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35 Found open positions

Advanced Practice Provider: Integrative Medicine

FH Clinical Research Division
Category: Advanced Practice Providers
Seattle, WA, US
Job ID: 18786

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Seattle Cancer Care Alliance is seeking a certified physician assistant (PA-C) or advanced registered nurse practitioner (ARNP) to provide an integrative medicine approach to the evaluation and medical management to Oncology and Hematology patients in the Seattle Cancer Care Alliance Integrative Medicine Program. The ARNP/PA-C will provide outpatient supportive care and integrative medicine services to a diverse patient population, will be an ambassador within and outside of SCCA as we continue to build this unique and innovative program. They will facilitate IM clinical research in this population. Integrative Medicine services may be offered from time of diagnosis to end of life. Integrative medicine therapies offered will focus on evidence-based symptom management, rather than cancer treatment, due to the available level of evidence at this time. Our vision is that an integrative medicine approach will become the standard of care for these patients.


The ARNP/PA-C will, within an integrative medicine framework, assess and manage basic health needs of patients, addresses treatment toxicities, perform integrative medicine procedures (e.g., acupressure, medical acupuncture), and consult with and refer to professional peers as needed. They will work collaboratively with the oncology treatment team to coordinate care of their patients. All clinical responsibilities are performed within the scope of practice, institutional privileges and under the supervision of an attending physician.

Responsibilities

Distinguishing Characteristics

The ARNP/PA-C at the SCCA functions within their scope of practice and collaborates effectively with other disciplines to provide state-of-the-art patient and family-centered integrative oncology care. 

  • Training in a formal integrative medicine program is required and at least one year of experience in the use of integrative medicine therapies and selfcare in the oncology setting, including use of dietary supplements, mind-body medicine therapies, acupuncture, acupressure and other evidence based IM therapies as well as lifestyle practices that have been shown improved cancer outcomes.
  • A working knowledge of basic oncology principles and practice.
  • Excellent communication skills are necessary to ensure optimum patient care outcomes in a complex care environment.
  • Respectful and ethical in their interactions with staff, patients and their family and caretakers alike.
  • Skilled clinicians, providing evidence-based diagnosis and management of integrative medicine therapies related to the acute, symptomatic, and palliative care needs of patients with cancer.
  • An effective educator teaching and providing information about disease processes, treatments, and management of treatment toxicities to patients, their family and other caregivers from an integrative medicine perspective.
  • An effective educator of MD’s, APP’s ,RN’s, MA’s and all other supportive care professionals at SCCA in the basic principles and practice of supportive oncology care, palliative care and integrative medicine therapies and how they can add value to patient care. The APP in this role needs to teach and communicate an effective and practical way to incorporate integrative medicine approaches into the patient’s plan of care.

Scope of Work

  • Takes responsibility for keeping up with current concepts in the management of patients in their care from an integrative medicine perspective.
  • Performs complex and problem-focused H & Ps and assessments for patients.
  • Evaluates and manages on-treatment and post-treatment side effects, as well as long-term surveillance and survivorship issues. Offers treatment recommendations from an integrative medicine perspective.
  • Performs procedures according to licensure, credentialing, and scope of practice
  • Collaborates and consults with other disciplines and services to ensure safe, effective, and timely treatment as well as continuity of patient care. Care will be coordinated in a multidisciplinary fashion with collaborating services which may include surgery, radiation oncology, medical oncology, medical nutrition, social work, physical therapy, spiritual health psychology, pain service, hospice, and palliative care. 
  • Continuously works with medical and operations leadership to continue to build and enhance the Integrative Medicine service
  • Participates in the conduct of cancer clinical research, including patient, caregiver, and peer education.
  • Communicates changes in patient’s health status or urgent patient issues to the patient’s primary oncologist in a timely manner.
  • Participates in patient rounds, conferences and committees
  • Actively participates in the development and maintenance of patient management algorithms and standing orders.
  • Documents patient care data in accordance with the SCCA and UWP policies
  • ACLS certified
  • Performs assessments of patient’s and caregivers’ knowledge, attitudes, and actions around the cancer diagnosis and treatment issues within an integrative medicine framework. Evaluates the physical and psychological state of the cancer patient.
  • Provides psychological support to patients and their caregivers by participating in patient and/or family teaching, counseling and rehabilitation.
  • Refers patients to community agencies and other resources to promote optimal adjustment and functioning in coordination with other SCCA supportive care services.
  • Member of the Rapid Response team
  • Other duties as assigned

Qualifications

Required qualifications

  • Completion of a formal integrative medicine program such as:
    • Andrew Weil Center for Integrative Medicine-Integrative Medicine Fellowship
    • Integrative Oncology Scholars Program
  • Licensure and credentialing:
    • Washington State Licensure as an ARNP or PA-C
    • Minimum of 2 years of experience as an ARNP or PA-C


Preferred qualifications

  • Training in mind-body medicine therapies
  • Training in medical acupuncture and/or auricular acupuncture
  • Training in acupressure
  • Experience in program development, educator mindset
  • Comfortable speaking publicly (peers and patients)
  • Experience as an Integrative Medicine Clinician


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Assistant or Associate Professor, Oncology (BMT/IMTX)

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 85613

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) are jointly recruiting a full-time faculty member at the Assistant Professor or Associate Professor level without tenure due to funding (WOT), commensurate with experience and qualifications in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This apposition would have an annual service period of 12 months [July 1-June 30]. The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to contribute to our mission of delivering outstanding clinical care and developing excellence in clinical research in transplantation and immunotherapy. All clinical and translational research experiences and interests will be considered. Fred Hutch and University of Washington faculty engage in teaching, research, and service. Teaching responsibilities will involve oversight of advanced practice providers and fellows during inpatient and outpatient rotations, and delivery of informal teaching sessions and formal lectures to providers and the general medical community.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.  

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Blood and Marrow Transplantation (BMT)/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 86103

For the Blood and Marrow Transplantation (BMT)/Immunotherapy fellowship, the Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in BMT and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, UW and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

This is a year-long fellowship program with the goal of becoming an expert in BMT and immunotherapy. Rotations will include outpatient and inpatient BMT (autologous and allogeneic, long-term follow-up, etc.) and immunotherapy services. The fellow will initially function as a primary provider with direct patient care responsibilities and will have increasing levels of clinical team leadership over the course of the year.  Approximately 8 months will be devoted to clinical activities with the remaining time available for clinically focused research projects.  University of Washington faculty engage in teaching, research, and service.

Anticipated start date: July 1, 2022.

Bone Marrow Transplant/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 73966

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine, Division of Medical Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The selected individual for the advertised position is expected to participate in a year-long fellowship program with the goal of becoming an expert in blood and marrow transplantation (BMT) and immunotherapy (IMTX) services at Fred Hutch. The individual holding this position will rotate through outpatient and inpatient BMT (autologous and allogeneic, long-term follow-up) and IMTX services, and initially function as a primary care provider with increasing levels of patient care responsibility over the course of the year.  Approximately 8 months will be devoted to clinical activities with the remaining time available for the opportunity to participate in clinically focused research projects.  University of Washington faculty engage in teaching, research and service.

Anticipated start date would be July 1, 2021.

Clinical Research Coordinator II

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 19244

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Clinical Research Coordinator (CRC) is responsible for day-to-day coordination of intervention Phase I-III clinical trials of various complexities. The position will perform tasks relating to the start-up, management and close-out of studies including implementing new study processes with relevant service areas, screening patients for eligibility, tracking patient visits, assuring adherence to protocol schedules of events, and maintaining study records.  The Coordinator will work independently on multiple studies for at least two investigators, augment CRC staff, provide back-up to the general team and provide regular updates on the progress of the studies.  The CRC reports directly to the Clinical Program Operations Director.

