Clinical Research Job Openings

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

This position primarily supports the Hematology-Oncology Fellowship Program as part of the Fellowship Program Office (FPO) within the Clinical Research Division (CRD), providing administrative support to all programmatic fellows, the Fellowship Program Administrator, and Program Directors. Primary responsibilities include assisting in the fellowship recruitment effort and annual orientations, delivering and monitoring completion of fellow, faculty, and clinical evaluations, managing core didactic conferences, distributing agendas and minutes of programmatic meetings, updating clinical rotation schedules, securing space and office resources for research fellows, and post-fellowship tracking and verifications. These responsibilities are done in accordance with all policies and procedures governing the Fellowship Program, the University of Washington Graduate Medical Education (GME) office, the National Institutes of Health, and other guidelines.

The Administrative Coordinator I primarily works under the direction of the Fellowship Program Administrator with opportunities for professional development and growth. This position requires an individual who can contribute to the ongoing success of the Fellowship Program and is committed to continuous process improvement. A team player with a positive attitude, a sense of humor, an ability to shift work priorities quickly, and who can also work independently and utilize available resources will be integral to advancing the mission of this ACGME (Accreditation Council for Graduate Medical Education) certified training program. The ideal candidate will have excellent communication skills (verbal and written), the ability to work in an often fast-paced environment that interfaces with multiple training sites and stakeholders, be customer service and detail oriented, self-starting, resourceful, and responsive to program needs.

Responsibilities

• Assist in the implementation of all FPO policies and procedures
• Represent the FPO and the program to all stakeholders across multiple institutions (UW Medical Center, Seattle Cancer Care Alliance, Harborview Medical Center, VA Puget Sound Health Care System, Bloodworks Northwest, Seattle Children's, Fred Hutch)
• Perform updates on various platforms unique to an ACGME accredited fellowship program including but not limited to: ACGME, ERAS, NRMP, ABIM, FREIDA.
• Update credentialing and scheduling information on MedHub, our residency/fellowship management system
• Prepare reimbursement requests
• Manage delivery and completion of fellow, faculty, and program evaluations
• Utilize MedHub to develop various reports and evaluation summaries integral to our trainees' development
• Maintain files and archival system in accordance with policies and guidelines
• Coordinate educational activities including core didactic conferences that support the program’s curriculum and adhere to ACGME training requirements
• Coordinate and/or staff various meetings (calendaring, notifications, agendas, minutes, catering, room set up, catering)
• Coordinate space for research fellows
• Outreach to past fellows; verification of training for past fellows
• Assist with annual recruitment including preparation of materials for applicants and faculty interviewers
• Administrative duties such as drafting correspondence and reports; editing and proofreading materials; photocopies/scanning materials; distributing mail etc.
• Administrative support as needed to program directors and fellowship program administrator

Qualifications

• BA/BS is required
• Two to five years work experience in a clinical, medical, hospital or research environment required
• Track record of progressively complex administrative positions ideal
• Proficiency in MS Office applications including Word, Outlook, PowerPoint and Excel required
• Available to work during non-traditional hours for projects and events as needed

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Reporting to the Senior Operations Director for the Clinical Research Division at the Fred Hutchinson Cancer Research Center, a highly skilled Administrative Coordinator is required to provide a wide range of management support to help implement the Division’s strategy in support of the Center’s mission.

The purpose of this role is to effectively support the Senior Operations Director and to help ensure the smooth and efficient running of the Division. The role offers varied, non-standard work across a range of skill sets in supporting the Senior Director in all tasks that are common to planning, effective decision-making, management and outreach at an executive level. As the Administrative Coordinator, you will often be the first point of contact for our internal and external colleagues, ‘customers’ and partners. Good knowledge of the organization, a commitment to providing excellent customer service, responsiveness, flexibility (both time and task), creativity, confidentiality and excellent organizational, technical and interpersonal skills will be required to succeed in this role. Adaptability to peaks in work flows, willingness to assist other members of the administrative team from time to time, and the commitment to meeting deadlines are essential.

As a key member of the Senior Director’s team, you will use independent judgment and initiative in managing an extensive calendar, troubleshooting arising issues, setting up meetings and preparing minutes for distribution to relevant parties, making efficient travel arrangements, screening incoming correspondence and calls directed to the Senior Director, forward and/or reply to calls and correspondence as appropriate, coordinate events, assist with report production, special analytical tasks and monitoring budgets. This position is considered mission critical since the role interacts with all levels of faculty, professional and technical staff, and partner collaborators (Seattle Cancer Care Alliance, UW, etc.) The position requires a strong fiduciary focus and sensitivity to remaining focused, professional, and ensuring the highest level of professionalism in support of the mission and goals of the Division.

This is an important position that offers opportunities for involvement at the Center, contributing to process improvement, enhancing communication and improving the quality of service we provide. You will work with other senior administrative staff on operational, financial, and human resource issues that are associated with a diverse organization. You must have excellent written and oral communication skills, be politically astute at all levels, and be able to network widely with colleagues inside and outside Fred Hutchinson Cancer Research Center. You will apply modern information communication technology tools for effective management in a complex organization and will contribute to improving efficiency and help to develop a culture of innovation.

Responsibilities

• Provide direct support to the Senior Director-Operations, relative to meeting management, Outlook, logistics, and other programmatic and Division-level planning and execution.  Ensure that all calendar needs and any related travel arrangements, to include reconciliation and processing of costs and reimbursements are prepared in accordance with Center policies and procedures and submitted on time.
• Act as a liaison as needed, with Center administration, Seattle Cancer Care Alliance, and the UW, on behalf of the Division, and under the direction of the Senior Director-Operations so that inquiries, and needs are resolved appropriately.   
• Serve as the primary coordinator of the Division's Monday Noon and Tuesday Clinical Grand Rounds, which will include thoughtful management and communication to ensure that faculty are scheduled, with appropriate calendar reminders (and their administrators), ensuring the communication (fliers, etc.) and other evaluations are distributed and collected, etc.  
• Draft agendas and ensure all documents and background information for committee meetings are received, collated and circulated in a timely manner. Ensure that the Senior Operations Director has all the materials needed for any external meetings well in advance. Organize and attend meetings, take minutes and distribute for review as directed, and track progress on action points.
• Deal effectively with correspondence of all types, diverting such correspondence to other staff where appropriate, relying to a range of issues on behalf of the Senior Director, or researching and preparing information/drafting replies, recognizing and respecting the confidential nature of many matters.
• Create and maintain the Division’s administrative calendar for effective long-term planning and management
• Provide logistical support to conferences, workshops, public events, etc. Plan, implement and manage division-wide events as requested. Oversee procurement of catering, equipment, decorative and rental needs as well as preparing or procuring the preparation of promotional materials.
• Ensure new Division employees receive all the information and access they need to integrate into the Center and to become active, engaged members of staff.
• Assist with implementation and communication of new policies and procedures.
• Create and maintain an effective electronic database of communication and other records of the Senior Director’s office. Improve systems for data management as appropriate.
• Manage budgets associated with the Senior Director’s office and organize financial items requiring review and approval, ensuring they are being handled in a timely manner.
• Perform other responsibilities and duties as assigned or required in support of the Director and Division Mission, Goals, and Vision.

Qualifications

• Bachelor's degree or equivalent experience
• Five years or more of progressively complex administrative experience, preferably in a research and/or clinical care environment
• Strong computer and on-line systems skills
• Experience working in a medical, clinical, and or health/research environment is highly desirable
• A focus on excellent customer service, strong interpersonal skills are required.
• Excellent administration and organizational skills; attention to detail and accuracy
• Experience with effective management of calendars, meetings, visitors, travel and other tasks

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Advanced Practice Provider (APP) provides care for blood and marrow transplant patients and immunotherapy patients in both the inpatient and outpatient settings under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team.  Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs perform bone marrow aspirations, lumbar punctures and are first assists with Bone Marrow Harvests and provide follow-up care of bone marrow donors under the supervision of attending physician.

Qualifications

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutchinson Cancer Research Center (either as an additional attachment on your profile or merged into the file that contains your resume.)

• Must be a graduate of a Physician Assistant training program or appropriate Nurse Practitioner program and be able to practice in the state of Washington (licensed).
• Have National Certification as appropriate for profession
• Must be licensed for schedule II drug authority.
• Strong oral and written communication skills required.
• Basic computer skills are essential.
• Must be able to work as part of a multi-disciplinary team.
• Must enjoy long-term relationships with patients undergoing intense therapy.
• Oncology or BMT experience preferred.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Advanced Practice Provider (APP) provides care for blood and marrow transplant patients and immunotherapy patients in both the inpatient and outpatient settings under the supervision of the attending physician.  The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team.  Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments.  APPs perform bone marrow aspirations, lumbar punctures and are first assists with Bone Marrow Harvests and provide follow-up care of bone marrow donors under the supervision of attending physician.

