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13 Found open positions

Post-Doctoral Research Fellow - Emerman Lab

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18579

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment. This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits. Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency. Expectation is to develop an independent project within the context of the grant. The responsibilities include those expected at a PhD level, including leading the technical aspects of the study, contributing intellectually to the overall study design, interpreting data, presenting the findings at meetings and writing manuscripts.

Responsibilities

A laboratory in the Human Biology Division at Fred Hutchinson Cancer Research Center is seeking a Post-Doctoral Fellow to work with an interactive collaborative team of scientists investigating the mechanisms of HIV-1 latency using CRISPR screens and validation in primary cell models of HIV latency. The applicant should be well organized, pay close attention to detail, be reliable and motivated to participate in multiple levels of lab activity. The fellow will perform standard routine and investigative laboratory work in support of scientific research specific to HIV latency and CRISPR screens.

 

Major duties:

  • Preform experiments at the bench level to support investigative work, potentially including, but not limited to molecular biology, viral infections and assays, DNA sequencing, PCR amplification, RT-PCR amplification, TC culture, BLS2/3 work, including making virus stocks and performing viral infection
  • CRISPR/Cas9 screening and editing, and analysis of results
  • Experiments with primary T cells
  • Recover, compile and verify accuracy of research data
  • Operate analytical instruments
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Present data at local and national meetings
  • Prepare manuscripts describing the data and their meaning to the field

Qualifications

Educational or Special Training Qualifications

  • Applicants must have a PhD (or equivalent degree) in Biomedical Sciences and basic techniques in molecular biology. Ability to think critically and design and interpret experiments is essential, as are strong communication skills.

 

Experience Requirements

  • Experience with molecular biology and biochemical methods
  • A strong interest in research in the area of HIV biology and HIV latency, infectious diseases and global health
  • Evidence of productivity appropriate to a postdoctoral fellow as measured by publications and presentations, abstracts and posters at conferences
  • Well-organized with strong attention to detail
  • Ability to work independently and perform experiments without day-to-day supervision will be required after training
  • Ability to work as part of a team and to participate in multiple projects in collaboration with different lab members and collaborations with outside labs


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Biology of Small Cell Lung Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17590

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Responsibilities

A Postdoctoral Fellow position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered mouse (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. Our lab works closely with thoracic oncologist collaborators at the Seattle Cancer Care Alliance to access patient samples and to help translate basic findings (e.g. see Augert et al, 2019, Science Signaling “Targeting NOTCH Activation in Small Cell Lung Cancer Through LSD1 Inhibition”). Some of these directions are supported by an NIH Lung Cancer SPORE award that promotes translational lung cancer research.  We are also interested in understanding basic mechanisms underlying SCLC tumor suppressor and oncogene function (e.g., see Augert et al, Cancer Cell 2020, “MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer” and Jia et al, 2018, Cancer Discovery “Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition”.) We are increasingly performing functional screens in vivo and in tissue culture cells applied to cells to understand genes important for SCLC and to identify new druggable vulnerabilities.  The specific project will be developed by both the candidate and Dr. MacPherson based on areas of shared interests.

Qualifications

  • Recent PhD in Biology or related fields
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • A record of publication in peer reviewed journals

Please include a cover letter detailing your research interest and suitability for this position and names and contact information of at least two references with your application. 

Post-Doctoral Research Fellow, Cancer Biology

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18366

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

A postdoctoral research position in cancer biology with a focus on single-cell and functional genomic technologies is available at the Fred Hutchinson Cancer Research Center. The Hutchinson Center provides a challenging academic and supportive multi-disciplinary research environment.

 

We are seeking a recent or prospective doctoral graduate (Ph.D. or equivalent qualification) with a background in cell and molecular biology and/or related subject areas to cancer biology, epigenetic regulation, and single-cell genomics. Candidates should have an interest in the investigation of novel, interdisciplinary research questions related to mechanisms of tumor cell quiescence and cell cycle egress/ingress.

