Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Gujral lab at the Fred Hutchinson Cancer Research Center has an opening for an unpaid internship that would be perfect for a senior student in biological sciences. This position will work with members of the laboratory of Dr. Taran Gujral in the Division of Human Biology to embark on an exciting journey to tackle two of the most burning issues in cancer treatment, metastasis and drug resistance, through an approach which combines cutting edge high-throughput methods and focused biology studies in cell lines and various mouse models. Students will gain hands-on experience in using state-of-the art technologies in proteomics and genomics.
The position will begin with the student completing general lab tasks to ensure an adequate time commitment is feasible and a copacetic atmosphere is maintained. If everything works out, there will be a training period (varies dependent on individual) before moving on to your own project. Projects could vary from tumor micro-environment to immuno-oncology to tumor metabolism and drug resistance. A student could participate in many of the aspects of the work in the lab and would be expected to learn how to develop a research question, design experiments to answer the question, perform experiments, interpret the results and design additional experiments based on the results. Depending on their specific interests, the student could learn about different cancer models including PDX, orthotopic, chemical-induced and xenograft, and many other current methodologies such as reverse phase lysate microarrays, high throughput live cell microscopy-based assays, immunofluorescence microscopy, western blot analysis, RNAseq, quantitative PCR and use of various data analysis software. In addition, students will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers. The intern will report directly to Dr. Gujral but is expected to integrate and function as team member at Gujral lab and Human Biology.
Some Universities/Colleges will apply credit for the work – please check with your individual institutions for their requirements.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A postdoctoral position is available in the MacPherson Lab at Fred Hutchinson Cancer Research Center. The project will focus on small cell lung cancer (SCLC), a neuroendocrine tumor type that exhibits initial sensitivity to chemotherapy but invariable emergence of chemoresistance. Our lab is interested in linking specific gene mutations in SCLC to therapeutic vulnerabilities and to chemoresistance. We have developed a panel of new genetically engineered murine models (e.g. see Jia et al, 2018 Cancer Discovery) and patient derived xenograft models that can be used in these efforts. Many projects in the lab incorporate genome-wide functional screens in cells and in vivo. These screens are used to identify functionally important genes for SCLC and genetic vulnerabilities that might lead to new avenues to therapeutically target SCLC. One available project includes interrogating the importance of candidate SCLC driver genes and linking specific SCLC-mutated genes to novel therapeutic approaches. Hits identified through functional screens are followed by therapeutic studies that employ GEM and PDX model. A second available project applies in vivo genome-wide screens to understand drivers of chemoresistance.
We are looking for a highly motivated individual with a PhD or MD and interests in cancer genetics, epigenetics, murine models, functional screening and/or therapeutics. The candidate should be able to drive an individual project but also be highly collaborative. A strong foundation in molecular and cell biology is essential. The candidate should be independent, enthusiastic and scientifically rigorous.
Please include a cover letter detailing your research interest and suitability for this position and names of at least two references with your application.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Tapscott Lab has an opening for a postdoctoral research associate who has interest and expertise in gene transcription in a chromatin context in normal development and disease, and/or immune modulation in early development or cancer. The candidate will complement and contribute to the active research program in developmental oncology, which includes studies of the molecular mechanisms of stem cell potential, cell specification, and immune modulation in normal development and disease. Recent work has focused on DUX4 and related factors and their role in establishing early pluripotent stem cell potential and an immune privileged environment in development, cancer, and other diseases. In addition, the lab studies the molecular and genomic regulation of cell specification using myogenesis and neurogenesis as model systems. This position will be compensated generally consistent with the NIH pay scale.
Minimum qualifications:
Application instructions: please submit a CV and a cover letter that describes your research accomplishments as well as your interest in the Tapscott laboratory research program.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Kugel Laboratory is seeking highly motivated postdoctoral fellows interested in exploring how the dysregulation of chromatin modifying enzymes and developmental pathways contribute to pancreatic cancer pathogenesis and, further, whether these pathways present liabilities that can be exploited for cancer therapy.
Successful candidates will learn to generate and exploit a series of cancer model systems including genetically engineered murine models (GEMMs), patient-derived xenografts and novel human cancer cell lines to understand fundamental pathogenic mechanisms underlying pancreatic cancer. To answer these questions the laboratory uses state-of-the-art techniques in murine models and genetics, molecular biology, cell biology, biochemistry, metabolism, RNA profiling, proteomics, pharmacology, genomics and computational biology.