Qualifications

• Must be a graduate of a Physician Assistant training program or appropriate Nurse Practitioner program and be able to practice in the state of Washington (licensed). 
• Have National Certification as appropriate for profession
• Must be licensed for schedule II drug authority. 
• Strong oral and written communication skills required. 
• Basic computer skills are essential. 
• Must be able to work as part of a multi-disciplinary team. 
• Must enjoy long-term relationships with patients undergoing intense therapy. 
• Oncology or BMT experience preferred.

Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutch (either as an additional attachment on your profile or merged into the file that contains your resume.)

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

We are seeking a part-time (60%) certified physician assistant (PA-C) or advanced registered nurse practitioner (ARNP) to provide mental health evaluation and management to Oncology patients at the Seattle Cancer Care Alliance (SCCA). All clinical responsibilities are performed within the scope of practice, institutional privileges and with the collaboration of physician colleagues.

The ARNP/PA-C at the SCCA functions within their scope of practice and collaborates effectively with other disciplines to provide state-of-the-art patient and family-centered mental health care.

• Training and experience in the delivery of mental health care including medication management.
• Excellent communication and clinical skills necessary to ensure optimum patient care outcomes in a complex care environment
• Respectful and ethical in their interactions with staff and patients alike
• Skilled clinicians, providing evidence-based diagnosis and management of the acute, symptomatic, and supportive care needs of patients with cancer
• Educator to patients, clinicians and staff - able to effectively communicate information about mental health processes, treatments, and management

Responsibilities

• Diagnose patients with mental illnesses; develop and implement patient treatment plans
• Works closely with psychiatrists and psychologists on the team.
• Collaborates and consults with other disciplines and services to ensure safe, effective, and timely treatment as well as continuity of patient care.  Care will be coordinated in a multidisciplinary fashion with collaborating services which may include surgery, radiation oncology, medical oncology, nutrition, social work, pain service, hospice, integrative medicine, and palliative care. 
• Participates in the conduct of cancer clinical research, including patient, caregiver, and peer education
• Communicates changes in patient’s health status or urgent patient issues to the patient’s primary oncologist in a timely manner.
• Participates in patient rounds, conferences and committees
• Actively participates in the development and maintenance of patient management algorithms and standardized orders.
• Documents patient care data in accordance with the SCCA and UW Physicians policies
• Performs assessments of patients’ and caregivers’ knowledge, attitudes, and actions around the mental health diagnosis and treatment issues. 
• Refers patients to community agencies and other resources to promote optimal adjustment and functioning.

Qualifications

• PA requirements: minimum of 2 years of experience in a mental health setting required. Prefer candidates with CAQ in Psychiatry
• ARNP requirements: minimum of 2 years of experience in a mental health setting and completion of a graduate certificate in Psychiatry/Mental Health NP (or equivalent) required
• Graduate of an accredited Physician Assistant or Nurse Practitioner program required.
• Washington state & DEA licensure required.
• Strong verbal and written communication skills required.
• EMR experience required; prefer experience with CPOE.
• Strong team player with a can-do attitude is a must! Ability to work as part of a multi-disciplinary team is essential.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

We offer great generous benefits, including relocation and tuition reimbursement.

The position will provide care to post-treatment patients in the Seattle Cancer Care Alliance (SCCA) Survivorship Clinic and provide care across the continuum from diagnosis to survivorship focused follow-up for patients in the SCCA Sarcoma Clinic.

Allocation of FTE: 50% survivorship, 25% sarcoma survivorship, 25% general sarcoma care. 

SCOPE OF RESPONSIBILITY

Within the Survivorship Clinic the Nurse Practitioner/Physician Assistant will be responsible for provision of clinical care and patient education for a broad range of cancer survivors, including  adult survivors of pediatric cancers.  They will work with a comprehensive team including the program director and co-director, the program nurse coordinator, and the program manager toward the goal of extending survivorship services to all oncology patients, regardless of age, place or type of treatment. They will collaborate with other providers within the Survivorship Clinic, within other SCCA oncology discipline clinics, and also with physicians and other health care professionals to define best practices of care, develop comprehensive survivorship care guidelines, and establish referral networks internal and external to the SCCA.

Within the Sarcoma Clinic the Nurse Practitioner/Physician Assistant will provide evaluation and medical management of Sarcoma patients at the SCCA.  They will follow patients during their chemotherapy and provide medical supportive care, as well as surveillance. The ARNP/PA-C assesses and manages basic health needs of patients, addresses treatment toxicities, performs procedures, monitors for cancer progression or recurrence, and consults with professional peers as needed.  They work collaboratively with the treatment team to coordinate care of their patients. The clinician in this role will be expected to see patients along the continuum of care for sarcoma patients, including long term follow-up of sarcoma survivors in the Survivorship clinic conducting survivorship focused visits as described below as well as carrying out surveillance plans following standard treatment pathways in collaboration with the sarcoma medical oncologists. 

Responsibilities

Survivorship Program - comprehensive onsite evaluations for cancer survivors including:

• Review of diagnosis, treatment, acute and chronic complications and co-morbidities
• Risk-adapted history and physical examination, laboratory and diagnostic studies
• Psychosocial and functional needs assessment
• Referral to appropriate subspecialties and services
• Preparation of treatment summary or review of treatment summary developed by survivorship RN, including guidelines and recommendations for follow-up
• Patient education
• Provide written (and oral when necessary) communication of survivors evaluation back to referring provider and/or primary care provider
• Other Duties as assigned by program director or program manager:
  • Participate in program outreach activities (e.g. local or regional presentations regarding survivorship, or the survivorship program survivor education conferences, and other related activities), including off-hours as necessary
  • Participate in program development activities (e.g. visits to internal or off-site clinics or hospitals, and other related activities, development of standard of care guidelines)
  • Develop educational materials for survivors (e.g. Survivor notebook, health links, etc.)
  • Create, review and maintain accuracy and completeness of survivorship database care plan recommendations  

Sarcoma Clinic:

• Performs complex and problem-focused evaluation and management for patients diagnosed with Sarcoma
• Evaluates and manages on-treatment and post-treatment side effects, as well as long- term surveillance.
• Performs procedures according to licensure, credentialing, and scope of practice
• Collaborates and consults with other disciplines and services to ensure safe, effective, and timely treatment as well as continuity of patient care.
• Participates in the conduct of cancer clinical research
• Provides patient, caregiver, and peer education
• Communicates effectively with inpatient and outpatient teams
• Participates in patient rounds, conferences and committees
• Active member of the SCCA Rapid Response/Code Team

PROFESSIONAL CONDUCT

Employees within the Survivorship Program are expected to maintain high standards of professionalism in their interactions with patients, referring providers and other team members. Professional conduct includes:

• Fosters positive and professional interpersonal relationships with patients, families, staff, referring physicians and other visitors.
• Actively promotes positive working relationships within survivorship team and all SCCA, Fred Hutch and UW Medical Center staff to create an affirming work environment.
• Is flexible and positive in accepting other duties or projects as assigned by the program director or program manager.
• Identifies and reports barriers to clinical and departmental effectiveness and facilitates/ suggests effective problem solving.
• Seeks positive resolution of interpersonal conflicts though self-awareness, mutual respect and skillful communication.
• Is aware of and follows policy and procedures regarding infection control, health, safety and security.
• Adheres to survivorship team and Fred Hutch, SCCA and departmental personnel policies including attendance, punctuality, and timekeeping standards.
• Supports Fred Hutch and the SCCA in its efforts to fulfill its mission.

Qualifications

• 1 year of ARNP or PA-C experience in Medical Oncology or BMT required
• Strong team player with a can-do attitude is a must! Ability to work as part of a multi-disciplinary team is essential.
• Graduate of an accredited Physician Assistant or Nurse Practitioner program required.
• Washington state & DEA licensure required.
• ACLS required
• Strong oral and written communication skills required.
• EMR experience required; prefer experience with CPOE

PAY, BENEFITS & WORK SCHEDULE

• Salary DOE + excellent benefits; 1.0 FTE position. Will require some evening hours.

Hematopoietic Cell Transplant (HCT) and Immunotherapy (IMTX) Programs

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical care and clinical research programs in hematopoietic cell transplantation and immunotherapy. All clinical research interests will be considered however, there is a particular interest in applicants with demonstrated experience in the field of immunotherapy. Applicants with extensive research experience will also be considered. University of Washington faculty engage in teaching, research and service.

