Human Biology Job Openings

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14 Found open positions

Bioinformatics Analyst II, Prostate Cancer Program

FH Human Biology Division
Category: Biostatistics, Bioinformatics and Computational Biology
Seattle, WA, US
Job ID: 13880

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Computational Biologist/Bioinformatics Analyst position in the Prostate Cancer Program (Peter Nelson, Michael Haffner, John Lee, and Valeri Vasioukhin) in the Division of Human Biology is available immediately. We are seeking a highly motivated individual who is interested in studying the genetics and epigenetics of cancer including single cell analysis using computational approaches. Candidates who are excited about large/complex ‘omics’ data analysis and cancer research are encouraged to apply. The position has a competitive salary with great benefits.

 

The Prostate Cancer Program uses new DNA sequencing technologies to study cancer genomes. The lab is also focused on research involving liquid biopsies, such as cell-free DNA and circulating tumor cells, and developing new computational approaches to leverage these data for genome discovery and cancer burden monitoring. The research interests/projects in the prostate cancer program include:

  • Analysis of cancer genomes to understand tumor progression/evolution, metastatic disease, non-coding genome alterations, copy number alterations, genome rearrangements and 3D structure, mutational signatures.
  • Development and analysis of sensitive approaches to detect tumor-derived DNA in cell-free DNA from patient blood plasma.
  • Analysis of tumor microenvironments and tumor heterogeneity using single-cell RNA sequencing.
  • Validation of genomics results using functional experiments.
  • Cancer immunotherapy
  • Development and analysis of preclinical models of cancer
  • Digital spatial profiling of multiple RNA/Protein markers

 

Candidates with strong interest and/or expertise in any of these research areas are highly encouraged to apply:

  • Cancer genomics, liquid biopsies, tumor evolution/heterogeneity, single-cell transcriptomics
  • Application of statistical modeling, algorithm design, artificial intelligence to study cancer and genetics
  • Analysis of large, complex genome, epigenome or transcriptome data

Qualifications

Applicants must have at least a Bachelor’s degree in one of these disciplines: computational biology, bioinformatics, computer science, data science, statistics, biostatistics, biomedical engineering, computer/electrical engineering, physics, or other related fields.

 

Applicants should have some of the following skills and experience:

  • Work well in team environments; strong communication skills; detail-oriented
  • Strong programming experience (R, Python, Matlab, Java, C/C++, Perl or other languages for research)
  • Experience with high performance computing environments or cloud computing environments is a plus
  • Experience with analyzing sequencing data is considered a strong asset.

 

To apply, please submit your application with the following:

  • Cover letter describing your experience and/or research interests
  • CV
  • Example of your code either as (1) an attachment or (2) link(s) to public repositories (e.g. GitHub)
  • Names and email addresses of three references

Lab Aide (Work Study), Prostate Cancer Program

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14088

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Vasioukhin Laboratory in the Prostate Cancer Program at Fred Hutch laboratory is recruiting a part-time work-study student to assist with ongoing studies.

Responsibilities

  • DNA extraction
  • PCR amplification
  • Gel analysis
  • Interpretation of results

Qualifications

  • Completion of a high school degree.
  • To be considered for this position, the applicant must be a current college student with work-study funding from the institution’s financial aid office.
  • The student must have work-study funding for the academic year. In addition, the student must have had biology coursework and knowledge of the basic laboratory techniques.

Post-Doctoral Research Fellow in Molecular Virology, Biochemistry and Biophysics

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 10974

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow.

 

A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin (Nature 2016, J. Virol 2017, Mol Cel Proteomics 2017). Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.

 

Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.

 

Additional information about research in the Avgousti lab can be found at:

https://research.fhcrc.org/avgousti/en.html

Responsibilities

The successful candidate will work on collaborative projects in the Avgousti Lab primarily focused on, but not limited to, the understanding the dynamics of protein VII-DNA complexes, protein VII-nucleosome complexes, binding partners and the impact of mutations on viral infection. Candidates should have excellent communication skills, value teamwork and can thrive in a fast-paced environment. 

Qualifications

We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Preference will be given to candidates with a background in structural biology for the study of viral proteins by crystallography or other biophysical techniques. Virology knowledge is beneficial but not required. Interested candidates should submit a CV, a summary of research experience and interests, and contact information for three references.

