Clinical Research Job Openings

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Advanced Practice Provider (APP) provides care for blood and marrow transplant patients and immunotherapy patients in both the inpatient and outpatient settings under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team.  Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs perform bone marrow aspirations, lumbar punctures and are first assists with Bone Marrow Harvests and provide follow-up care of bone marrow donors under the supervision of attending physician.

Qualifications

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutchinson Cancer Research Center (either as an additional attachment on your profile or merged into the file that contains your resume.)

• Must be a graduate of a Physician Assistant training program or appropriate Nurse Practitioner program and be able to practice in the state of Washington (licensed).
• Have National Certification as appropriate for profession
• Must be licensed for schedule II drug authority.
• Strong oral and written communication skills required.
• Basic computer skills are essential.
• Must be able to work as part of a multi-disciplinary team.
• Must enjoy long-term relationships with patients undergoing intense therapy.
• Oncology or BMT experience preferred.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The pediatric advanced practice provider (APP) provides care for pediatric blood and marrow transplant patients in both inpatient and outpatient setting under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team. Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs provide follow-up care of bone marrow donors under the supervision of attending physician.  PALS certification is required for this position within 3 months of hiring date.

Qualifications

• Must be a graduate of a Physician Assistant  or Nurse Practitioner program (appropriate for care of Pediatric patients)
• Eligible for licensure in the State of Washington
• Have National Certification as appropriate for profession
• DEA licensure required
• Strong oral and written communication skills required. 
• EMR based computer skills and experience with CPOE preferred
• Strong team player with a can-do attitude is a must!  Ability to work as part of a multi-disciplinary team is essential.
• Must enjoy long-term relationships with patients undergoing intense therapy. 
• Pediatrics, Oncology or BMT experience preferred.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

We offer great generous benefits, including relocation and tuition reimbursement.

The position will provide care to post-treatment patients in the Seattle Cancer Care Alliance (SCCA) Survivorship Clinic and provide care across the continuum from diagnosis to survivorship focused follow-up for patients in the SCCA Sarcoma Clinic.

Allocation of FTE: 50% survivorship, 25% sarcoma survivorship, 25% general sarcoma care. 

SCOPE OF RESPONSIBILITY

Due to the unique nature of this position, training in the care of sarcoma patients and in providing survivorship focused care will be provided.  Within the Survivorship Clinic the Nurse Practitioner/Physician Assistant will be responsible for provision of clinical care and patient education for a broad range of cancer survivors, including  adult survivors of pediatric cancers.  They will work with a comprehensive team including the program director and co-director, the program nurse coordinator, and the program manager toward the goal of extending survivorship services to all oncology patients, regardless of age, place or type of treatment. They will collaborate with other providers within the Survivorship Clinic, within other SCCA oncology discipline clinics, and also with physicians and other health care professionals to define best practices of care, develop comprehensive survivorship care guidelines, and establish referral networks internal and external to the SCCA.

Within the Sarcoma Clinic the Nurse Practitioner/Physician Assistant will provide evaluation and medical management of Sarcoma patients at the SCCA.  They will follow patients during their chemotherapy and provide medical supportive care, as well as surveillance. The ARNP/PA-C assesses and manages basic health needs of patients, addresses treatment toxicities, performs procedures, monitors for cancer progression or recurrence, and consults with professional peers as needed.  They work collaboratively with the treatment team to coordinate care of their patients. The clinician in this role will be expected to see patients along the continuum of care for sarcoma patients, including long term follow-up of sarcoma survivors in the Survivorship clinic conducting survivorship focused visits as described below as well as carrying out surveillance plans following standard treatment pathways in collaboration with the sarcoma medical oncologists. 

Responsibilities

Survivorship Program - comprehensive onsite evaluations for cancer survivors including:

• Review of diagnosis, treatment, acute and chronic complications and co-morbidities
• Risk-adapted history and physical examination, laboratory and diagnostic studies
• Psychosocial and functional needs assessment
• Referral to appropriate subspecialties and services
• Preparation of treatment summary or review of treatment summary developed by survivorship RN, including guidelines and recommendations for follow-up
• Patient education
• Provide written (and oral when necessary) communication of survivors evaluation back to referring provider and/or primary care provider
• Other Duties as assigned by program director or program manager:
  • Participate in program outreach activities (e.g. local or regional presentations regarding survivorship, or the survivorship program survivor education conferences, and other related activities), including off-hours as necessary
  • Participate in program development activities (e.g. visits to internal or off-site clinics or hospitals, and other related activities, development of standard of care guidelines)
  • Develop educational materials for survivors (e.g. Survivor notebook, health links, etc.)
  • Create, review and maintain accuracy and completeness of survivorship database care plan recommendations  

Sarcoma Clinic:

• Performs complex and problem-focused evaluation and management for patients diagnosed with Sarcoma
• Evaluates and manages on-treatment and post-treatment side effects, as well as long- term surveillance.
• Performs procedures according to licensure, credentialing, and scope of practice
• Collaborates and consults with other disciplines and services to ensure safe, effective, and timely treatment as well as continuity of patient care.
• Participates in the conduct of cancer clinical research
• Provides patient, caregiver, and peer education
• Communicates effectively with inpatient and outpatient teams
• Participates in patient rounds, conferences and committees
• Active member of the SCCA Rapid Response/Code Team

PROFESSIONAL CONDUCT

Employees within the Survivorship Program are expected to maintain high standards of professionalism in their interactions with patients, referring providers and other team members. Professional conduct includes:

• Fosters positive and professional interpersonal relationships with patients, families, staff, referring physicians and other visitors.
• Actively promotes positive working relationships within survivorship team and all SCCA, Fred Hutch and UW Medical Center staff to create an affirming work environment.
• Is flexible and positive in accepting other duties or projects as assigned by the program director or program manager.
• Identifies and reports barriers to clinical and departmental effectiveness and facilitates/ suggests effective problem solving.
• Seeks positive resolution of interpersonal conflicts though self-awareness, mutual respect and skillful communication.
• Is aware of and follows policy and procedures regarding infection control, health, safety and security.
• Adheres to survivorship team and Fred Hutch, SCCA and departmental personnel policies including attendance, punctuality, and timekeeping standards.
• Supports Fred Hutch and the SCCA in its efforts to fulfill its mission.

