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7 Found open positions

Post-Doctoral Research Fellow - Emerman Lab

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18579

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Emerman lab was awarded an Avant-Garde Award from NIDA to study HIV latency. We have developed a novel screening technology called HIV-CRISPR technology to comprehensively discover the pathways of HIV latency maintenance and establishment. This postdoctoral position will further explore HIV latency by developing new variations of these CRISPR screens and by validating and further exploring mechanisms of the hits. Preference for new PhD with expertise in one of the following areas: chromatin biology, transcription factors, primary T cell culture, or models of HIV latency. Expectation is to develop an independent project within the context of the grant. The responsibilities include those expected at a PhD level, including leading the technical aspects of the study, contributing intellectually to the overall study design, interpreting data, presenting the findings at meetings and writing manuscripts.

Responsibilities

A laboratory in the Human Biology Division at Fred Hutchinson Cancer Research Center is seeking a Post-Doctoral Fellow to work with an interactive collaborative team of scientists investigating the mechanisms of HIV-1 latency using CRISPR screens and validation in primary cell models of HIV latency. The applicant should be well organized, pay close attention to detail, be reliable and motivated to participate in multiple levels of lab activity. The fellow will perform standard routine and investigative laboratory work in support of scientific research specific to HIV latency and CRISPR screens.

 

Major duties:

  • Preform experiments at the bench level to support investigative work, potentially including, but not limited to molecular biology, viral infections and assays, DNA sequencing, PCR amplification, RT-PCR amplification, TC culture, BLS2/3 work, including making virus stocks and performing viral infection
  • CRISPR/Cas9 screening and editing, and analysis of results
  • Experiments with primary T cells
  • Recover, compile and verify accuracy of research data
  • Operate analytical instruments
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Present data at local and national meetings
  • Prepare manuscripts describing the data and their meaning to the field

Qualifications

Educational or Special Training Qualifications

  • Applicants must have a PhD (or equivalent degree) in Biomedical Sciences and basic techniques in molecular biology. Ability to think critically and design and interpret experiments is essential, as are strong communication skills.

 

Experience Requirements

  • Experience with molecular biology and biochemical methods
  • A strong interest in research in the area of HIV biology and HIV latency, infectious diseases and global health
  • Evidence of productivity appropriate to a postdoctoral fellow as measured by publications and presentations, abstracts and posters at conferences
  • Well-organized with strong attention to detail
  • Ability to work independently and perform experiments without day-to-day supervision will be required after training
  • Ability to work as part of a team and to participate in multiple projects in collaboration with different lab members and collaborations with outside labs


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Biology of Small Cell Lung Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17590

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Responsibilities

A Postdoctoral Fellow position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered mouse (GEM) and patient derived xenograft (PDX) models towards understanding genes mutated in SCLC and basis of response towards conventional and novel therapies. Our lab works closely with thoracic oncologist collaborators at the Seattle Cancer Care Alliance to access patient samples and to help translate basic findings (e.g. see Augert et al, 2019, Science Signaling “Targeting NOTCH Activation in Small Cell Lung Cancer Through LSD1 Inhibition”). Some of these directions are supported by an NIH Lung Cancer SPORE award that promotes translational lung cancer research.  We are also interested in understanding basic mechanisms underlying SCLC tumor suppressor and oncogene function (e.g., see Augert et al, Cancer Cell 2020, “MAX Functions as a Tumor Suppressor and Rewires Metabolism in Small Cell Lung Cancer” and Jia et al, 2018, Cancer Discovery “Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition”.) We are increasingly performing functional screens in vivo and in tissue culture cells applied to cells to understand genes important for SCLC and to identify new druggable vulnerabilities.  The specific project will be developed by both the candidate and Dr. MacPherson based on areas of shared interests.

Qualifications

  • Recent PhD in Biology or related fields
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • A record of publication in peer reviewed journals

Please include a cover letter detailing your research interest and suitability for this position and names and contact information of at least two references with your application. 

 

 

Post-Doctoral Research Fellow, mRNA Translation in Cancer

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18969

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A postdoctoral position is immediately available in the Hsieh Lab at the Fred Hutchinson Cancer Research Center. The core focus of the Hsieh Lab is to interrogate the mechanisms by which post-transcriptional gene regulation governs cancer cell behavior at a molecular, cellular, and organismal level (Hsieh et al. Nature 2012, Schuster and Hsieh Trends in Cancer 2019, Winters et al. JCI Insight 2019, and Liu et al. Science Translational Medicine).

