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15 Found open positions

Advanced Practice Provider: Pediatric Bone Marrow Transplant

FH Clinical Research Division
Category: Advanced Practice Providers
Seattle, WA, US
Job ID: 17566

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The pediatric advanced practice provider (APP) provides care for pediatric blood and marrow transplant patients in both inpatient and outpatient setting under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team.  Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs provide follow-up care of bone marrow donors under the supervision of attending physician.  PALS certification is required for this position within 3 months of hiring date.

Qualifications

  • Must be a graduate of a Physician Assistant  or Nurse Practitioner program (appropriate for care of Pediatric patients)
  • Eligible for licensure in the State of Washington
  • Have National Certification as appropriate for profession
  • DEA licensure required
  • Strong oral and written communication skills required. 
  • EMR based computer skills and experience with CPOE preferred
  • Strong team player with a can-do attitude is a must!  Ability to work as part of a multi-disciplinary team is essential.
  • Must enjoy long-term relationships with patients undergoing intense therapy. 
  • Pediatrics, Oncology or BMT experience preferred.

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutch (either as an additional attachment on your profile or merged into the file that contains your resume.)

Assistant or Associate Professor, Oncology (HCT / IMTX)

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 65999

Hematopoietic Cell Transplant (HCT) and Immunotherapy (IMTX) Programs

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical care and clinical research programs in hematopoietic cell transplantation and immunotherapy. All clinical research interests will be considered however, there is a particular interest in applicants with demonstrated experience in the field of immunotherapy. Applicants with extensive research experience will also be considered. University of Washington faculty engage in teaching, research and service.

Anticipated start date January 2, 2019

Assistant or Associate Professor, Oncology (Hematopoietic Cell Transplant Program)

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 70543

Hematopoietic Cell Transplant Program

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology, are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical research and clinical care programs in hematopoietic cell transplantation and immunotherapy. The successful candidate will be a prominent thought leader in the field of Stem Cell Transplantation who is engaged in innovative laboratory-based research investigating the mechanisms and/or treatment of malignant relapse after transplantation, which may include leukemia intrinsic and/or immunological mechanisms of immune escape. Fred Hutch and University of Washington faculty engage in teaching, research and service.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

Anticipated start date would be June 1, 2020.

Bioinformatician- Cancer Biology

FH Clinical Research Division
Category: Biostatistics, Bioinformatics and Computational Biology
Seattle, WA, US
Job ID: 17640

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine via patient selection and characterization of novel therapeutic targets. The lab has a major focus on mass spectrometry (MS)-based proteomics (both untargeted and multiple reaction monitoring), as well as integrating proteomic data with genomic and metabolomic data. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

 

This is a terrific opportunity within the Paulovich lab for a data scientist to work closely with our interdisciplinary team of chemists, biologists, clinicians, and statisticians to leverage multi-omic datasets to understand and predict human cancer responses to therapies. We are looking for a highly motivated, interactive, Bioinformatics/ Computational Biologist to join our proteomics team to help drive translational projects forward towards clinical applications by performing analysis and interpretation of multidimensional “-omics” datasets (DNA, RNA, protein, metabolite, and clinical phenotype) from human tumors and preclinical models. The candidate will participate in the development of data pipelines, plan and conduct analyses, interpret results, design and implement data visualizations, and help prepare figures and text for funding proposals, reports, and publications. The ideal candidate should have the ability to work independently as one hub in an interdisciplinary team.

Responsibilities

  • Apply data analysis tools and methods to enable the integration and management of large and complex “omics” datasets
  • Interpret data analyses results and write methods and results for publications and reports
  • Collaborate with statisticians, chemists, biologists, and clinicians on consortium projects
  • Research and evaluate new methods and algorithms for integrating into our existing pathway and network analysis tools
  • Perform other job-related duties as assigned

Qualifications

Required

  • Bachelor's degree in data science or life science discipline and hands-on biological data science experience (especially with proteomics, RNA sequencing, next generation sequencing datasets)
    • Bioinformatics Analyst I: less than 2 years relevant experience
    • Bioinformatics Analyst II: 3-6 years relevant experience
    • Bioinformatics Analyst III: 6-9 years relevant experience
  • Understanding of molecular biology, cancer biology, and an ability to contemplate the biological implications of results from multi-omic datasets
  • Strong programming skills (e.g. C/C++, R and Python/Perl/Java), with knowledge of the appropriate tools and libraries for working with biological data, including best software development practices (e.g. design, testing, documentation, code review)
  • Experience in pathway and network analysis as demonstrated by peer-reviewed publications and/or software packages
  • Familiarity with pathway and network databases and analysis algorithms
  • Programming in UNIX/LINUX environment
  • Excellent presentation skills and written/verbal communication skills
  • Ability to multi-task and prioritize tasks in a deadline-driven environment
  • Intellectually curious with innovative and creative problem-solving skills
  • Motivated, self-starting, detailed-oriented, organized
  • Ability to learn new technologies at a fast pace
  • Ability to lead data analysis activities independently and with feedback from the group