Anticipated start date January 2, 2019

Hematopoietic Cell Transplant Program

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology, are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30].  The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical research and clinical care programs in hematopoietic cell transplantation and immunotherapy. The successful candidate will be a prominent thought leader in the field of Stem Cell Transplantation who is engaged in innovative laboratory-based research investigating the mechanisms and/or treatment of malignant relapse after transplantation, which may include leukemia intrinsic and/or immunological mechanisms of immune escape. Fred Hutch and University of Washington faculty engage in teaching, research and service.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

Anticipated start date would be June 1, 2020.

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) invite exceptional candidates to apply for a full-time faculty appointment at the rank of Assistant Member/Assistant Professor or Associate Member/Associate Professor level, commensurate with experience, in the Clinician-Scholar pathway in the Clinical Research Division of the Fred Hutch and in the Department of Pathology at UW without tenure due to funding (WOT). Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch provides a unique environment for conducting translational research and clinical care. Fred Hutch, in collaboration with its clinical and research partners, the University of Washington, Seattle Childrens Hospital, and Seattle Cancer Care Alliance (SCCA) is a National Cancer Institute-designated comprehensive cancer center.

The selected individual is expected to enhance our clinical care and clinical research programs in anatomic pathology, with particular focus in hematopoietic cell transplantation and immunotherapy.  Based on qualifications, this position could entail a leadership role. We offer access to a highly collaborative and diverse research environment, modern laboratory space and state-of-the-art core facilities.  Research is a core priority at the Hutch and successful candidates will be expected to maintain an active clinical research interest, as demonstrated by peer reviewed publications.  The primary appointment will be in the Clinical Research Division of Fred Hutch with secondary appointment with the Department of Pathology at the University of Washington.

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) are jointly recruiting a full-time laboratory-based faculty member at the Assistant/Associate Member, and Assistant/Associate Professor level WOT (without tenure due to funding), on the Physician/Scientist pathway in the Clinical Research Division of Fred Hutch and the Division of Pediatric Hematology/Oncology, Department of Pediatrics at the UW. The Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. Fred Hutch in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is a National Cancer Institute-designated comprehensive cancer center.

The goal is to recruit a prominent scientist/thought leader and translational researcher in the field of pediatric malignancy, with solid malignancies a priority. The successful candidate has an MD, MD/PhD, or PhD, ad is expected to engage in active laboratory and clinical research related to the molecular pathogenesis, genomics/epigenomics, intracellular signaling pathways, or targeted translational therapeutics of neoplasms common in children. Physician faculty member would also participate in the care of patients with pediatric malignancies either in oncology or stem cell transplant service. Candidates must demonstrate a track-record of high-quality peer-reviewed publications, as well as independent research funding or competitive funding potential.

The primary appointment will be in the Clinical Research Division of Fred Hutch. Applicants must have an MD, MD/PhD, or PhD degree (or foreign equivalent) and US Board certification in Pediatric Hematology/Oncology (for physician candidates). Physician candidates, in order to be eligible for sponsorship for an H-1B visa, graduates of foreign (non-U.S.) medical schools must show successful completion of all three steps of the U.S. Medical Licensing Exam (USMLE), or equivalent as determined by the Secretary of Health and Human Services. Fred Hutch and University of Washington faculty engage in teaching, research and service.

Interested candidates should submit a curriculum vitae, and a letter summarizing research goals and career plans to Dr. Soheil Meshinchi at smeshinc@fredhutch.org.

The Fred Hutchinson Cancer Research Center and the University of Washington are affirmative action, equal opportunity employers. Both institutions are dedicated to building culturally diverse faculties and strongly encourage applications from women, minorities, individuals with disabilities and protected veterans.

The Fred Hutchinson Cancer Research Center invites applications from scientists working in the area of breast cancer research to lead a translational research program. Applicants will be considered at the rank of Associate or Full Faculty member, and we are seeking individuals who share our goals to advance an understanding of the biological basis of breast cancer, and to translate findings to the clinic.

We will consider PhD, MD/PhD, or MD scientists working in areas that include, but are not limited to: steroid receptors, signaling pathways, microenvironment, metastasis, systems biology, computational biology, and the biology of therapeutic response/resistance, genetics/genomics. A track record of relevant publication and funding commensurate with appointment level is highly desirable. Physician-scientists in any relevant medical discipline are encouraged to apply.

The successful candidate will enter a vibrant and dynamic research environment with opportunities to collaborate with basic and clinical researchers across diverse disciplines. The Breast and Ovary Cancer Program is one of 8 designated research programs in the Fred Hutch/University of Washington Cancer Consortium.

Opportunities exist for joint and/or affiliate appointment in the Fred Hutch Divisions of Human Biology, Clinical Research, Basic Sciences, Public Health Sciences, or Vaccine and Infectious Disease, as well as the University of Washington, depending on mutual interests. Applicants will also be eligible for membership in the Fred Hutch-based Seattle Translational Tumor Research (STTR) program, a multidisciplinary consortium of more than 500 faculty from Fred Hutch, the University of Washington, and Seattle Children’s, who work collaboratively on all aspects of solid tumor basic, translational, and clinical research.

Additional information about Fred Hutch and the Scientific Divisions can be found at:

http://www.fhcrc.org/science/

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

We are looking for a Clinical Research Coordinator to join our dynamic team of dedicated and skilled research staff working on clinical trials in the field of hematologic malignancies. The Clinical Research Coordinator will participate in the planning, coordination, and implementation of multiple industry- sponsored and investigator-initiated clinical trials involving human subjects.

This individual will work under the supervision of the Clinical Program Operations Director and will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines.

Responsibilities

• Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy.
• Review study candidates’ medical records in detail for study eligibility.
• Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained.
• Educate clinical teams, ancillary departments, and patients to ensure safe and accurate protocol implementation.
• Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders.   Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
• Initiate scheduling of patient clinic visits, and on-going study visits.  Attend patient visits and ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
• Complete requisition forms, assemble kits for upcoming research visits, transport laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.
• Collaborate with Investigational Drug Services (IDS) on drug assignment, dispensation information, and maintain regular communication regarding status of study subjects.
• Ensure study drug self-administration and accountability with patients, perform non-clinical ECGs, administer study questionnaires and other protocol-driven non-clinical assessments.
• Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies. 
• Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner. 
• Coordinate monitoring visits and respond to queries and other requests from study monitors.
• Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy.
• Understand clinical trial budget and billing plans for patients enrolled on clinical trials. Participate in the review of charges for patients on clinical trials to ensure billing compliance.
• Provide input regarding IRB correspondence and regulatory documentation. 
• Travel for industry sponsored investigator meetings.
• Maintain thorough knowledge in the field through attending related project meetings and symposia, reading related literature, and maintaining professional associations.
• Provide back up for other Clinical Trial Coordinators as needed. Provide back up for Data Coordinator on applicable trials.

Qualifications

• Bachelor’s degree.  
• Minimum of two years of clinical research or related experience.  Previous experience in oncology research is preferred. 
• This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment. 
• Must be a self-starter with the ability to locate resources and operate productively in an environment where standard operating procedures, guidelines and policies are not always available.
• Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills.
• Must have the flexibility to manage patients visits that may occur before or after regular work hours.
• CCRP or CCRC accreditation preferred.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

This individual will work under the supervision of the Principal Investigator(s) and will be required to perform their esponsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines. The ability to work across Fred Hutchinson, University of Washington and Seattle Cancer Care Alliance will be critical.

The ideal candidate will be able to address the full set of responsibilities in this listing and commit to a 1.0 FTE position.

Responsibilities

• Principal Investigator Support:
  • Serve as designee of the Principal Investigator (PI) to manage the daily clinical operations of assigned research studies in accordance with regulatory, GCP guidelines and institutional policy
  • Liase with SCCA clinical and administrative teams to identify appropriate and effective recruitment pathways

• Recruitment and Enrollment
  • Review study candidates’ medical records for study eligibility
  • Ensure informed consent, initiate patient enrollment, and ensure accurate enrollment records are maintained

• Education
  • Educate clinical teams, co-investigators, ancillary departments, and patients to ensure safe and accurate protocol implementation

• Protocol Implementation
  • Because the nature of the clinical study may vary within this job, the CRC must be capable of moving seamlessly between different protocols
  • Develop and maintain tools for study implementation, which may include data collection tools, study reference materials, and study specific orders. Revise and utilize tools as necessary to fulfill the aims of the clinical trial.
  • Initiate scheduling of patient clinic visits, and on-going study visits. Ensure clinical procedures, lab test, and other protocol specific activities are completed as outlined in the protocols.
  • Complete requisition forms, assemble kits for upcoming research visits, transport laboratory samples, and ensure samples are processed and shipped according to study specific guidelines, while tracking and maintaining research supplies.