Responsibilities

For this position, the applicant will utilize murine genetics, whole transcriptome ribosome profiling, functional genomics, RNA labeling/sequencing techniques, various cellular and molecular assays, and a one-of-a-kind biorepository of primary and metastatic human prostate and bladder cancer samples to understand how the translation apparatus promotes cancer phenotypes.

 

Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals. In addition, both the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.

Qualifications

Minimum qualifications
We are looking for exceptional candidates with a recent PhD and/or MD, a record of productive research, and the ability to work independently as well as in collaborative research efforts.


Preferred qualifications
A strong background in murine work, high throughput methods, RNA biology, and/or computational biology are highly desirable. Excellent verbal and written communication skills are required.

 

Application instructions:

To apply for this position, please provide the following:

  • Cover letter summarizing your research interest
  • CV
  • Contact information for three references


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Postdoctoral Research Fellow, Geballe Lab

FH Human Biology Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18196

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A postdoctoral position is immediately available in the Geballe Lab at the Fred Hutchinson Cancer Research Center. The Geballe Laboratory studies the roles, mechanisms and evolution of antagonism of host cell defenses during infections by large DNA viruses, especially herpesviruses and and vaccinia virus. Additional project focus on control of gene expression at the translational level.

Responsibilities

The postdoctoral scientist will initially join in ongoing projects focusing either on foreign nucleic acids sensors and viral genes that inhibit these sensors or on translational control of viral gene expression.  Later, they will be expected to develop a new independent project within general area of host viral interactions and mechanisms and evolution of viral antagonism of host defenses. 

 

Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals. In addition, both the Student/Postdoc Advisory Committee and the Office of Scientific Career Development offer diverse mentoring and career development opportunities.


Scope of responsibilities:

Applicant will design, conduct, analyze and report original experiments probing the mechanisms and evolution of viral antagonists of host defense systems or the regulation of translation by viruses.  This position is funded for at least 2 years but with the possibility of additional years, depending on success in obtaining independent funding.


Job duties:

  • Design, conduct, interpret experiments focusing on the molecular biology and virology of virus-host interactions
  • Experiments require work with BSL2 viruses, so must be able to work carefully and comply with biosafety regulations
  • Participate in group meetings including presentations several times each year
  • Prepare publications results from the experiments
  • Assist in maintaining general operations of the laboratory
  • Aid in mentoring junior scientists
  • Apply for postdoctoral grants

Qualifications

  • Highly motivated and careful scientist who is able to work independently as well as part of a team
  • PhD with experience in virology, including studies of host defenses, and molecular biology.  Experience in biochemistry, computational methods, and translational control mechanisms would be advantageous.
  • Experience with BSL2 containment methods
  • Familiarity with intrinsic host defense systems such as the interferon pathway
  • Excellent verbal and written communication skills are required

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Research Technician I-II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18275

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



This position will support projects to discover and characterize new antiviral factors. Lab tasks including CRISPR knock outs, PCR, DNA sequencing including next generation library preps, cell culture experiments, transformations, ligations, bacterial culture, minipreps, transfections, Western blot. Antiviral immune responses studied may include those that inhibit HIV, ZIKA and/or Coronaviruses. Data and samples must be well-organized and precisely tracked. The most critical qualities in a successful candidate will be organization, precision, and initiative.

 

Under the direction and close supervision of the Principal Investigator or higher-level laboratory personnel in the lab, the applicant will gain practical experience in the following areas:

  • coordinating and performing support for a research laboratory that focuses on understanding innate immune responses to HIV and other viral infections
  • performing state of the art CRISPR screening, in some cases in primary cell systems and validation of genes identified in such screens. Other basic molecular biology techniques will be developed as part of this work, including including learning the basics of molecular cloning, PCR, DNA sequencing, RT-PCR, flow cytometry, cell culture and transfection, and data analysis.