Post-Doctoral Research Fellow, Cancer Genetics

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12348

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A postdoctoral position is available in the MacPherson Lab at Fred Hutchinson Cancer Research Center. The project will focus on small cell lung cancer (SCLC), a neuroendocrine tumor type that exhibits initial sensitivity to chemotherapy but invariable emergence of chemoresistance. Our lab is interested in linking specific gene mutations in SCLC to therapeutic vulnerabilities and to chemoresistance. We have developed a panel of new genetically engineered murine models (e.g. see Jia et al, 2018 Cancer Discovery) and patient derived xenograft models that can be used in these efforts.  Many projects in the lab incorporate genome-wide functional screens in cells and in vivo.  These screens are used to identify functionally important genes for SCLC and genetic vulnerabilities that might lead to new avenues to therapeutically target SCLC.  One available project includes interrogating the importance of candidate SCLC driver genes and linking specific SCLC-mutated genes to novel therapeutic approaches. Hits identified through functional screens are followed by therapeutic studies that employ GEM and PDX model.  A second available project applies in vivo genome-wide screens to understand drivers of chemoresistance.

Qualifications

We are looking for a highly motivated individual with a PhD or MD and interests in cancer genetics, epigenetics, murine models, functional screening and/or therapeutics. The candidate should be able to drive an individual project but also be highly collaborative.  A strong foundation in molecular and cell biology is essential. The candidate should be independent, enthusiastic and scientifically rigorous.

 

Please include a cover letter detailing your research interest and suitability for this position and names of at least two references with your application. 

Post-Doctoral Research Fellow, Epithelial Growth in Development and Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13660

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Beronja Lab in the Human Biology Division at Fred Hutchinson Cancer Research Center is looking for a recent MD, PhD, or MD/PhD graduate to join our growing research program. We employ mouse models of epithelial cancers, rapid gene targeting in skin, oral and mammary tissues, and intravital microscopy to identifying molecular and cellular mechanisms of tumorigenesis.

Qualifications

MD, PhD, or MD/PhD in biology or related field is required.


Candidates should have an outstanding record of research productivity. A skill set that includes molecular and biochemical techniques, microscopy, and bioinformatics is a plus. A strong work ethic, eagerness to learn, and a passion for science are essential.


To apply, please submit your CV, a cover letter detailing your research accomplishments as well your interest in the Beronja Lab research program, and contact information for three references.

Post-Doctoral Research Fellow, Functional Cancer Genomics

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13071

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp. The ideal candidate will have a formal background in cancer biology, expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. 

Responsibilities

The applicant will apply state of the art functional genomic and high-throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network. We currently have identified several high-value targets that are in stages of validation in patient derived tumor organoids.

Qualifications

Minimum qualifications:

  • A PhD in molecular biology, biochemistry, cancer biology, genetics, or related discipline.
  • Demonstrated track record of productive, independent research.

Preferred qualifications:

  • Experience with drug development would be a plus.  

To apply, please submit your CV and a cover letter detailing your research accomplishments, and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.

Post-Doctoral Research Fellow, HPV and DNA Damage

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12864

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

A highly motivated Post-Doctoral research fellow is sought to carry out research in the laboratory of Dr. Denise Galloway at Fred Hutchinson Cancer Research Center in Seattle, WA. Recent postdocs or graduate students at the end of their training program, who are eligible for participation in NIH-funded training grants and fellowships, are especially encouraged to apply.


About the Galloway Lab:

The primary focus of the Galloway lab is the role that small DNA viruses, such as human papillomavirus (HPV), and Merkel Cell polyomavirus (MCPyV) play in cancer. We have taken a broad approach including mechanistic studies into how viral oncoproteins contribute to neoplasia and molecular epidemiologic studies into the natural history of viral infections and risk factors associated with cancer development. We are currently studying 1) the long-term memory to HPV vaccination or infection; 2) mechanisms by which high-risk HPVs perturb the response to DNA damage.; and 3) the functions of a newly identified protein, ALTO, in the MCPyV life cycle.

 

Responsibilities

The fellow will focus on HPV biology, investigating the mechanisms by which the E6 and E7 oncoproteins perturb the response to DNA damage. In addition to performing research the post-doc will have the opportunity to present their work at local and other meetings.

Qualifications

Successful applicants will have:

  • A recent PhD in a relevant biological field
  • A strong background in standard molecular/cellular biology techniques
  • Extensive experience with tissue culture
  • Experience with genome analysis, RNAi technology, and developmental virology is highly desirable
  • A demonstrated track record of productive research, with at least 2 first author publications
  • An ability to work independently as well as part of laboratory team

Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.