 

This position will be under the direction of Drs. Patrick Paddison, Professor of the Human Biology Division, and Anoop Patel, affiliate member of the Human Biology Division and Assistant Professor in the Department of Neurological Surgery (UW).  For this project, the team also includes a staff scientist, post-doc, technician, and Dr. Eric Holland, director of the Human Biology Division at Fred Hutch.

 

The Postdoctoral Research Associate will be co-mentored by Drs. Paddison and Patel and engaged in studying novel regulators of tumor cell quiescence. Work includes use of single-cell genomic and functional genetic tools in animal models and human samples.

Qualifications

  • A Ph.D. or equivalent degree is required with background in cell and molecular biology, cancer biology, and/or functional genomics
  • Experience with single-cell genomic methodologies and analysis is preferred
  • Experience with in vivo murine models of cancer is preferred
  • The candidate must show initiative, the willingness to take up new skills and responsibilities, and be a team player
  • Excellent attention to detail and the ability to work independently are essential to success in this position, as are good communication and organizational skills
  • Demonstrated ability to work well within interdisciplinary teams and collaborations


Applicants must submit:

  • Cover letter discussing your interest in this position
  • Curriculum Vitae


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Intratumoral Microbiome Environment

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18038

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.



The Bullman Laboratory is an interdisciplinary and highly collaborative team of clinical microbiologists, computational biologists, biochemists and cancer geneticists. The core mission of our laboratory is to improve diagnosis and treatment of human cancer to ultimately extend the lives of cancer patients, with a particular focus on gastrointestinal cancers. Using cutting edge technologies and methodologies, we endeavor to move smoothly between large human data sets and in vivo and in vitro model systems to gain a deeper functional understanding of the tumor microbiota in cancer progression, metastasis and response to treatment

Responsibilities

The Bullman Laboratory in the Human Biology Division at the Fred Hutchinson Cancer Research Center is recruiting a highly motivated Postdoctoral Fellow with expertise in murine models of cancer and mammalian cell biology to join our tumor microbiome efforts. An interest in microbiome research is required but hands on experience is not required as ample training can be provided.

 

Our goal is to understand the interaction of the colon cancer microbiota with the tumor microenvironment. This individual will utilize state-of-the-art spatial imaging technologies, in addition to genomics and informatics techniques in a highly collaborative, stimulating, and collegial research environment. This position will provide opportunities for professional development and the acquisition of cutting-edge skills in single cell sequencing, small molecule screens, analysis of clinical specimens, tissue imaging approaches, host-microbiome interactions, research planning and strategy, and data analysis and interpretation.

Qualifications

Please include a cover letter with your application, detailing your interest and suitability for this position.

 

Minimum qualifications:

  • PhD in biological sciences, cancer biology, computational biology, pathology, microbiology, or a related field
  • A record of scientific accomplishment as shown by peer-reviewed publication
  • A collaborative, curious, creative, proactive and organized temperament
  • A commitment to advancing fundamental knowledge of the cancer microbiome and to translating that knowledge to the development of novel therapeutic approaches

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Lee Lab

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18251

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The Lee Lab in the Human Biology Division at Fred Hutch is seeking a postdoctoral fellow. This is a laboratory-based science position that focuses on delineating the molecular mechanisms of advanced bladder cancer with the opportunity for translational studies evaluating the efficacy of novel therapeutics. This position works under the direction of Dr. John K. Lee and uses discretion and judgment in performance of duties.


The major focus of the Lee Lab is to understand the biological determinants of aggressive prostate and bladder cancer and to exploit inherent molecular vulnerabilities in these diseases. Particular areas of emphasis include characterizing the functional contribution of specific oncogenic events to cancer initiation and progression, identifying cancer differentiation-specific cell surface antigens, and developing immune-based strategies for precision cancer medicine.