Qualifications

• 1 year of ARNP or PA-C experience in Medical Oncology or BMT preferred
• Strong team player with a can-do attitude is a must! Ability to work as part of a multi-disciplinary team is essential.
• Graduate of an accredited Physician Assistant or Nurse Practitioner program required.
• Washington state & DEA licensure required.
• ACLS required
• Strong oral and written communication skills required.
• EMR experience required; prefer experience with CPOE

PAY, BENEFITS & WORK SCHEDULE

• Salary DOE + excellent benefits; 1.0 FTE position. Will require some evening hours.

Hematopoietic Cell Transplant (HCT) and Immunotherapy (IMTX) Programs

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical care and clinical research programs in hematopoietic cell transplantation and immunotherapy. All clinical research interests will be considered however, there is a particular interest in applicants with demonstrated experience in the field of immunotherapy. Applicants with extensive research experience will also be considered. University of Washington faculty engage in teaching, research and service.

Anticipated start date January 2, 2019

Hematopoietic Cell Transplant Program

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology, are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical research and clinical care programs in hematopoietic cell transplantation and immunotherapy. The successful candidate will be a prominent thought leader in the field of Stem Cell Transplantation who is engaged in innovative laboratory-based research investigating the mechanisms and/or treatment of malignant relapse after transplantation, which may include leukemia intrinsic and/or immunological mechanisms of immune escape. Fred Hutch and University of Washington faculty engage in teaching, research and service.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

Anticipated start date would be June 1, 2020.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Clinical Research Coordinator, Center for Accelerated Translation in Pancreas Cancer (CATPAC) is responsible for day-to-day coordination of clinical and preclinical studies under the direction of the PI and the Hingorani Translational Research Program Manager. This part-time position represents an excellent opportunity for an experienced, highly motivated individual with a passion for research to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.

The Coordinator will be primarily responsible for the operations of our pancreas cancer biorepository program and other pancreas cancer research team studies. This will involve implementing study processes, assisting with protocol development, coordinating collections and shipments, assuring adherence to regulatory guidelines and maintaining study records. This position will define and implement best practices for data and materials management. 

Responsibilities

• Maintain standard operating procedures (SOPs) for the CATPAC pancreas biorepository and ensure program compliance with SOPs
• Coordinate operations of the biorepository project and assist with resource planning
• Prepare study templates and documentation for collection and distribution of specimens; ensure regulatory compliance
• Manage priorities for a team of data coordinators responsible for consent, collection and day-to-day collection activities
• Manage specimen distribution process; pickup at UW Medical Center and courier samples to their destinations and/or coordinate pickup and distribution with the assistance of on-call staff
• Manage protocol modifications and annual reporting requirements
• As needed, review medical records to ascertain study eligibility and consent study subjects to biorepository protocol
• May attend clinic visits when appropriate to provide education about study requirements
• Coordinate and ensure quality of clinical data abstraction
• Identify and communicate procedural problems
• Create and maintain project web sites
• Manage project databases and tracking tools; maintain knowledge of database definitions and usage and work with programmers to modify as needed
• Monitor project/study expenses and prepare financial reports
• Serve as a point of contact for protocol procedures, data and specimen collection requirements and other study related operations
• Support multiple projects in varied environments with frequently competing deadlines and changing priorities

Qualifications

• Bachelor’s degree, preferably in a biological field
• Minimum of two years of clinical research or related experience, previous experience in oncology research is preferred
• Excellent problem-solving skills with ability to grasp details of situation quickly and volunteer and facilitate solutions
• Strong verbal and written communication skills
• Must be highly organized with the ability to multitask in a fast-paced environment
• Excellent critical thinking with ability to synthesize a large amount of information and anticipate needs
• Demonstrated ability to quickly and independently learn new technologies
• High level of proficiency with Microsoft Office applications and data management tools
• Must be flexible and quickly adapt to changing priorities
• Ability to work independently and efficiently under pressure
• Occasional nights and/or weekends will be required

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

This individual will work under the supervision of the Principal Investigator(s) and will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines. The ability to work across Fred Hutchinson, University of Washington and Seattle Cancer Care Alliance will be critical.

The ideal candidate will be able to address the full set of responsibilities in this listing and commit to a 1.0 FTE position.

Responsibilities

• Principal Investigator Support:
  • Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy
  • Liase with SCCA clinical and administrative teams to identify appropriate and effective recruitment pathways

• Recruitment and Enrollment
  • Review study candidates’ medical records for study eligibility
  • Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained

• Education
  • Educate clinical teams, co-investigators, ancillary departments, and patients to ensure safe and accurate protocol implementation

• Protocol Implementation
  • Because the nature of the clinical study may vary within this job, the CRC must be capable of moving seamlessly between different protocols
  • Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders. Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
  • Initiate scheduling of patient clinic visits, and on-going study visits. Ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
  • Complete requisition forms, assemble kits for upcoming research visits, transport laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.

• Budget & Billing
  • Understand clinical trial budget and billing plans for patients enrolled on clinical trials or studies
  • Work with internal partners to obtain and submit budget and billing information

• Other Duties Which May Be Required
  • Assist the Principal Investigator (PI) with protocol development, revision, and study analysis
  • Collaborate with Investigational Drug Services (IDS) on drug assignment, dispensation information, and maintain regular communication regarding status of study subjects
  • Ensure study drug self-administration and accountability with patients
  • Perform non-clinical ECGs
  • Administer study questionnaires and disperse study-related payments
  • Conduct study interviews and participate in focus groups
  • Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies
  • Maintain or assist in maintaining IRB correspondence and regulatory documentation.  Prepare or assist in preparing consent forms, continuation review reports, protocol submissions and modifications, and other study reports
  • Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner
  • Coordinate monitoring visits and respond to queries and other requests from study monitors
  • Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy
  • Participate in the review of charges for patients on clinical trials to ensure billing compliance
  • Travel for industry sponsored investigator meetings
  • Maintain knowledge in the field through attending related project meetings, reading related literature, and maintaining professional associations
  • Other duties as assigned

Qualifications

• Associate degree required, with Bachelor’s degree preferred
• Applicant must have a minimum of one to two years of clinical research or related experience.
• Previous experience in biobehavioral intervention studies (e.g. web apps, acupuncture) is preferred
• Previous experience in oncology research and clinical data collection is preferred
• Previous experience in investigator-initiated and industry-sponsored drug studies is preferred
• Previous experience in survey research and qualitative interviewing is preferred
• This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment
• Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

We are seeking a highly motivated individual who is interested in supporting a large, mission-critical, clinical research data management system used to treat and address cancer. Candidates who are excited about the mission of the Fred Hutchinson Center and cancer research in general are encouraged to apply. The position has a competitive salary with great benefits.