Preferred

  • Ph.D., M.A., or M.S. candidates with degrees in both data science-related disciplines and biology-related disciplines (e.g. a computational biology, bioinformatics, computer science, biostatistics, or mathematics degree, plus a cancer biology, molecular biology, or biochemistry degree) 
  • 2+ years of hands-on biological data science experience (especially with proteomics, RNA sequencing, next generation sequencing datasets)
  • Experience with data visualization tools (e.g. D3.js, Vega, Google Charts, etc.)
  • Familiarity with biomedical ontologies
  • Familiarity with dimensionality reduction, regression models, machine learning and/or cloud infrastructure for scalable scientific computing
  • Experience with graph databases
  • Knowledge of SQL, JSON, and XML
  • Knowledge of statistics and machine learning algorithms

Bone Marrow Transplant/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 73966

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The selected individual for the advertised position is expected to participate in a year-long fellowship program with the goal of becoming an expert in blood and marrow transplantation (BMT) and immunotherapy (IMTX) services at Fred Hutch. The individual holding this position will rotate through outpatient and inpatient BMT (autologous and allogeneic, long-term follow-up) and IMTX services, and initially function as a primary care provider with increasing levels of patient care responsibility over the course of the year.  Approximately 8 months will be devoted to clinical activities with the remaining time available for the opportunity to participate in clinically focused research projects.  University of Washington faculty engage in teaching, research and service.

Anticipated start date would be July 1, 2020.

Data Coordinator II

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 14884

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Data Coordinator (DC) is responsible for the documentation and monitoring of Phase 1-3 clinical trials, including the collection, coordination, processing and quality control of clinical trial data. The position will track clinical activity and subject visits, and abstract and report data. The DC will work on studies for at least two investigators, and regularly update those investigators on progress and activity. The DC will work closely with a Clinical Research Coordinator and will report directly to the Clinical Program Operations Director.

Responsibilities

  • Abstracts patient/participant data from medical records timely, according to protocol reporting guidelines
  • Maintains databases and shadow charts with source documentation, demonstrates knowledge of database definitions
  • Tracks study timelines and assures that procedures are completed per protocol
  • Identifies procedural problems and communicates to the study coordinator, PI and program director as appropriate
  • Resolves database queries and inaccuracies timely
  • Creates and maintains tracking tools
  • Performs routine audits to ensure quality and completeness of the data submitted, identifies missing data and corrects deficiencies
  • May occasionally attend clinic visits when appropriate to provide education about study requirements or obtain data
  • Serves as a resource to investigators, subjects, and collaborating physicians, service areas and organizations with questions about study procedures and operations
  • May assist in the development of databases and case report forms
  • Serves as main point of contact with study monitors, schedules monitoring visits and completes associated tasks
  • Prepares research sample collection kits, delivers to collection sites, and assures samples are collected and routed appropriately
  • Performs other duties as assigned including archiving records of closed studies, maintaining shared drive files, requesting medical records from outside providers
  • In collaboration with the Investigator and study coordinator, anticipates and plans for data deadlines
  • Keeps knowledge and skills current by completing mandated training and attending meetings with the study team and the Consortium, such as the monthly coordinator meeting, relevant brown bags, faculty and administrative presentations, and other opportunities of interest

Qualifications

  • Associate degree or equivalent experience required
  • One to two years of experience working in healthcare environment with oncology and/or research experience required
  • Strong computer skills and experience with data entry and databases. Prefer experience with Medidata RAVE
  • Competency in Microsoft Office software
  • Excellent attention to detail and ability to organize work
  • Ability to communicate effectively both verbally and in writing
  • Demonstrated ability to work independently, under supervision, and be a team player
  • Ability to adapt and respond appropriately to competing priorities in a fast-paced environment
  • Knowledge of FDA, GCP, and NIH requirements preferred
  • Strong preference given to candidates with previous experience conducting clinical trials in hematologic malignancies

Pediatric Bone Marrow Transplant/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 73967

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Pediatrics, Division of Hematology Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The selected individual for the advertised position is expected to participate in a year-long fellowship program with the goal of becoming an expert in bone marrow transplantation and Immunotherapy. This position will rotate through outpatient Hematopoietic Cell Transplantation (HCT) services (autologous and allogeneic BMT, IMTX, Long Term Follow Up) and inpatient services initially as a primary care provider with increasing levels of independent patient care responsibility over the course of the year. Approximately 75% of the year will be devoted to clinical activities with the remaining time available for the opportunity to participate in clinically focused research projects, which will be determined based on identification of mentors and projects. University of Washington faculty engage in teaching, research and service.

