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5 Found open positions

Post-Doctoral Research Fellow, Protein Synthesis Control in Bladder Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17589

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level (Hsieh et al. Nature 2012, Schuster and Hsieh Trends in Cancer 2019, Winters et al. JCI Insight 2019, and Liu et al. Science Translational Medicine 2019).

Responsibilities

For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, functional genomics, RNA labeling/sequencing techniques, various cellular and molecular assays, and a one-of-a-kind biorepository of primary and metastatic human bladder cancer samples to understand how the translation apparatus promotes cancer phenotypes.

 

Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals. In addition, both the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.

Qualifications

Required qualifications:

We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts. Excellent verbal and written communication skills are required.

 

Preferred qualifications:

A strong background in mouse work, high throughput methods, RNA biology, and/or computational biology are highly desirable.

 

To apply for this position, please provide the following:

  • Cover letter summarizing your research interest
  • CV
  • Contact information for three references

Post-Doctoral Research Fellow, Biology of Small Cell Lung Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17590

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Postdoctoral Fellow position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered mouse (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. Our lab works closely with thoracic oncologist collaborators at the Seattle Cancer Care Alliance to access patient samples and to help translate basic findings (e.g. see Augert et al, 2019, Science Signaling “Targeting NOTCH Activation in Small Cell Lung Cancer Through LSD1 Inhibition”). Some of these directions are supported by an NIH Lung Cancer SPORE award that promotes translational lung cancer research.  We are also interested in understanding basic mechanisms underlying SCLC tumor suppressor and oncogene function (e.g., see Augert et al, Cancer Cell 2020, “MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer” and Jia et al, 2018, Cancer Discovery “Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition”.) We are increasingly performing functional screens in vivo and in tissue culture cells applied to cells to understand genes important for SCLC and to identify new druggable vulnerabilities.  The specific project will be developed by both the candidate and Dr. MacPherson based on areas of shared interests.

Qualifications

  • Recent PhD in Biology or related fields
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • A record of publication in peer reviewed journals

Please include a cover letter detailing your research interest and suitability for this position and names and contact information of at least two references with your application. 

Postdoctoral Research Fellow, Comprehensive Discovery of HIV Latency Factors

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17484

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment.  This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits.   Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency. Expectation is to develop an independent project within the context of the grant. The responsibilities include those expected at a PhD level, including leading the technical aspects of the study, contributing intellectually to the overall study design, interpreting data, presenting the findings at meetings and writing manuscripts.

 

We are are seeking a Post-Doctoral Fellow to work with an interactive collaborative team of scientists investigating the mechanisms of HIV-1 latency using CRISPR screens and validation in primary cell models of HIV latency.  The applicant should be well organized, pay close attention to detail, be reliable and motivated to participate in multiple levels of lab activity.

Responsibilities

The fellow will perform standard routine and investigative laboratory work in support of scientific research specific to HIV latency and CRISPR screens. Major duties include:

  • Perform experiments at the bench level to support investigative work, potentially including, but not limited to molecular biology, viral infections and assays, DNA sequencing, PCR amplification, RT-PCR amplification, TC culture, BLS2/3 work, including making virus stocks and performing viral infection
  • CRISPR/Cas9 screening and editing, and analysis of results
  • Conduct experiments with primary T cells
  • Recover, compile and verify accuracy of research data
  • Operate analytical instruments
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Present data at local and national meetings
  • Prepare manuscripts describing the data and their meaning to the field

Qualifications

Educational or Special Training Qualifications

  • BA/BS required in a scientific field
  • Applicants should have a PhD (or equivalent degree) in Biomedical Sciences and basic techniques in molecular biology
  • Ability to think critically and design and interpret experiments is essential, as are strong communication skills

Experience Requirements

  • Experience with molecular biology and biochemical methods
  • A strong interest in research in the area of HIV biology and HIV latency, infectious diseases and global health
  • Evidence of productivity appropriate to a postdoctoral fellow as measured by publications and presentations, abstracts and posters at conferences
  • Well-organized with strong attention to detail
  • Ability to work independently and perform experiments without day-to-day supervision will be required after training
  • Ability to work as part of a team and to participate in multiple projects in collaboration with different lab members and collaborations with outside labs

Please include a cover letter with your application, describing your research accomplishments as well as detailing your interest and suitability for this position.

Postdoctoral Research Fellow, Tumor Microenvironment

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 14943

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

The Gujral Lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow interested in studying the tumor microenvironment. Our lab combines approaches from molecular genetics with cell and systems biology to study the interactions between tumor cells and host cells in the tumor microenvironment.


Although progress has been made in the past several decades in understanding and developing treatments for cancer, there is still a huge unmet need for effective treatment to stop metastasis which accounts for 90% of deaths due to cancer. A major focus of our lab is to study how cancer cells and immune cells influence the growth and functions of each other in advanced stage solid tumors by integrating recently developed proteomics and computational methods with specific cellular system (Gujral et al., PNAS, 2014Gujral et al., Cell, 2014.) In our lab, we leverage different data-driven approaches (e.g. Protein arrays, transcriptomic profiling, high throughput live cell imaging, screening tools) to inform the work of focused biology which utilizes conventional tools including transgenic murine models, molecular and biochemical approaches. The goal is to be able to study cell system as a whole and at microscopic levels in order to find solutions for cancer and other diseases.

Qualifications

Successful candidates will have:

  • A recent PhD in a relevant field
  • Knowledge and experience in cancer biology, biochemistry, and immunology
  • Track record of productive research, with at least one first-author publication
  • Experience with in vivo cancer models is preferred

Please include a cover letter with your application, describing your past research accomplishments as well as your interest and suitability for this position.

Research Technician II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14811

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.

Responsibilities

The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Perform other duties as required
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
  • Assist in the design of experiments; may be responsible for the performance of individual research projects
  • Conduct literature reviews to assist in determining most suitable methods to be used in research
  • Assist in publication of results by proofreading, editing, and contributing ideas
  • May perform statistical analyses, write computer programs, or manage research database

Qualifications

Required:

  • Bachelor’s degree in Biology, Biochemistry or related field in life sciences
  • At least two years’ experience working in a laboratory
  • Independent research experience outside of laboratory course work
  • Experience with standard molecular biological techniques (DNA and RNA extraction) and biochemical approaches (gel electrophoresis, immunoblotting, immunoprecipitation)
  • Attention to detail, time management skills and a collaborative disposition

 

Preferred:

  • Murine handling experience
  • Mammalian cell culture experience

 

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

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