This person will serve in a full-time role of data analyst/programmer, working as a lead data analyst. The person will be focused on:

• building expertise on the internal clinical research dataset and data systems
• understanding and supporting the different business functions that our systems coordinate, both for research users on the Fred Hutch side and clinical users engaged in patient care and clinical operations at the Seattle Cancer Care Alliance (SCCA)
• working with scientific researchers to analyze and understand clinical data
• supporting clinical operations of SCCA and Fred Hutch (including system data interfaces with external institutions of the Consortium)
• programming and automating reports to extract and deliver clinical data to investigators, clinicians and clinical support staff
• providing research application of our clinical data integrated with external data sources (Amalga) on behalf of the Clinical Research Division's scientific mission

Qualifications

Required:

• Bachelor’s degree
• 6-9 years of directly related experience
• Experience in working with Microsoft SQL Server and related Microsoft SQL products
• Strong skills in analyzing relational data and problem solving
• Excellent verbal and written communication skills, including working directly with users

Preferred:

• Experience in working in the health care and/or medical research fields

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

• Abstract clinical research data from patient medical charts. Data includes diagnosis information, pathology results, imaging results, medication data, procedure notes and more.
• Key enter data into Clinical Division research data base, or record on specific data forms for electronic research files
• Check research files for missing data and download records as needed
• Check for protocol compliance
• Perform other duties as requested by supervisor

Qualifications

• Bachelor's degree or two-year degree in the medical field required
• Requires minimum 1 year of medical chart review/data abstraction experience
• Strong knowledge of medical terminology, ability to read and interpret lab, pathology, imaging and other medical documents
• Prior Oncology or HSCT experience preferred

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Data Coordinator (DC) is responsible for the documentation and monitoring of Phase 1-3 clinical trials, including the collection, coordination, processing and quality control of clinical trial data. The position will track clinical activity and subject visits, and abstract and report data. The DC will work on studies for at least two investigators, and regularly update those investigators on progress and activity. The DC will work closely with a Clinical Research Coordinator and will report directly to the Clinical Program Operations Director.

Responsibilities

• Abstracts patient/participant data from medical records timely, according to protocol reporting guidelines
• Maintains databases and shadow charts with source documentation, demonstrates knowledge of database definitions
• Tracks study timelines and assures that procedures are completed per protocol
• Identifies procedural problems and communicates to the study coordinator, PI and program director as appropriate
• Resolves database queries and inaccuracies timely
• Creates and maintains tracking tools
• Performs routine audits to ensure quality and completeness of the data submitted, identifies missing data and corrects deficiencies
• May occasionally attend clinic visits when appropriate to provide education about study requirements or obtain data
• Serves as a resource to investigators, subjects, and collaborating physicians, service areas and organizations with questions about study procedures and operations
• May assist in the development of databases and case report forms
• Serves as main point of contact with study monitors, schedules monitoring visits and completes associated tasks
• Prepares research sample collection kits, delivers to collection sites, and assures samples are collected and routed appropriately
• Performs other duties as assigned including archiving records of closed studies, maintaining shared drive files, requesting medical records from outside providers
• In collaboration with the Investigator and study coordinator, anticipates and plans for data deadlines
• Keeps knowledge and skills current by completing mandated training and attending meetings with the study team and the Consortium, such as the monthly coordinator meeting, relevant brown bags, faculty and administrative presentations, and other opportunities of interest

Qualifications

• Associate degree or equivalent experience required
• One to two years of experience working in healthcare environment with oncology and/or research experience required
• Strong computer skills and experience with data entry and databases. Prefer experience with Medidata RAVE
• Competency in Microsoft Office software
• Excellent attention to detail and ability to organize work
• Ability to communicate effectively both verbally and in writing
• Demonstrated ability to work independently, under supervision, and be a team player
• Ability to adapt and respond appropriately to competing priorities in a fast-paced environment
• Knowledge of FDA, GCP, and NIH requirements preferred
• Strong preference given to candidates with previous experience conducting clinical trials in hematologic malignancies

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine via patient selection and characterization of novel therapeutic targets. The lab has a major focus on mass spectrometry (MS)-based proteomics (both untargeted and multiple reaction monitoring), as well as integrating proteomic data with genomic and metabolomic data. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity within the Paulovich lab for a data scientist to work closely with our interdisciplinary team of chemists, biologists, clinicians, and statisticians to leverage multi-omic datasets to understand and predict human cancer responses to therapies. We are looking for a highly motivated, interactive, Bioinformatics/ Computational Biologist to join our proteomics team to help drive translational projects forward towards clinical applications by performing analysis and interpretation of multidimensional “-omics” datasets (DNA, RNA, protein, metabolite, and clinical phenotype) from human tumors and preclinical models. The candidate will participate in the development of data pipelines, plan and conduct analyses, interpret results, design and implement data visualizations, and help prepare figures and text for funding proposals, reports, and publications. The ideal candidate should have the ability to work independently as one hub in an interdisciplinary team.

Responsibilities

• Apply data analysis tools and methods to enable the integration and management of large and complex “omics” datasets
• Interpret data analyses results and write methods and results for publications and reports
• Collaborate with statisticians, chemists, biologists, and clinicians on consortium projects
• Research and evaluate new methods and algorithms for integrating into our existing pathway and network analysis tools
• Perform other job-related duties as assigned

Qualifications

Required

• Ph.D., M.A., or M.S. candidates with degrees in both data science-related disciplines and biology-related disciplines (e.g. a computational biology, bioinformatics, computer science, biostatistics, or mathematics degree, plus a cancer biology, molecular biology, or biochemistry degree) 
• Minimum 2 years of hands-on biological data science experience (especially with proteomics, RNA sequencing, next generation sequencing datasets)
• Understanding of molecular biology, cancer biology, and an ability to contemplate the biological implications of results from multi-omic datasets
• Strong programming skills (e.g. C/C++, R and Python/Perl/Java), with knowledge of the appropriate tools and libraries for working with biological data, including best software development practices (e.g. design, testing, documentation, code review)
• Experience in pathway and network analysis as demonstrated by peer-reviewed publications and/or software packages
• Familiarity with pathway and network databases and analysis algorithms
• Programming in UNIX/LINUX environment
• Excellent presentation skills and written/verbal communication skills
• Ability to multi-task and prioritize tasks in a deadline-driven environment
• Intellectually curious with innovative and creative problem-solving skills
• Motivated, self-starting, detailed-oriented, organized
• Ability to learn new technologies at a fast pace
• Ability to lead data analysis activities independently and with feedback from the group

Preferred

• Experience with data visualization tools (e.g. D3.js, Vega, Google Charts, etc.)
• Familiarity with biomedical ontologies
• Familiarity with dimensionality reduction, regression models, machine learning and/or cloud infrastructure for scalable scientific computing
• Experience with graph databases
• Knowledge of SQL, JSON, and XML
• Knowledge of statistics and machine learning algorithms

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab (https://research.fhcrc.org/silberstein/en.html) is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project.