• Budget & Billing
  • Understand clinical trial budget and billing plans for patients enrolled on clinical trials or studies
  • Work with internal partners to obtain and submit budget and billing information

• Other Duties Which May Be Required
  • Assist the Principal Investigator (PI) with protocol development, revision, and study analysis
  • Collaborate with Investigational Drug Services (IDS) on drug assignment, dispensation information, and maintain regular communication regarding status of study subjects
  • Ensure study drug self-administration and accountability with patients
  • Perform non-clinical ECGs
  • Administer study questionnaires and disperse study-related payments
  • Conduct study interviews and participate in focus groups
  • Function as a protocol liaison with clinical teams, patients, and when necessary, other institutions or drug companies
  • Maintain or assist in maintaining IRB correspondence and regulatory documentation.  Prepare or assist in preparing consent forms, continuation review reports, protocol submissions and modifications, and other study reports
  • Maintain appropriate source documentation, and complete or assist with accurate data entry into case report forms in a timely manner
  • Coordinate monitoring visits and respond to queries and other requests from study monitors
  • Identify and report adverse events in accordance with protocol, regulatory guidelines, and institutional policy
  • Participate in the review of charges for patients on clinical trials to ensure billing compliance
  • Travel for industry sponsored investigator meetings
  • Maintain knowledge in the field through attending related project meetings, reading related literature, and maintaining professional associations
  • Other duties as assigned

Qualifications

• Associate degree required, with Bachelor’s degree preferred
• Applicant must have a minimum of one to two years of clinical research or related experience.
• Previous experience in biobehavioral intervention studies (e.g. web apps, acupuncture) is preferred
• Previous experience in oncology research and clinical data collection is preferred
• Previous experience in investigator-initiated and industry-sponsored drug studies is preferred
• Previous experience in survey research and qualitative interviewing is preferred
• This position requires excellent organizational skills, attention to detail, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment
• Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

• Provide basic administrative support to the faculty, financial team and laboratory staff as needed
• Assist with weekly expenditures, pulling information and data from multiple electronic sources and creating backup documents for records
• Perform related administrative support duties as required

Working Conditions:

• Needs to be able to lift up to 25 pounds (boxes, packages, books, etc)
• Most work will be done on a computer
• May need to walk or shuttle to other campuses to deliver materials
• Shift is variable Monday through Friday and consists of <20 hours/week

Qualifications

Minimum qualifications:

• High school diploma or equivalent AND a minimum of six months entry-level office experience is desired
• Candidate must be currently state work-study eligible through an academic institution
• Computer experience including e-mail, Microsoft Office (Excel, Access, PowerPoint and Word), etc. is also required
• Must be reliable, trustworthy, and have strong work ethic
• Must be comfortable with and discrete when handling confidential information

Preferred qualifications:

• Strong communication and interpersonal skills
• Advanced Excel skills
• Possesses previous experience with administrative work (filing, sorting, organizing, etc)
• Effective team player and able to assimilate information quickly

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

• Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)

• Perform HPLC separations and maintain HPLC instruments

• Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)

• Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments

• Contribute to the analysis of proteomic (mass spectrometry) datasets

• Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics

• Collaborate with others to develop new methods and tools that support research objectives

• Maintain research results files and databases

• Assist with written progress reports and development of standard operating protocols (SOP)

• Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

• Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline is required
• The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
• The position includes drafting reports and manuscripts for publication, as well as presenting experimental results to the research team and collaborators. Thus, excellent writing and oral communication skills are required
• Previous experience in a CLIA or clinical lab environment is a plus
• A demonstrated track record of authorship on peer-reviewed journal publications is a plus

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab (https://research.fhcrc.org/silberstein/en.html) is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project.

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote HSC function in bone marrow failure and to enhance post-transplant hematopoietic reconstitution. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and discovered several novel niche factors using proximity-based single cell analysis (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

A successful candidate will be studying the effect of extrinsic HSC regulators on the bone marrow function and disease progression in preclinical models of myelodysplastic syndrome. In parallel, they will also be involved in a project which investigates the role of newly-defined niche factors in HSC aging and stress response. 

They will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle). There will be ample opportunities for data presentation and informal discussions. They will be encouraged to develop research ideas and branch out into more independent projects. Mentorship and support for post-doctoral fellowship applications will be provided. 

Qualifications

The candidate is expected to have a PhD and/or MD and a strong interest in stem cell research and commitment to basic/translational science in hematopoiesis. Applications from trainee hematologists who are willing to undertake a laboratory-based research project are welcome. Previous experience of working with murine models is not essential, but would be preferred. Excellent verbal and written communication skills are required.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

Postdoctoral Research Fellows in immuno-oncology – Novel cancer immunotherapies

Immunotherapies, such as checkpoint inhibition and adoptive T cell therapies, represent a paradigm shift in the treatment of cancer, inducing impressive responses in diverse malignancies. However, not all patients respond to current immunotherapies and novel therapeutic approaches are needed to circumvent these obstacles.

Post-Doctoral Research Fellow positions are available in the Immunotherapy Integrated Research Center at the Fred Hutchinson Cancer Research Center. The successful applicants will join a collaborative team that combines clinical research, animal modeling, computational biology and multiplexed immuno-histochemistry to understand the basic mechanisms of antitumor immunity and apply them to the development of novel immunotherapies.

This research program includes the laboratories of: Dr. Aude Chapuis, a translational immuno-oncologist who specializes in adoptive T cell therapies; Dr. Anthony Rongvaux, an immunologist who develops innovative humanized murine models to study the tumor/immune interface; Dr. Raphael Gottardo, a biostatistician with expertise in high-dimensional single cell data analysis; and Dr. Robert Pierce, a pathologist and expert in tumor microenvironment analyses who previously developed tissue-based biomarkers for Merck’s anti-PD-1 pembrolizumab antibody.

Our research is focused on understanding the biology and improving clinical outcomes after immune-boosting treatments. Human adoptive immunotherapy trials are initiated and being conducted using the robust Fred Hutch clinical platform. We are performing detailed analysis of patient outcomes to inform next-generation trials. , and developing humanized murine models of checkpoint inhibition and adoptive T cell therapy against solid and liquid cancers. We are using single cell RNA sequencing, genome editing and genomic screens in humanized murine to understand how anti-tumoral immunity functions, why it fails in some patients, and how we can overcome current limitations. We use multiparametric immunohistochemistry to validate humanized mouse results in humans, using a large biorepository of annotated patient specimens.

The scientific questions being addressed include:

• How can we arm tumor-specific T cells to enhance their efficacy upon adoptive transfer in patients?
• Can we modulate the immunosuppressive properties of cells found in the tumor microenvironment, particularly macrophages?
• Can we identify additional immune checkpoints and develop novel inhibitors?

The overall objective of this interdisciplinary project is to provide the scientific basis for future clinical trials, leveraging Fred Hutch’s continuing leadership in the design, clinical testing and commercialization of successful anticancer drugs and immunotherapies.

Qualifications

Desired skills and experience of the applicants:

• PhD or MD/PhD degree in Immunology, Immuno-oncology, Cellular & Molecular Biology or a closely related field
• Strong knowledge/understanding of basic immunology
• Advanced training and experience with animal procedures, flow cytometry, primary cell isolation and culture, molecular biology and/or computational immunology

The successful candidates will be scientifically driven individuals who enjoy working in a highly collaborative environment, with a track record of productive research, demonstrated by at least one first author publication, and with excellent communication skills.

Please apply online with a letter summarizing previous work experience, personal strengths and future interests, a resume, and contact information for three professional references.

Related publications:

Chapuis lab:

Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.

Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.

Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229.

Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts IM, Coffey DG, Warren E, Robbins H, Greenberg PD, Yee C.

Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8(+) T Cells In Vivo.

Sci Immunol. 2017 Feb;2(8). PMID: 28367538.

Chapuis AG, Lee SM, Thompson JA, Roberts IM, Margolin KA, Bhatia S, Sloan HL, Lai I, Wagener F, Shibuya K, Cao J, Wolchok JD, Greenberg PD, Yee C.

Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.

J Exp Med. 2016 Jun 27;213(7):1133-9. PMID: 27242164.

Rongvaux lab:

Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.

Development and function of human innate immune cells in a humanized mouse model.

Nat Biotechnol. 2014 Apr;32(4):364-72. PMID: 24633240.

Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.

Human hemato-lymphoid system mice: current use and future potential for medicine.

Annu Rev Immunol. 2013;31:635-674. PMID: 23330956.

Gottardo lab:

McDavid A, Finak G, Gottardo R.