Anticipated start date would be July 1, 2020.

Post-Doctoral Research Fellow, Immunotherapy

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 12846

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

 

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

  • Study the function of human T cells
  • Molecular bench work with PCR, cloning, and vector design
  • Single cell RNA sequencing
  • Biostatistics and some basic programing skills
  • Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections
  • Validation through functional and killing assays.

Qualifications

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology
  • Dynamic and driven – engaging and encouraging in team environments
  • Willingness to write and apply for funding opportunities and abstracts
  • A strong research background
  • Proficient in molecular biology and cellular immunology technique and knowhow
  • Virology knowledge will assist in the AIM of this position
  • Flow cytometry and cell signaling based assays
  • Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage


To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.

Post-Doctoral Research Fellow, Pancreatic Cancer Research

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 11911

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani (https://research.fhcrc.org/hingorani/en.html) at Fred Hutchinson Cancer Research Center in Seattle, WA.

 

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis.  The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program.  Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies.  Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

Successful applicants will have:

  • A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
  • Experience with standard molecular and cellular biology techniques
  • A demonstrated track record of productive research
  • Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
  • Ability to develop create approaches to experimental design
  • Ability to work both independently and as part of a laboratory team  

Post-Doctoral Research Fellow, Protein Therapeutics for Acute Myeloid Leukemia

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17449

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

The Walter Laboratory in the Clinical Research Division is recruiting an outstanding postdoctoral research fellow to work as part of a team investigating new treatments for patients with acute myeloid leukemia (AML) primarily focused on improving existing, and developing novel, antibody-based immunotherapies, and rendering them safer for clinical application. Current projects include preclinical drug development/testing (in part with academic and industry partners), studies on mechanisms of action and resistance of antibody-based therapeutics and identification of strategies to overcome these limitations, and development of approaches to protect normal tissues from the toxicities of AML-targeted therapies (e.g. via use of genome editing). We anticipate this position will commence July/August 2020.

Responsibilities

The newly hired fellow will work under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Generation of recombinant antibodies and other protein therapeutics via transient and permanent expression systems
  • Conduct of immunization strategies to raise new antibodies
  • Generation of engineered/gene-edited human leukemia cells
  • Tissue culture of mammalian cell lines and patient-derived primary human cells
  • Antibody drug conjugate (ADC) cytotoxicity, antibody-dependent cellular cytotoxicity, T-cell and NK-cell cytotoxicity assays
  • Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
  • Purification, cloning, and manipulation of RNA, cDNA and genomic DNA
  • PCR and RT-PCR, including quantitative assays using qPCR
  • Lentiviral vector modification, lentiviral particle preps and viral transduction
  • Protein gels, immunoprecipitation, western blotting, immunofluorescence microscopy
  • General laboratory duties and maintenance of laboratory equipment

Qualifications

Required qualifications:

  • A recent PhD in a relevant field of biology such as immunology, cell and molecular biology, genetics, biochemistry, pathology, bioinformatics, or genome sciences
  • Ability to drive an individual project but also be highly collaborative with academic and industrial partners
  • Ability to work independently and with scientific rigor
  • Interest in academic career and applying for independent funding support
     

To be successful in this position, the postdoctoral research fellow must be organized, clear and concise in their communication, enthusiastic, a team player, and have a desire to establish a career as a future independent investigator. Fellowship opportunities are available through several philanthropic and government organizations; fellow will have administrative support for the application process.

 

Applicants must include:

  • Cover letter discussing your interest in this position, research interests and career goals
  • Curriculum Vitae
  • Contact information for three references

Post-Doctoral Research Fellow: Hematologic Malignancy

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 15328

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

A postdoctoral position is immediately available in the laboratory of Dr. Stanley Lee at Fred Hutchinson Cancer Research Center. The Lee lab has a longstanding interest in understanding how defects in RNA processing and chromatin regulation drive hematologic malignancies, and how to devise mechanism-based strategies to therapeutically target these pathways in cancer (PMIDs: 30107174, 27135740, 27603132, 31334570.) Fred Hutch also offers a great research environment including state-of-the-art Shared Resources and Core Facilities and a robust Postdoctoral Fellowship Program to provide advanced training for future scientific leaders.