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote HSC function in bone marrow failure and to enhance post-transplant hematopoietic reconstitution. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and discovered several novel niche factors using proximity-based single cell analysis (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

A successful candidate will be studying the effect of extrinsic HSC regulators on the bone marrow function and disease progression in preclinical models of myelodysplastic syndrome. In parallel, they will also be involved in a project which investigates the role of newly-defined niche factors in HSC aging and stress response. 

They will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle). There will be ample opportunities for data presentation and informal discussions. They will be encouraged to develop research ideas and branch out into more independent projects. Mentorship and support for post-doctoral fellowship applications will be provided. 

Qualifications

The candidate is expected to have a PhD and/or MD and a strong interest in stem cell research and commitment to basic/translational science in hematopoiesis. Applications from trainee hematologists who are willing to undertake a laboratory-based research project are welcome. Previous experience of working with murine models is not essential, but would be preferred. Excellent verbal and written communication skills are required.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

Postdoctoral Research Fellows in immuno-oncology – Novel cancer immunotherapies

Immunotherapies, such as checkpoint inhibition and adoptive T cell therapies, represent a paradigm shift in the treatment of cancer, inducing impressive responses in diverse malignancies. However, not all patients respond to current immunotherapies and novel therapeutic approaches are needed to circumvent these obstacles.

Post-Doctoral Research Fellow positions are available in the Immunotherapy Integrated Research Center at the Fred Hutchinson Cancer Research Center. The successful applicants will join a collaborative team that combines clinical research, animal modeling, computational biology and multiplexed immuno-histochemistry to understand the basic mechanisms of antitumor immunity and apply them to the development of novel immunotherapies.

This research program includes the laboratories of: Dr. Aude Chapuis, a translational immuno-oncologist who specializes in adoptive T cell therapies; Dr. Anthony Rongvaux, an immunologist who develops innovative humanized murine models to study the tumor/immune interface; Dr. Raphael Gottardo, a biostatistician with expertise in high-dimensional single cell data analysis; and Dr. Robert Pierce, a pathologist and expert in tumor microenvironment analyses who previously developed tissue-based biomarkers for Merck’s anti-PD-1 pembrolizumab antibody.

Our research is focused on understanding the biology and improving clinical outcomes after immune-boosting treatments. Human adoptive immunotherapy trials are initiated and being conducted using the robust Fred Hutch clinical platform. We are performing detailed analysis of patient outcomes to inform next-generation trials, and developing humanized murine models of checkpoint inhibition and adoptive T cell therapy against solid and liquid cancers. We are using single cell RNA sequencing, genome editing and genomic screens in humanized murine to understand how anti-tumoral immunity functions, why it fails in some patients, and how we can overcome current limitations. We use multiparametric immunohistochemistry to validate humanized mouse results in humans, using a large biorepository of annotated patient specimens.

The scientific questions being addressed include:

• How can we arm tumor-specific T cells to enhance their efficacy upon adoptive transfer in patients?
• Can we modulate the immunosuppressive properties of cells found in the tumor microenvironment, particularly macrophages?
• Can we identify additional immune checkpoints and develop novel inhibitors?

The overall objective of this interdisciplinary project is to provide the scientific basis for future clinical trials, leveraging Fred Hutch’s continuing leadership in the design, clinical testing and commercialization of successful anticancer drugs and immunotherapies.

Qualifications

Desired skills and experience of the applicants:

• PhD or MD/PhD degree in Immunology, Immuno-oncology, Cellular & Molecular Biology or a closely related field
• Strong knowledge/understanding of basic immunology
• Advanced training and experience with animal procedures, flow cytometry, primary cell isolation and culture, molecular biology and/or computational immunology

The successful candidates will be scientifically driven individuals who enjoy working in a highly collaborative environment, with a track record of productive research, demonstrated by at least one first author publication, and with excellent communication skills.

Please apply online with a letter summarizing previous work experience, personal strengths and future interests, a resume, and contact information for three professional references.

Related publications:

Chapuis lab:

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229.

Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts IM, Coffey DG, Warren E, Robbins H, Greenberg PD, Yee C.

Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8(+) T Cells In Vivo.

Sci Immunol. 2017 Feb;2(8). PMID: 28367538.

Chapuis AG, Lee SM, Thompson JA, Roberts IM, Margolin KA, Bhatia S, Sloan HL, Lai I, Wagener F, Shibuya K, Cao J, Wolchok JD, Greenberg PD, Yee C.

Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.

J Exp Med. 2016 Jun 27;213(7):1133-9. PMID: 27242164.

Rongvaux lab:

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Development and function of human innate immune cells in a humanized mouse model.

Nat Biotechnol. 2014 Apr;32(4):364-72. PMID: 24633240.

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.

Human hemato-lymphoid system mice: current use and future potential for medicine.

Annu Rev Immunol. 2013;31:635-674. PMID: 23330956.

Gottardo lab:

McDavid A, Finak G, Gottardo R.

The contribution of cell cycle to heterogeneity in single-cell RNA-seq data.

Nat Biotechnol. 2016 Jun 9;34(6):591-3. PMID: 27281413.

Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M, Linsley PS, Gottardo R.

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.

Genome Biol. 2015 Dec 10;16:278. PMID: 26653891.

Pierce lab:

Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR.

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.

Cancer Immunol Res. 2017 Nov;5(11):978-991. PMID: 29066497.

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.

PD-1 blockade induces responses by inhibiting adaptive immune resistance.

Nature. 2014 Nov 27;515(7528):568-71. PMID: 25428505.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

• Study the function of human T cells
• Molecular bench work with PCR, cloning, and vector design
• Single cell RNA sequencing
• Biostatistics and some basic programing skills
• Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections
• Validation through functional and killing assays.

