Mahan Fellowship

**Please check back Fall 2021 for updates regarding the next application cycle**

The Herbold Computational Biology Program of Fred Hutchinson Cancer Research Center in Seattle, Washington invites applications for the Mahan postdoctoral fellowship. The fellowship will provide an exceptional individual with an early start on their career as an independent scientist by providing a 21-month stipend to pursue their proposed research project in the laboratory of a Fred Hutch Computational Biologist mentor.

Faculty of any discipline or rank from the Fred Hutch, UW, or any other institute may be proposed as co-mentors. The project must be focused on a topic of biological interest, must involve a computational or mathematical component, and may include an experimental component. A laboratory trained scientist may satisfy the computational and mathematical requirement by including a training component in their proposal. Computationally strong candidates may include a laboratory training component as well. The research direction should reflect the interests and ideas of the applicant, although the final research proposal may be jointly designed; see Additional Information for more details on the application process and for a list of potential mentors.

Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, the Center’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion. 

Please direct all questions to Melissa Alvendia, Computational Biology Program Operations Director.

Current Fellows

Yapeng Su

Yapeng Su

Project: Mapping cell-state transition trajectories of therapeutic T cells during adoptive cell therapy for solid tumors.

My research focuses on investigating the plasticity and heterogeneity of therapeutic T cells during adoptive cell therapy within solid tumors. I am working on using systems-level big data at bulk and single-cell resolution to map the signaling dynamics, epigenetic landscape of the therapeutic T cells within the context of the tumor microenvironment. Overall, my project will help us understand how to better engineering our T cells as a powerful weapon to treat cancer.

Previous Fellows

Past Mahan fellows brought scientific and academic perspectives from around the world. They explored a variety of biological topics, from infectious disease to genetic expression. Students have gone on to pursue careers in laboratory science, which some staying on at Fred Hutch labs.

Tal Einav

Tal Einav

Project: Modeling the complex web of our polyclonal immunity

I study the n-body problem of our immune system. How does human serum, with its millions of different antibodies, protects us against pathogens? A lot of groups are examining how single antibodies fight flu or HIV, but few are investigating collective antibody action. As the field moves in this direction, it will shed light on the full repertoire our immune system unleashes against viral invaders.

Guo-Liang Chew, Ph.D.

Guo-Liang Chew, Ph.D.

Project: Understanding the disparate effects of DUX4 misexpression in muscular dystrophy and cancer

It is paradoxical how the misexpression of the same gene (DUX4) can cause disparate cellular phenotypes in two different diseases: muscle wasting in Facioscapulohumeral Muscular Dystrophy (FSHD), but uncontrolled cell proliferation in a subtype of B-cell precursor Acute Lymphoblastic Leukemia (BCP-ALL). By analyzing the RNA expression in patient samples from both these diseases, Guo-Liang aims to understand the molecular basis of DUX4-induced pathology in both diseases, as well as to use the insights gained from one disease to develop therapies for the other.

Gytis Dudas, Ph.D.

Gytis Dudas, Ph.D.

Project: Sequence data analysis in emerging infectious disease outbreaks

Sequence data from emerging infectious disease epidemics are becoming a universal tool for gaining insight into how pathogens spread and how to control them efficiently. The project focused on rapidly evolving RNA viruses and how their evolution can be used to understand their patterns of transmission. The West African Ebola virus epidemic of 2013-2016 was a primary focus of the project, where the factors affecting the virus' ability to spread and proliferate within the region were determined. Simultaneously, in collaboration with Nathan Grubaugh and Kristian Andersen at Scripps, as well as researchers from University of Oxford, the project also investigated the nature of a Zika virus outbreak in Florida in 2016. The final part of the project focusing on reconstructing the epidemiology of Middle East respiratory syndrome-associated coronavirus (MERS-CoV) at the interface between its two known major hosts, humans and camels, is currently in review.

Ying Qi "Shirleen" Soh, Ph.D.

Ying Qi "Shirleen" Soh, Ph.D.

Project: Mapping host genetic barriers to zoonotic viral infection

My research focuses on how viruses such as influenza evolve to infect diverse host species. Zoonotic transmission of influenza from avian and swine hosts to humans have the potential to result in pandemics with severe public health consequences. I am working to map the evolutionary pathways by which influenza can adapt to new species, and using this map to assess adaptation and thus pandemic risk of novel influenza strains. Overall, these studies will help us understand the specifics of influenza adaptation, and more broadly, how viral evolution is shaped by host genetics.