Post-Doctoral Research Fellow, Kemp Laboratory of Functional Precision Medicine

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13963

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp.  The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics.  Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.  We currently have identified a number of high value targets that are in stages of validation in patient derived tumor organoids.  The ideal candidate will have a formal background in cancer biology and genetics, with expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.  

Responsibilities

The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics.  Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.

 

The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.

Qualifications

  • A PhD in molecular biology, biochemistry, cancer biology, genetics, or related discipline.
  • Experience in standard molecular biology techniques, including qRT-PCR, immunoblotting, shRNA and CRISPR vector design and construction.
  • Experience with drug development would be a plus.
  • Demonstrated track record of productive, independent research.

Please include a cover letter detailing your research accomplishments, go forward interests, and suitability for this position with your application.   At least two letters of recommendation will be requested as part of the screening process.

Post-Doctoral Research Fellow, Post-Transcriptional Control in Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 10877

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level.

Responsibilities

For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, RNA labeling/sequencing techniques, various cellular and molecular assays, and a repository of primary human cancer samples to understand how the shape of mRNA direct their translation and cancer phenotypes. Applicants should be interested in the application of basic science research towards clinically intractable problems faced by cancer patients and will be expected to be scientifically intrepid.

Qualifications

Minimum qualifications:

 

We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts.

 

Preferred qualifications:

 

A strong background in high throughput methods, RNA biology, and/or computational biology are highly desirable. Excellent verbal and written English communication skills are required.

To apply for this position, please provide the following:

 

  • Cover letter summarizing your research interest
  • CV
  • Three references

Research Administrator IV (Grants & Contracts)

FH Human Biology Division
Category: Grants and Contracts
Seattle, WA, US
Job ID: 14101

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Human Biology Division at Fred Hutch is seeking an experienced Research Administrator (RA) (level III or IV depending on experience). In this position, the RA plans for and ensures compliant and effective funding, budget and regulatory administration and general administrative support for one or several Principal Investigators and their labs/departments. The RA collaborates with Principal Investigators and interfaces with other departments as needed on administrative and strategic planning and works autonomously to complete nonscientific grant content and tasks, advise the PIs on relevant matters and develop effective solutions to related issues.

Responsibilities

Budget/Fiscal Management

  • Participate in strategic planning activities such as setting goals and defining annual objectives
  • Develop, monitor, track and project the budgets for a complex portfolio of projects with multi-variable aspects (multi-site, sub awards etc.)
  • Develop, run and analyze reports aimed at oversight of over/under spending, compliance with regulations and forecasting future expenses.
  • Funding Source Administration- Lead the process of preparing grant submissions and post award activities by conducting tasks such as:
  • Working with faculty to develop strategies for responses/requests
  • Completion of all technical/non-scientific steps and assigned technical or scientific portions of submissions
  • Prepare and review budgets, identify discrepancies and provide recommendations to the PI on scenarios to resolve the issues with appropriate stakeholders

Regulatory Support

  • Prepare/Consult/Advise PIs on non-scientific portions of regulatory applications/submissions
  • Identify missing regulatory components that are required and resolve issues to ensure successful submission or renewal
  • May advise or consult with Center leadership on changes to Center-wide policies/procedures and help create implementation plans in response to changing regulatory requirements (e.g. Uniform Guidance)
  • Serve as a central point of contact to answer questions and facilitate solutions

Administrative Support

  • Identify administrative needs for the department or PI(s); prioritize and ensure related tasks are completed
  • Identify space and resource shortages and develop recommendations to resolve related issues
  • Oversees the management of projects including occasional event planning and management
  • Communicates with other departments/entities on Primary Investigator (PI)’s behalf.
  • Resolves discrepancies and issues with stakeholders on PI’s behalf
  • Perform other responsibilities as required

Leadership

  • Coach and develop lower level staff

Qualifications

  • Bachelor's degree or equivalent
  • Three or more years of work experience building, overseeing, and managing budgets
  • Previous work experience in grants and contracts field 
  • Knowledge of relevant regulatory guidelines related to funding such as IRB, IACUC, MUA
  • Excellent written and verbal communication skills. Ability to tailor communications to specific audiences
  • Advanced computer skills:
    • MS Word, Access, Adobe Acrobat and advanced knowledge of Excel required
    • Working knowledge of Excel formulas and functions within Excel (e.g. working with Pivot Tables)
  • Demonstrated ability to multi-task in a fast-paced fiscal management environment
  • Demonstrated ability to work effectively in a team environment as well as individually
  • Ability to problem-solve and process information quickly with a high attention to detail

Research Technician I

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14128

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network.  Careers Start Here.