Qualifications

• MD and/or a PhD in a biological science with a diverse knowledge of immunology
• Dynamic and driven – engaging and encouraging in team environments
• Willingness to write and apply for funding opportunities and abstracts
• A strong research background
• Proficient in molecular biology and cellular immunology technique and knowhow
• Virology knowledge will assist in the AIM of this position
• Flow cytometry and cell signaling based assays
• Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage

To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Turtle Lab is looking for a post-doctoral research fellow who will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic malignancies within the Program in Immunology and Clinical Research Division at Fred Hutch. The successful applicant will employ strategies for genetic modification of human T cells to enable their expression of chimeric antigen receptors (CARs) and redirection of specificity to antigens expressed by hematologic malignancies. In vitro studies using human T cells and in vivo xenogeneic models will be used to develop and test novel T cell therapies that can be studied in future human clinical trials.

Qualifications

• Applicants will have a PhD in a biological science and/or a MD
• The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including lentiviral vector design and cloning, virus production, cell culture, flow cytometry, ELISPOT, and T cell cytotoxicity assays
• To be successful in this position, the post-doctoral research fellow must be highly motivated to establish a career as a future independent investigator

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani (https://research.fhcrc.org/hingorani/en.html) at Fred Hutchinson Cancer Research Center in Seattle, WA.

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis.  The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program.  Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies.  Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

Successful applicants will have:

• A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
• Experience with standard molecular and cellular biology techniques
• A demonstrated track record of productive research
• Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
• Ability to develop create approaches to experimental design
• Ability to work both independently and as part of a laboratory team  

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Stem Cell and Gene Therapy Program laboratory that studies hematopoietic stem cell biology and develops novel gene therapy and gene editing strategies is recruiting a postdoctoral fellow to develop novel in vivo gene therapy approaches for the modification of primary hematopoietic stem cells using preclinical animal models. The position involves responsibilities, such as the development and optimization of viral vectors, follow up analyses for tracking of modified cells after delivery of the vector or formulation, processing of primary tissue samples, and culture/analysis of cells modified with nanoparticles and/or viruses. The candidate will be expected to publish and present their work in both internal and external events.

Qualifications

A PhD or MD in a scientific field is required. The individual must possess knowledge of hematopoietic stem cell biology. Experience in animal models, transduction of primary cells with viral vectors and gene therapy and editing tools are required. Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, viral vector platforms, flow cytometry/flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR. Previous experience in basic bioinformatics, and/or GLP/GMP techniques is desired, but not required.

To be successful in this position, the candidate must be highly motivated and able to work independently to design and execute experiments, possess a high level of initiative and attention to detail, and must also be able to multi-task and prioritize work at short notice. They must also be capable of working independently in a team environment. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Adair laboratory, housed within the Clinical Research Division, is recruiting a postdoctoral fellow or research associate to study blood cell gene therapy for genetic and infectious diseases and cancer. The post-doctoral fellow will investigate and develop methods to efficiently introduce genetic editing into stem cells and/or T cells and assess phenotypical and biological changes and performance in these cells. The fellow will work under the PI and other senior members of the research team and will be expected to publish and present their work in both internal and external events.

Qualifications

Required

• A PhD or MD in a scientific field
• Motivation to work independently and design and execute experiments
• Publication record in virology/molecular biology
• Advanced knowledge of molecular biology skills, tissue culture, and viral assays

Preferred

• Experience with development of nanoparticle technologies for nucleotide and protein delivery to primary cells
• Experience in studies involving  stem cell cultures, immunology, flow cytometry, animal models, and bioinformatics

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward toward clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

• Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
• Perform HPLC separations and maintain HPLC instruments
• Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
• Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
• Contribute to the analysis of proteomic (mass spectrometry) datasets
• Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
• Collaborate with others to develop new methods and tools that support research objectives
• Maintain research results files and databases
• Assist with written progress reports and development of standard operating protocols (SOP)
• Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

• Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline
• The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
• The position includes drafting reports and manuscripts for publication, as well as presenting experimental results to the research team and collaborators. Thus, excellent writing and oral communication skills are required
• Proteomics experience
• Previous experience in a CLIA or clinical lab environment is a plus
• A demonstrated track record of authorship on peer-reviewed journal publications is a plus

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Divisions of Hematology and Medical Oncology at the University of Washington (UW) are seeking a Program Administrator (PA) for their accredited fellowship in adult hematology/oncology.  The PA is responsible for the day-to-day administration of the Accreditation Council for Graduate Medical Education (ACGME) Hematology-Oncology Fellowship Program (Program).  The PA works closely with and assists the Program Director (PD), Associate PD, Assistant PDs and Key Clinical Faculty in developing and maintaining the educational quality of the training Program and ensuring compliance with ACGME accreditation standards and other regulatory requirements.  The PA functions as a liaison between the PD, fellows, UW GME Office, participating training sites, the Divisions of Hematology and Medical Oncology, and other departments, and must be knowledgeable about patient care/operational activities at the various training sites in which fellows rotate.

Responsibilities

• The PA is responsible for the coordination and oversight of fellow training activities at UW Medical Center, Harborview Medical Center, Veterans Administration of Puget Sound Health Care System, Bloodworks Northwest, the Seattle Cancer Care Alliance (SCCA) and SCCA affiliates.
• Scheduling and monitoring clinical rotations, collecting, tracking and reporting evaluations and assisting the faculty preceptors.
• The PA works closely with Program leadership and key clinical faculty to maintain, distribute and update curricular goals and objectives, to schedule teaching conferences and other educational activities and to coordinate the fellow review committees.
• Through these roles, the PA is expected to gain an intimate knowledge of ACGME requirements and to participate in local and national GME workshops and trainings to further their own career development in management and administration.
• The PA is expected to understand the training requirements of ABIM and other accrediting and regulatory bodies that impact fellow education.
• This position involves training and supervising junior support personnel who work within the Program.
• The PA also closely interacts with administrative personnel at the various clinical sites and within the Divisions of Hematology and Medical Oncology and at UW GME.
• Management of an annual budget, including tracking, auditing and reporting payroll and expenditures.

Qualifications

Required:

• BA/BS, Master’s degree desired.
• Minimum 8+ years related program management experience in medical education and healthcare.
• Experience with grants and contracts and strong budgetary supervisory skills are required.
• Demonstrated ability to manage complex activities in a research setting.
• This position requires high-level problem-solving and decision-making abilities along with organizational, time management and supervisory skills.
• The successful candidate must possess initiative, maturity, professionalism and excellent interpersonal and communication (written, verbal, cross-cultural) skills.
• The PA must be proficient with Microsoft Office applications and be familiar with web-based information systems and applications.
• The successful PA must be able to work independently and as part of a collaborative team, with diplomacy, compassion and a sense of humor.