Qualified applicants will have recently obtained a PhD and/or MD, or be nearing completion of their graduate studies and have an interest in cancer research. A track record of productive research is strongly preferred. Applicants with specific expertise in RNA biology, biochemistry, cell biology, cancer genomics, murine models or computational biology are highly encouraged to apply. Excellent verbal and written communication skills are required. Fellowship opportunities are available through several philanthropic and government organizations; and recruits who join the lab will be supported in their applications.
Please apply by submitting a CV, a brief description of past research experiences and future goals (not more than 1-2 pages) and contact information for three references.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp. The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets. We currently have identified a number of high value targets that are in stages of validation in patient derived tumor organoids. The ideal candidate will have a formal background in cancer biology and genetics, with expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.
The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.
The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.
Please include a cover letter detailing your research accomplishments, go forward interests, and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level.
For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, RNA labeling/sequencing techniques, various cellular and molecular assays, and a repository of primary human cancer samples to understand how the shape of mRNA direct their translation and cancer phenotypes. Applicants should be interested in the application of basic science research towards clinically intractable problems faced by cancer patients and will be expected to be scientifically intrepid.
Minimum qualifications:
We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts.
Preferred qualifications:
A strong background in high throughput methods, RNA biology, and/or computational biology are highly desirable. Excellent verbal and written communication skills are required.
To apply for this position, please provide the following:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Bullman Laboratory is an interdisciplinary and highly collaborative team of clinical microbiologists, computational biologists, biochemists and cancer geneticists. The core mission of our laboratory is to improve diagnosis and treatment of human cancer to ultimately extend the lives of cancer patients, with a particular focus on gastrointestinal cancers. Using cutting edge technologies and methodologies, we endeavor to move smoothly between large human data sets and in vivo and in vitro model systems to gain a deeper functional understanding of the tumor microbiome in cancer progression, metastasis and response to treatment.
The Bullman Laboratory in the Human Biology Division at the Fred Hutchinson Cancer Research Center is recruiting a highly motivated Postdoctoral Fellow with expertise in multi-parametric tissue imaging approaches (e.g. FISH, CISH, immunocytochemistry, immunohistochemistry) and mammalian cell biology (mammalian cell culture, murine models) to join our tumor microbiome efforts. An interest in microbiome research is required but hands on experience is not required as ample training can be provided.
Our goal is to understand the interaction of the colon cancer microbiota with the tumor microenvironment. This individual will utilize state-of-the-art spatial imaging technologies, in addition to genomics and informatics techniques in a highly collaborative, stimulating, and collegial research environment. This position will provide opportunities for professional development and the acquisition of cutting-edge skills in single cell sequencing, small molecule screens, analysis of clinical specimens, tissue imaging approaches, host-microbiome interactions, research planning and strategy, and data analysis and interpretation.
Required:
Preferred:
Please include a cover letter with your application, decribing your research accomplishments as well as detailing your interest and suitability for this position.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow.
A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin (Nature 2016, J. Virol 2017, Mol Cel Proteomics 2017). Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.
Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.
The successful candidate will work on collaborative projects in the Avgousti Lab primarily focused on, but not limited to, the understanding the dynamics of protein VII-DNA complexes, protein VII-nucleosome complexes, binding partners and the impact of mutations on viral infection. Candidates should have excellent communication skills, value teamwork and can thrive in a fast-paced environment.
We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Preference will be given to candidates with a background in structural biology for the study of viral proteins by crystallography or other biophysical techniques. Virology knowledge is beneficial but not required.
Interested candidates should submit a CV, a summary of research experience and interests, and contact information for three references.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A highly motivated Post-Doctoral research fellow is sought to carry out research in the laboratory of Dr. Denise Galloway at Fred Hutchinson Cancer Research Center in Seattle, WA. Recent postdocs or graduate students at the end of their training program, who are eligible for participation in NIH-funded training grants and fellowships, are especially encouraged to apply.
