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10 Found open positions

Post-Doctoral Research Fellow, Cancer Genetics

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12348

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A postdoctoral position is available in the MacPherson Lab at Fred Hutchinson Cancer Research Center. The project will focus on small cell lung cancer (SCLC), a neuroendocrine tumor type that exhibits initial sensitivity to chemotherapy but invariable emergence of chemoresistance. Our lab is interested in linking specific gene mutations in SCLC to therapeutic vulnerabilities and to chemoresistance. We have developed a panel of new genetically engineered murine models (e.g. see Jia et al, 2018 Cancer Discovery) and patient derived xenograft models that can be used in these efforts.  Many projects in the lab incorporate genome-wide functional screens in cells and in vivo.  These screens are used to identify functionally important genes for SCLC and genetic vulnerabilities that might lead to new avenues to therapeutically target SCLC.  One available project includes interrogating the importance of candidate SCLC driver genes and linking specific SCLC-mutated genes to novel therapeutic approaches. Hits identified through functional screens are followed by therapeutic studies that employ GEM and PDX model.  A second available project applies in vivo genome-wide screens to understand drivers of chemoresistance.

Qualifications

We are looking for a highly motivated individual with a PhD or MD and interests in cancer genetics, epigenetics, murine models, functional screening and/or therapeutics. The candidate should be able to drive an individual project but also be highly collaborative.  A strong foundation in molecular and cell biology is essential. The candidate should be independent, enthusiastic and scientifically rigorous.

 

Please include a cover letter detailing your research interest and suitability for this position and names of at least two references with your application. 

Post-Doctoral Research Fellow, Developmental Oncology

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 14488

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Tapscott Lab has an opening for a postdoctoral research associate who has interest and expertise in gene transcription in a chromatin context in normal development and disease, and/or immune modulation in early development or cancer.  The candidate will complement and contribute to the active research program in developmental oncology, which includes studies of the molecular mechanisms of stem cell potential, cell specification, and immune modulation in normal development and disease. Recent work has focused on DUX4 and related factors and their role in establishing early pluripotent stem cell potential and an immune privileged environment in development, cancer, and other diseases. In addition, the lab studies the molecular and genomic regulation of cell specification using myogenesis and neurogenesis as model systems. This position will be compensated generally consistent with the NIH pay scale.

Qualifications

Minimum qualifications:

  • Recent MD, DVM, or PhD
  • A strong foundation in molecular and cell biology
  • Broad knowledge of molecular biology techniques
  • Highly motivated and well-organized individual who thinks independently but enjoys working as part of a dynamic and collaborative team
  • Excellent verbal and written communication skills
  • A track record of productive research

Application instructions: please submit a CV and a cover letter that describes your research accomplishments as well as your interest in the Tapscott laboratory research program. 

Post-Doctoral Research Fellow, Functional Cancer Genomics

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13071

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp. The ideal candidate will have a formal background in cancer biology, expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. 

Responsibilities

The applicant will apply state of the art functional genomic and high-throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics. Through functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network. We currently have identified several high-value targets that are in stages of validation in patient derived tumor organoids.

Qualifications

Minimum qualifications:

  • A PhD in molecular biology, biochemistry, cancer biology, genetics, or related discipline.
  • Demonstrated track record of productive, independent research.

Preferred qualifications:

  • Experience with drug development would be a plus.  

To apply, please submit your CV and a cover letter detailing your research accomplishments, and suitability for this position with your application. At least two letters of recommendation will be requested as part of the screening process.

Post-Doctoral Research Fellow, Kemp Laboratory of Functional Precision Medicine

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 13963

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

We are seeking a highly motivated postdoctoral scientist to lead a project in cancer drug target discovery based in the laboratory of Dr. Christopher Kemp.  The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics.  Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.  We currently have identified a number of high value targets that are in stages of validation in patient derived tumor organoids.  The ideal candidate will have a formal background in cancer biology and genetics, with expertise in cell culture, including tumor organoids, molecular biology, genetic analysis, and the use of animal models. The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.  

Responsibilities

The applicant will apply state of the art functional genomic and high throughput screening approaches to identify genes required for cancer cell survival and sensitizers to current cancer therapeutics.  Through bioinformatic curation, functional cellular assays, and animal models, the applicant will prioritize and validate these as candidate drug targets.