 

A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin. Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.

 

Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.

Responsibilities

The incumbent will be responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.

 

Job Duties:

 

  • Perform experiments at the bench level to support investigative work.
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines.
  • Perform and modify documented protocols and assays.
  • Maintain laboratory records and compile data on experiments and assays.
  • Interpret and report on experimental results.
  • Perform statistical analysis of test results and prepare written reports on work performed.
  • Operate and carry out basic maintenance of laboratory equipment.
  • Order and maintain appropriate levels of supplies.
  • May supervise work-study students.
  • Participate in lab meetings and journal clubs.
  • Perform other duties as required.

Qualifications

BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is preferred.

Research Technician II - Prostate Cancer Molecular Pathology

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13662

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.

Responsibilities

The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Perform other duties as required
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
  • Assist in the design of experiments; may be responsible for the performance of individual research projects
  • Conduct literature reviews to assist in determining most suitable methods to be used in research
  • Assist in publication of results by proofreading, editing, and contributing ideas
  • May perform statistical analyses, write computer programs, or manage research data base

Qualifications

Required:

  • Bachelor's degree in Biology, Biochemistry or related field in life sciences
  • At least two years’ experience working in a laboratory
  • Independent research experience outside of laboratory course work
  • Experience with standard molecular biological techniques (DNA and RNA extraction) and biochemical approaches (gel electrophoresis, immunoblotting, immunoprecipitation) 
  • Attention to detail, time management skills and a collaborative disposition

Preferred:

  • Mouse handling experience
  • Mammalian cell culture experience

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

Staff Scientist, Cancer Biology

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 13799

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


A Staff Scientist position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered murine (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. We are also interested in understanding how to augment immune responses in SCLC. The Staff Scientist would help advance translational research in the lab by working both on independent and collaborative projects. The candidate may contribute to a recent translational NIH Lung SPORE grant, including study of patient samples and derived models.

Responsibilities

  • Perform independent research and also contribute as a part of a team in various projects as needed
  • Conduct therapeutic studies using murine models and perform molecular analyses to understand treatment responses
  • Revise animal protocols and help the lab maintain regulatory requirements
  • There is potential to mentor trainees
  • Present results in group meetings and prepare data for publication

Qualifications

  • PhD and 3-5 years of postdoctoral experience (5 years preferred)
  • Significant experience with murine models is essential
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • Must have a record of publication in peer reviewed journals

Staff Scientist, Transcriptional Control in Development and Disease

FH Human Biology Division
Category: Staff Scientist
Seattle, WA, US
Job ID: 13088

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Tapscott Lab seeks a Staff Scientist to manage the lab with an interactive group of scientists investigating lineage specification and cell differentiation. The lab focuses on gene transcription in a chromatin context in normal development and disease. Areas of research include gene expression in cell culture models of cell specification and differentiation that includes myogenesis, neurogenesis, and pluripotent stem cells to identify the molecular bases of totipotency, pluripotency, specification, and differentiation. Models derived from these developmental systems are applied to understand human diseases, including cancers and degenerative diseases.

Responsibilities

The incumbent will work independently under the guidance of and in conjunction with the Principal Investigator in accomplishing the goals of the laboratory and use discretion and judgment in carrying out experiments. Job duties will include:

  • Supervise the daily operations of the research laboratory
  • Conduct research independently as well as contribute to research being done by other team members
  • Address and resolve technical or procedural problems and advise technicians on the interpretation of results
  • Develop and document new technologies and protocols into the laboratory
  • Recruit, hire, train, and evaluate Research and Laboratory Technicians
  • Monitor lab safety
  • Act as a liaison to other research and administrative departments
  • Establish laboratory standards and maintain records
  • Write reports and contribute to scientific publication as warranted by the research
  • Assist in the design and review of laboratory space, equipment procurement, and supply purchases

Qualifications

Required:

 

  • PhD in a biological science and at least 3 years of relevant experience
  • Excellent knowledge of fundamental molecular and cell biology
  • A broad understanding of the techniques performed in the laboratory that include standard molecular biology techniques such as cloning, sequencing, RNA and DNA preparations, RT-PCR, Western blots, and tissue culture, as well as experience training individuals in these techniques

Preferred:

 

  • PhD in a biological science and at least 5 years of relevant experience
     

To be considered for this opportunity, please submit your CV and a cover letter describing your research accomplishments, as well as contact information for three references.

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