The contribution of cell cycle to heterogeneity in single-cell RNA-seq data.

Nat Biotechnol. 2016 Jun 9;34(6):591-3. PMID: 27281413.

Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M, Linsley PS, Gottardo R.

MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.

Genome Biol. 2015 Dec 10;16:278. PMID: 26653891.

Pierce lab:

Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR.

T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.

Cancer Immunol Res. 2017 Nov;5(11):978-991. PMID: 29066497.

Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.

PD-1 blockade induces responses by inhibiting adaptive immune resistance.

Nature. 2014 Nov 27;515(7528):568-71. PMID: 25428505.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.

The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

• Study the function of human T cells
• Molecular bench work with PCR, cloning, and vector design
• Single cell RNA sequencing
• Biostatistics and some basic programing skills
• Cell Culture, cell sorting, flow cytometry, intercellular staining, and transfections
• Validation through functional and killing assays.

Qualifications

• MD and/or a PhD in a biological science with a diverse knowledge of immunology
• Dynamic and driven – engaging and encouraging in team environments
• Willingness to write and apply for funding opportunities and abstracts
• A strong research background
• Proficient in molecular biology and cellular immunology technique and knowhow
• Virology knowledge will assist in the AIM of this positon
• Flow cytometry and cell signaling based assays
• Experience in analysis of TCR signaling pathways and in lentiviral modification of T cells will be an advantage

To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Turtle Lab is looking for a post-doctoral research fellow who will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic malignancies within the Program in Immunology and Clinical Research Division at Fred Hutch. The successful applicant will employ strategies for genetic modification of human T cells to enable their expression of chimeric antigen receptors (CARs) and redirection of specificity to antigens expressed by hematologic malignancies. In vitro studies using human T cells and in vivo xenogeneic models will be used to develop and test novel T cell therapies that can be studied in future human clinical trials.

Qualifications

• Applicants will have a PhD in a biological science and/or a MD
• The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including lentiviral vector design and cloning, virus production, cell culture, flow cytometry, ELISPOT, and T cell cytotoxicity assays
• To be successful in this position, the post-doctoral research fellow must be highly motivated to establish a career as a future independent investigator

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

Responsibilities

A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani (https://research.fhcrc.org/hingorani/en.html) at Fred Hutchinson Cancer Research Center in Seattle, WA.

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis.  The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program.  Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies.  Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

Successful applicants will have:

• A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
• Experience with standard molecular and cellular biology techniques
• A demonstrated track record of productive research
• Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
• Ability to develop create approaches to experimental design
• Ability to work both independently and as part of a laboratory team  

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Hadland Lab (http://research.fhcrc.org/hadland/en.html) is seeking a talented postdoctoral fellow interested in studying the mechanisms regulating hematopoietic stem cell (HSC) emergence. The focus of our lab is to unravel the dynamic intercellular interactions and signal pathways governing the generation of blood and immune cells during embryonic development, and in turn apply this knowledge toward engineering novel approaches for the study and treatment of blood and immune disorders.

Responsibilities

This is a basic science position that focuses on utilizing emerging single cell technologies and computational approaches for the functional and molecular analysis of the dynamics of HSC development.  The position will also provide opportunities to develop novel translational applications in the areas of gene and cellular therapies, disease modeling, and/or drug discovery, and for collaborations with colleagues in Genome Sciences, Bioengineering, and other departments.  This position is ideally suited for a candidate who is an independent thinker but who also enjoys working collaboratively across disciplines.

Qualifications

• PhD in a relevant field (molecular biology, cell biology, genome sciences, developmental biology, immunology, or related fields).
• Track record of productive research, with high quality first-author publications.
• Experience in molecular biology and cell culture techniques is required.
• Experience in bioinformatics and use of computational algorithms to address complex biological questions is desired.
• Additional experience in culture and differentiation of pluripotent stem cells, flow cytometry, viral transfection, gene editing, transcriptomics/proteomics, immunohistochemistry, and/or microscopy is a plus.
• Excellent verbal and written communication skills are essential.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

A Stem Cell and Gene Therapy Program laboratory that studies hematopoietic stem cell biology and develops novel gene therapy and gene editing strategies is recruiting a postdoctoral fellow to develop novel in vivo gene therapy approaches for the modification of primary hematopoietic stem cells using preclinical animal models. The position involves responsibilities, such as the development and optimization of viral vectors, follow up analyses for tracking of modified cells after delivery of the vector or formulation, processing of primary tissue samples, and culture/analysis of cells modified with nanoparticles and/or viruses. The candidate will be expected to publish and present their work in both internal and external events.

Qualifications

A PhD or MD in a scientific field is required. The individual must possess knowledge of hematopoietic stem cell biology. Experience in animal models, transduction of primary cells with viral vectors and gene therapy and editing tools are required. Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, viral vector platforms, flow cytometry/flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR. Previous experience in basic bioinformatics, and/or GLP/GMP techniques is desired, but not required.

To be successful in this position, the candidate must be highly motivated and able to work independently to design and execute experiments, possess a high level of initiative and attention to detail, and must also be able to multi-task and prioritize work at short notice. They must also be capable of working independently in a team environment. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Adair laboratory, housed within the Clinical Research Division, is recruiting a postdoctoral fellow or research associate to study blood cell gene therapy for genetic and infectious diseases and cancer. The post-doctoral fellow will investigate and develop methods to efficiently introduce genetic editing into stem cells and/or T cells and assess phenotypical and biological changes and performance in these cells. The fellow will work under the PI and other senior members of the research team and will be expected to publish and present their work in both internal and external events.

Qualifications

Required

• A PhD or MD in a scientific field
• Motivation to work independently and design and execute experiments
• Publication record in virology/molecular biology
• Advanced knowledge of molecular biology skills, tissue culture, and viral assays

Preferred

• Experience with development of nanoparticle technologies for nucleotide and protein delivery to primary cells
• Experience in studies involving  stem cell cultures, immunology, flow cytometry, animal models, and bioinformatics

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Program in Transplantation Biology in the Clinical Research Division is seeking a program assistant in research monitoring for the myeloablative and non-myeloablative transplant program.

Responsibilities

The Program Assistant will work under the supervision of the Principal Investigators and Research Staff Manager to assist in data entry, specimen tracking, document review, patient outcome assessment and regulatory support for a wide variety of transplant protocols. Responsibilities include, but are not limited to:

• Review patient records and update patient database
• Assist in coordination of patient disease restaging, research specimens, and appointments with the SCCA, Long Term Follow-Up Department, Seattle Children’s, and local physicians
• Assist with outside center support
• Deliver documents, kits, and other research support items between campus buildings
• Case report form data entry
• Serve as a resource for data projects using Access
• Assist with regulatory support
• Perform other duties, as assigned

Qualifications

• A bachelor’s degree and a minimum of one year experience in a support role in a medical, scientific, or research setting is required.  (The equivalent combination of education and experience is acceptable.)
• Strong attention to detail and excellent organizational and communication skills are essential.
• Must work well in a team-oriented environment.
• To be successful in this position, the program assistant must be able to provide consistency across complex documents.
• Must be highly proficient using Microsoft Word and Excel, proficiency with ACCESS highly desirable.
• Must be able to handle a high-volume work load.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Project Coordinator, Center for Accelerated Translation in Pancreas Cancer (CATPAC) is responsible for day-to-day coordination of clinical and preclinical studies under the direction of the PI and the Hingorani Translational Research Program Manager. This part-time position represents an excellent opportunity for an experienced, highly motivated individual with a passion for research to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.

The Project Coordinator will be primarily responsible for the operations of our pancreas cancer biorepository program and other pancreas cancer research team studies. This will involve implementing study processes, assisting with protocol development, coordinating collections and shipments, assuring adherence to regulatory guidelines and maintaining study records. This position will define and implement best practices for data and materials management and will also conduct literature reviews to assist in determining most suitable methods to be used in team projects.