 

The position requires a prior record of scientific productivity, excellent communication skills, and scientific ambition. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cancer biology, drug screening, and the evaluation of novel therapeutics in preclinical models. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

Qualifications

  • Ph.D degree in molecular biology, cell biology, immunology, genetics or a related field with a track record of high-quality publications is required
  • Experience in one of the following areas is required: bioinformatics, biomarker characterization, antibody therapy, adoptive T cell therapy, or analysis of immune cell subsets. Knowledge/exposure in cancer biology, genomics, transcriptomics, proteomics, biobanking, murine xenograft models, and biostatistics is desired. Expertise in molecular and cellular biology techniques – molecular cloning, cell culture, immunoblotting, immunohistochemistry, flow cytometry, ELISA, cell viability and cytotoxicity assays is a prerequisite.
  • Attention to detail, time management skills and a collaborative disposition
  • Excellent verbal and written communication skills

 

Application instructions:

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Pancreas and Biliary Cancer Pathogenesis

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18070

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


 

Responsibilities

The Kugel Laboratory is seeking a highly motivated postdoctoral fellow interested in exploring how the dysregulation of chromatin modifying enzymes and developmental pathways contribute to pancreas and biliary cancer pathogenesis and, further, whether these pathways present liabilities that can be exploited for cancer therapy.

 

Successful candidates will learn to generate and exploit a series of cancer model systems including genetically engineered murine models (GEMMs), patient-derived xenografts and novel human cancer cell lines to understand fundamental pathogenic mechanisms underlying pancreatic cancer. To answer these questions the laboratory uses state-of-the-art techniques in murine models and genetics, molecular biology, cell biology, biochemistry, metabolism, RNA profiling, proteomics, pharmacology, genomics and computational biology.

Qualifications

Qualified applicants will have recently obtained a PhD and/or MD or be nearing completion of their graduate studies and have an interest in cancer research. A track record of productive research is strongly preferred. Applicants with specific expertise in RNA biology, biochemistry, cell biology, cancer genomics, murine models or computational biology are highly encouraged to apply. Proficiency in written and verbal English is required. Fellowship opportunities are available through several philanthropic and government organizations; and recruits who join the lab will be supported in their applications.

 

Please apply by submitting a CV, a brief description of past research experiences and future goals (not more than 1-2 pages) and contact information for three references.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow- Galloway Lab

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18074

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


A highly motivated Post-Doctoral research fellow is sought to carry out research in the laboratory of Dr. Denise Galloway at Fred Hutchinson Cancer Research Center in Seattle, WA. Recent postdocs or graduate students at the end of their training program, who are eligible for participation in NIH-funded training grants and fellowships, are especially encouraged to apply.

 

The primary focus of the Galloway lab is the role that small DNA viruses, such as human papillomavirus (HPV), and Merkel Cell polyomavirus (MCPyV) play in cancer. We have taken a broad approach including mechanistic studies into how viral oncoproteins contribute to neoplasia and molecular epidemiologic studies into the natural history of viral infections and risk factors associated with cancer development. We are currently studying 1) the long-term memory to HPV vaccination or infection; 2) mechanisms by which high-risk HPVs perturb the response to DNA damage.; and 3) the functions of a newly identified protein, ALTO, in the MCPyV life cycle.

Responsibilities

The fellow will focus on HPV biology, investigating the mechanisms by which the E6 and E7 oncoproteins perturb the response to DNA damage. In addition to performing research the post-doc will have the opportunity to present their work at local and other meetings.

Qualifications

Successful applicants will have:

  • A recent PhD in a relevant biological field
  • A strong background in standard molecular/cellular biology techniques
  • Extensive experience with tissue culture
  • Experience with genome analysis, RNAi technology, and developmental virology is highly desirable
  • A demonstrated track record of productive research, with at least 2 first author publications
  • An ability to work independently as well as part of laboratory team

Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.


statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Postdoctoral Research Fellow, Geballe Lab

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18196

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A postdoctoral position is immediately available in the Geballe Lab at the Fred Hutchinson Cancer Research Center. The Geballe Laboratory studies the roles, mechanisms and evolution of antagonism of host cell defenses during infections by large DNA viruses, especially herpesviruses and and vaccinia virus. Additional project focus on control of gene expression at the translational level.

Responsibilities

The postdoctoral scientist will initially join in ongoing projects focusing either on foreign nucleic acids sensors and viral genes that inhibit these sensors or on translational control of viral gene expression.  Later, they will be expected to develop a new independent project within general area of host viral interactions and mechanisms and evolution of viral antagonism of host defenses. 