Preferred:

• Previous experience working in GME and at the level of university administration are strongly preferred.
• The PA should have familiarity with ACGME, ABIM, and other accrediting and regulatory bodies and the standards that impact fellow education and training.
• The PA should possess excellent interpersonal and communication (written, verbal, cross-cultural) skills, problem-solving abilities and independent decision-making skills.
• The PA should be confident, proactive and willing to take initiative; in addition to being adaptable to rapid changes in work requirements and assignments. Maturity and professionalism are mandatory; and the PA should exhibit diplomacy, compassion and a sense of humor.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Reporting to the Senior Operations Director, the Research Administration Manager II, an essential part of the Stem Cell and Gene Therapy Program and of the Clinical Research Division (CRD) Administrative team, will work under the direction of the Program Head. Investigators within the Stem Cell & Gene Therapy Program conduct research using large and small vertebrate animals and infectious agents, as well as clinical trials requiring GMP, FDA and IND compliance. Responsibilities of the Research Administration Manager II will include management and oversight for program finance and administration, grants and contracts, and regulatory compliance, as well as compliance with Center policies and procedures. The Manager also plays an important role in staff recruitment, training and performance management.

Responsibilities

• Manage grants, contracts and research agreements awarded by a variety of funders including Federal agencies, private foundations and commercial enterprises
• Ensure compliance with sponsor-specific reporting requirements, including tracking deadlines for progress reports, quarterly/annual financial reports and project closeouts
• Establish and monitor budgets and spending, ensuring compliance with regulations/guidelines
• Proactively communicating about issues or concerns that may impact successful completion of the research
• Preparing regular, relevant and timely reports for PIs and the CRD regarding spending, staffing, and future projections
• Monitoring program employees’ effort and salary allocation; assisting PIs with monthly effort reporting
• Coordinating the preparation of new and renewal grant applications, reviewing application guidelines, communicating requirements to the PIs, and facilitating submission together with relevant departments in Fred Hutch administration
• Serving as a liaison with administrative departments within Fred Hutch and at collaborating institutions, including the University of Washington
• Partnering with the University of Washington and other organizations on collaborative proposals, reporting, and budget management
• Assisting Human Resources by providing documents for annual merit & performance evaluations, employee on- and off-boarding and international work visas when required
• Preparing administrative documents and ensuring regulations are followed for Human Subjects, Vertebrate Animals, and Hazardous Materials research
• Assisting laboratory personnel as needed with purchasing, shared resources access, and training requirements
• Performing other administrative tasks needed to ensure an efficient and orderly research operation

Qualifications

Required:

• Bachelor’s degree in Accounting, Finance, Public Administration, or related field
• Five years in pre-award and post-award grant and contract management
• Experience with industry sponsored contracts
• Knowledge of relevant regulatory requirements affecting sponsored research, and ability to apply this knowledge
• At least three years of management experience with direct reports and conducting performance appraisals
• Effective and professional oral and written communication skills, with the ability to tailor communications to specific audiences
• Ability to navigate complex internal systems and departments while exercising sound judgement and discretion
• Proficient with complex budget development and use of reporting tools
• Proficient in fiscal and budgetary management
• Advanced skills in Word, Adobe Acrobat Pro, and Outlook
• Advanced skills in Excel including familiarity with pivot tables
• Excellent time management and prioritization skills, with the ability to effectively manage multiple and competing demands
• Demonstrated ability to function independently while exercising skill and informed professional judgment
• Highly organized and detail oriented
• Demonstrated ability to work successfully as part of a diverse team
• Excellent written and oral communication skills and the ability to communicate effectively with personnel in a variety of roles

Preferred:

• Master’s degree
• Seven years of progressive experience in administration and grant and contraction administration
• The ability to work independently, soliciting direction or assistance from the Program Head as required
• Experience with contract negotiation
• Experience reviewing IRB and IACUC administrative documents
• Experience working in a research organization, a university/medical school setting, or other complex non-profit organization

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support the development of immunotherapy for cancer. This individual will have the opportunity to work with a variety of cutting-edge cellular and molecular research techniques. This person will be responsible for maintaining meticulous records and organizing and reporting on experimental results.

Responsibilities

• Plan and perform in vitro immunology cellular and molecular assays reliably according to laboratory protocols
• Process and cryopreserve human samples including blood and bone marrow
• Assist in ordering, lab maintenance and quality control and improvement activities
• Learn new techniques as required
• Assist post-doctoral scientists as required
• Analyze, organize and present data
• Identify methodological problems in research protocols and implement modifications to optimize experimental results
• Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data
• Assist in the design and implementation of experiments; may be responsible for the performance of individual research projects
• Conduct literature reviews to assist in determining most suitable methods to be used in research
• Assist in publication of results by proofreading, editing, and contributing ideas
• May perform statistical analyses, manage research data bases

Please note that part of the job responsibilities include collecting and/or processing samples from patients enrolled on clinical trials, which may require working outside of typical work hours and infrequently on weekends.

Qualifications

A bachelor’s degree in a biological science and some bench research experience outside of course work is essential. Experience in cell separation and selection, tissue culture, flow cytometry, chromium release assays, ELISPOT and ELISA is desirable. Experience in molecular techniques including PCR, DNA sequencing, western blotting, molecular cloning, viral vector construction is also desirable. Strong communication skills and ability to perform tasks independently and in teams are required.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Silberstein lab is seeking to recruit a Research Technician I-II.

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote hematopoietic stem cell function in bone marrow failure and to enhance hematopoietic reconstitution after bone marrow transplantation. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

Responsibilities

A successful candidate will work as a part of the highly collaborative team and focus on conducting animal experiments which involve stem cell transplantation, fluorescently-activated cell sorting/analysis and molecular studies of stem cells/progenitors. They will also share responsibility for murine colony maintenance.

The incumbent will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle).

Qualifications

Required:

• Bachelor's degree in a related scientific discipline
• Strong interest in stem cell research/bone marrow disorders
• Excellent written and verbal communication skills
• A short cover letter explaining why a candidate has chosen to apply to the position

Preferred:

• Bachelor's degree in a related scientific discipline and 2 or more years of relevant professional research experience, or a Master's degree in a relevant scientific discipline (can substitute for 2 years of professional research experience)
• Previous experience of working with murine models is not essential, but one of the chief responsibilities will involve handling the animals daily and performing standard
• Some multi-parameter flow cytometry experience (undergraduate research or post graduation)
• Candidates considering medical/graduate schools are encouraged to apply

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

A Research Technician I is needed in an immunology laboratory of Dr. Seth Pollack.  The person will be responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.

