As a program within the Biostatistics Program in the Public Health Sciences Division of the Fred Hutchinson Cancer Research Center, COMPASS has been directing multi-center studies in public health research for over 30 years.
The COMPASS organization grew out of our experience establishing and coordinating the Carotene and Retinol Efficacy Trial (CARET), a multi-center lung cancer prevention trial that began in 1983. Since that time, we have expanded and now manage several large-scale research networks and studies, including the Early Detection Research Network (EDRN), Population-based Research to Optimize the Screening Process (PROSPR), Transdisciplinary Research on Energetics and Cancer (TREC), New-Onset Diabetes (NOD) cohort, and Translational Liver Cancer (TLC) Consortium, and have been involved in numerous smaller collaborations.
PI: Chu Chen, Ph.D., N.R.C.C., D.A.B.C.C.
Co-Investigators: Gary Goodman, M.D., M.S.; Mark Thornquist, Ph.D.; Marian Neuhouser, Ph.D.; Charles Kooperberg, Ph.D.; Noel Weiss, D.P.H.
Visit the public website for CARET
The Carotene and Retinol Efficacy Trial (CARET) was a randomized, double-blind, placebo-controlled trial of the cancer prevention efficacy and safety of a daily combination of 30 mg of ß-carotene and 25,000 IU of retinyl palmitate in 18,314 persons at high risk for lung cancer. We studied two high-risk populations: 4,060 men with extensive occupational exposure to asbestos, and 7,965 men and 6,289 women with at least 20 pack-years of cigarette smoking history.
CARET began in 1985 with two pilot studies and expanded to six sites beginning in 1988. The CARET intervention was halted in January 1996, 21 months ahead of schedule, with the twin conclusions for definitive evidence of no benefit and substantial evidence of a harmful effect of the intervention on both lung cancer incidence and total mortality (NEJM 334:1150-5, 1996; JNCI 88:1550-9, 1996). Lung cancer incidence and cardiovascular disease mortality findings during the first six years of post-intervention follow-up were published in 2004 (JNCI 96:1743-50, 2004).
As of June 30, 2005, CARET stopped active follow-up of CARET participants. CARET continues to support the extensive biological repository and ancillary studies that utilize the CARET samples and data.
PIs: Ziding Feng, Ph.D.; Margaret Pepe, Ph.D.; Mark Thornquist, Ph.D.
Visit the public website for EDRN
The Early Detection Research Network (EDRN) is a national network funded in 1999 for the development, evaluation, and validation of biomarkers for early detection and risk assessment for cancer. Biomarkers are cellular, biochemical, molecular, or genetic alterations by which a normal or abnormal biologic process can be recognized or monitored. Biomarkers are measurable in biological media, such as fluids, tissues, or cells.
In addition to the National Cancer Institute (NCI), which funds the EDRN, there are four components to the network: Biomarker Development Laboratories, Biomarker Validation Laboratories, Clinical Validation Centers, and a Data Management and Coordinating Center (DMCC). Under the direction of Principal Investigators Ziding Feng, Ph.D., Mark Thornquist, Ph.D., and Margaret Pepe, Ph.D., the DMCC provides logistical, informatics, and statistical services to the EDRN.
The EDRN DMCC, funded in 2000, provides logistical support and coordination for 59 institutions in EDRN; coordinates meetings, conference calls, and workshops; develops and manages the EDRN secure website; develops and maintains, in collaboration with the Jet Propulsion Laboratories, the EDRN Research Network Exchange (ERNE); participates in the review of validation studies and associate member applications; manages and coordinates EDRN validation studies; develops and maintains the Validation Study Information Management System (VSIMS) for data collection and management; specimen tracking and study monitoring; and conducts statistical methodology research for EDRN.
The DMCC, operated by COMPASS, Fred Hutch, the University of Washington, and statisticians at the University of Texas MD Anderson Cancer Center, provides coordination and data management for the EDRN under the direction of the Steering Committee and develops statistical and analytical methods in response to the scientific needs of the network. Specific tasks performed by at the DMCC include:
PI: Ziding Feng, Ph.D.
For more information about participating in the NOD cohort, visit the public website
The New-Onset Diabetes (NOD) cohort is jointly funded by NCI and NIDDK and is part of the Consortium for the study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). The CPDPC sub-contracted NOD coordination to the Early Detection Research Network - Data Management and Coordinating Center. The goals of NOD are to prospectively assemble a cohort of subjects >50 and ≤85 years of age with New-Onset Diabetes (NOD), called the NOD Cohort, in order to:
PIs: Christopher Li, M.D., Ph.D.; William Barlow, Ph.D.; Yingye Zheng, Ph.D.
Visit the public website for PROSPR
The Population-based Research to Optimize the Screening Process(PROSPR) is a National Institutes of Health (NIH)-funded initiative with seven Research Centers and one Statistical Coordinating Center. The PROSPR Statistical Coordinating Center (SCC) established and operates a repository for pooled data (gathered by Research Centers) on the screened populations, the screening process, and clinical outcomes involving breast, cervical and colorectal cancers. The Statistical Coordinating Center:
PI: Mark Thornquist, Ph.D.
The Transdisciplinary Research on Energetics and Cancer (TREC) was a National Institutes of Health (NIH) initiative that supported eight Research Centers and one Coordination Center in two separate funding cycles, 2005-2010 and 2011-2016. The TREC Coordination Center, in partnership with the four Research Centers in each grant cycle, fostered collaboration among transdisciplinary teams of scientists with the goal of accelerating progress toward reducing cancer incidence, morbidity, and mortality associated with obesity, low levels of physical activity, and poor diet. The Centers also provided training opportunities for new and established scientists who could carry out integrative research on energy balance and cancer outcomes. The TREC initiative complemented NCI’s other energy balance research endeavors as well as efforts of the NIH Obesity Task Force. COMPASS served as the Coordination Center (CC), by supporting communication, dissemination, data sharing, and collaboration across the TREC initiative in both cycles, and continued until May 31, 2017."