 

The applicant will be expected to interact with an interdisciplinary local team (computational scientists, clinicians, cancer biologists) and with the national CTD2 network.

Qualifications

  • A PhD in molecular biology, biochemistry, cancer biology, genetics, or related discipline.
  • Experience in standard molecular biology techniques, including qRT-PCR, immunoblotting, shRNA and CRISPR vector design and construction.
  • Experience with drug development would be a plus.
  • Demonstrated track record of productive, independent research.

Please include a cover letter detailing your research accomplishments, go forward interests, and suitability for this position with your application.   At least two letters of recommendation will be requested as part of the screening process.

Post-Doctoral Research Fellow, Post-Transcriptional Control in Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 10877

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level.

Responsibilities

For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, RNA labeling/sequencing techniques, various cellular and molecular assays, and a repository of primary human cancer samples to understand how the shape of mRNA direct their translation and cancer phenotypes. Applicants should be interested in the application of basic science research towards clinically intractable problems faced by cancer patients and will be expected to be scientifically intrepid.

Qualifications

Minimum qualifications:

 

We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts.

 

Preferred qualifications:

 

A strong background in high throughput methods, RNA biology, and/or computational biology are highly desirable. Excellent verbal and written communication skills are required.

To apply for this position, please provide the following:

 

  • Cover letter summarizing your research interest
  • CV
  • Three references

Post-Doctoral Research Fellow, Prostate Cancer Program

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 14621

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Program in Prostate Cancer Research and the Division of Human Biology seek a Postdoctoral Fellow to perform studies exploring the molecular mechanisms underlying metastatic prostate cancer in Dr. Peter Nelson’s research group.

 

The particular areas of emphasis for this position center on studies of cancer genomics, tumor microenvironment, epigenetics, cell-free DNA, prostate cancer biomarkers, and their translation to improve treatment strategies. We are recruiting a post-doctoral fellow to engage in laboratory-based studies of these processes. This is a basic science position that focuses on delineating the molecular mechanisms of metastatic prostate cancer with the opportunity for translational studies evaluating the efficacy and outcome of novel therapeutics

Qualifications

M.D. degree or Ph.D. degree in biology; biochemistry; genetics; molecular biology; cell biology; immunology or related field is required. Additionally, experience in one of the following areas is required: medicine/urology, genomics/genetics, analysis of inflammation/immune composition, biomarker characterization. Knowledge/exposure in biobanking, clinical trial design, and biostatistics is desired, as well as a demonstrated track record of high-quality publications. Expertise/skills in molecular biology techniques is desired: RT-PCR, immunohistochemistry, ELISA, cell culture, drug toxicity assays. Candidates need to be highly-motivated, organized individuals who think independently but enjoy working as part of a dynamic, collaborative, and multidisciplinary team. Excellent verbal and written communication skills are essential

Post-Doctoral Research Fellow, Viral Control of Host Chromatin

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 10974

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Avgousti lab at the Fred Hutchinson Cancer Research Center has an opening for a postdoctoral fellow.

 

A hallmark of many diseases and cancers is the aberrant regulation of chromatin. Much like the cellular genome, viral genomes are compacted in virus particles with small basic molecules to maximize space and be poised for gene expression. Some DNA viruses use cellular histone proteins to compact their genomes whereas others use small basic molecules. The Avgousti lab in the Human Biology Division at Fred Hutch uses a multidisciplinary approach to uncover the mechanisms by which viruses hijack chromatin (Nature 2016, J. Virol 2017, Mol Cel Proteomics 2017). Our goal is to advance basic understanding of viral manipulation of chromatin and reveal new aspects of chromatin biology thereby providing new avenues for possible therapeutic advances.

 

Our current research efforts are divided among studies of (1) a small basic protein from adenovirus, protein VII, that serves to compact its genome while wreaking havoc on the host genome, (2) host histones found on herpesvirus genomes during infection and how they can be exploited to block infection, and (3) using viral tools to block inflammation and cancer progression.

Responsibilities

The successful candidate will work on collaborative projects in the Avgousti Lab primarily focused on, but not limited to, the understanding the dynamics of protein VII-DNA complexes, protein VII-nucleosome complexes, binding partners and the impact of mutations on viral infection. Candidates should have excellent communication skills, value teamwork and can thrive in a fast-paced environment. 