 

Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals. In addition, both the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.


Scope of responsibilities:

Applicant will design, conduct, analyze and report original experiments probing the mechanisms and evolution of viral antagonists of host defense systems or the regulation of translation by viruses.  This position is funded for at least 2 years but with the possibility of additional years, depending on success in obtaining independent funding.


Job duties:

  • Design, conduct, interpret experiments focusing on the molecular biology and virology of virus-host interactions
  • Experiments require work with BSL2 viruses, so must be able to work carefully and comply with biosafety regulations
  • Participate in group meetings including presentations several times each year
  • Prepare publications results from the experiments
  • Assist in maintaining general operations of the laboratory
  • Aid in mentoring junior scientists
  • Apply for postdoctoral grants

Qualifications

  • Highly motivated and careful scientist who is able to work independently as well as part of a team
  • PhD with experience in virology, including studies of host defenses, and molecular biology.  Experience in biochemistry, computational methods, and translational control mechanisms would be advantageous.
  • Experience with BSL2 containment methods
  • Familiarity with intrinsic host defense systems such as the interferon pathway
  • Excellent verbal and written communication skills are required

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Administrator III-IV

FH Human Biology Division
Category: Grants and Contracts
Seattle, WA, US
Job ID: 18550

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The Division of Human Biology seeks a Research Administrator III-IV with 3-5 years of experience to proactively provide a full range of fiscal, regulatory, and general administrative services for the Principal Investigators of the Prostate Cancer Program. This position reports directly to the Associate Operations Director, but will operate autonomously in executing the bulk of their responsibilities. The incumbent will collaborate with PIs, laboratory staff, and other departments (internal and external) to provide effective and efficient support and develop solutions to identified departmental and Programmatic issues. Additionally, this position will work with Programmatic staff to develop and execute strategic planning goals as well as participate in Division-centered initiatives.

 

Budget/Fiscal Management

  • Participate in yearly fiscal planning for the Department
  • Develop, monitor, track, and project the budgets for a complex portfolio of projects with multi-variable aspects (multi-site, international subawards, etc.)
  • Provide financial analysis and advice to PIs for all funding sources
  • Develop customized report formats to share information with broad audiences across the organization

Funding Source Administration

 

Lead the process of preparing grant submissions and post award activities by conducting tasks such as:

  • Working with faculty to develop strategies for responses/requests
  • Completion of all technical/non-scientific steps and assigned technical or scientific portions of submissions 
  • Prepare and review budgets, identify discrepancies and provide recommendations to the PI on scenarios to resolve the issues with appropriate stakeholders

Regulatory Support 

  • Prepare/Consult/Advise PIs on non-scientific portions of regulatory applications/submissions
  • Identify missing regulatory components that are required and resolve issues to ensure successful submission or renewal
  • Serve as a central point of contact to answer questions and facilitate solutions for associated internal (IRO, OSR, EHS) and external (ACURO, HRPO) departments
  • Determine impact of and develop implementation plans in response to applicable regulatory changes and/or revisions to Center policies and procedures

Administrative Support

  • Identify administrative needs and work collaboratively with the Program and Division to streamline and/or resolve problems
  • Monitor publications for compliance with NIH Public Access Policy
  • Oversees the management of projects including occasional event planning and coordination
  • Assist with HR issues (onboarding, offboarding, recruitment)
  • Communicates with other departments/entities on Primary Investigator (PI)’s behalf

Leadership

  • Act as a divisional resource and assist with training for lower level staff

Qualifications

Required

  • High School diploma or equivalent required. Associate or Bachelor’s degree preferred
  • 3 to 5 years of grants administration in pre and post award, ideally in a research or not-for-profit environment preferred
  • Experience in participating in and executing strategic plans
  • Technical and computing expertise sufficient to independently utilize a variety of electronic or web-based systems
  • Advanced knowledge of Excel formulas and functions, and proficiency with Microsoft Office Suite/Adobe
  • Superior written and verbal skills, with the ability to tailor communications to specific audiences
  • Ability to navigate complex internal systems and departments while exercising sound judgement and discretion
  • Familiarity with relevant regulatory guidelines (IRB, IACUC, MUA)
  • Ability to work collaboratively to achieve results in high-stress, deadline-driven situations
  • Multi-project grant experience; experience with P50/P01/U54 awards desired
  • Excellent time management and organizational skills
  • Ability to appropriately interpret and implement relevant regulations
     