Inclusion of a cover letter explaining your interest in this position is preferred

Responsibilities

  • Perform CRISPR KO screens and individual KOs
  • Culturing of cell lines and primary T cells
  • Prepare libraries for Illumina sequencing and analyze deep sequencing data
  • Perform RNA seq
  • Perform Western blots and other methods to measure gene/protein inactivation
  • Perform molecular biology techniques such as PCR, RT-PCR, and ddPCR
  • Assist with molecular cloning and tissue culture for a variety of projects, including studies of viral antibodies and the viral reservoir
  • Maintain laboratory records and compile and verify the accuracy of data on experiments and assays
  • Present experimental results in both oral and written report
  • Perform other related duties as assigned
  • Keep up to date on literature related to research projects

Qualifications

Minimum qualifications:

  • A bachelor’s degree in Biology, Chemistry, or Biochemistry and bench research experience:  
    • Research Technician I minimum qualifications - Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is usually necessary. 
    • Research Technician II minimum qualifications - Intermediate level position requiring 2 years previous experience working in a laboratory. Independent research experience outside of laboratory course work is usually necessary.
  • Must have sound laboratory skills, including molecular techniques and cell culture
  • Must demonstrate exquisite organizational skills, laboratory precision, reliability and work initiative required to operate with minimal daily supervision
  • Willingness to work in a HIV laboratory after suitable training (BSL2+)


Preferred qualifications:

  • Scientific knowledge of virology, immunology and/or RNA sequence analyses
  • Some experience with large data sets
  • Previous laboratory experience with experiment design, execution, optimization, troubleshooting, and data analysis
  • Demonstrated competence in careful and critical experimental design and execution.
  • Lab management (inventory, ordering, equipment maintenance, etc.)
  • Previous research experience in a BSL 2 laboratory, including tissue culture work


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

Research Technician II

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14811

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   


The Prostate Program in the Human Biology Division at Fred Hutch is seeking a Research Technician to perform standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries. This position works under the direction of the Principal Investigator or higher-level laboratory personnel and uses discretion and judgment in performance of duties.

Responsibilities

The position requires attention to detail and good communication skills. The candidate should be able to work independently and as part of a team. This position provides a rich environment to learn about cell biology and the drug discovery process. Candidates will also have the opportunity to present their research during lab meetings and scientific conferences and to write, submit, and publish scientific papers.

  • Perform experiments at the bench level to support investigative work
  • Prepare and maintain laboratory reagents, stocks, cultures or cell lines
  • Perform and modify documented protocols and assays
  • Maintain laboratory records and compile data on experiments and assays
  • Interpret and report on experimental results
  • Perform statistical analysis of test results and prepare written reports on work performed
  • Operate and carry out basic maintenance of laboratory equipment
  • Order and maintain appropriate levels of supplies
  • May supervise work-study students
  • Perform other duties as required
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
  • Assist in the design of experiments; may be responsible for the performance of individual research projects
  • Conduct literature reviews to assist in determining most suitable methods to be used in research
  • Assist in publication of results by proofreading, editing, and contributing ideas
  • May perform statistical analyses, write computer programs, or manage research database

Qualifications

Required:

  • Bachelor’s degree in Biology, Biochemistry or related field in life sciences
  • At least two years’ experience working in a laboratory
  • Independent research experience outside of laboratory course work
  • Experience with standard molecular biological techniques (DNA and RNA extraction) and biochemical approaches (gel electrophoresis, immunoblotting, immunoprecipitation)
  • Attention to detail, time management skills and a collaborative disposition

 

Preferred:

  • Murine handling experience
  • Mammalian cell culture experience

 

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

 

 

Staff Scientist, Small Cell Lung Cancer Biology - MacPherson Lab

FH Human Biology Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19503

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


 

A Staff Scientist position is available in the MacPherson lab, which is focused on the biology of small cell lung cancer (SCLC). We apply functional screens and analyses of genetically engineered murine (GEM) and patient derived xenograft (PDX) models toward understanding genes mutated in SCLC and basis of response toward conventional and novel therapies. We are also interested in understanding how to augment immune responses in SCLC. The Staff Scientist would help advance translational research in the lab by working both on independent and collaborative projects. The candidate may contribute to a translational NIH Lung SPORE grant, including study of patient samples and derived models.

Responsibilities

  • Perform independent research and also contribute as a part of a team in various projects as needed
  • Conduct therapeutic studies using murine models and perform molecular analyses to understand treatment responses
  • Conduct cell-based functional CRISPR screens
  • Revise animal protocols and help the lab maintain regulatory requirements
  • There is potential to mentor trainees
  • Present results in group meetings and prepare data for publication

Qualifications

  • PhD and 2+ years of postdoctoral experience
  • Proficiency with murine models and with molecular biology/biochemistry
  • Excellent oral and written communication skills
  • Must be able to design and execute experiments, interpret data and present results
  • Must have a record of publication in peer-reviewed journals

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through your work at Fred Hutch is requested of all finalists.

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