Responsibilities

The successful candidate will be responsible for project design, execution, management and data analysis relating to RNA processing/chromatin regulation in stem cell biology and blood cancers. Projects will use a variety of experimental and computational approaches including in vitro and in vivo models (genetically engineered murine models (GEMMs) and patient derived xenografts (PDXs)), transcriptomic, epigenomic and proteomic analyses, molecular assays and functional genomics approaches. The fellow will work directly with the PI, members of the laboratory and external collaborators. The fellow will be expected to acquire a thorough understanding of the scientific literature, present in internal and external meetings, and draft manuscripts for peer-reviewed publications.

Qualifications

  • A recent PhD or MD/PhD in a relevant field
  • Strong background in RNA biology, chromatin biology, cancer genetics, and/or computational biology is highly desirable
  • Some experience in stem cell biology, immunology, and/or developmental biology
  • Experience in flow cytometry, cell culture and murine models
  • Research publications from graduate work
  • Excellent verbal and written communication skills
  • Ability to think and work independently and collaboratively in a team environment

Please apply online and include a CV, cover letter with a brief description of past research experience and future goals, and contact information for three references.

Research Administration Manager II

FH Clinical Research Division
Category: Research Administration & Faculty Affairs
Seattle, WA, US
Job ID: 17583

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


Reporting to the Senior Operations Director, the Research Administration Manager II, an essential part of the Stem Cell and Gene Therapy Program and of the Clinical Research Division (CRD) Administrative team, will work under the direction of the Program Head. Investigators within the Stem Cell & Gene Therapy Program conduct research using large and small vertebrate animals and infectious agents, as well as clinical trials requiring GMP, FDA and IND compliance. Responsibilities of the Research Administration Manager II will include management and oversight for program finance and administration, grants and contracts, and regulatory compliance, as well as compliance with Center policies and procedures. The Manager also plays an important role in staff recruitment, training and performance management.

Responsibilities

  • Manage grants, contracts and research agreements awarded by a variety of funders including federal agencies, private foundations and commercial enterprises
  • Ensure compliance with sponsor-specific reporting requirements, including tracking deadlines for progress reports, quarterly/annual financial reports and project closeouts
  • Establish and monitor budgets and spending, ensuring compliance with regulations/guidelines
  • Proactively communicating about issues or concerns that may impact successful completion of the research
  • Preparing regular, relevant and timely reports for PIs and the CRD regarding spending, staffing, and future projections
  • Monitoring program employees’ effort and salary allocation; assisting PIs with monthly effort reporting
  • Coordinating the preparation of new and renewal grant applications, reviewing application guidelines, communicating requirements to the PIs, and facilitating submission together with relevant departments in Fred Hutch administration
  • Serving as a liaison with administrative departments within Fred Hutch and at collaborating institutions, including the University of Washington
  • Partnering with the University of Washington and other organizations on collaborative proposals, reporting, and budget management
  • Assisting Human Resources by providing documents for annual merit & performance evaluations, employee on- and off-boarding and international work visas when required
  • Preparing administrative documents and ensuring regulations are followed for Human Subjects, Vertebrate Animals, and Hazardous Materials research
  • Assisting laboratory personnel as needed with purchasing, shared resources access, and training requirements
  • Performing other administrative tasks needed to ensure an efficient and orderly research operation

Qualifications

Required:

  • Bachelor’s degree in Accounting, Finance, Public Administration, or related field
  • Five years in pre-award and post-award grant and contract management
  • Experience with industry sponsored contracts
  • Knowledge of relevant regulatory requirements affecting sponsored research, and ability to apply this knowledge
  • At least three years of management experience with direct reports and conducting performance appraisals
  • Effective and professional oral and written communication skills, with the ability to tailor communications to specific audiences
  • Ability to navigate complex internal systems and departments while exercising sound judgement and discretion
  • Proficient with complex budget development and use of reporting tools
  • Proficient in fiscal and budgetary management
  • Advanced skills in Word, Adobe Acrobat Pro, and Outlook
  • Advanced skills in Excel including familiarity with pivot tables
  • Excellent time management and prioritization skills, with the ability to effectively manage multiple and competing demands
  • Demonstrated ability to function independently while exercising skill and informed professional judgment
  • Highly organized and detail oriented
  • Demonstrated ability to work successfully as part of a diverse team
  • Excellent written and oral communication skills and the ability to communicate effectively with personnel in a variety of roles