Application Overview (CLOSED)

Qualifications

  • A Ph.D. awarded after June 2018 in a computational, quantitative or biological discipline.
  • The degree must be awarded prior to the start of the fellowship.
  • Applicants who have held faculty or scientific staff positions are not eligible. 

Key application dates

Pre-application Deadline:

December 11, 2020 (CLOSED)

Notifications to proceed with Full Proposals:

January 1, 2021

Full Proposal Deadline:

February 12, 2021 (CLOSED)

Notification of Final Selection:

March 1, 2021

Earliest Start Date

June 1, 2021


Pre-Application Phase (CLOSED)

Please submit a:

  • Curriculum vitae
  • 1-page (maximum) proposed research statement (not inclusive of references, tables and figures)
  • One letter of recommendation
  • Select a primary mentor (optional)

 

Take me to the Interfolio Application

Final Application Phase (if invited) (CLOSED)

Upon invitation by the review committee, please submit a:

  • Three to five-page (maximum) research statement 
    • Single-spaced
    • 11pt font size
    • Not inclusive of references, tables and figures
    • May be co-written with the proposed mentor
  • A 1-page (maximum) diversity, equity, and inclusion statement (see details below)
  • Two additional letters of recommendation.

Full proposals are due February 12, 2021.

Additional information:

  • The start date of the fellowship is flexible but should start within 1 year of the award.
  • Applicants may contact a potential mentor (see list below) but this is not required.
  • Mentors may be contacted to get a statement of interest in the area, to assess the lab resources to see if they are adequate, or other general questions. However, the research idea(s) in the research statement need to be substantively those of the candidate. 
  • Candidates who are invited to submit a full proposal may work more closely with the mentor at that time.

Eligible Faculty Mentors

Trevor Bedford           
Alice Berger               
Jesse Bloom              
Ivana Bozic (UW)
Phil Bradley                
Robert Bradley                       
Raphael Gottardo      
Gavin Ha
Kelley Harris (UW)
Ollivier Hyrien            
Georg Luebeck                                  
Erick Matsen  
Evan Newell                           
Armita Nourmohammad (UW)
Rasi Subramaniam     

Diversity, Equity & Inclusion Statement

Fred Hutch is committed to equity, diversity and inclusion. We ask that candidates submit a one- page statement that reflects upon their experiences and demonstrates a commitment to these issues. We are interested in learning how personal and/or professional experiences and events have shaped your perspective and what ideas you might implement as a post-doctoral fellow at Fred Hutch.   

Applicant Diversity, Equity & Inclusion Statement

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity, equity, and inclusion are critical to our mission of eliminating cancer and related diseases. We seek researchers who bring new ways of seeing the world and solving problems.  

Fred Hutch is committed to ensuring that all candidates hired for post-doctoral positions share our commitment to diversity, equity, and inclusion. In order to identify candidates who share this vision, we require all candidates to submit a personal statement describing their experience and commitment to these issues.

Reviewers of applications will consider a candidate’s statement as part of a comprehensive and transparent evaluation of their qualifications.

Guidelines for Writing a Diversity, Equity & Inclusion Statement

The Diversity, Equity & Inclusion Statement may include:

  • Description of the candidate’s commitment to diversity and inclusion.
  • Demonstration of candidate’s understanding of the importance of diversity and inclusion.
  • Description of the candidate’s commitment to mentorship particularly in relation to those underrepresented in science.
  • Description of your past efforts, as well as future plans to advance diversity, equity, and inclusion.


Preferably, candidates will leverage examples from both their personal and professional lives. This may include how these topics are integrated into the process or fabric of your approach to scientific problems or their applicability to underserved populations.

Mentoring/Tutoring:  This includes leading or participating in mentoring, advising, teaching, or tutoring activities for underrepresented groups (URGs) including colleagues, trainees, or the broader community.

Educational Outreach:  This includes outreach efforts aimed at underrepresented students; attendance at a conference aimed at recruiting, supporting or advancing URGs; participation in panels or talks as a speaker on related issues.

Committee Service: This includes serving on committees or boards that focus on diversity, equity, and/or inclusion.

Research Activities: This includes research (articles, editorials, etc.) relevant to health disparities and/or that contributes to understanding the barriers facing URGs in higher education or that otherwise contributes to diversity and equal opportunity.

Other (e.g. recruitment/retention/teaching): These include efforts to diversify your research group or lab; other efforts to diversify your department or field.

 

Contact Melissa Alvendia

Program Operations Director