Responsibilities

  • Prepares study start-up templates and documentation including eligibility checklists, study-specific clinic orders and study calendars
  • Serves as main point of contact with sponsors and keeps investigators informed about enrollment opportunities
  • Screens and registers patients; ensures eligibility requirements are met
  • Assures consent forms are completed correctly and in entirety and that the consent process is appropriately documented
  • Proposes orders for study related clinic procedures such as blood draws, exams, infusions and other procedures according to protocol requirements; coordinates with clinic, pharmacy staff and other clinical service areas to ensure proper documentation and timing of research-related procedures
  • Attends clinic visits to update concomitant medications and adverse events and assure subject understanding of study requirements
  • Responsible for the maintenance of study databases, including the abstraction and entry of data and CRF interpretation, potentially with data coordinator assistance
  • Identifies procedural problems, communicates to the PI and research manager, and completes patient safety net reporting
  • Manages Serious Adverse Event reporting to study sponsors and the IRB
  • Screens third party safety reports per institutional procedures
  • Assures adherence to research protocols and maintains protocol deviation documentation
  • Requests insurance authorization and assures the process is complete prior to initiation of study procedures
  • Collaborates with study monitors and responds to findings
  • Creates and maintains patient tracking tools; communicates status to sponsors, investigators, management and relevant departments
  • Acts as a resource to physicians, investigators, other staff members, and other organizations regarding protocol procedures, data collection requirements and other study related operations
  • Maintains OnCore records timely
  • Maintains study financial trackers
  • Keeps knowledge and skills current by completing mandated training and attending meetings with the study team and the Consortium, such as the monthly coordinator meeting, relevant brown bags, faculty and administrative presentations, and other opportunities of interest

Qualifications

  • Bachelor’s degree required
  • Applicant must have a minimum of two years of clinical oncology research and/or social services experience
  • This position requires excellent organizational skills, attention to detail, high motivation, ability to problem solve and to prioritize multiple competing tasks in a dynamic environment and work independently
  • Collaborative focus is essential, as well as strong written and verbal communication skills, including computer skills.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Faculty Position, Oncology (Lung Cancer SPORE)

Clinical Research Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 79917

The Fred Hutch Lung SPORE invites applications for an open full-time faculty position at the assistant, associate or full professor level on the Physician/Scientist pathway within the Clinical Research Division (CRD) of the Fred Hutchinson Cancer Research Center (Fred Hutch). We seek a laboratory-based scientist to conduct innovative, independent, and collaborative basic or translational research focused on lung cancer.

For consideration, the candidate must hold a PhD or MD (or foreign equivalent). Although most competitive applicants will have an established independently funded laboratory-based research program in lung cancer science, the committee will also consider applications at the assistant professor level. Pertinent research areas include (but are not limited to) molecular and genetic determinants of lung cancer initiation and progression, therapeutic resistance to targeted- and immune based therapies, tumor-initiating lung epithelial cell populations, and lung cancer early detection.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Fred Hutch, together with the University of Washington, Seattle Children’s, and the Seattle Cancer Care Alliance, is an NCI-designated Comprehensive Cancer Center with active training programs for graduate students and postdoctoral fellows. In addition, Fred Hutch has outstanding facilities and cutting-edge shared resources to support faculty success. Collaborative opportunities exist for joint and/or affiliate appointments in the Fred Hutch Divisions of Public Health Sciences, Human Biology, Basic Sciences, or Vaccine and Infectious Disease, as well as the University of Washington, depending upon candidate interest and qualifications.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion. 

Anticipated start date would be July 1, 2021.

Lab Aide

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19384

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

A lab at Fred Hutchinson Cancer Research Center is seeking a lab aide. The lab uses yeast and mammalian cells genetics, chemical genetics, tissue culture and murine models to understand how chromatin affects DNA replication, aging and cancer. This is a great opportunity for undergraduate students interested in science to get hands on experience in the laboratory. Responsibilities include:

  • Prepare media and reagents, such as stock solutions
  • Assist with cloning, PCR, CRISP-genome editing, and chemical library screening

Qualifications

  • Graduation from High School or equivalent with interest in the sciences
  • Some lab experience and/or college level biology and chemistry courses preferred
  • A commitment of at least 6-8 hours and up to 16-19 hours a week is required depending on schedule and changes in work demand in the lab.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Pediatric Blood and Marrow Transplantation (BMT)/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 86102

For the Pediatric Blood and Marrow Transplantation (BMT)/Immunotherapy fellowship, the Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Pediatrics, Division of Hematology Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in BMT and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the UW and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The selected individual for the advertised position is expected to participate in a year-long fellowship program with the goal of becoming an expert in BMT and Immunotherapy. This position will rotate through outpatient Hematopoietic Cell Transplantation (HCT) services (autologous and allogeneic transplant, immunotherapy, Long Term Follow Up) and on the inpatient transplant service initially as a primary care provider with increasing levels of independent patient care responsibility over the course of the year.  Exposure to some of our unique clinical programs, including non-malignant transplantation, high risk leukemia, and survivorship, will be part of the learning experience as well.  Approximately 75% of the year will be devoted to clinical activities with the remaining time available for the opportunity to participate in clinically focused research projects, which will be determined based on identification of mentors and projects. University of Washington faculty engage in teaching, research and service.

Anticipated start date: July 1, 2022.

Pediatric Bone Marrow Transplant/Immunotherapy Fellow

Clinical Research Division
Category: Internships
Seattle, WA, US
Job ID: 73967

The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Pediatrics, Division of Hematology Oncology are jointly recruiting a full-time faculty member at the Research Associate/Acting Instructor level. This is a full-time, 12-month service period, annual appointment. The primary appointment will be in the Clinical Research Division of Fred Hutch.

The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.

The selected individual for the advertised position is expected to participate in a year-long fellowship program with the goal of becoming an expert in bone marrow transplantation and Immunotherapy. This position will rotate through outpatient Hematopoietic Cell Transplantation (HCT) services (autologous and allogeneic transplant, immunotherapy, Long Term Follow Up) and on the inpatient transplant service initially as a primary care provider with increasing levels of independent patient care responsibility over the course of the year.  Exposure to some of our unique clinical programs, including non-malignant transplantation, high risk leukemia, and survivorship, will be part of the learning experience as well.  Approximately 75% of the year will be devoted to clinical activities with the remaining time available for the opportunity to participate in clinically focused research projects, which will be determined based on identification of mentors and projects. University of Washington faculty engage in teaching, research and service.

Anticipated start date would be July 1, 2021.

Post-Doctoral Research Fellow

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18362

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


The Bleakley laboratory in the Program in Immunology and the Clinical Research Division is looking for a highly motivated individual to support the development of immunotherapy for cancer.

Responsibilities

The post-doctoral research fellow will work on projects in the Bleakley Lab primarily on laboratory studies including, but not limited to, cancer antigen discovery, molecular cloning and evaluation of T cell receptors (TCRs) and transgene constructs in vitro and in vivo patient derived-xenograft models, and tracking T cell responses to cancer antigens in patient tissue samples.

 

The successful applicant will employ strategies such as functional T cell assays, cell culture, multi-parametric flow cytometry, flow sorting, DNA extraction for TCR sequencing, analysis of TCR sequencing data, isolation of cancer-specific T cells from human peripheral blood, experimentation in patient-derived xenografts, quantitative PCR and bioinformatics analysis.

 

This is a full-time position with a salary based on the NIH scale and excellent benefits.

Qualifications

Applicants will have a PhD in a biological science and/or a MD. The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including flow cytometry, T cell functional assays, DNA and RNA extraction, molecular cloning, PCR and quantitative PCR. Desirable skills include bioinformatics analysis, scientific writing and presentations.

 

To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced, collaborative and dynamic environment. This position is suited to someone who enjoys mastering new skills, multitasking and working in a team science environment.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow - Simon Lab

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18746

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


This position is in a laboratory in the Clinical Research Division and Human Biology Division that is developing new biologically active compounds as drugs and probes of pathways important to cancer and other diseases. The research effort involves interdisciplinary techniques ranging from cell and molecular biology to pharmacology to chemistry but requires experimental expertise in cell biology.

Responsibilities

  • Play a major role in projects testing investigational compounds using in vitro and in vivo models.
  • Design, execute and interpret experiments in cellular and molecular biology.
  • Lead a leading drug evaluation project and assist other members of the lab as needed to carry out a drug evaluation project and assist other members of the lab as needed.
  • help with preparation of figures for publication and writing and editing of manuscripts.