Preferred:

  • Master’s degree
  • Seven years of progressive experience in administration and grant and contraction administration
  • The ability to work independently, soliciting direction or assistance from the Program Head as required
  • Experience with contract negotiation
  • Experience reviewing IRB and IACUC administrative documents
  • Experience working in a research organization, a university/medical school setting, or other complex non-profit organization

Research Administrator III-IV

FH Clinical Research Division
Category: Research Administration & Faculty Affairs
Seattle, WA, US
Job ID: 15146

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

The Research Administrator III-IV proactively provides compliant and effective funding, budget and regulatory administration and general administrative support for one or several Principal Investigators and their labs/departments

 

The Research Administrator III-IV collaborates with Principal Investigator(s) and interfaces with other departments as needed to provide research administration and to contribute to strategic planning as it relates to their work portfolio. The Research Administrator III-IV may work in an autonomous manner to complete non-scientific grant content, tasks, and to advise PI(s) on relevant matters.

Responsibilities

Budget/Fiscal Support

  • Participate and support strategic planning activities of the PI such as providing relevant fiscal information
  • Develop, monitor, track and project complex multi variable budgets
  • Develop, run and analyze reports to identify issues and escalate as needed
  • Develop custom report formats to share information with the team/department
  • Partner with finance to resolve identified budget and expense issues
  • Identify and discern discrepancies with expenses, find solutions and escalate as needed
  • Work closely with fiscal research administrator for clinical trials to support industry trials

 

Funding Source Administration

  • Lead the grant submission process by conducting key tasks such as: creation and communication of timelines to appropriate stakeholders, completion of nontechnical and assigned technical/non-scientific portions of submission, and oversight of institutional signoff
  • Perform key post award activities such as:  Interpreting the notice of award, flagging unique aspects or budget adjustments and monitoring and adjusting the teams’ commitments across the portfolio of projects based on awards

 

Regulatory Support

  • In consultation with PI(s), prepare non-scientific portions of regulatory applications/submissions; prepare portions of applications as necessary.
  • Manage renewal timelines and ensure completion of regulatory documents in a timely manner
  • Identify necessary regulatory components of submissions, confirm that required items are in place, resolve issues (escalating as appropriate)
  •  Determine impact of and develop implementation plans in response to applicable regulatory changes and/or revisions to Center policies and procedures
  • May serve as a central point of contact to answer questions, escalating issues as needed

 

Administrative Support

  • Complete or delegate key administrative tasks such as travel coordination, editing CVs and publications, and purchasing and maintenance of supplies and equipment
  • Identifying administrative issues for discussion with leadership
  • Assist with the development of lower level staff
  • May coach and develop lower level staff
  • May manage projects including occasional event planning and management
  • Leadership
  • May act as a divisional resource and assist with training for lower level staff

 

Clinical Trials Addendum

  • Create, negotiate, and manage budget based on protocol (Core)
  • Set up and pay bills to third parties (Core)
  • Partner with external organizations to get pricing
  • Create payment invoices for sponsors
  • Set up Clinical Trials Agreements (CTAs)
  • Ensure regulatory documents are in place (CT)
  • Responsible for Clinical Trials Billing including the creation of payment invoices.
  • Tracking and Auditing of procedures to ensure compliance (CT)
  • Set up and maintain study document tracking systems (CT)
  • Amend budget through the life of a study (Core)
  • Attend study implementation meetings as needed (CT)
  • Manage multi-site components (sub awards) (Core)

Qualifications

Required:

  • BA in Accounting, Finance, Public Administration, or related field or equivalent experience
    • RA III level requirement- 3+ years in pre and post award grant and contract management
    • RA IV level requirement- 5+ years in pre and post award grant and contract management
  • Industry contracts experience required
  • Knowledge of relevant regulatory requirements affecting sponsored research, and ability to apply this knowledge
  • Effective and professional oral and written communication skills, with the ability to tailor communications to specific audiences
  • Ability to navigate complex internal systems and departments while exercising sound judgement and discretion
  • Proficient with complex budget development and use of reporting tools (ability to reconcile, manage, report budget information, etc.)
  • Basic knowledge of accounting terminology
  • Intermediate skills in Word, Adobe Acrobat Pro, and Outlook
  • Intermediate skills in Excel including familiarity with pivot tables
  • Ability to edit SharePoint sites or basic web page Knowledge/prior experience with Enterprise Software Systems
  • Knowledge of relevant regulatory guidelines such as IRB, IACUC, MUA
  • Basic knowledge of accounting terminology
  • Excellent time management and prioritization skills, with the ability to effectively manage multiple and competing demands
  • Demonstrated ability to function independently while exercising skill and informed professional judgment
  • Highly organized and detail oriented
  • Demonstrated ability to work successfully as part of a diverse team