Qualifications

We are looking for exceptional candidates with a recent PhD, a record of productive research (at least one first-author publication), with knowledge and experience in biochemistry and molecular biology. Preference will be given to candidates with a background in structural biology for the study of viral proteins by crystallography or other biophysical techniques. Virology knowledge is beneficial but not required.

 

Interested candidates should submit a CV, a summary of research experience and interests, and contact information for three references.

Research Technician I-II, Developmental Oncology

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14573

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

The Tapscott Lab is composed of an interactive group of scientists investigating lineage specification and cell differentiation. The lab focuses on gene transcription in a chromatin context in normal development and disease. Areas of research include gene expression in cell culture models of cell specification and differentiation that includes myogenesis, neurogenesis, and pluripotent stem cells to identify the molecular bases of totipotency, pluripotency, specification, and differentiation. Models derived from these developmental systems are applied to understand human diseases, including cancers and degenerative diseases.

Responsibilities

Research technicians are responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. Job duties include:

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Participate in lab meetings and journal clubs

Qualifications

Research Technician I: Bachelor’s degree in biology or related fields is required. Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is required.

 

Research Technician II: Bachelor’s degree in biology or related fields and two years of professional research experience working in a laboratory. A master's degree may, in some cases, substitute for two years of post-graduation lab experience.

 

A successful candidate will have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills and the ability to work and think independently. The candidate must have a track record of reliability and good verbal and written communication skills. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school.

Research Technician II (Lab Manager)

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14711

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

The Gujral Lab is seeking a Research Technician II to serve as lab manager. The successful candidate will culture and maintain a collection of mammalian cancer cell lines, prepare samples for reverse phase lysate microarrays, run microscopy-based assays to characterize the effect of panels of small molecules and siRNA’s on phenotypes of these cell lines, and use various software packages to analyze data from these assays. The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

Responsibilities

Research technicians are responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. Job duties include:

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Participate in lab meetings and journal clubs

Qualifications

Bachelor’s degree in biology or related fields and two years of professional research experience working in a laboratory. A master's degree may, in some cases, substitute for two years of post-graduation lab experience.

 

A successful candidate will have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills and the ability to work and think independently. The candidate must have a track record of reliability and good verbal and written communication skills. This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate school.

Staff Scientist, Transcriptional Control in Development and Disease

FH Human Biology Division
Category: Staff Scientist
Seattle, WA, US
Job ID: 13088

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Tapscott Lab seeks a Staff Scientist to manage the lab with an interactive group of scientists investigating lineage specification and cell differentiation. The lab focuses on gene transcription in a chromatin context in normal development and disease. Areas of research include gene expression in cell culture models of cell specification and differentiation that includes myogenesis, neurogenesis, and pluripotent stem cells to identify the molecular bases of totipotency, pluripotency, specification, and differentiation. Models derived from these developmental systems are applied to understand human diseases, including cancers and degenerative diseases.

Responsibilities

The incumbent will work independently under the guidance of and in conjunction with the Principal Investigator in accomplishing the goals of the laboratory and use discretion and judgment in carrying out experiments. Job duties will include:

  • Supervise the daily operations of the research laboratory
  • Conduct research independently as well as contribute to research being done by other team members
  • Address and resolve technical or procedural problems and advise technicians on the interpretation of results
  • Develop and document new technologies and protocols into the laboratory
  • Recruit, hire, train, and evaluate Research and Laboratory Technicians
  • Monitor lab safety
  • Act as a liaison to other research and administrative departments
  • Establish laboratory standards and maintain records
  • Write reports and contribute to scientific publication as warranted by the research
  • Assist in the design and review of laboratory space, equipment procurement, and supply purchases

Qualifications

Required:

 

  • PhD in a biological science and at least 3 years of relevant experience
  • Excellent knowledge of fundamental molecular and cell biology
  • A broad understanding of the techniques performed in the laboratory that include standard molecular biology techniques such as cloning, sequencing, RNA and DNA preparations, RT-PCR, Western blots, and tissue culture, as well as experience training individuals in these techniques

Preferred:

 

  • PhD in a biological science and at least 5 years of relevant experience
     

To be considered for this opportunity, please submit your CV and a cover letter describing your research accomplishments, as well as contact information for three references.

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