Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Geoff Hill Lab, in Seattle’s Fred Hutchinson Cancer Research Center Clinical Research Division, Program in Transplantation and Immunology, is recruiting a Staff or Senior Staff Scientist. The objective of the lab is to gain a better understanding of the fundamental mechanisms that initiate and maintain graft-versus host disease, graft-versus leukemia and pathogen-specific immunity after stem cell transplantation. The goal is to develop innovative immunological therapies that can be translated to the clinic in order to prevent GVHD and/or improve leukemia and pathogen-specific immunity.
Responsibilities for this highly-skilled laboratory scientist will include: designing, performing and analyzing experiments and troubleshooting technical issues and mentoring junior lab members. The successful candidate will also be expected to contribute to the preparation of manuscripts and grant proposals and oversee large programs that include collaborating laboratories.
Applicants should be highly-motivated scientists, with a MD or PhD degree in Immunology and four or more years of post-Ph.D. laboratory experience required. An ideal candidate will have a working knowledge of transplant and cancer immunology, and experience with technologies used in the lab, including mouse models, high parameter flow cytometry and single-cell RNA sequencing. A track record of high impact publications and early success in grant applications is expected.
Required experience includes:
A successful candidate will also have:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Advanced Practice Provider (APP) provides care for blood and marrow transplant patients and immunotherapy patients in both the inpatient and outpatient settings under the supervision of the attending physician. The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team. Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments. APPs perform bone marrow aspirations, lumbar punctures and are first assists with Bone Marrow Harvests and provide follow-up care of bone marrow donors under the supervision of attending physician.
Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutch (either as an additional attachment on your profile or merged into the file that contains your resume.)
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
Under the supervision of an attending physician, Transplant and Immunotherapy Advanced Practice Providers (APP) provide care for patients undergoing treatment with Immunotherapy and/or Stem Cell Transplant. The APP is an integral member of both the inpatient and outpatient multidisciplinary teams and is responsible for the primary care of the patient. This includes assessment, triage and management of all aspects of care (history & physical exam, order & review diagnostic studies, fluid, electrolyte, and antibiotic management, perform bone marrow aspirations, lumbar punctures. The APP actively participates in the conduct of cancer clinical research, including patient, caregiver, and peer education.
Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutchinson Cancer Research Center (either as an additional attachment on your profile or merged into the file that contains your resume.)
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We offer great generous benefits, including relocation and tuition reimbursement.
The pediatric advanced practice provider (APP) provides care for pediatric blood and marrow transplant patients in both inpatient and outpatient setting under the supervision of the attending physician. The APP is responsible for the primary care of the patient to include assessment, triage and management of the transplant patient as part of a collaborative transplant team. Responsibilities include obtain medical history, perform physical examinations, review and order diagnostic studies, radiographs and prescribe treatments. APPs provide follow-up care of bone marrow donors under the supervision of attending physician. PALS certification is required for this position within 3 months of hiring date.
Please include a cover letter when applying for this job that includes your specific interest in the Advanced Practice Provider position and working for Fred Hutch(either as an additional attachment on your profile or merged into the file that contains your resume).
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We offer great generous benefits, including relocation and tuition reimbursement.
The position will provide care to post-treatment patients in the SCCA Survivorship Clinic and provide care across the continuum from diagnosis to survivorship focused follow-up for patients in the SCCA Sarcoma Clinic.
Allocation of FTE: 50% survivorship, 25% sarcoma survivorship, 25% general sarcoma care.
SCOPE OF RESPONSIBILITY
Within the Survivorship Clinic the Nurse Practitioner/Physician Assistant will be responsible for provision of clinical care and patient education for a broad range of cancer survivors, including adult survivors of pediatric cancers. S/he will work with a comprehensive team including the program director and co-director, the program nurse coordinator, and the program manager toward the goal of extending survivorship services to all oncology patients, regardless of age, place or type of treatment. S/he will collaborate with other providers within the Survivorship Clinic, within other SCCA oncology discipline clinics, and also with physicians and other health care professionals to define best practices of care, develop comprehensive survivorship care guidelines, and establish referral networks internal and external to the SCCA.