Qualifications

  • A doctoral degree in molecular or cellular biology is required
  • Expertise in tissue culture, molecular biology techniques including cloning, transfection/transduction and lentiviral production is required.
  • Skills in mammalian cell culture and cell biology and/or pharmacology are desirable
  • Computer skills (Mac, PC) are also highly desirable
  • You must be able to work in a team environment with a significant degree of independence

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Grady Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18645

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

A postdoctoral position is available immediately in the Grady lab at Fred Hutch. The applicant will perform data-driven research using state-of-the-art bioinformatics and computational biology tools across various research projects to advance translational research in epi/genomics of gastrointestinal cancers Adherence to principles of reproducible research, motivation to keep up with cutting-edge data analysis tools, and willingness to team-work in multi-disciplinary research programs will be vital to success in this position. The laboratory is situated in the Clinical Research Division at Fred Hutch.

Qualifications

Minimum qualifications:

  • The successful candidate will have a PhD in bioinformatics, computational biology, or related field
  • Established experience in analyzing data from RNA seq, genome-wide DNA methylation and multi-omics is desirable
  • A track record of excellent first author publications is essential
  • This position requires experience in managing computing servers, proficiency in computer languages including R/Bioconductor

 

Highly motivated candidates are encouraged to apply.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Houghton Lab

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 19260

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A highly motivated post-doctoral research fellow is sought to carry out a research project in the lab of Dr. A. McGarry Houghton at Fred Hutchinson Cancer Research Center in Seattle, WA.

 

About the Lab

Lung cancer is the leading cause of cancer deaths worldwide, accounting for ~160,000 lives each year in the US alone.  The Houghton Lab’s current research program focus is to comprehensively study the host immune response to non-small cell lung cancer (NSCLC).  The lab also studies the role of myeloid lineage cells within the lung tumor microenvironment.  Studies in this area are centered upon the mechanisms by which neutrophil lineage cells antagonize lymphocyte functions within the tumor microenvironment.

Responsibilities

The Post-Doctoral Fellow will contribute to the Lab’s research agenda with a focus on the role of neutrophil subtypes in lung cancer. The fellow will conduct independent and collaborative research resulting in presentations and publications.

 

The techniques involved will include working with mouse models of lung cancer (Kras/p53, Pten/Lkb1, LLC syngeneic models, etc.) and carefully studying the immune response to the tumor using flow cytometry, multiplexed-immunohistochemistry, gene expression analyses (qPCR), protein assessment (ELISA) and others. Manipulation of these model systems with immune-based and other oncology drugs are commonplace in the lab. These in vivo studies will be supplemented by in vitro studies involving multicellular culture system, assays of cellular chemotaxis, function and viability and other standard protocols. The ability to analyze the complex datasets resulting from the above experimentation is essential.

Qualifications

To be considered, candidates must have:

  • A recent PhD, MD/PhD, or MD in a relevant biological field
  • Candidate is expected to have project leadership experience in a team environment, and must be able to work independently with little supervision.
  • Excellent written and verbal communications skills are essential. 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Immunology

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 19266

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A Post-Doctoral Research Fellow position is available immediately under the guidance of Dr. Matthias Stephan, M.D., Ph.D. , (visit the lab webpage by clicking here) to explore the fast-developing and highly interdisciplinary field of immunobioengineering. Using next-generation immunomodulatory synthetic materials, the Post-Doctoral Fellow will develop new approaches - beyond existing T-cell-based therapies - to therapeutically manipulate the immune system against cancer. The successful applicants will fabricate stimulatory biomaterial devices, drug delivery systems and bioactive substances and test their therapeutic potential in preclinical tumor models of adoptive T-cell therapy. The successful candidate will be a scientifically driven, well organized self-starter.

Responsibilities

  • Designing mRNA nanoparticles for the in situ programming of disease-specific immune cells
  • Designing implantable biomaterials to locally deliver and functionally support tumor-reactive T cells.
  • The position will involve the fabrication of nanoparticles, repeated administration into mice, immune phenotyping, bioluminescent tumor imaging, but cell culture, cell sorting, flow cytometry, intercellular staining, transfections, ELISPOT and Chromium Release Assays

Qualifications

  • Suitable applicants should have a recent PhD in immunology or a related field
  • The ideal candidate will work well in an interactive scientific environment, be intellectually curious, and have experience in all aspects of cellular immunology
  • Critical skills include extensive animal science knowledge and extensive experience with animal handling, direct, hands-on experience with, and extensive knowledge of, cellular immunology, oncology, cell-based immune functional assays, flow cytometric analysis and isolation of transformed and primary cells, modulation of tumor microenvironments, and relevant statistical analysis


Please include a cover letter describing your interest in this opportunity and suitability for the role with your application.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Innate Immunity to HIV-1

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18949

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


 

A Post-Doctoral Research Fellow position is available with Dr. Anthony Rongvaux, Ph.D. at Fred Hutchinson Cancer Research Center. The Rongvaux Lab uses state of the art humanized murine models to study innate immune responses specific to the human species. This research project focuses on the fundamental mechanisms of innate immunity to HIV-1 infection.

Responsibilities

Over 35 million people are living with HIV-1 worldwide. About 40% of them don’t have access to antiretroviral therapies, resulting in over half a million deaths annually.

 

Acute HIV-1 infection induces a rapid inflammatory response, characterized by the production of large amounts of cytokines. However, this immune response is ineffective at controlling the virus. As a consequence, the virus can establish chronic infection and, if not treated, progresses to a lethal disease. Understanding why the natural immune response to HIV-1 infection does not confer protection, but rather contributes to pathogenesis, could help us design more effective therapies and vaccine strategies.

 

Using state of the art humanized murine models, single-cell RNA sequencing and genome editing, the postdoctoral fellow will study the mechanisms by which the immune system detects, and responds to infected cells. This work will result in a better understanding of the contribution of the innate immune system, in vivo, to antiviral activity vs. immune dysfunction and pathogenesis.

Qualifications

  • Applicants will have a recent PhD in Immunology, Virology, Molecular Biology or a closely related field
  • The ideal candidate will have a strong background in HIV-1 research and/or in immunology with robust skills in molecular and cellular biology. Desirable skills include animal studies and bioinformatics analysis.
  • To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by at least one first author publication(s), and willing to work in a highly collaborative, fast paced, collaborative and dynamic environment.
  • This positions is suited to someone who enjoys mastering new skills, and working in a multidisciplinary team environment.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Pancreatic Cancer Research

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18796

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani at Fred Hutchinson Cancer Research Center in Seattle, WA.

 

Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis.  The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program.  Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies.  Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.

Qualifications

Successful applicants will have:

  • A Ph.D. in the field of molecular biology, biomedical engineering, biochemistry, biophysics, cancer biology, immunology or genetics
  • Experience with standard molecular and cellular biology techniques
  • A demonstrated track record of productive research
  • Experience with generation and characterization of genetically engineered murine models, advanced imaging techniques, and/or gene targeting is highly desired
  • Ability to develop create approaches to experimental design
  • Ability to work both independently and as part of a laboratory team


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Post-Doctoral Research Fellow, Protein Therapeutics for Acute Myeloid Leukemia

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 17449

Overview

Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

 

The Walter Laboratory in the Clinical Research Division is recruiting an outstanding postdoctoral research fellow to work as part of a team investigating new treatments for patients with acute myeloid leukemia (AML) primarily focused on improving existing, and developing novel, antibody-based immunotherapies, and rendering them safer for clinical application. Current projects include preclinical drug development/testing (in part with academic and industry partners), studies on mechanisms of action and resistance of antibody-based therapeutics and identification of strategies to overcome these limitations, and development of approaches to protect normal tissues from the toxicities of AML-targeted therapies (e.g. via use of genome editing).

