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8 Found open positions

Post-Doctoral Research Fellow

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18074

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


A highly motivated Post-Doctoral research fellow is sought to carry out research in the laboratory of Dr. Denise Galloway at Fred Hutchinson Cancer Research Center in Seattle, WA. Recent postdocs or graduate students at the end of their training program, who are eligible for participation in NIH-funded training grants and fellowships, are especially encouraged to apply.

 

The primary focus of the Galloway lab is the role that small DNA viruses, such as human papillomavirus (HPV), and Merkel Cell polyomavirus (MCPyV) play in cancer. We have taken a broad approach including mechanistic studies into how viral oncoproteins contribute to neoplasia and molecular epidemiologic studies into the natural history of viral infections and risk factors associated with cancer development. We are currently studying 1) the long-term memory to HPV vaccination or infection; 2) mechanisms by which high-risk HPVs perturb the response to DNA damage.; and 3) the functions of a newly identified protein, ALTO, in the MCPyV life cycle.

Responsibilities

The fellow will focus on HPV biology, investigating the mechanisms by which the E6 and E7 oncoproteins perturb the response to DNA damage. In addition to performing research the post-doc will have the opportunity to present their work at local and other meetings.

Qualifications

Successful applicants will have:

  • A recent PhD in a relevant biological field
  • A strong background in standard molecular/cellular biology techniques
  • Extensive experience with tissue culture
  • Experience with genome analysis, RNAi technology, and developmental virology is highly desirable
  • A demonstrated track record of productive research, with at least 2 first author publications
  • An ability to work independently as well as part of laboratory team

Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.


statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Protein Synthesis Control in Bladder Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17589

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

 

A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level (Hsieh et al. Nature 2012, Schuster and Hsieh Trends in Cancer 2019, Winters et al. JCI Insight 2019, and Liu et al. Science Translational Medicine 2019).

Responsibilities

For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, functional genomics, RNA labeling/sequencing techniques, various cellular and molecular assays, and a one-of-a-kind biorepository of primary and metastatic human bladder cancer samples to understand how the translation apparatus promotes cancer phenotypes.

 

Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals. In addition, both the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.

Qualifications

Required qualifications:

We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts. Excellent verbal and written communication skills are required.

 

Preferred qualifications:

A strong background in murine work, high throughput methods, RNA biology, and/or computational biology are highly desirable.

 

To apply for this position, please provide the following:

  • Cover letter summarizing your research interest
  • CV
  • Contact information for three references

Post-Doctoral Research Fellow, Biology of Small Cell Lung Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17590

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Responsibilities

A Postdoctoral Fellow position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered mouse (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. Our lab works closely with thoracic oncologist collaborators at the Seattle Cancer Care Alliance to access patient samples and to help translate basic findings (e.g. see Augert et al, 2019, Science Signaling “Targeting NOTCH Activation in Small Cell Lung Cancer Through LSD1 Inhibition”). Some of these directions are supported by an NIH Lung Cancer SPORE award that promotes translational lung cancer research.  We are also interested in understanding basic mechanisms underlying SCLC tumor suppressor and oncogene function (e.g., see Augert et al, Cancer Cell 2020, “MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer” and Jia et al, 2018, Cancer Discovery “Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition”.) We are increasingly performing functional screens in vivo and in tissue culture cells applied to cells to understand genes important for SCLC and to identify new druggable vulnerabilities.  The specific project will be developed by both the candidate and Dr. MacPherson based on areas of shared interests.

Qualifications

  • Recent PhD in Biology or related fields
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • A record of publication in peer reviewed journals

Please include a cover letter detailing your research interest and suitability for this position and names and contact information of at least two references with your application. 

Post-Doctoral Research Fellow, Intratumoral Microbiome Environment

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18038

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.



The Bullman Laboratory is an interdisciplinary and highly collaborative team of clinical microbiologists, computational biologists, biochemists and cancer geneticists. The core mission of our laboratory is to improve diagnosis and treatment of human cancer to ultimately extend the lives of cancer patients, with a particular focus on gastrointestinal cancers. Using cutting edge technologies and methodologies, we endeavor to move smoothly between large human data sets and in vivo and in vitro model systems to gain a deeper functional understanding of the tumor microbiota in cancer progression, metastasis and response to treatment

Responsibilities

The Bullman Laboratory in the Human Biology Division at the Fred Hutchinson Cancer Research Center is recruiting a highly motivated Postdoctoral Fellow with expertise in murine models of cancer and mammalian cell biology to join our tumor microbiome efforts. An interest in microbiome research is required but hands on experience is not required as ample training can be provided.

 

Our goal is to understand the interaction of the colon cancer microbiota with the tumor microenvironment. This individual will utilize state-of-the-art spatial imaging technologies, in addition to genomics and informatics techniques in a highly collaborative, stimulating, and collegial research environment. This position will provide opportunities for professional development and the acquisition of cutting-edge skills in single cell sequencing, small molecule screens, analysis of clinical specimens, tissue imaging approaches, host-microbiome interactions, research planning and strategy, and data analysis and interpretation.

Qualifications

Please include a cover letter with your application, detailing your interest and suitability for this position.

