Help us understand why some people get sick from the common cold more than others. We are currently recruiting about 200 people to participate in our study. We hope that this study may provide information to help with designing a vaccine for Rhinovirus or for other viruses. Rhinoviruses are responsible for causing 30-50% of common colds. Some people report getting a lot of colds each year while others report never getting sick.
This study will compare the immune response to the common cold (rhinovirus) between people who feel like they rarely have cold symptoms versus those who have them more often. We hope that by closely following the body’s specific immune responses in someone who has exposure to the common cold, we can better understand which responses may be required for a successful vaccine against the common cold.
Participants will be in the study for about a year. They will come to the clinic once at the beginning of the study and once at the end. During the 12 months, participants will fill out monthly surveys and collect nasal swabs if they have cold symptoms. Participants in the study will not receive any study drugs or vaccines.
Study visits will be conducted by the Vaccine and Infectious Diseases research team. The Vaccine and Infectious Diseases Division is a program of Fred Hutch and meet with study participants in the Fred Hutch Prevention Center.
Dr. Michael Boeckh is an expert in infections that affect patients whose immune systems are weakened by illness, chemotherapy or blood stem cell transplantation. His research focuses on herpes viruses, respiratory viruses and the genetic factors that make individuals susceptible to them. His group conducts clinical trials testing ways to prevent and treat infection by common viruses such as cytomegalovirus, respiratory syncytial virus, parainfluenza virus and rhinovirus.