Responsibilities

The newly hired fellow will work under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Generation of recombinant antibodies and other protein therapeutics via transient and permanent expression systems
  • Conduct of immunization strategies to raise new antibodies
  • Generation of engineered/gene-edited human leukemia cells
  • Tissue culture of mammalian cell lines and patient-derived primary human cells
  • Antibody drug conjugate (ADC) cytotoxicity, antibody-dependent cellular cytotoxicity, T-cell and NK-cell cytotoxicity assays
  • Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
  • Purification, cloning, and manipulation of RNA, cDNA and genomic DNA
  • PCR and RT-PCR, including quantitative assays using qPCR
  • Lentiviral vector modification, lentiviral particle preps and viral transduction
  • Protein gels, immunoprecipitation, western blotting, immunofluorescence microscopy
  • General laboratory duties and maintenance of laboratory equipment

Qualifications

Required qualifications:

  • A recent PhD in a relevant field of biology such as immunology, cell and molecular biology, genetics, biochemistry, pathology, bioinformatics, or genome sciences
  • Ability to drive an individual project but also be highly collaborative with academic and industrial partners
  • Ability to work independently and with scientific rigor
  • Interest in academic career and applying for independent funding support
     

To be successful in this position, the postdoctoral research fellow must be organized, clear and concise in their communication, enthusiastic, a team player, and have a desire to establish a career as a future independent investigator. Fellowship opportunities are available through several philanthropic and government organizations; fellow will have administrative support for the application process.

 

Applicants must include:

  • Cover letter discussing your interest in this position, research interests and career goals
  • Curriculum Vitae
  • Contact information for three references

Post-Doctoral Research Fellow, T Cell Immunotherapy - Chapuis Lab

FH Clinical Research Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 18676

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

 


 

The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis' laboratory developing adoptive T cell immunotherapy within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. This highly translational research will involve the development of novel TCR-based cellular therapies for clinical translation; development of next-generation humanized murine models to gain insights into the in vivo barriers to effective therapy; and may include monitoring patients through-out the course of treatment with T cell therapies.  Additionally, the successful applicant will employ strategies for improving current immunotherapy treatments, including and not limited to; cloning and characterizing T cell receptors (TCRs) specific for cancer-associated antigens, developing cutting-edge strategies for genetic modification of human T cells including CRISPR-based gene editing, and developing/testing new approaches for overcoming immunosuppressive signals in the tumor microenvironment.

 

Dr. Chapuis is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. This is a full-time position with a salary based on the NIH scale and excellent benefits.

Responsibilities

  • Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections
  • Molecular bench work with PCR, cloning, and vector design
  • NGS including, Single cell RNA sequencing, WEX, WGS
  • Validation through functional and killing assays
  • Write and submit grants and first author papers to peer reviewed journals
  • Stay current with relevant publications and apply knowledge to research
  • Compile data and synthesize innovative problem-solving methods
  • Collaborate and present data with a wide range of stakeholders and partners
  • Train others on protocols
  • Mentor and lead undergraduate and graduate students
  • Assist with lab maintenance and function

Qualifications

Minimum qualifications

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology
  • Proficient in immunology technique and knowhow
  • Strong scientific writing skills, ability to write and apply for funding opportunities and abstracts
  • Able to digest complex material and synthesize innovative ideas
  • Compile and clearly present data to an eclectic audience, both orally and written
  • Well versed in flow cytometry

 

Preferred qualifications

  • Experience with molecular techniques lentiviral modification of T cells
  • Experience in analysis of TCR signaling pathways and T cell function
  • Experience with in vivo murine experimentation
  • Familiarity with biostatistics, R and Python languages
  • Ability to derive and maintain T cell tissue cultures
  • Have a good understanding of SRAs and/or phase I/II clinical trials

 

To be successful, the post-doctoral research fellow must be: highly motivated and driven, able to work independently and with others, be open to receive and provide feedback for scientific discussion and general lab work, possess an acute attention to detail and organizational skills, think critically and problem solve and be excellent at note taking and reproducibility.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Regulatory Affairs Associate

FH Clinical Research Division
Category: Clinical Research Support Services
Seattle, WA, US
Job ID: 19375

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


 

The Regulatory Affairs Associate or Sr. Regulatory Affairs Associate will work with faculty and staff in the program to ensure all clinical trials are covered for regulatory and patient enrollment compliance. The role combines both regulatory duties and clinical coordination duties to support the protocols in the program.  The primary focus will be regulatory compliance by coordinating regulatory submissions and monitoring as well as assisting with the resolution of compliance issues. The incumbent is expected to work independently within a framework of established regulations and guidelines and demonstrate initiative and sound judgment in problem solving and providing regulatory guidance. Clinical research studies in the program include both investigator-initiated and industry-initiated protocols. The incumbent will prepare IRB documents and FDA correspondence, maintain regulatory files, and facilitate regulatory oversight of safety reporting. The role includes some coverage of the clinical monitoring of studies for compliance. This position requires independent decision making in all aspects of the research study start up process as well as ongoing regulatory study maintenance. This position will be responsible for expeditious coordination of the regulatory submissions in the study start-up phase to meet sponsor and institutional timelines.

Responsibilities

  • Independently prepare IRB documents, maintain regulatory files, and facilitate regulatory oversight of safety reporting.
  • In concert with IND Sponsors, prepare and review IND submissions, communicate with the FDA, and prepare for FDA audits.
  • Coordinate the regulatory documents from each participating site for studies where the Fred Hutch Cord Blood Transplant Program serves as the Coordinating Center and Fred Hutch serves as the Central IRB of record. Coordinate protocol activation process and communicate activation communications allowing enrollment to start once regulatory documents (e.g. DSMB review) are in place.
  • Lead study start-up: prepare and submit all required regulatory documents for new study applications and successfully open new studies from inception to accrual.
  • Submit all regulatory documents to the IRB and other governing bodies to maintain study compliance with GCP, institutional, and federal regulations.
  • Prepare, track and maintain all correspondence and regulatory documentation required by the IRB, FDA, IND Sponsors, and other institutional and federal oversight committees, including drafting and reviewing content as appropriate.
  • Process IND safety reports, maintain documentation of PI review and submit safety reports to the IRB as appropriate.
  • Maintain study regulatory binders and electronic files in accordance with institutional and sponsor requirements.
  • Direct the clinical team to ensure all facets of each protocol are compliant and fully covered.
  • Perform internal audit and quality assurance checks on regulatory documents.
  • With input from PIs and study team, draft consent forms and study documents.
  • Report non-compliances and unanticipated problems to the IRB as applicable.
  • Stay abreast of new impacts/areas of knowledge and regulatory changes and disseminate this knowledge to the study team.
  • Coordinate monitoring and auditing visits with Clinical Research Support (CRS), industry sponsors, and third-party auditors.
  • Independently follow-up and resolve all issues related to regulatory concerns identified during monitoring visits.
  • Maintain and update Investigator Brochure and regulatory forms per IND Sponsor and federal requirements.

Qualifications

Knowledge, Skills and Abilities:

The level of Regulatory Affairs Associate or Regulatory Affairs Associate Lead will be determined based on the qualifications below.

  • Bachelor’s Degree, or IRB work experience for more than 5 years.
    • Minimum requirement for Regulatory Affairs Associate- 3-5 years experience
    • Minimum requirement for Sr. Regulatory Affairs Associate- 5+ years experience
  • Previous regulatory experience related to multi-site clinical trials and deep understanding of coordinating center operations, strong knowledge of the regulatory requirements for single IRB review and must be able to nimbly respond to changes in the implementation of this new policy across many different institutions. Strong scientific and regulatory background to understand the study and anticipate other regulatory and institutional requirements that may apply at each site and affect the IRB process.
  • Experience with IND submissions, FDA communications, and FDA audits.
  • Experience designing regulatory management tools and interpreting federal regulations and guidelines for the study team.
  • Experience with IRB procedures and practices.
  • Effective written and verbal communication skills.
  • Proficient with IT tools including remote work systems, databases, clinical trial systems. 
  • Proficient in word processing and previous experience with MS office programs (MS word, Access, Excel) required.
  • High degree of organizational skills, effective time management, logical thinking, and close attention to detail; ability to remain calm, professional, diplomatic, and positive.


Preferred qualifications:

  • Greater than 5 years of regulatory experience in the conduct of interventional, treatment, and/or FDA-regulated, transplant study experience a plus.
  • Advance degree (MPH or similar).
  • Advanced knowledge of FDA regulations, GCP guidelines, and other applicable federal regulations.
  • Advanced knowledge of MS Word, Excel, and Acrobat.
  • Professional Society Certification (SOCRA, RAC, etc).
  • Prior experience using RedCap database.
  • Project management experience a plus.

