working with laboratory rodents, including transgenic, knockout, and immunodeficient strains of mice in a veterinary pathologist role.
• Possess board certification by ACVP or ECVP or be board-eligible.
• Be conversant in the technology required to produce and maintain genetically modified populations of rodents and in the genetic monitoring necessary to assure their integrity.
• Be able to accurately describe and interpret gross and microscopic morphologic findings, present a pathologic diagnosis(s).
• Make recommendations for subsequent investigative studies at the cellular, ultrastructural, and/or molecular level to support the morphologic evaluations.

Fred Hutch has a mandatory COVID-19 vaccine requirement, with exceptions only for approved medical or religious accommodations.
As a condition of employment, newly hired employees must provide proof of vaccination or initiate the accommodations process before their first day of employment.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.