Preferred:

  • Experience with National Institute of Health (NIH) awards
  • Experience with Electronic Medical Records (EMR)
  • Industry sponsored clinical trials experience
  • International funding experience

Research Techn I or II

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 17551

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support the development of immunotherapy for cancer. This individual will have the opportunity to work with a variety of cutting-edge cellular and molecular research techniques. This person will be responsible for maintaining meticulous records and organizing and reporting on experimental results. Duties will include:

  1. Plan and perform in vitro immunology cellular and molecular assays reliably according to laboratory protocols.
  2. Process and cryopreserve human samples including blood and bone marrow
  3. Assist in ordering, lab maintenance and quality control and improvement activities
  4. Learn new techniques as required
  5. Assist post-doctoral scientists as required
  6. Analyze, organize and present data
  7. Identify methodological problems in research protocols and implement modifications to optimize experimental results.
  8. Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data.
  9. Assist in the design and implementation of experiments; may be responsible for the performance of individual research projects.
  10. Conduct literature reviews to assist in determining most suitable methods to be used in research.
  11. Assist in publication of results by proofreading, editing, and contributing ideas.
  12. May perform statistical analyses, manage research data bases.

 

Please note that part of the job responsibilities include collecting and/or processing samples from patients enrolled on clinical trials, which may require working outside of typical work hours and infrequently on weekends.

Qualifications

Minimum qualifications:

  • This position requires a bachelor’s degree in a biological science and some research experience or laboratory knowledge
    • Research Techn I minimum qualifications- BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills.  Independent research experience in addition to school lab experience is usually necessary.

    • Research Techn II minimum qualifications- Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS. Independent research experience outside of laboratory course work is usually necessary.

  • Laboratory experience with cell cultures and/or molecular biological techniques is required
  • Self-motivated candidates with excellent organizational skills, written and oral communication skills, and those who work well in a multidisciplinary team environment are encouraged to apply
  • To be successful in this position, the technician must be highly motivated, have a high level of initiative, work carefully, and keep detailed records. They must also be capable of working independently in a teamwork environment and have excellent interpersonal and communication skills.

Research Technician I-II

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 17538

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Clinical Research Division laboratory that studies the biology of blood and marrow stem cells and develops novel stem cell gene therapies as well as genome editing technologies is recruiting a research technician I/II with a focus on bench research. This position will support research activities that include but are not limited to:

  • Performing sterile tissue culture techniques for viral vector production and gene transfer experiments in primary cells such as hematopoietic stem cells and T lymphocytes
  • Titration of viral vectors by transducing cell lines and flow cytometry analysis
  • Measuring infectious titers of vectors using Q-PCR
  • Assisting with development of novel gene transfer vectors
  • Creating plasmid constructs using molecular biology techniques, including bacterial plasmid preps, PCR, and cloning
  • Maintaining detailed laboratory records
  • Performing other tasks supporting experiments guided by PI and staff scientist

Qualifications

Minimum qualifications:

  • This position requires a bachelor’s degree in a biological science and some research experience or laboratory knowledge
    • Research Techn I minimum qualifications- BA/BS in a scientific field required. Must have scientific knowledge in the area of study and basic laboratory skills.  Independent research experience in addition to school lab experience is usually necessary.

    • Research Techn II minimum qualifications- Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS. Independent research experience outside of laboratory course work is usually necessary.

  • Laboratory experience with cell cultures and/or molecular biological techniques is required
  • Self-motivated candidates with excellent organizational skills, written and oral communication skills, and those who work well in a multidisciplinary team environment are encouraged to apply
  • To be successful in this position, the technician must be highly motivated, have a high level of initiative, work carefully, and keep detailed records. They must also be capable of working independently in a teamwork environment and have excellent interpersonal and communication skills.


Preferred qualifications:

  • At least two years of laboratory experience is preferred but candidates with less experience will be considered
  • Experience with cell culture techniques and viral vector production is desirable

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