Preferred

  • Experience with complex DOD, NIH, and Foundation awards

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I - II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18207

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Geballe Laboratory studies the roles, mechanisms and evolution of antagonism of host cell defenses during infections by large DNA viruses, especially herpesviruses and and vaccinia virus. Additional project focus on control of gene expression at the translational level.


The Research Technician is responsible for performing standard investigative laboratory experiment work in support of scientific research in virology, virus evolution, and virus-host cell interactions. The job will entail performing experiments, operating analytical instruments, compiling and verifying the accuracy of research data, performing calculations, preparing charts, graphs, summaries and presentations.

Responsibilities

The technician works under the direction of the Principal Investigator or higher-level laboratory personnel. The ideal candidate uses discretion and judgment in performance of duties. The work will require working with viruses, including herpesviruses, in cell culture and molecular and cell biological methods to dissect interactions of host cellular defenses and viruses and to investigate translational control mechanisms used by DNA and RNA viruses


Job Duties

  • Research Technician I
    • Conduct molecular biological and virological experiment under direction of higher-level personnel
    • Maintain clear and accurate laboratory notebooks documenting experimental details and results
    • Participate in lab research meetings, including presenting to small groups of scientists
    • Assist in publication of results by proofreading and editing
    • May manage research data bases
    • Assist in general laboratory duties
  • Research Technician II: same as duties for Research Technician I plus:
    • Identify methodological problems in research protocol and implement modifications to optimize experimental results
    • Assist in the design of experiments
    • May be responsible for the performance of individual research projects
    • Conduct literature reviews to assist in determining most suitable methods to be used in research
    • Assist in publications by literature reviewing and contributing ideas
    • Assist in training new personnel

Qualifications

Self-motivated, curious candidates who are eager to learn and contribute, with excellent organizational skills, written and oral communication skills, and those who work well in a multidisciplinary team environment are encouraged to apply. This position requires a bachelor’s degree in a biological science and some research experience. To be successful in this position, the technician must be highly motivated, take a high level of initiative, work carefully, and keep detailed accurate records. They must also be capable of working independently and with other team members and have excellent interpersonal skills.

 

Research Technician I minimum qualifications

  • BA/BS in a relevant scientific field required
  • Must have scientific knowledge of molecular and cellular biology and virology
  • Must have some experience in molecular biology, cell culture and/or microbiology in a laboratory setting

 

Research Technician II minimum qualifications – As for Research Tech I plus:

  • 2 years previous experience working in a laboratory, including experience with cell culture and/or molecular biological techniques

 

Preferred qualifications:

  • Knowledge and training in virology, especially herpesvirology
  • Comfort with math, statistics, and common molecular biology software
  • Cell culture experience

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I-II, Pancreas and Biliary Cancer Pathogenesis

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18333

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The Kugel Laboratory is accepting applications for a Research Technician position. The laboratory uses basic and translational research approaches to explore pathogenic mechanisms and novel targeted therapies in cholangiocarcinoma, a highly lethal malignancy of the liver bile ducts. Successful candidates will learn to generate and exploit a series of fundamental cancer model systems including genetically engineered murine models (GEMMs), patient-derived xenografts and novel human cancer cell lines.

 

In addition, the incumbent will have the opportunity to become involved with all the steps of research being completed by the group and contribute to publications, with the ultimate goal of translating their findings into novel clinical trials for cholangiocarcinoma patients. Scientific methodologies and areas of focus include animal models and murine genetics, molecular biology, cell biology and metabolism, proteomics, biochemistry, pharmacology, and genomics. The experience gained in the lab will useful for pursuing a career as a researcher or physician. 