Responsibilities

• Maintain standard operating procedures (SOPs) for the CATPAC pancreas biorepository and ensure program compliance with SOPs
• Coordinate operations of the biorepository project and assist with resource planning
• Prepare study templates and documentation for collection and distribution of specimens; ensure regulatory compliance
• Manage priorities for a team of data coordinators responsible for consent, collection and day-to-day collection activities
• Manage specimen distribution process; pickup at UW Medical Center and courier samples to their destinations and/or coordinate pickup and distribution with the assistance of on-call staff
• Manage protocol modifications and annual reporting requirements
• As needed, review medical records to ascertain study eligibility and consent study subjects to biorepository protocol
• May attend clinic visits when appropriate to provide education about study requirements
• Coordinate and ensure quality of clinical data abstraction
• Identify and communicate procedural problems
• Create and maintain project web sites
• Regularly communicate status to team
• Manage project databases and tracking tools; maintain knowledge of database definitions and usage and work with programmers to modify as needed
• Monitor project/study expenses and prepare financial reports
• Serve as a point of contact for protocol procedures, data and specimen collection requirements and other study related operations
• Support multiple projects in varied environments with frequently competing deadlines and changing priorities
• Perform other duties as assigned

Qualifications

• Bachelor’s degree, preferably in a biological field
• Minimum of three years of experience in a clinical or laboratory research setting
• Experience managing projects from inception through closure
• Excellent problem-solving skills with ability to grasp details of situation quickly and volunteer and facilitate solutions
• Strong verbal and written communication skills
• Must be highly organized with the ability to multitask in a fast-paced environment.
• Excellent critical thinking with ability to synthesize a large amount of information and anticipate needs
• Demonstrated ability to quickly and independently learn new technologies
• High level of proficiency with Microsoft Office applications and data management tools
• Must be flexible and quickly adapt to changing priorities
• Ability to work independently and efficiently under pressure
• Occasional nights and/or weekends will be required

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

• Transition existing clinical data base to REDCap database working with the Center sponsor for REDCap and previous database sponsor; provide ongoing training as necessary to Cord Blood Program on use of REDCap data base; maintain the REDCap database for existing studies; set up new studies in the database and train staff on use of the database for new studies; extract data from REDCap as necessary for manuscripts, protocols, and grant writing and reports
• Assist with organization of subject data for all program studies and other research related tasks
• Assist with manuscript preparation and submission –assist faculty with writing, references, and submitting manuscripts for publication; format content and references according to journal-specific guidelines using EndNote, Microsoft Word, and PowerPoint program; use PubMed and other online search engines to find and verify references; use EndNote to create/manage libraries and format citations/bibliographies
• Ongoing coordination of manuscript process for faculty in the Cord Blood Program including management of End Note libraries and set up/maintenance of a system for tracking manuscripts and publications that are in process; ensure publications from NIH-supported projects are compliant with the NIH Public Access Policy
• Support faculty in the program with maintaining CVs and NCBI Bibliographiess
• Assist faculty with ORCID implementation and ongoing maintenance of ORCID profiles
• Writing sections for grants, protocols, public relations narratives, philanthropy, website
• Assist faculty in grant submissions
• Edit and proof grant summaries/progress reports
• Data Collection and analysis in support of manuscripts, protocols, grant writing and reports using MS Excel and other statistical data formats
• Study operations for AML study including the regulatory requirements, patient enrollment, data collection, clinical trial agreement and reporting to sponsor; working with collaborative team of investigators from different departments
• Create/update forms and other processes related to institutional review board protocols
• Ongoing study and research support for new and existing studies as needed by program
• Participate in weekly clinical meeting discussion of protocol status, IRB status, and patient reports

Qualifications

• BA or BS in health-related field
• Prior clinical study experience preferred
• REDCap database experience preferred
• Experience with CRF and industry sponsored studies preferred
• Work as part of team, flexible hours may be required

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The focus of research conducted in Dr. William Grady’s laboratory in the Clinical Research Division of Fred Hutchinson Cancer Research Center Research is the study of the molecular and cell biology of gastrointestinal cancer as well as the role of genetic and epigenetic alterations in cancer. Under general supervision of the PI and the Principal Staff Scientist in the lab, the Research Technician will perform varied support functions requiring knowledge and skills specific to the research study.

Responsibilities

• Collection and processing of human and murine tissue samples
• DNA, RNA extraction from fresh frozen or formalin fixed paraffin-embedded human tissue samples
• Proficient with real-time PCR technology
• Protein extraction, cell fractionation, western blot, and immunoprecipitation
• Responsible for the organization of specimen inventory in short-term and long-term storage
• In vitro cell culture experiments
• Maintain a database used for organizing the current inventory and tracking the location of specific information/specimens
• Collect and analyze data
• Monitor adherence to study protocol
• Inform PI of deviations from study protocol
• Attend project meetings
• Keep detailed records for experiments
• Maintain a high level of accuracy for all work

Qualifications

To be successful in this position, the technician must be highly self-motivated and trustworthy. They should be willing to take up new skills and responsibilities, follow instructions, and capable of working independently in a teamwork environment.

• A bachelor’s degree major in one of the biological sciences
• Strong background in molecular biology and cell biology
• Excellent interpersonal and communication skills
• Competency with Microsoft Excel, Word, and PowerPoint, and Adobe Photoshop
• Prior knowledge and skills in epi/genetic studies are preferred

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab has an open position for Research Technician I. This position will be available in June 2020.

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote hematopoietic stem cell function in bone marrow failure and to enhance hematopoietic reconstitution after bone marrow transplantation. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

A successful candidate will be responsible for maintaining the murine colony and conducting animal experiments which involve stem cell transplantation, fluorescently-activated cell sorting/analysis and molecular studies of stem cells/progenitors.

The incumbent will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle).

Qualifications

Research Technician I required qualifications: Bachelor's degree in a related scientific discipline and prior research laboratory experience.

The candidate must have an interest in stem cell research. Applications from candidates considering medical/graduate schools are encouraged. Previous experience of working with murine models is not essential, but the position requires that a candidate to handle the animals on a daily basis and perform standard animal procedures (appropriate training will be provided). Excellent written and verbal communication skills are required.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Silberstein lab is seeking to recruit a Research Technician I-II.

The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote hematopoietic stem cell function in bone marrow failure and to enhance hematopoietic reconstitution after bone marrow transplantation. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).

A successful candidate will be responsible for maintaining the murine colony and conducting animal experiments which involve stem cell transplantation, fluorescently-activated cell sorting/analysis and molecular studies of stem cells/progenitors.

The incumbent will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle).

Qualifications

Research Technician I required qualifications: Bachelor's degree in a related scientific discipline and prior research laboratory experience.

Research Technician II required qualifications: Bachelor's degree in a related scientific discipline and 2 or more years of relevant professional research experience. A Master's degree in a relevant scientific discipline can substitute for 2 years of professional research experience.

The candidate must have an interest in stem cell research. Applications from candidates considering medical/graduate schools are encouraged. Previous experience of working with murine models is not essential, but the position requires that a candidate handle the animals on a daily basis and perform standard animal procedures (appropriate training will be provided). Excellent written and verbal communication skills are required.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Hematologic Malignancies Program in the Clinical Research Division (CRD) is recruiting a Research Technician I/II to work in the pre-clinical research laboratory of Dr. Stanley Lee.

Responsibilities

The laboratory of Dr. Stanley Lee in the Clinical Research Division (CRD) studies how derangement in transcriptional regulation drives blood cancers such as myelodysplasia and acute myeloid leukemia. The laboratory combines hematopoietic stem cell biology assays, cell culture, clinically-relevant in vivo leukemia models, cutting-edge functional genomics and next generation sequencing technologies to understand how mutations in RNA splicing factors and chromatin regulators drive leukemia development and how to therapeutically target these leukemic cells (Lee SC et al., Nature Medicine 2016; Lee SC et al., Cancer Cell, 2018).

A successful Research Technician II candidate will be responsible for contributing to all aspects of laboratory research including performing experiments, analyzing data, keeping detailed laboratory records, maintaining laboratory equipment, reagents and stocks, and supporting other on-going laboratory projects and events. Routine experimental techniques include analysis of murine models, maintenance of mouse colony, flow cytometry, molecular biology assays (DNA and RNA extraction, PCR, RT-PCR, qPCR), protein analysis including western blot and immunoprecipitation, and cell culture. The successful candidate will under the direct supervision of the Principal Investigator or senior laboratory personnel. The candidate will have opportunities to interact with researchers from other Programs within the CRD. 

Qualifications

Required:

• Mammalian cell culture experience
• Molecular biology technical experience
• Excellent written and verbal communication skills
• Must be proactive, detail-oriented and adept at working in a team environment
  
  • Research Tech I level: A bachelor's degree in a biological field, prior laboratory research experience
  • Research Tech II level: A bachelor’s degree in a biological field, 2 or more years of relevant professional post-bachelor’s laboratory research experience

Preferred:

• Previous experience of working with murine models is desired but not essential (appropriate training will be provided)
• Flow cytometry experience
• Experience with protein analysis including western blot and immunoprecipitation
• Candidates considering medical school and/or graduate school are highly encouraged to apply

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Immunopathology Lab in the Clinical Research Division is seeking a well-organized and highly motivated Research Technician II to join the Multiplex Immunohistochemistry (mIHC) Team with a focus on image acquisition and analysis. The Lab utilizes cutting-edge technologies in a Team Science approach to interrogate the tumor microenvironment through tissue-based analyses of immunotherapy clinical and pre-clinical trials.