 


Other Requirements

  • Multitask without loss of efficiency or accuracy. This includes the ability to perform multiple duties received from multiple sources and/or situations requiring speed
  • Work and sustain attention with distractions and/or interruptions
  • Interact professionally with a variety of individuals, both internal and external, such as coworkers and teammates, customers, study participants and patients
  • Work effectively under stressful circumstances, such as tight deadlines
  • Maintain regular attendance and be punctual
  • Understand, remember and follow simple and/or detailed oral and written instructions
  • Complete assigned tasks with minimal or no supervision
  • Exercise independent judgment and make appropriate decisions


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Administrator II-III - Clinical Research

FH Clinical Research Division
Category: Research Administration & Faculty Affairs
Seattle, WA, US
Job ID: 19218

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


 

The Research Administrator II-III supports 4-5 faculty and their labs/departments to ensure compliant and effective funding, budget management, regulatory compliance and general administrative duties. The Research Administrator II-III collaborates with the faculty and interfaces with other departments as needed to complete administrative tasks and nonscientific grant content, and to advise the PIs on relevant matters while working with a supervisor to develop effective solutions to related issues. Consults with supervisor for complex or unique situations.

Responsibilities

Budget/Fiscal Support

  • Develop, monitor, track and project the budgets for a portfolio of projects with multi-variable aspects (multi-site, sub awards, milestone-based budgets etc.)
  • Monitor spending for adherence to grant guidelines and policies, as well as internal policies
  • Develop, run, and analyze reports to identify funding issues and develop recommendations
  • Develop customized report formats to share information with each faculty and for broad audiences across the organizatio

Funding Source Administration

  • Provides guidance on grant submissions and post award activity by conducting tasks such as:
    • Working with faculty to respond to requests from other departments and external organizations
    • Completing/collating of all technical/non-scientific steps and assigned technical or scientific portions of funding/grant submissions
    • Review budgets, identify discrepancies and provide recommendations to the PI on scenarios to resolve the issues with appropriate stakeholders
    • Identify/forecast personnel and other resource requirements (including long-range forecasting across multiple budget years

Regulatory Support

  • Prepare non-scientific portions of regulatory applications/submissions
  • Identify missing regulatory components that are required and resolve issues to ensure successful submission, modification, or renewal
  • Serve as a central point of contact to answer questions and facilitate solutions
  • Prepare/consult/advise PIs and maintain Data/Material Use Agreements and other data compliance documentation
  • May advise or consult with Center leadership on changes to Center-wide policies/procedures and help create implementation plans in response to changing regulatory requirements (e.g. Uniform Guidance)

Administrative Support

  • Identify administrative needs for the department or PI(s); prioritize and ensure related tasks are completed.
  • Delegate appropriate tasks to Admin Coordinator and follow up as necessary
  • Identify space and resource shortages and collaborate with administration to resolve any issues
  • Oversee the management of projects including occasional event planning and special work groups
  • Communicate with other departments/entities on PI’sbehalf.
  • Resolves discrepancies and issues with stakeholders on PI’s behalf

Leadership

  • Act as a divisional resource and assist with training for new or lower level staff

Clinical Trials Support

  • Facilitate Clinical Trials Agreements (CTAs)
  • Create, negotiate, and manage budget based on protocol; amend as necessary through lifecycle of protocol; Process invoices to sponsor based on budget developed, insure accurate posting to projects
  • Partner with external organizations to get pricing for research studies, pay invoices based on the pricing and pateitns enrollment
  • Set up and maintain study document tracking systems, manage multi-site components (if applicable)
  • Attend study implementation meetings as needed

Qualifications

Required

  • Bachelors degree required. Relevant experience can substitute for educational requirement:
    • Research Administrator II minimum requirements: Two years in pre-award and post-award grants and contract management or other related grant or contract management experience
    • Research Administrator III minimum requirements: Three years in pre-award and post-award grants and contract management
  • Technical experience sufficient to allow proficiency doing remote work
  • Experience creating and executing strategic plans
  • The ability to delegate tasks to appropriate resources
  • Grants experience with a wide variety of funding sources
  • The ability to analyze and interpret regulations, determine impact, and manage change
  • Multitask without loss of efficiency or accuracy. This includes the ability to perform multiple duties received from multiple sources and/or situations requiring speed while appropriately prioritizing the urgent tasks
  • Work and sustain attention with distractions and/or interruptions
  • Interact professionally with a variety of individuals, both internal and external, such as coworkers and teammates, faculty, service area personnel.
  • Work effectively under stressful circumstances, such as tight deadlines.
  • Maintain regular attendance and be punctual.
  • Understand, remember and follow simple and/or detailed oral and written instructions.
  • Complete assigned tasks with minimal or no supervision.
  • Exercise independent judgment and make appropriate decisions.
  • Communicate to supervisor capacity of workload balance and openly ask questions as needed about policy and regulations

Preferred

  • Five years of relevant experience, Three years as a research administrator preferably with principal investigators/academics/non-profit

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch.

Research Data Analyst Assistant II Grady Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19023

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A Research Data Analyst level II/III position is available immediately in the Grady lab at Fred Hutch. The applicant will perform data analysis using state-of-the-art bioinformatics and computational biology tools for various research projects, grant proposals and manuscript preparation, focusing on translational epi/genomics of gastrointestinal cancers. Adherence to principles of reproducible research, motivation to keep up with cutting-edge data analysis tools, and willingness to team-work in multi-disciplinary research programs will be vital to success in this position

Responsibilities

  • Use R/Bioconductor to perform proper QC, normalization and transformation of Illumina Human Methylation array data and perform basic/advanced statistical analyses
  • Support data collection, collation, and organization efforts in collaboration with experimental scientists, Shared Resources and external collaborators
  • Extract, harmonize, and analyze data from multiple repositories (TCGA, UCSD Genome Browser, Gene Expression Omnibus, COSMIC, dbSNP, 1000Genomes project, dbGaP etc.)
  • Present analysis results and methods to interdisciplinary scientific teams
  • Document workflows, software, and modules used in research and analysis
  • As needed: perform emerging data analysis tasks as required

Qualifications

Required qualifications:

  • Bachelor’s degree with minimum of 3 years of applied research experience in bioinformatics/computational biology
  • Experience applying routine statistical analyses to high-throughput array data and/or sequencing data
  • Proficiency in R/Bioconductor libraries
  • Strong oral and written communication
  • Must be organized, detail-oriented, and collaborative in an inter-disciplinary research team

 

Preferred qualifications:

  • Master’s Degree in bioinformatics or computational biology or related fields
  • Scripting experience for preprocessing, QC, and analysis of Illumina Human Methylation array data and RNA-seq data
  • Experience using python for database development and management

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18979

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A highly collaborative laboratory-based research group in the Clinical Research Division is recruiting an outstanding part-time research technician to work as part of a team investigating new treatments for patients with acute myeloid leukemia (AML) primarily focused on improving existing, and developing novel, antibody-based immunotherapies, and rendering them safer for clinical application. Current projects include preclinical drug development/testing (in part with academic and industry partners), studies on mechanisms of action and resistance of antibody-based therapeutics and identification of strategies to overcome these limitations, and development of approaches to protect normal tissues from the toxicities of AML-targeted therapies (e.g. via use of genome editing.)

Responsibilities

The newly hired Part-time Research Technician will work under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Generation of recombinant antibodies and other protein therapeutics via transient and permanent expression systems
  • Conduct of immunization strategies to raise new antibodies
  • Generation of engineered/gene-edited human leukemia cells
  • Tissue culture of mammalian cell lines and patient-derived primary human cells
  • Antibody drug conjugate (ADC) cytotoxicity, antibody-dependent cellular cytotoxicity, T-cell and NK-cell cytotoxicity assays
  • Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
  • Purification, cloning, and manipulation of RNA, cDNA and genomic DNA
  • PCR and RT-PCR, including quantitative assays using qPCR
  • Lentiviral vector modification, lentiviral particle preps and viral transduction
  • Protein gels, immunoprecipitation, western blotting, immunofluorescence microscopy
  • General laboratory duties and maintenance of laboratory equipment

 

To be successful in this position the applicant must be: organized, independent, open to learning, and provide clear and concise communication. Comprehensive laboratory record keeping is mandatory, experience with statistical analysis and data presentation is desirable.

