Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A Computational Biologist/Bioinformatics Analyst position in the Prostate Cancer Program (Peter Nelson, Michael Haffner, John Lee, and Valeri Vasioukhin) in the Division of Human Biology is available immediately. We are seeking a highly motivated individual who is interested in studying the genetics and epigenetics of cancer including single cell analysis using computational approaches. Candidates who are excited about large/complex ‘omics’ data analysis and cancer research are encouraged to apply. The position has a competitive salary with great benefits.
The Prostate Cancer Program uses new DNA sequencing technologies to study cancer genomes. The lab is also focused on research involving liquid biopsies, such as cell-free DNA and circulating tumor cells, and developing new computational approaches to leverage these data for genome discovery and cancer burden monitoring. The research interests/projects in the prostate cancer program include:
Candidates with strong interest and/or expertise in any of these research areas are highly encouraged to apply:
Applicants must have at least a Bachelor’s degree in one of these disciplines: computational biology, bioinformatics, computer science, data science, statistics, biostatistics, biomedical engineering, computer/electrical engineering, physics, or other related fields.
Applicants should have some of the following skills and experience:
To apply, please submit your application with the following:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Vasioukhin Laboratory in the Prostate Cancer Program at Fred Hutch laboratory is recruiting a part-time work-study student to assist with ongoing studies.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow.
A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin (Nature 2016, J. Virol 2017, Mol Cel Proteomics 2017). Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.
Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.
Additional information about research in the Avgousti lab can be found at:
https://research.fhcrc.org/avgousti/en.html
The successful candidate will work on collaborative projects in the Avgousti Lab primarily focused on, but not limited to, the understanding the dynamics of protein VII-DNA complexes, protein VII-nucleosome complexes, binding partners and the impact of mutations on viral infection. Candidates should have excellent communication skills, value teamwork and can thrive in a fast-paced environment.
We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Preference will be given to candidates with a background in structural biology for the study of viral proteins by crystallography or other biophysical techniques. Virology knowledge is beneficial but not required. Interested candidates should submit a CV, a summary of research experience and interests, and contact information for three references.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A postdoctoral position is available in the MacPherson Lab at Fred Hutchinson Cancer Research Center. The project will focus on small cell lung cancer (SCLC), a neuroendocrine tumor type that exhibits initial sensitivity to chemotherapy but invariable emergence of chemoresistance. Our lab is interested in linking specific gene mutations in SCLC to therapeutic vulnerabilities and to chemoresistance. We have developed a panel of new genetically engineered murine models (e.g. see Jia et al, 2018 Cancer Discovery) and patient derived xenograft models that can be used in these efforts. Many projects in the lab incorporate genome-wide functional screens in cells and in vivo. These screens are used to identify functionally important genes for SCLC and genetic vulnerabilities that might lead to new avenues to therapeutically target SCLC. One available project includes interrogating the importance of candidate SCLC driver genes and linking specific SCLC-mutated genes to novel therapeutic approaches. Hits identified through functional screens are followed by therapeutic studies that employ GEM and PDX model. A second available project applies in vivo genome-wide screens to understand drivers of chemoresistance.
We are looking for a highly motivated individual with a PhD or MD and interests in cancer genetics, epigenetics, murine models, functional screening and/or therapeutics. The candidate should be able to drive an individual project but also be highly collaborative. A strong foundation in molecular and cell biology is essential. The candidate should be independent, enthusiastic and scientifically rigorous.
Please include a cover letter detailing your research interest and suitability for this position and names of at least two references with your application.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Beronja Lab in the Human Biology Division at Fred Hutchinson Cancer Research Center is looking for a recent MD, PhD, or MD/PhD graduate to join our growing research program. We employ mouse models of epithelial cancers, rapid gene targeting in skin, oral and mammary tissues, and intravital microscopy to identifying molecular and cellular mechanisms of tumorigenesis.
MD, PhD, or MD/PhD in biology or related field is required.
Candidates should have an outstanding record of research productivity. A skill set that includes molecular and biochemical techniques, microscopy, and bioinformatics is a plus. A strong work ethic, eagerness to learn, and a passion for science are essential.