Responsibilities

• Acquire images of brightfield and fluorescence immunohistochemistry, to include 7 or more markers, on a variety of scanning microscopes
• Carry out image analyses of brightfield, standard fluorescence, and multiplex immunohistochemistry images including spatial analysis
• Work with bioinformatics collaborators to maximize data throughput and interpretation
• Act as a digital pathology resource for collaborators
• Perform immunohistochemistry and immunofluorescence on automated platforms
• Maintain sample and reagent inventories
• Make buffers and aliquot reagents
• Maintain laboratory records and compile data on experiments and assays in shared databases
• Provide methods, images, and data for analysis reports, grant applications, manuscripts, and posters
• Participate in weekly lab meetings and perform other duties as required

Qualifications

Minimum qualifications:

• BA/BS in biology, immunology, or related field extensive digital pathology experience (4+ years)
• Expertise in image analysis software, such as Definiens or Indica Labs’ HALO (2+ years)
• Proficiency with scanning microscopes, such as Leica Aperio or Akoya (PerkinElmer) Vectra systems
• Must be able to work in a fast-pace environment and multi-task
• Detail oriented with good organizational skills
• Excellent teamwork with strong written/oral communication skills
• Work independently and troubleshoot technical problems
• Strong PC computer skills
• Microsoft Office proficiency, particularly design and use of spreadsheets

Additional Preferred Experience:

• Proficiency with immunofluorescence using manual and/or automated platforms
• Experience with image management systems such as Indica Labs HALO Link or Leica eSlide Manager

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

This position will support two laboratories in the development of research projects using in vivo murine models. The Rongvaux Lab in the Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support fundamental research on the mechanisms of immune responses to infection and cancer. This individual will also support translational studies of CRISPR gene editing in the Adair Lab in the Program in Cell and Gene Therapy, also in the Clinical Research Division. They should be capable of maintaining a large murine colony and perform diverse in vivo experimental procedures. This position requires a high level of organization, capacity to coordinate experiments with diverse researchers and collaborators, maintenance of detailed records, and excellent communication skills. Additional laboratory skills (tissue culture, molecular biology) are highly desirable.

Responsibilities

• Maintain a large murine colony
• Perform specialized procedures, such as injections, blood draws and irradiation
• Schedule and coordinate experiments with researchers
• Purify and cryopreserve human hematopoietic cells
• Perform basic flow cytometry analyses
• Produce lentiviruses and transduce human primary cells
• Other duties as assigned by supervisor will be performed as necessary

Qualifications

Research Technician II - A bachelor’s degree in biological science and animal research experience beyond course work are absolutely essential. The candidate should have at least two years of full-time, post-bachelor's laboratory experience.

Research Technician III - As Research Technician II but with five or more years of full-time post-bachelor's laboratory experience.

Experience working with murine models is required. Experience with mammalian cell culture and flow cytometry are preferred.

Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

As a Research Tech Level II, the position acts both independently and as a team collaborator within the lab to lead multiple laboratory projects including but not limited to isolation, enrichment, transduction and expansion of T cells/Stem Cells, complex analytical procedures, data compilation/interpretation, and generating detailed technical reports/presentations. In addition, this position helps identify emerging technologies and automation, monitors industry trends and conducts evaluations for feasibility. This position works with and under the guidance of a lab supervisor for experimental design, study execution, data analysis and data interpretation. The candidate also interacts heavily with internal and external research and principal investigator labs, GMP manufacturing, Quality Control, Quality Assurance, and other scientific/administrative staff, as needed.

Responsibilities

The position focuses on the development, optimization, and transfer of cellular and gene therapy unit operations including cell selections from starting materials, genetic modifications (viral transduction, electroporation, etc.), growth/expansion conditions, media/cytokine formulations, cell harvests, cryopreservation, and freeze-thaw recovery. In addition, this position collaborates to develop robust and repeatable analytical methods to characterize starting, in-process and final, formulated cellular products. Ultimately, development activities generate robust, repeatable and scalable processes to support toxicology studies, technology transfer/product introduction into the Fred Hutch GMP Cell Processing manufacturing facility, and IND generation to enable clinical trial initiation. 

Qualifications

Required Qualifications:

• Research Tech II: BS/MS in a biological sciences discipline, and 2+ years' (BS) or 1+ years' (MS) experience in mammalian cell culture
• Research Tech III: BS/MS in a biological sciences discipline, and 5+ years' experience in mammalian cell culture or Process Development
• Experience in one or more of the following technical areas:
  • Adherent and/or suspension cell cultures in flasks and/or bioreactors (fed-batch, perfusion, disposable bioreactor systems, etc.).
  • Cell culture media development and optimization.
  • Associated upstream and downstream unit operations such as cell banking, virus removal, purification, etc.
  • Cryopreservation and recovery of cryopreserved cells.
  • Experience with gene editing platforms (i.e. Crispr/cas9 system)

Preferred Experience:

• Demonstrated experience trouble-shooting issues associated with process scale-up, transfer into a GMP manufacturing setting, and generating process transfer documentation.
• Direct experience in a Process Development environment supporting aseptic cell culture-based manufacturing operations
• 1+ years hands-on experience with flow cytometry and T-cell/stem cell isolation/expansion protocols

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Immunopathology Lab in the Clinical Research Division is seeking a well-organized and highly motivated Research Technician to join the Multiplex Immunohistochemistry (mIHC) Team with a focus on image acquisition and analysis. The Lab utilizes cutting-edge technologies in a Team Science approach to interrogate the tumor microenvironment through tissue-based analyses of immunotherapy clinical and pre-clinical trials. Determination of Technician II vs III will be based on experience.

Responsibilities

• Acquire images of brightfield and fluorescence immunohistochemistry, to include 7 or more markers, on a variety of scanning microscopes
• Carry out image analyses of brightfield, standard fluorescence, and multiplex immunohistochemistry images including spatial analysis
• Work with bioinformatics collaborators to maximize data throughput and interpretation
• Act as a digital pathology resource for collaborators
• Perform immunohistochemistry and immunofluorescence on automated platforms
• Maintain sample and reagent inventories
• Make buffers and aliquot reagents
• Maintain laboratory records and compile data on experiments and assays in shared databases
• Provide methods, images, and data for analysis reports, grant applications, manuscripts, and posters
• Participate in weekly lab meetings

Qualifications

Requirements:

• BA/BS in biology, immunology, or related field or digital pathology experience (2+ years)
• Expertise in image analysis software, such as Definiens or Indica Labs’ HALO (1+ years)
• Must be able to work in a fast-pace environment and multi-task
• Detail oriented with good organizational skills
• Excellent teamwork with strong written/oral communication skills
• Work independently and troubleshoot technical problems
• Strong PC computer skills
• Microsoft Office proficiency, particularly design and use of spreadsheets

Additional Preferred Experience:

• Proficiency with scanning microscopes, such as Leica Aperio or Akoya (PerkinElmer) Vectra systems
• Proficiency with immunofluorescence using manual and/or automated platforms
• Experience with image management systems such as Indica Labs HALO Link or Leica eSlide Manager

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The laboratory of Dr. Stanley Lee in the Clinical Research Division (CRD) studies how derangement in transcriptional regulation drives blood cancers such as myelodysplasia and acute myeloid leukemia. The laboratory combines hematopoietic stem cell biology assays, cell culture, clinically-relevant in vivo leukemia models, cutting-edge functional genomics and next generation sequencing technologies to understand how mutations in RNA splicing factors and chromatin regulators drive leukemia development and how to therapeutically target these leukemic cells (Lee SC et al., Nature Medicine 2016; Lee SC et al., Cancer Cell, 2018).

The Hematologic Malignancies Program in the Clinical Research Division (CRD) is recruiting a Research Technician II/III to work in the pre-clinical research laboratory of Dr. Stanley Lee.

Responsibilities

A successful Research Technician II candidate will be responsible for contributing to all aspects of laboratory research including performing experiments, analyzing data, keeping detailed laboratory records, maintaining laboratory equipment, reagents and stocks, and supporting other on-going laboratory projects and events. Routine experimental techniques include analysis of murine models, maintenance of mouse colony, flow cytometry, molecular biology assays (DNA and RNA extraction, PCR, RT-PCR, qPCR), protein analysis including western blot and immunoprecipitation, and cell culture. The successful candidate will under the direct supervision of the Principal Investigator or senior laboratory personnel.

A successful Research Technician III candidate will be responsible for the above duties in addition to supervising other laboratory personnel, being responsible for the daily operation of the lab, assisting in experimental design and editing/writing reports of research as author or co-author. The candidate will have opportunities to interact with researchers from other Programs within the CRD.