Qualifications

A Bachelor’s degree in a field of biology such as immunology, cell and molecular biology, genetics, biochemistry, pathology, bioinformatics or genome sciences with 0-2+ years of laboratory experience outside of coursework. Must have scientific knowledge in the area of study and basic laboratory skills. 

 

Applicants must submit:

  • Cover letter discussing your interest in this position
  • Curriculum Vitae
  • Contact information for three references

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19247

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



A clinical research laboratory of the Program in Immunology is seeking a highly motivated research technician whose duties will include both assisting with ongoing research efforts and serving as support for the laboratory. The individual in this position will be responsible for research activities whose primary focus is the isolation and characterization of human CD8+ and CD4+ T lymphocytes that specifically recognize human tumor cells, and the identification and characterization of the genes that encode the antigens recognized by these T cells. There will be many opportunities to train and learn about the laboratory and research.

Responsibilities

  • Perform experiments at the bench level to support investigative work, including but not limited to extraction of genomic DNA, RNA, and synthesis of cDNA from primary human cells and cell lines
  • Preparing and processing molecular samples including bacterial DNA isolation
  • Perform and modify documented protocols and assays
  • Data Management - document all procedures clearly and extensively
  • Interpret and report on experimental results
  • Prepare and maintain laboratory reagents, cultures, and mammalian tissue cultures
  • Order and maintain appropriate levels of supplies - inventory
  • Prepare laboratory biohazard and sharps waste for disposal
  • Establish and maintain laboratory standards, ensuring that all laboratory equipment are maintained in good operating condition
  • Maintain web-based electronic inventory of cryopreserved cells stored in liquid nitrogen freezers
  • Some light clerical duties to assist administrator
  • Perform other responsibilities, as required

Qualifications

  • A bachelor’s degree in the biological sciences with knowledge in the area of study and basic laboratory skills required.
  • Familiarity with molecular biology and basic immunology is essential and highly desired.
  • Independent research experience in addition to college lab experience is strongly preferred, including experience with mammalian tissue culture and routine molecular biology techniques, such as transformation of bacteria, isolation and purification of DNA and RNA, analysis of DNA and RNA by gel electrophoresis, synthesis of complementary DNA, and amplification of DNA by PCR.
  • The individual will be trained in all of the techniques used in this position.
  • To be successful in this laboratory, the technician must have excellent communication skills and be able to work well within an interactive team environment.
  • This position will require someone who is comfortable working in a lab that utilizes murine models.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I - II - Riddell Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19287

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


 

The Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support the development of genetically modified T cell immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity. The technician will work in the laboratory and be closely involved in the preclinical development of new T cell therapies and their translation into clinical trials. She/he should be capable of maintaining detailed laboratory records, analyzing data, managing supplies and reporting experimental results in a fast-paced environment.

 

Responsible for performing standard and investigative laboratory work in support of scientific research in immunology by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.

Responsibilities

 

This position works under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Tissue culture of mammalian cell lines and (patient-derived) primary human cells
  • Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
  • Lentiviral vector construction, modification, and viral transduction 
  • T-cell cytotoxicity assays, cytokine production and proliferation assays
  • Purification, cloning, and manipulation of genomic/plasmid DNA, cDNA, and RNA
  • PCR and RT-PCR, including Taqman quantitative assays
  • General laboratory duties and maintenance of laboratory equipment

Qualifications

  • A bachelor’s degree in a biological science and research experience is required.
    • Research Technician I minimum qualifications - Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is usually necessary.
    • Research Technician II minimum qualifications - Intermediate level position requiring 2 years previous experience working in a laboratory. Independent research experience outside of laboratory course work is usually necessary.
  • The candidate must be detail-oriented, a teamplayer and a fast and willing learner.
  • The ideal candidate has prior experience with cellular biology techniques including cell culture, multicolor flow cytometry and biological sample handling.
  • Experience working with primary T cells, FACS sorting and mice handling are highly desirable.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician I/II - Olson Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19262

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


A highly motivated candidate is sought to join the laboratory of James M. Olson, MD, PhD, in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. The focus of research conducted in our group is the discovery and advancement of novel therapeutics. The candidate will join a highly innovative program as a Research Technician I/II in the protein sciences group to produce, purify, and characterize novel peptides.

Responsibilities

  • Support all aspects of the production, purification, and characterization of novel proteins using mammalian expression platforms
  • Mammalian cell culture, lentivirus generation, protein purification using affinity and size-exclusion chromatography, and analytical protein biochemistry
  • Provide laboratory support with reagent preparation and the ordering and management of the lab's consumable inventory. 

Qualifications

  • A bachelor’s degree in Biology, Chemistry, or Biochemistry and bench research experience:  
    • Research Technician I minimum qualifications - Must have scientific knowledge in the area of study and basic laboratory skills. Independent research experience in addition to school lab experience is usually necessary. 
    • Research Technician II minimum qualifications - Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS. Independent research experience outside of laboratory course work is usually necessary.
  • Experience with standard molecular biology techniques, mammalian protein expression systems, and protein chromatography is preferred
  • Demonstrated willingness to learn
  • High level of organizational skill, the ability to manage multiple projects at once, and excellent communication skills
  • Ability to thrive in a team environment

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19261

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


 

Dr. Chapuis clinical research laboratory in the Program in Immunology is seeking a highly motivated research technician whose duties will include both assisting with ongoing research efforts and serving as support for the laboratory. The individual in this position will be responsible for research activities whose primary focus is the isolation and characterization of human CD8+ and CD4+ T lymphocytes that specifically recognize human tumor cells, and the identification and characterization of the genes that encode the antigens recognized by these T cells.

Responsibilities

  • Perform experiments at the bench level to support investigative work, including but not limited to extraction of genomic DNA, RNA, and synthesis of cDNA from primary human cells and cell lines
  • Preparing and processing molecular samples including bacterial DNA isolation
  • Perform and modify documented protocols and assays
  • Data Management - document all procedures clearly and extensively
  • Interpret and report on experimental results
  • Prepare and maintain laboratory reagents, cultures, and mammalian tissue cultures
  • Order and maintain appropriate levels of supplies - inventory
  • Prepare laboratory biohazard and sharps waste for disposal
  • Establish and maintain laboratory standards, ensuring that all laboratory equipment are maintained in good operating condition
  • Maintain web-based electronic inventory of cryopreserved cells stored in liquid nitrogen freezers
  • Some light clerical duties to assist administrator
  • Perform other responsibilities, as required

Qualifications

  • A bachelor’s degree in the biological sciences with knowledge in the area of study and basic laboratory skills required.
  • Experience working in a clinical research laboratory.
  • Familiarity with molecular biology and basic immunology is essential and highly desired.
  • Independent research experience in addition to college lab experience is strongly preferred, including experience with mammalian tissue culture and routine molecular biology techniques, such as transformation of bacteria, isolation and purification of DNA and RNA, analysis of DNA and RNA by gel electrophoresis, synthesis of complementary DNA, and amplification of DNA by PCR.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19087

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
 


 

The Greenberg Lab is looking for a highly motivated individual to support the development of immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity to cancer. The technician will be closely involved in the preclinical development of new TCR-based therapies and their translation into clinical trials. The candidate should be capable of maintaining detailed laboratory records, analyzing data, and reporting experimental results.

Responsibilities

This position works under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Assist in the design, implementation and interpretation of experiments involving murine and human T lymphocytes engineered to target tumor cells. These studies are specifically aimed at identifying ways to increase the therapeutic activity of tumor-reactive T lymphocytes.
  • Perform tissue culture and molecular biology techniques: Generation of antigen-specific T cells, transduction with retroviral and lentiviral vectors, passaging cell lines, FACS sorting and expanding T cells in vitro.
  • Analyze T cell phenotype, function and metabolism using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, and T cell cytolytic assays.
  • Assist with the management and organization of a fast-paced lab. Other duties as assigned by supervisor will be performed as necessary including conducting literature reviews to assist in determining most suitable methods to be used in research.
  • Contribute to the preparation and presentation of written and oral progress reports concerning studies and assist in publications.