Responsibilities

• Perform experiments at the bench level to support investigative work
• Prepare and maintain laboratory reagents, stocks, cultures or cell lines
• Perform and modify documented protocols and assays
• Maintain laboratory records and compile data on experiments and assays
• Interpret and report on experimental results
• Perform statistical analysis of test results and prepare written reports on work performed
• Operate and carry out basic maintenance of laboratory equipment
• Order and maintain appropriate levels of supplies
• May supervise work-study students
• Perform other duties as required

Qualifications

Required

• BA/BS in a scientific field required
• Mammalian cell culture experience
• Must have scientific knowledge in the area of study and basic laboratory skills

Preferred

• Ideal candidates will have some experience with lab work outside of school
• Experience with flow cytometry
• Experience wiith qPCR

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Specialized Mouse Services (SMS) core provides access to immune compromised murine and xenograft technical services for preclinical studies by investigators with limited murine technical resources. The SMS core maintains production colonies of immune compromised murine, and conducts a full range of xenografting, monitoring, imaging and tissue sampling services.

Responsibilities

The applicant must have experience handling murine, be well organized, maintain good records, and display excellent communication skills. Main responsibilities will include performing various technical services, such as injections, blood draws, non-invasive imaging, and tissue harvests. The applicant will also assist in maintaining the Core database, inputting data into spreadsheets, billing and other administrative duties. Working an occasional weekend and holiday may be required for supporting the research.

Qualifications

• Bachelor’s degree in biological science
• A minimum of 2 years of experience handling mice
• Must have experience with murine blood draws and IP injections
• Proficiency using Microsoft Excel and Word
• Must be able to work in a fast-paced environment
• Must be able to prioritize assignments and complete procedures in a timely manner
• Must be willing to work as part of a team
• Attention to detail and meticulous record-keeping
• Demonstrated ability to learn new techniques

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Stem Cell and Gene Therapy (SCGT) program is recruiting a Research Technician II with a focus on bench research. Duties may include processing and analysis of primary blood and tissue samples for flow cytometry, PCR, sterile cell culture work with cell lines and primary cells, ELISA assays.

The position involves additional responsibilities, such as culture/analysis of cells infected with HIV and related viruses. The candidate should be motivated to participate in sample processing and analysis from preclinical modeling experiments. This position affords the motivated technician an opportunity to develop/utilize both tissue culture and molecular biology skills. The candidate must also be comfortable working with potentially infectious material and biosafety level 2+ techniques.

Qualifications

• A Bachelor's degree is required. A Master’s degree is preferred, in biological science with at least two years of laboratory experience
• Candidates with excellent organizational and communication skills (written and oral) plus an ability to work well in a multidisciplinary team environment are encouraged to apply
• To be successful in this position, the candidate must be highly motivated, possess a high level of initiative and attention to details
• They must also be capable of working independently on multiple projects in a team environment
• Experience with cell culture, multicolor flow cytometry, and/or molecular biology techniques e.g. quantitative PCR is strongly desired
• Previous experience with blood and tissues samples processing and ELISA is desired, but not required
• Knowledge or experience maintaining and ordering materials is preferred in addition to excellent record keeping skills
• The ideal candidate would be familiar with computer programs including Microsoft Office, FlowJo, Graphpad Prism, and/or similar products

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Clinical Research Division laboratory that studies hematopoietic cell biology and develops novel gene therapy and gene editing strategies is recruiting a Research Technician II to assist with in vivo modeling studies. The position involves various responsibilities, including collection of primary tissue samples, calculation and administration of medications, and precise and accurate record keeping. Studies include multiple models of human disease, including work with HIV and HIV-like viruses. This position also affords the motivated technician an opportunity to develop/utilize both tissue culture and molecular biology skills.

Qualifications

• A Bachelor's degree is required in a biological science with 2 or more years of relevant professional research experience. A Master's degree in a relevant scientific discipline can substitute for 2 years of professional experience.
• At least 1 year of research experience in in vivo models.
• Previous experience in gene therapy/gene editing, hematopoietic cell cultures, and/or project management is desired, but not required.

Candidates with excellent organizational skills and communication skills (written and oral) plus an ability to work well in a multidisciplinary team environment are encouraged to apply. To be successful in this position, the candidate must be highly motivated, possess a high level of initiative and attention to details. They must also be capable of working independently in a team environment.

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

This position will support two laboratories in the development of research projects using in vivo murine models. The Rongvaux Lab in the Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support fundamental research on the mechanisms of immune responses to infection and cancer. This individual will also support translational studies of CRISPR gene editing in the Adair Lab in the Program in Cell and Gene Therapy, also in the Clinical Research Division. They should be capable of maintaining a large murine colony and perform diverse in vivo experimental procedures. This position requires a high level of organization, capacity to coordinate experiments with diverse researchers and collaborators, maintenance of detailed records, and excellent communication skills. Additional laboratory skills (tissue culture, molecular biology) are highly desirable.

Responsibilities

• Maintain a large murine colony
• Perform specialized procedures, such as injections, blood draws and irradiation
• Schedule and coordinate experiments with researchers
• Purify and cryopreserve human hematopoietic cells
• Perform basic flow cytometry analyses
• Produce lentiviruses and transduce human primary cells
• Other duties as assigned by supervisor will be performed as necessary

Qualifications

Research Technician II - A bachelor’s degree in biological science and animal research experience beyond course work are absolutely essential. The candidate should have at least two years of full-time, post-bachelor's laboratory experience.

Research Technician III - As Research Technician II but with five or more years of full-time post-bachelor's laboratory experience.

Experience working with murine models is required. Experience with mammalian cell culture and flow cytometry are preferred.

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Bernstein Lab is recruiting a technician II/III to engage in studies of the role of the Notch pathway in hematopoiesis and in T cell development.

The research in the Bernstein lab has primarily focused on developmental aspects of normal and leukemic hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. Current studies of normal hematopoiesis are aimed at determining the role of the Notch pathway to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. These efforts are currently being extended in studies of CAR T-cell self renewal and differentiation. Recent studies of leukemia focus on how cells in the marrow microenvironment protect the leukemic stem cells from therapy.

Qualifications

Experience with flow cytometry essential and a broad range of standard molecular biology techniques is preferred

Research Technician II - A bachelor’s degree in biological science and research experience beyond course work are absolutely essential. The candidate should have at least two years of full-time, post-bachelor's laboratory experience.