Qualifications

Required:

  • A bachelor’s degree in biology, molecular biology, biochemistry or related fields
  • The ideal candidate will be detail-oriented, organized, and able to work independently as well as part of a team in a challenging environment
  • Excellent communication and organizational skills are necessary
  • Significant research experience outside of coursework (less than two years for research technician I and more than two years of professional experience for research technician II)

 

Preferred:

  • Experience with mammalian cell culture and murine models is desirable.

 

Application Instructions:

Please apply by submitting your resume and a brief letter of intent (less than one page).  Recent college graduates are encouraged to apply.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14811

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.

Responsibilities

The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Perform other duties as required
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
  • Assist in the design of experiments; may be responsible for the performance of individual research projects
  • Conduct literature reviews to assist in determining most suitable methods to be used in research
  • Assist in publication of results by proofreading, editing, and contributing ideas
  • May perform statistical analyses, write computer programs, or manage research database

Qualifications

Required:

  • Bachelor’s degree in Biology, Biochemistry or related field in life sciences
  • At least two years’ experience working in a laboratory
  • Independent research experience outside of laboratory course work
  • Experience with standard molecular biological techniques (DNA and RNA extraction) and biochemical approaches (gel electrophoresis, immunoblotting, immunoprecipitation)
  • Attention to detail, time management skills and a collaborative disposition

 

Preferred:

  • Murine handling experience
  • Mammalian cell culture experience

 

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

Research Technician II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18275

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



This position will support projects to discover and characterize new antiviral factors. Lab tasks including CRISPR knock outs, PCR, DNA sequencing including next generation library preps, cell culture experiments, transformations, ligations, bacterial culture, minipreps, transfections, Western blot. Antiviral immune responses studied may include those that inhibit HIV, ZIKA and/or Coronaviruses. Data and samples must be well-organized and precisely tracked. The most critical qualities in a successful candidate will be organization, precision, and initiative.

 

Under the direction and close supervision of the Principal Investigator or higher-level laboratory personnel in the lab, the applicant will gain practical experience in the following areas:

  • coordinating and performing support for a research laboratory that focuses on understanding innate immune responses to HIV and other viral infections
  • performing state of the art CRISPR screening, in some cases in primary cell systems and validation of genes identified in such screens. Other basic molecular biology techniques will be developed as part of this work, including including learning the basics of molecular cloning, PCR, DNA sequencing, RT-PCR, flow cytometry, cell culture and transfection, and data analysis.

Responsibilities

  • Perform CRISPR KO screens and individual KOs
  • Culturing of cell lines and primary T cells
  • Prepare libraries for Illumina sequencing and analyze deep sequencing data
  • Perform RNA seq
  • Perform Western blots and other methods to measure gene/protein inactivation
  • Perform molecular biology techniques such as PCR, RT-PCR, and ddPCR
  • Assist with molecular cloning and tissue culture for a variety of projects, including studies of viral antibodies and the viral reservoir
  • Maintain laboratory records and compile and verify the accuracy of data on experiments and assays
  • Present experimental results in both oral and written report
  • Perform other related duties as assigned
  • Keep up to date on literature related to research projects

Qualifications

Minimum qualifications:

  • BS required with extensive knowledge of cell and molecular biology
  • Minimum of 2 years experience working in a laboratory
  • Some scientific knowledge of virology and/or immunology is desirable
  • Some experience with large data sets is desirable
  • Must have sound laboratory skills, including molecular techniques and cell culture
  • Must demonstrate exquisite organizational skills, laboratory precision, reliability and work initiative required to operate with minimal daily supervision
  • Previous research experience in a BSL 2 laboratory, including tissue culture work is desirable
  • Willingness to work in a HIV laboratory after suitable training (BSL2+)


Preference will be given to candidates with experience in the following areas:

  • Scientific knowledge of virology, immunology and/or RNA sequence analyses
  • Previous laboratory experience (experiment design, execution, optimization, troubleshooting, data analysis)
  • Demonstrated competence in careful and critical experimental design and execution.
  • Lab management (inventory, ordering, equipment maintenance, etc.)


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

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