About the Galloway Lab:
The primary focus of the Galloway lab is the role that small DNA viruses, such as human papillomavirus (HPV), and Merkel Cell polyomavirus (MCPyV) play in cancer. We have taken a broad approach including mechanistic studies into how viral oncoproteins contribute to neoplasia and molecular epidemiologic studies into the natural history of viral infections and risk factors associated with cancer development. We are currently studying 1) the long-term memory to HPV vaccination or infection; 2) mechanisms by which high-risk HPVs perturb the response to DNA damage.; and 3) the functions of a newly identified protein, ALTO, in the MCPyV life cycle.
The fellow will focus on HPV or MCPyV biology, investigating the mechanisms by which these viruses cause cancer. In addition to performing research the post-doc will have the opportunity to present their work at local and other meetings.
Successful applicants will have:
Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
The Gujral Lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow interested in studying the tumor microenvironment. Our lab combines approaches from molecular genetics with cell and systems biology to study the interactions between tumor cells and host cells in the tumor microenvironment.
Although progress has been made in the past several decades in understanding and developing treatments for cancer, there is still a huge unmet need for effective treatment to stop metastasis which accounts for 90% of deaths due to cancer. A major focus of our lab is to study how cancer cells and immune cells influence the growth and functions of each other in advanced stage solid tumors by integrating recently developed proteomics and computational methods with specific cellular system (Gujral et al., PNAS, 2014, Gujral et al., Cell, 2014.) In our lab, we leverage different data-driven approaches (e.g. Protein arrays, transcriptomic profiling, high throughput live cell imaging, screening tools) to inform the work of focused biology which utilizes conventional tools including transgenic mouse models, molecular and biochemical approaches. The goal is to be able to study cell system as a whole and at microscopic levels in order to find solutions for cancer and other diseases.
Successful candidates will have:
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
The Tapscott Lab is composed of an interactive group of scientists investigating lineage specification and cell differentiation. The lab focuses on gene transcription in a chromatin context in normal development and disease. Areas of research include gene expression in cell culture models of cell specification and differentiation that includes myogenesis, neurogenesis, and pluripotent stem cells to identify the molecular bases of totipotency, pluripotency, specification, and differentiation. Models derived from these developmental systems are applied to understand human diseases, including cancers and degenerative diseases.
Research technicians are responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. Job duties include:
Research Technician I: Bachelor’s degree in biology or related fields is required. Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is required.
Research Technician II: Bachelor’s degree in biology or related fields and two years of professional research experience working in a laboratory. A master's degree may, in some cases, substitute for two years of post-graduation lab experience.
A successful candidate will have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills and the ability to work and think independently. The candidate must have a track record of reliability and good verbal and written communication skills. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Saha Laboratory for Liver Cancer Research is accepting applications for a Research Technician position. The laboratory uses basic and translational research approaches to explore pathogenic mechanisms and novel targeted therapies in cholangiocarcinoma, a highly lethal malignancy of the liver bile ducts. Successful candidates will learn to generate and exploit a series of fundamental cancer model systems including genetically engineered murine models (GEMMs), patient-derived xenografts and novel human cancer cell lines.
In addition, the incumbent will have the opportunity to become involved with all the steps of research being completed by the group and contribute to publications, with the ultimate goal of translating their findings into novel clinical trials for cholangiocarcinoma patients. Scientific methodologies and areas of focus include animal models and murine genetics, molecular biology, cell biology and metabolism, proteomics, biochemistry, pharmacology, and genomics. The experience gained in the lab will useful for pursuing a career as a researcher or physician.
Required:
Preferred:
Please apply by submitting your CV, a brief letter of intent (less than one page), and a list of three references. Recent college graduates are encouraged to apply.
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
The Gujral Lab is seeking a Research Technician II to serve as lab manager. The successful candidate will culture and maintain a collection of mammalian cancer cell lines, prepare samples for reverse phase lysate microarrays, run microscopy-based assays to characterize the effect of panels of small molecules and siRNA’s on phenotypes of these cell lines, and use various software packages to analyze data from these assays. The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.
Research technicians are responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. Job duties include:
Bachelor’s degree in biology or related fields and two years of professional research experience working in a laboratory. A master's degree may, in some cases, substitute for two years of post-graduation lab experience.
A successful candidate will have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills and the ability to work and think independently. The candidate must have a track record of reliability and good verbal and written communication skills. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school.
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