Research Technician III - As Research Technician II but with five or more years of full-time post-bachelor's laboratory experience.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

As a Research Tech Level II, the position acts both independently and as a team collaborator within the lab to lead multiple laboratory projects including but not limited to isolation, enrichment, transduction and expansion of T cells/Stem Cells, complex analytical procedures, data compilation/interpretation, and generating detailed technical reports/presentations. In addition, this position helps identify emerging technologies and automation, monitors industry trends and conducts evaluations for feasibility. This position works with and under the guidance of a lab supervisor for experimental design, study execution, data analysis and data interpretation. The candidate also interacts heavily with internal and external research and principal investigator labs, GMP manufacturing, Quality Control, Quality Assurance, and other scientific/administrative staff, as needed.

Responsibilities

The position focuses on the development, optimization, and transfer of cellular and gene therapy unit operations including cell selections from starting materials, genetic modifications (viral transduction, electroporation, etc.), growth/expansion conditions, media/cytokine formulations, cell harvests, cryopreservation, and freeze-thaw recovery. In addition, this position collaborates to develop robust and repeatable analytical methods to characterize starting, in-process and final, formulated cellular products. Ultimately, development activities generate robust, repeatable and scalable processes to support toxicology studies, technology transfer/product introduction into the Fred Hutch GMP Cell Processing manufacturing facility, and IND generation to enable clinical trial initiation. 

Qualifications

Required Qualifications:

• Research Tech II: BS/MS in a biological sciences discipline, and 2+ years' (BS) or 1+ years' (MS) experience in mammalian cell culture
• Research Tech III: BS/MS in a biological sciences discipline, and 5+ years' experience in mammalian cell culture or Process Development
• Experience in one or more of the following technical areas:
  • Adherent and/or suspension cell cultures in flasks and/or bioreactors (fed-batch, perfusion, disposable bioreactor systems, etc.).
  • Cell culture media development and optimization.
  • Associated upstream and downstream unit operations such as cell banking, virus removal, purification, etc.
  • Cryopreservation and recovery of cryopreserved cells.
  • Experience with gene editing platforms (i.e. Crispr/cas9 system)

Preferred Experience:

• Demonstrated experience trouble-shooting issues associated with process scale-up, transfer into a GMP manufacturing setting, and generating process transfer documentation.
• Direct experience in a Process Development environment supporting aseptic cell culture-based manufacturing operations
• 1+ years hands-on experience with flow cytometry and T-cell/stem cell isolation/expansion protocols

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Cures Start Here.

The Hill Lab within the Transplantation Program of the Clinical Research Division is looking for a highly motivated individual to support preclinical and translational research on the use of stem cell transplantation for the treatment of serious blood diseases. The successful candidate will be involved in a variety of cutting edge cellular and molecular techniques to study murine and human immune responses.

Responsibilities

This is expected to be a long-term position and the successful applicant will help oversee the day to day running of the laboratory in liaison with senior graduate laboratory members. The candidate will also contribute to multiple projects studying stem cell transplantation, with the ultimate aim to generate testable therapeutic interventions that attenuate graft-versus-host disease and improve leukemia and pathogen-specific effects after transplantation. The technician will be closely involved in research projects using both in vivo murine models of transplantation and handling/preparation of clinical samples for analysis.

The successful applicant will ideally have an excellent knowledge of immunology, relevant regulatory activities, laboratory management with previous experience in laboratory mouse handling, genotyping, cell culture, basic flow cytometry and be capable of maintaining detailed laboratory records. Ability to analyze and report primary data would be advantageous.

In conjunction with other senior Research Techs, key duties will include:

1. Preparation and maintenance of regulatory documents.
2. Oversight of flow cytometry equipment within the laboratory staff.
3. Helping in the maintenance of a large murine colony; help to schedule and coordinate experiments with other lab members and with collaborators.
4. Oversight of laboratory reagents, stocks, media and maintenance of appropriate levels of laboratory supplies.
5. Oversight of stem cell transplants and therapeutics in mice, monitoring of animal well-being.
6. Oversight of clinical sample repository.

Qualifications

Research Technician II – A Bachelor’s degree with at least two years of professional lab experience in a related field with relevant techniques is required. A Master’s degree in a related field can substitute for two years of professional lab experience.

Research Technician III – A Bachelor’s degree with at least five years of professional lab experience in a related field with relevant techniques is required. A Master’s degree in a related field can substitute for two years of professional lab experience.

Research Technician IV - A Bachelor’s degree with at least eight years of professional lab experience in a related field with relevant techniques is required. A Master’s degree in a related field can substitute for two years of professional lab experience.

Required

• Experience with murine models and murine colony maintenance

Preferred

• Experience with regulatory oversight and documentation (IACUC, IRB, etc.)
• Experience with flow cytometry
• Demonstrated ability to independently provide laboratory management with minimal supervision

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

• Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
• Perform HPLC separations and maintain HPLC instruments
• Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
• Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
• Contribute to the analysis of proteomic (mass spectrometry) datasets
• Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
• Collaborate with others to develop new methods and tools that support research objectives
• Maintain research results files and databases
• Assist with written progress reports and development of standard operating protocols (SOP)
• Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

• Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline and 3+ years of post-doctoral experience is required
• The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
• The position includes drafting manuscripts for publication and, thus a demonstrated track record of first author peer-reviewed journal publications, as well as excellent written communication skills are required.
• The position includes giving oral presentations at local meetings, on consortium teleconferences, and at national and international meetings; thus excellent oral communication skills are required.
• Previous experience in a CLIA or clinical lab environment is a plus
• Proteomics experience

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Bernstein Lab is recruiting a staff scientist to engage in studies of the role of the Notch pathway in normal and malignant hematopoiesis and in T cell development.

The research in the Bernstein lab has primarily focused on developmental aspects of normal and leukemic hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells. Current studies of normal hematopoiesis are aimed at determining the role of the Notch pathway to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. These efforts are currently being extended in studies of CAR T-cell self renewal and differentiation. Recent studies of leukemia focus on how cells in the marrow microenvironment protect the leukemic stem cells from therapy.

Qualifications

Required:

• Ph.D. degree in immunology, cellular and molecular biology, or a closely-related field.
• Significant experience with flow cytometry essential as is a strong background in stem cell biology or cellular immunonology.
• Three years of postdoctoral training/research experience.

Preferred:

• Five years of postdoctoral training/research experience.