 

Minimum qualifications:

  • PhD in biological sciences, cancer biology, computational biology, pathology, microbiology, or a related field
  • A record of scientific accomplishment as shown by peer-reviewed publication
  • A collaborative, curious, creative, proactive and organized temperament
  • A commitment to advancing fundamental knowledge of the cancer microbiome and to translating that knowledge to the development of novel therapeutic approaches

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Postdoctoral Research Fellow, Comprehensive Discovery of HIV Latency Factors

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17484

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

 

The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment.  This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits.   Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency. Expectation is to develop an independent project within the context of the grant. The responsibilities include those expected at a PhD level, including leading the technical aspects of the study, contributing intellectually to the overall study design, interpreting data, presenting the findings at meetings and writing manuscripts.

 

We are are seeking a Post-Doctoral Fellow to work with an interactive collaborative team of scientists investigating the mechanisms of HIV-1 latency using CRISPR screens and validation in primary cell models of HIV latency.  The applicant should be well organized, pay close attention to detail, be reliable and motivated to participate in multiple levels of lab activity.

Responsibilities

The fellow will perform standard routine and investigative laboratory work in support of scientific research specific to HIV latency and CRISPR screens. Major duties include:

  • Perform experiments at the bench level to support investigative work, potentially including, but not limited to molecular biology, viral infections and assays, DNA sequencing, PCR amplification, RT-PCR amplification, TC culture, BLS2/3 work, including making virus stocks and performing viral infection
  • CRISPR/Cas9 screening and editing, and analysis of results
  • Conduct experiments with primary T cells
  • Recover, compile and verify accuracy of research data
  • Operate analytical instruments
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Present data at local and national meetings
  • Prepare manuscripts describing the data and their meaning to the field

Qualifications

Educational or Special Training Qualifications

  • BA/BS required in a scientific field
  • Applicants should have a PhD (or equivalent degree) in Biomedical Sciences and basic techniques in molecular biology
  • Ability to think critically and design and interpret experiments is essential, as are strong communication skills

Experience Requirements

  • Experience with molecular biology and biochemical methods
  • A strong interest in research in the area of HIV biology and HIV latency, infectious diseases and global health
  • Evidence of productivity appropriate to a postdoctoral fellow as measured by publications and presentations, abstracts and posters at conferences
  • Well-organized with strong attention to detail
  • Ability to work independently and perform experiments without day-to-day supervision will be required after training
  • Ability to work as part of a team and to participate in multiple projects in collaboration with different lab members and collaborations with outside labs

Please include a cover letter with your application, describing your research accomplishments as well as detailing your interest and suitability for this position.

Research Technician I-II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18152

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

This position will work with members of the laboratory of Dr. Taran Gujral in the Division of Human Biology to culture and maintain a collection of cell lines, prepare samples and carry out biochemical and PCR-based assays, assist in murine experiments, and use various software packages to analyze data from these assays. The position requires attention to detail, high level of initiative and excellent communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

Qualifications

  • Research Technician I minimum qualifications: BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills.  Independent research experience in addition to school lab experience is usually necessary.

 

  • Research Technician II minimum qualifications:  Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS. Independent research experience outside of laboratory course work is usually necessary.

 

Application Instructions:

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14811

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.

Responsibilities

The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Perform other duties as required
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
  • Assist in the design of experiments; may be responsible for the performance of individual research projects
  • Conduct literature reviews to assist in determining most suitable methods to be used in research
  • Assist in publication of results by proofreading, editing, and contributing ideas
  • May perform statistical analyses, write computer programs, or manage research database

Qualifications

Required:

  • Bachelor’s degree in Biology, Biochemistry or related field in life sciences
  • At least two years’ experience working in a laboratory
  • Independent research experience outside of laboratory course work
  • Experience with standard molecular biological techniques (DNA and RNA extraction) and biochemical approaches (gel electrophoresis, immunoblotting, immunoprecipitation)
  • Attention to detail, time management skills and a collaborative disposition

 

Preferred:

  • Murine handling experience
  • Mammalian cell culture experience

 

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

Research Technician II, Protein Synthesis Control

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18034

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


 

The Hsieh Lab in the Division of Human Biology at the Fred Hutchinson Cancer Research Center is looking for a highly motivated individual who is interested in studying how the way cells make proteins or protein synthesis control ultimately determine specific behaviors that can lead to and potentiate cancer. Our work will include mechanistic studies in cell lines, mouse models, and human tissue samples with the ultimate goal of learning how to target and drug the protein synthesis machinery. The individual will be responsible for performing investigative lab work at the bench along side Dr. Hsieh, postdoctoral fellows and existing Research Technician. The ability to work in a team will be essential.

Responsibilities

The technician will work under the direction of the Dr. Hsieh and other high-level laboratory personnel. The candidate’s time will be divided into two parts: 80% effort to conduct cutting edge research and 20% effort for laboratory maintenance. Dr. Hsieh or a senior postdoctoral fellow will initially work closely with the technician, but it is anticipated that they will be able to drive their own project after they demonstrate proficiency with all necessary techniques.

Qualifications

Required qualifications:

  • BA/BS or higher level of education in a scientific field
  • 2+ years experience working in a laboratory
  • Must have scientific knowledge in the area of biological science and basic laboratory skills
  • Must have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions and good organizational skills
  • Applications must include a cover letter stating interest and future plans

Preferred qualifications:

  • Ability to work independently and perform experiments with little supervision will be required after training
  • Familiarity and expertise in cell/tissue culture, PCR, Flow Cytometry, Genotyping, DNA/RNA isolation and extraction, and murine work
  • A candidate with interest in contributing significantly to publications, advancing their CV, and going to graduate school or medical school is highly desirable
  • Independent research experience in addition to school lab experience is preferred

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through work at Fred Hutch is requested of all finalists.

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