To apply, please submit your CV, a cover letter detailing your research accomplishments as well your interest in the Beronja Lab research program, and contact information for three references.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp. The ideal candidate will have a formal background in cancer biology, expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models.
The applicant will apply state of the art functional genomic and high-throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network. We currently have identified several high-value targets that are in stages of validation in patient derived tumor organoids.
Minimum qualifications:
Preferred qualifications:
To apply, please submit your CV and a cover letter detailing your research accomplishments, and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A highly motivated Post-Doctoral research fellow is sought to carry out research in the laboratory of Dr. Denise Galloway at Fred Hutchinson Cancer Research Center in Seattle, WA. Recent postdocs or graduate students at the end of their training program, who are eligible for participation in NIH-funded training grants and fellowships, are especially encouraged to apply.
About the Galloway Lab:
The primary focus of the Galloway lab is the role that small DNA viruses, such as human papillomavirus (HPV), and Merkel Cell polyomavirus (MCPyV) play in cancer. We have taken a broad approach including mechanistic studies into how viral oncoproteins contribute to neoplasia and molecular epidemiologic studies into the natural history of viral infections and risk factors associated with cancer development. We are currently studying 1) the long-term memory to HPV vaccination or infection; 2) mechanisms by which high-risk HPVs perturb the response to DNA damage.; and 3) the functions of a newly identified protein, ALTO, in the MCPyV life cycle.
The fellow will focus on HPV biology, investigating the mechanisms by which the E6 and E7 oncoproteins perturb the response to DNA damage. In addition to performing research the post-doc will have the opportunity to present their work at local and other meetings.
Successful applicants will have:
Please apply with a letter summarizing previous work experience, suitability for this position and future research interests, as well as contact information for three professional references.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp. The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets. We currently have identified a number of high value targets that are in stages of validation in patient derived tumor organoids. The ideal candidate will have a formal background in cancer biology and genetics, with expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.
The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.
The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.
Please include a cover letter detailing your research accomplishments, go forward interests, and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level.
For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, RNA labeling/sequencing techniques, various cellular and molecular assays, and a repository of primary human cancer samples to understand how the shape of mRNA direct their translation and cancer phenotypes. Applicants should be interested in the application of basic science research towards clinically intractable problems faced by cancer patients and will be expected to be scientifically intrepid.
Minimum qualifications:
We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts.
Preferred qualifications:
A strong background in high throughput methods, RNA biology, and/or computational biology are highly desirable. Excellent verbal and written English communication skills are required.
To apply for this position, please provide the following:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Human Biology Division at Fred Hutch is seeking an experienced Research Administrator (RA) (level III or IV depending on experience). In this position, the RA plans for and ensures compliant and effective funding, budget and regulatory administration and general administrative support for one or several Principal Investigators and their labs/departments. The RA collaborates with Principal Investigators and interfaces with other departments as needed on administrative and strategic planning and works autonomously to complete nonscientific grant content and tasks, advise the PIs on relevant matters and develop effective solutions to related issues.
Budget/Fiscal Management
Regulatory Support
Administrative Support
Leadership
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin. Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.
Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression. |
The incumbent will be responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.
Job Duties:
BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is preferred.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.
The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.
Required:
Preferred:
Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A Staff Scientist position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered murine (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. We are also interested in understanding how to augment immune responses in SCLC. The Staff Scientist would help advance translational research in the lab by working both on independent and collaborative projects. The candidate may contribute to a recent translational NIH Lung SPORE grant, including study of patient samples and derived models.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Tapscott Lab seeks a Staff Scientist to manage the lab with an interactive group of scientists investigating lineage specification and cell differentiation. The lab focuses on gene transcription in a chromatin context in normal development and disease. Areas of research include gene expression in cell culture models of cell specification and differentiation that includes myogenesis, neurogenesis, and pluripotent stem cells to identify the molecular bases of totipotency, pluripotency, specification, and differentiation. Models derived from these developmental systems are applied to understand human diseases, including cancers and degenerative diseases.
The incumbent will work independently under the guidance of and in conjunction with the Principal Investigator in accomplishing the goals of the laboratory and use discretion and judgment in carrying out experiments. Job duties will include:
Required:
Preferred:
To be considered for this opportunity, please submit your CV and a cover letter describing your research accomplishments, as well as contact information for three references.
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