Qualifications

Required:

• Two years’ experience working with murine models
• Mammalian cell culture experience
• Molecular biology technical expertise
• Flow cytometry experience
• Excellent written and verbal communication skills
• Must be proactive, detail-oriented and adept at working in a team environment
  • Research Tech II level: A bachelor’s degree in a biological field, 2 or more years of relevant professional post-bachelor’s laboratory research experience
  • Research Tech III level: Extensive laboratory experience. Generally, the incumbent will possess a Master's degree in a related scientific field.

Preferred:

• Prior leukemia research experience
• Hematopoietic morphology expertise

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.

This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.

Responsibilities

• Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
• Perform HPLC separations and maintain HPLC instruments
• Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
• Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
• Contribute to the analysis of proteomic (mass spectrometry) datasets
• Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
• Collaborate with others to develop new methods and tools that support research objectives
• Maintain research results files and databases
• Assist with written progress reports and development of standard operating protocols (SOP)
• Assist with writing scientific manuscripts for peer-reviewed journals

Qualifications

• Ph.D. degree in Protein Chemistry, Analytical Chemistry, Biochemistry, or related discipline and 3+ years of experience is required
• The work is rigorously quantitative, and exquisite attention to detail and the ability to adhere to standard operating protocols (SOP) and maintaining records are critical
• The position includes drafting manuscripts for publication and, thus a demonstrated track record of first author peer-reviewed journal publications, as well as excellent written communication skills are required.
• The position includes giving oral presentations at local meetings, on consortium teleconferences, and at national and international meetings; thus excellenT oral communication skills are required.
• Previous experience in a CLIA or clinical lab environment is a plus

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Responsibilities

The Fred Hutch core center for excellence in hematology vector production and development facility assists researchers in the production of viral vector preparations for use in research experiments in their laboratories. The position involves managing the research viral vector core facility, driving vector development and application of new viral manufacturing processes as well as training and supervision of core technicians to ensure the facilities performance standards are met.

The manager is responsible for keeping the facility equipment operational and ensuring safety during production in accordance to Fred Hutch and NIH guidelines. The position involves ensuring all consumables and other supplies needed for vector production are available and that orders of such products by the core are billed correctly. Another responsibility is organizing and overseeing storage of cell lines and plasmids used by the facility as well as storage of final viral products.

The position requires the manager to maintain and archive production records of the viral products generated and tested. This includes documentation of client work-orders filed with the vector core as well as creating and passing on billing information to Fred Hutch Shared Resources Billing to ensure proper charge of services provided by the core.

The manager is responsible for assembling and providing data on vector production volume and development progress for reports to the funding agency. The position also includes performing client consulting services in terms of viral vector design and choice of preparation possibilities offered by the core in order to plan and develop transfer vectors fitting individual project requirements.

Qualifications

The position requires a PhD degree in an appropriate and laboratory intensive scientific field with a minimum of at least 2 years additional productive work experience in a research laboratory that includes specific experience in constructing new recombinant DNA molecules. Required educational expertise is strong background in the fields of genetics, virology as well as cell- and microbiology.

Detailed understanding of viral gene delivery systems and experience in design and testing of DNA vectors is required. Furthermore a qualified researcher should have technical expertise in mammalian tissue culture, recombinant DNA technology, molecular cloning, viral vector production, flow cytometry, DNA gel electrophoresis and PCR methods including real time PCR.

A statement of research interests and/or a cover letter are required. 

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

The Program of Immunology and Clinical Research Division are seeking an experienced Staff Scientist to work in a collaborative environment to help develop and optimize novel TCR gene therapy products for clinical translation, and to support current and future TCR gene therapy clinical trials.

Responsibilities

• Cell and Molecular Biology: independently perform routine and non-routine experiments that are moderate to complex: Experiments include cell separation using the FACSorter and autoMACs, analyzing cell phenotype and function using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, chromium release assays and ELISpots, and viral transduction of human and murine cells.
• Cell culture and tissue processing: Establishing and maintaining primary cell culture, including human DCs and long-term culture of human T cells
• Handle projects independently, including literature reviews to assist in determining most suitable methods to be used in research.
• Contribute to the preparation and presentation of written or oral reports concerning studies and assist in publication of results by proofreading, editing, and contributing ideas.
• Assist with the management and organization of a fast-paced lab, and perform other duties as assigned by supervisor as necessary.

Qualifications

• PhD in a related scientific field.
• Extensive scientific knowledge and acumen: In particular, an in depth understanding of immunology is required, and a solid knowledge of T cell biology is preferred.
• Extensive experience of at least six years, especially in sterile cell culture techniques and flow analysis, including experience in maintaining long term primary cell cultures, particularly T-cells and/or DCs.
• Strong analytical and organizational skills: Ability to identify problems and troubleshoot solutions with limited direction in a fast-paced, goal-oriented environment with the ability to analyze data statistically and present it logically.
• Excellent oral and written communication skills; good interpersonal communication and organizational skills; and flexibility to work in a highly collaborative team environment and interact effectively with different cross-functional groups and potential collaborators on a daily basis.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

Lead Immunotherapy Bioinformatician - Staff Scientist

Fred Hutch is a leading force in cancer immunotherapy research, a field dedicated to understanding how we can harness the immune system to treat cancer. This research arena spans an incredibly diverse spectrum of scientific questions ranging from understanding the form and function of the tumor immune microenvironment, augmenting the endogenous immune response to tumors, to crafting custom immune responses through gene editing approaches. The Adair, Bleakley, Dudakov, Headley, and Rongvaux labs, a core group of Junior Faculty within the Fred Hutch Immunotherapy and Translational Data Science Integrated Research Centers (IIRC and TDS-IRC), are seeking a PhD level bioinformatician to fill a Staff Scientist position working within and across the five groups.

The Staff Scientist will implement existing analysis platforms and help drive the development of cutting-edge new tools and technologies targeted at understanding the cellular and molecular underpinnings of immune responses to cancer. This position provides the opportunity to work on a diverse range of datatypes from transcriptomic and epigenomic analysis (both bulk and single cell), trajectory analysis of immune cell differentiation, high dimensional protein analysis through flow cytometry and CITEseq, and mutational analysis in gene-edited cells. The incumbent will participate in grant and manuscript preparation, experimental design and execution, and presentation of results in local and national meetings. They will also have the opportunity to participate in multidisciplinary collaborations involving laboratory-based scientists (immunologists, cancer researchers), clinical investigators, biostatisticians, data scientists, programmers and computational biologists through associations with the Fred Hutch IIRC and TDS-IRCs. We are looking for an individual who is truly passionate about applying data science to big questions in cancer immunotherapy.

We as a group value inclusion and a diversity of backgrounds and perspectives to inform our work. We believe in supporting each other through mentorship and providing resources for professional development. Given these values, we strive to make our recruitment and promotion processes fair and transparent. Therefore, we strongly encourage all individuals with an interest in the position to apply. To learn more about our groups please visit our lab websites and those of the Immunotherapy and Translational Data Sciences IRCs.

• Adair Lab
• Bleakley Lab
• Dudakov Lab
• Headley Lab
• Rongvaux Lab
• Fred Hutch IIRC
• Fred Hutch TDS-IIRC

Responsibilities

• Provide dedicated and collaborative bioinformatic support to the Adair, Bleakley, Dudakov, Headley, and Rongvaux labs across a diverse range of projects and modalities
• Manage and set scientific priorities across projects
• Develop and optimize computational pipelines to enable the integration and management of large and complex data sets
• Interpret results from computational and statistical analysis
• Assist with study design and analysis of pre-clinical and clinical trials
• Identify and implement new and cutting-edge analysis approaches for relevant data types
• Participate in the dissemination of research findings
• Co-author manuscripts for publication
• Educate savvy postdoctoral fellows, graduate students, and research technicians in basic tools to visualize their complex datasets

Qualifications

Minimum qualifications:

• PhD or equivalent degree in bioinformatics, computational biology, biostatistics, statistics, computer science, or a related field.
• Experience in analysis of next generation sequencing data
• Excellent programming skills (python, R, C/C++, Java) including best software development practices (e.g. design, unit tests, documentation, code review)
• Excellent interpersonal, oral and written communication skills
• Strong work ethic
• Ability to work in a team, and supervise junior team members
• Ability to manage multiple projects and to meet deadlines

Preferred qualifications:

• Understanding of immunology and/or immunotherapy
• Experience in single-cell analysis
• Experience in clonal and mutational analysis
• Experience in ATACseq analysis
• Experience in analysis of high dimensional flow cytometry