Qualifications

  • A bachelor’s degree in a biological science and 2+ years of bench research experience is required
  • The candidate must be detail-oriented, a team player and a fast and willing learner
  • The ideal candidate has prior experience with cellular biology techniques including cell culture, multicolor flow cytometry and biological sample handling
  • Experience working with primary T cells, FACS sorting and murine handling are highly desirable
  • Experience with next-gen sequencing techniques including single cell RNAseq (10x), and CRISPR-based gene editing preferred


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II - Riddell Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
US-WA-
Job ID: 18942

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support the development of genetically modified T cell immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity. The technician will work in the laboratory and be closely involved in the preclinical development of new T cell therapies and their translation into clinical trials. The incumbent should be capable of maintaining detailed laboratory records, analyzing data, managing supplies and reporting experimental results in a fast-paced environment.

 

The technician is responsible for performing standard and investigative laboratory work in support of scientific research in immunology by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.

Responsibilities

This position works under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Tissue culture of mammalian cell lines and (patient-derived) primary human cells
  • Flow cytometry-based immunophenotyping, FACS isolation of mammalian cells
  • Lentiviral vector construction, modification, and viral transduction
  • T-cell cytotoxicity assays, cytokine production and proliferation assays
  • Purification, cloning, and manipulation of genomic/plasmid DNA, cDNA, and RNA
  • PCR and RT-PCR, including Taqman quantitative assays
  • General laboratory duties and maintenance of laboratory equipment

Qualifications

  • A bachelor’s degree in a biological science and 2+ years of bench research experience is required.
  • The candidate must be detail-oriented, a team player and a fast and willing learner.
  • The ideal candidate has prior experience with cellular biology techniques including cell culture, multicolor flow cytometry and biological sample handling.
  • Experience working with primary T cells, FACS sorting and mice handling are highly desirable.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II or III

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19376

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The research in the Bernstein lab has primarily focused on developmental aspects of hematopoiesis with the specific goal of developing novel therapeutic modalities. In these efforts we have identified maturation linked cell surface antigens and have utilized this information for developing methods for targeted therapy of hematologic malignancies and for isolating and characterizing normal and malignant human hematopoietic stem cells.  Current studies of normal hematopoiesis are aimed at determining methods to direct primitive hematopoietic precursors to commit to a particular maturational pathway or to self-renew. The studies focus on the role of Notch signaling in the regulation of cell fate decisions during hematopoietic differentiation.


This position will be responsible for performing standard and investigative laboratory work in the Bernstein Lab, including performing bench-level experiments, operating analytical instruments, compiling and verifying the accuracy of research data as well as preparing charts, graphs and summaries.

Responsibilities

The Research Technician II/III works under the direction of the Principal Investigator and senior laboratory personnel. This position will conduct experiments involving tissue culture with cell lines and primary cells, multi-color flow cytometry staining and analysis, and molecular biology methods, including PCR, etc. 

  • Carry out tissue culture experiments involving cell lines and/or primary cells
  • Perform multi-color flow cytometry assays including staining, cytometer operation and analysis
  • Perform molecular biology methods, including PCR/RT-PCR
  • Perform additional assays as needed, such as ELISA
  • Maintain detailed records of all experiments and data

Qualifications

  • BA/BS or MS in the areas of cell biology, molecular biology or related field and 2 years lab experience required
  • Independent research experience outside of laboratory course work is required
  • The Research Technician III position is a senior level position requiring extensive experience in a laboratory and generally a master's degree in a related scientific field.
  • Excellent knowledge of multi-color and intracellular flow cytometry, and data analysis using FlowJo software preferred
  • A background in hematopoietic stem cell biology is highly desired
  • The candidate must be highly motivated, able to work independently to carry-out experiments and multi-task. The ideal candidate will have superior organization and communication skills, be detail oriented and be able to interact cooperatively will all levels of staff

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II-III

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19144

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 



The Greenberg Lab is looking for a highly motivated individual to support the development of immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity to cancer. The technician will be closely involved in the preclinical development of new TCR-based therapies and their translation into clinical trials. The candidate should be capable of maintaining detailed laboratory records, analyzing data, and reporting experimental results. The successful candidate will be offered the technician level that corresponds to their experience level.

Responsibilities

This position works under the direction of the Principal Investigator and senior laboratory personnel and will be involved in the following techniques/duties:

  • Assist in the design, implementation and interpretation of experiments involving murine and human T lymphocytes engineered to target tumor cells. These studies are specifically aimed at identifying ways to increase the therapeutic activity of tumor-reactive T lymphocytes.
  • Perform tissue culture and molecular biology techniques: Generation of antigen-specific T cells, transduction with retroviral and lentiviral vectors, passaging cell lines, FACS sorting and expanding T cells in vitro.
  • Analyze T cell phenotype, function and metabolism using techniques including flow cytometry, proliferation assays, PCR, RT-PCR, sequencing, and T cell cytolytic assays.
  • Assist with the management and organization of a fast-paced lab. Other duties as assigned by supervisor will be performed as necessary including conducting literature reviews to assist in determining most suitable methods to be used in research.
  • Contribute to the preparation and presentation of written and oral progress reports concerning studies and assist in publications.
  • Experience with next-gen sequencing techniques including single cell RNAseq (10x), and CRISPR-based gene editing preferred.

Qualifications

Research Technician II: Intermediate level position requiring 2 years previous experience working in a laboratory and BA/BS in a biological science. Independent research experience outside of laboratory course work is usually necessary. A Master’s degree in a relevant field is optional.

 

Research Technician III: Advanced position requiring a minimum of 3 years prior experience in a laboratory setting performing experiments with a high degree of independence and a BA/BS in a biological science. A Master’s degree in a relevant field is desired.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II-III, Immunology

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18556

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here. 
 
At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion. 
 
A Research Technician’s position is available immediately in the Clinical Research Division of the Fred Hutchinson Cancer Research Center (FHCRC), Seattle, WA.  The successful applicant will work with Dr. Matthias Stephan, M.D., Ph.D. to explore the fast-developing and highly interdisciplinary field of immunobioengineering (https://www.nature.com/articles/s41467-020-19486-2). Using next-generation immunomodulatory synthetic materials, the Research Technician will help develop new approaches beyond existing T-cell-based therapies to therapeutically manipulate the immune system against cancer (https://www.nature.com/magazine-assets/d41586-017-08701-8/d41586-017-08701-8.pdf). 

Responsibilities

The Research Technician II is responsible for performing standard and investigative laboratory work in support of scientific research by performing bench-level experiments, operating analytical instruments, recovering, compiling and verifying the accuracy of research data; performing calculations; preparing charts, graphs and summaries.  
 
Responsibilities include:

  • Perform experiments at the bench level to support investigative work. Prepare and maintain laboratory reagents, stocks, cultures or cell lines. Perform and modify documented protocols and assays. Maintain laboratory records and compile data on experiments and assays. 
  • Interpret and report on experimental results. Perform statistical analysis of test results and prepare written reports on work performed 
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results 
  • Prepare and present written or oral progress reports concerning studies including assembly, organization, and interpretation of data 
  • Assist in the design of experiments; may be responsible for the performance of individual research projects 
  • Conduct literature reviews to assist in determining most suitable methods to be used in research 
  • Assist in publication of results by proofreading, editing, and contributing ideas 
  • May perform statistical analyses, write computer programs, or manage research data base 

 

The Research Technician III Performs the duties of the Research Technician II plus:

  • May lead or supervise other laboratory personnel and be responsible for the daily operation of the laboratory. 
  • Collaborate with primary investigator and assist in designing experiments; examine proposals to determine projects and methodologies best suited to research objectives and the overall goals of the laboratory. 
  • Summarize and write for publication or presentation the results of research projects, often as co-author or author.  Edit and write reports of research. 
  • Consult with the Principal Investigator and others in the scientific community on problems and related projects. 
  • Determine the most suitable methods to be used in research; determine appropriate experimental controls. 
  • Conduct literature reviews to assist in determining most suitable methods to be used in research. 

Qualifications

  • BS or MS in the areas of immunology, cell biology, biochemistry or related field.  
  • Intermediate level position requiring 2 years previous experience working in a laboratory 
  • Independent research experience outside of laboratory course work is usually necessary 
  • The Research Technician III position is a senior level position requiring extensive experience in a laboratory. Generally, the incumbent will possess a master's degree in a related scientific field.  
  • Excellent knowledge of multi-color and intracellular flow cytometry, and data analysis using FlowJo software desired. 
  • Strong proficiency in the development and execution of cell-based assays for immune cell function (T-cell proliferation, cytokine release, and cytotoxicity assays) with murine and human primary T cells is required.  

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists. 

Research Technician II-III, Pancreas Cancer Research

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 19377

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


 

The Hingorani Laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based treatment strategies. Our ultimate aim is to take our discoveries and reduce them to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.


This Research Technician II/III position represents an excellent opportunity for an experienced, highly motivated individual with a passion for science to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.

Responsibilities

The research technician will be involved in all aspects of murine preclinical studies including but not limited to breeding, genotyping, ultrasound and other imaging techniques, drug treatments, and performing necropsies to obtain tissues for histology and cell lines. The technician may be involved in derivation, maintenance and study of primary cell lines; isolation of DNA, RNA, and proteins; as well as other techniques such as FACS sorting and expanding cells in vitro, analyzing cell phenotype and function using techniques including flow cytometry, proliferation assays, cytotoxicity assays, PCR, RT-PCR, sequencing, and ELISpot. Molecular techniques used in the lab include cloning, transfection/transduction of cell lines, gene targeting and northern and Southern blotting. Biochemical and cellular techniques include SDS-PAGE, western blotting, immunofluorescence, and immunohistochemistry. The technician may assist in the design, analyses and reporting of team and independent experiments. The technician will also assist with the management and organization of a fast-paced lab and perform other duties as assigned by supervisor.

Qualifications

  • Research Technician II: Intermediate level position requiring a minimum of 2 years previous experience working in a laboratory and BA/BS in bioengineering, biophysics or a biological science. Independent research experience outside of laboratory course work is necessary.
  • Research Technician III: Advanced position requiring a minimum of 4 years prior experience in a laboratory setting performing experiments with a high degree of independence and a BA/BS in in bioengineering, biophysics or a biological science
  • Laboratory research experience including small animal surgeries and injections, cell tissue culture, flow cytometry, and molecular biology techniques are required
  • Computer skills: Microsoft Excel, Prism (Graphpad), FlowJo, and statistical programs for data analysis
  • Excellent organizational and interpersonal skills are required
  • Strong troubleshooting skills and the ability to multi-task with precise attention to detail is especially critical
  • Experience with genetically engineered murine models of pancreas cancer or other solid tumors is desired

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Research Technician II/III - Kiem Lab

FH Clinical Research Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 18806

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.


 

Responsibilities

A Clinical Research Division laboratory, Kiem Lab, that studies hematopoietic stem cell and T cell biology is recruiting a Research Technician II/III to participate in projects focused on novel gene therapy and gene editing strategies for HIV cure.  Using established preclinical and in vivo models of HIV persistence, the technician will optimize and perform diverse immunological assays, process primary tissue samples, and participate in novel assay development. Although the position will focus primarily on samples infected with HIV and related viruses, applying similar approaches for other diseases and pathologies will also be explored. The technician will work under the PI and a senior member of the laboratory, within a diverse team of technicians, graduate students, and post-graduate researchers.

Qualifications

  • Bachelor’s degree required. A Master’s or equivalent degree is preferred.
    • Research Technician II minimum qualifications - Intermediate level position requiring at least 3 years previous experience working in a laboratory and BA/BS. Independent research experience outside of laboratory course work is usually necessary.
    • Research Technician III minimum qualifications- Senior level position requiring extensive experience in a laboratory.  Generally, the incumbent will possess a Master's degree in a related scientific field.
  • The individual must have experience with multicolor flow cytometry
  • Previous experience in infectious and/or genetic diseases, and a background in hematopoietic stem cell and/or T cell biology are highly desired
  • Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, chimeric antigen receptor (CAR) T cell manufacturing, in vivo studies, flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR and plasmid cloning.
  • Previous experience in gene therapy/gene editing, and/or basic bioinformatics is desired, but not required.

 

To be successful in this position, the candidate must be highly motivated and able to work independently to design and execute experiments, possess a high level of initiative and attention to detail, and must also be able to multi-task. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Staff Scientist, Human Genetics

FH Clinical Research Division
Category: Staff Scientist
Seattle, WA, US
Job ID: 18069

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here. 

 

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.
 



The Geraghty Lab seeks an exceptionally skilled, experienced molecular biologist to join their team. A summary of Dr. Geraghty's research can be found here.

Responsibilities

The Staff Scientist will work in a research laboratory that performs state of the art genotyping for disease association studies.  The laboratory collaborates with local and international labs to carry out anthropological, clinical, and basic disease studies that are aimed at a better understanding and development of data and tools for diagnosis and treatment of a variety of human diseases. 

 

A core goal is to facilitate the use of immune genetic data both as a predictive tool in anticipating clinical outcomes (diagnosis) and as knowledge and information relevant to the biological processes causal of those outcomes (therapeutics.) Precisely such application has long been active in support of hematopoietic cell transplants (HCTs) and plans are to expand and extend use to infectious disease, autoimmunity, and cancer.  This work includes two fronts in expanding the genetic testing capacities of our genotyping systems and developing new analytic capabilities for data application. Novel typing systems focusing on heretofore untested immune response variation are being developed by building on the core systems supporting HLA. For novel analytics, study cohorts have been assembled to apply machine learning/artificial intelligence tools to identify patterns of immune genetic variation predictive of clinical outcomes in HCTs (for replication with and extension with new methods and added data) and for COVID-19 as a model of infectious disease.

Qualifications

A PhD in a biological science or related with an understanding of the fundamentals of molecular genetics is required. Familiarity with the genetics of the immune response would be a significant advantage – in particular with the HLA system. To be successful in this position, one must have the ability to communicate effectively with coworkers, working together in executing tasks that engage multiple complementary activities in parallel. In addition to benchwork, these activities include data analysis and effective interaction with the laboratory’s software and data analysis group. The ability and willingness to take initiative in problem solving and suggestions for workflow improvements will be a key to advancement and associated benefits.  

 

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Staff Scientist, Immunology

FH Clinical Research Division
Category: Staff Scientist
Seattle, WA, US
Job ID: 19179

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

 


 

The Staff Scientist will work on independent and collaborative projects in the Greenberg laboratory under the direction of Dr. Thomas Schmitt developing adoptive T cell immunotherapies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. This highly translational research will involve the development of novel TCR-based cellular therapies for clinical translation; CRISPR screens to elucidate the processing and presentation of T cell epitopes; and development of next-generation humanized mouse models to gain insights into the in vivo barriers to effective therapy.  The successful applicant will employ various genetic engineering techniques and T cell functional assays to develop and evaluate novel strategies for improving current T cell-based immunotherapy treatments. Dr. Schmitt is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach.

Responsibilities

  • Cell Culture, cell sorting, flow cytometry, intracellular staining, and transfections
  • Molecular bench work including PCR, cloning and vector design, CRISPR-based gene editing
  • NGS including, Single cell RNA sequencing, WEX, WGS
  • Biostatistics and some basic programing skills preferred
  • Validation of TCR/therapeutic constructs through functional and killing assays
  • Write and submit grants and first author papers to peer reviewed journals
  • Stay current with relevant publications and apply knowledge to research
  • Compile data and synthesize innovative problem-solving methods
  • Collaborate and present data with a wide range of stakeholders and partners
  • Train others on protocols
  • Assist with lab maintenance and function

Qualifications

Minimum Qualifications

  • MD and/or a PhD in a biological science with a diverse knowledge of immunology
  • Proficient in immunology technique and knowhow
  • Strong scientific writing skills
  • Able to digest complex material and synthesize innovative ideas
  • Compile and clearly present data to an eclectic audience, both orally and written
  • Well versed in flow cytometry
  • A cover letter with a statement interest is required


Preferred Qualifications

  • Experience with molecular techniques lentiviral modification of T cells
  • Experience in analysis of TCR signaling pathways and T cell function
  • Familiarity with biostatistics, R and Python languages
  • Ability to derive and maintain T cell tissue cultures
  • Have a good understanding of SRAs and/or phase I/II clinical trials

 

To be successful, the Scientist must be: highly motivated and driven, able to work independently and with others, be open to receive and provide feedback for scientific discussion and general lab work, possess an acute attention to detail and organizational skills, think critically and problem solve and be excellent at note taking and reproducibility.


A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

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