Within the Sarcoma Clinic the Nurse Practitioner/Physician Assistant will provide evaluation and medical management of Sarcoma patients at the Seattle Cancer Care Alliance. They will follow patients during their chemotherapy and provide medical supportive care, as well as surveillance. The ARNP/PA-C assesses and manages basic health needs of patients, addresses treatment toxicities, performs procedures, monitors for cancer progression or recurrence, and consults with professional peers as needed. They work collaboratively with the treatment team to coordinate care of their patients. The clinician in this role will be expected to see patients along the continuum of care for sarcoma patients, including long term follow-up of sarcoma survivors in the Survivorship clinic conducting survivorship focused visits as described below as well as carrying out surveillance plans following standard treatment pathways in collaboration with the sarcoma medical oncologists.
Survivorship Program: Comprehensive onsite evaluations for cancer survivors including:
Sarcoma Clinic:
PROFESSIONAL CONDUCT
Employees within the Survivorship Program are expected to maintain high standards of professionalism in their interactions with patients, referring providers and other team members. Professional conduct includes:
PAY, BENEFITS & WORK SCHEDULE
Hematopoietic Cell Transplant (HCT) and Immunotherapy (IMTX) Programs
The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) Department of Medicine are jointly recruiting a full-time faculty member at the Assistant Member/Assistant Professor or Associate Member/Associate Professor level without tenure due to funding (WOT), commensurate with experience, in the Clinical Research Division of the Fred Hutch and the Division of Medical Oncology, Department of Medicine at the UW. This position has an annual service period of 12 months [July 1-June 30]. The Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is a National Cancer Institute-designated comprehensive cancer center.
The primary appointment will be in the Clinical Research Division of Fred Hutch. The selected individual for the advertised position is expected to enhance our clinical care and clinical research programs in hematopoietic cell transplantation and immunotherapy. All clinical research interests will be considered however, there is a particular interest in applicants with demonstrated experience in the field of immunotherapy. Applicants with extensive research experience will also be considered. University of Washington faculty engage in teaching, research and service.
Anticipated start date January 2, 2019
The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) invite exceptional candidates to apply for a full-time faculty appointment at the rank of Assistant Member/Assistant Professor or Associate Member/Associate Professor level, commensurate with experience, in the Clinician-Scholar pathway in the Clinical Research Division of the Fred Hutch and in the Department of Pathology at UW without tenure due to funding (WOT). Fred Hutch, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation and immunotherapy, Fred Hutch provides a unique environment for conducting translational research and clinical care. Fred Hutch, in collaboration with its clinical and research partners, the University of Washington, Seattle Childrens Hospital, and Seattle Cancer Care Alliance (SCCA) is a National Cancer Institute-designated comprehensive cancer center.
The selected individual is expected to enhance our clinical care and clinical research programs in anatomic pathology, with particular focus in hematopoietic cell transplantation and immunotherapy. Based on qualifications, this position could entail a leadership role. We offer access to a highly collaborative and diverse research environment, modern laboratory space and state-of-the-art core facilities. Research is a core priority at the Hutch and successful candidates will be expected to maintain an active clinical research interest, as demonstrated by peer reviewed publications. The primary appointment will be in the Clinical Research Division of Fred Hutch with secondary appointment with the Department of Pathology at the University of Washington.
The Fred Hutchinson Cancer Research Center (Fred Hutch) and the University of Washington (UW) are jointly recruiting a full-time laboratory-based faculty member at the Assistant/Associate Member, and Assistant/Associate Professor level WOT (without tenure due to funding), on the Physician/Scientist pathway in the Clinical Research Division of Fred Hutch and the Division of Pediatric Hematology/Oncology, Department of Pediatrics at the UW. The Fred Hutchinson Cancer Research Center, home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone marrow transplantation and immunotherapy, Fred Hutch and the UW provide a unique environment for conducting translational research and clinical care. Fred Hutch in collaboration with its clinical and research partners, the University of Washington and Seattle Children's, is a National Cancer Institute-designated comprehensive cancer center.
The goal is to recruit a prominent scientist/thought leader and translational researcher in the field of pediatric malignancy, with solid malignancies a priority. The successful candidate has an MD, MD/PhD, or PhD, ad is expected to engage in active laboratory and clinical research related to the molecular pathogenesis, genomics/epigenomics, intracellular signaling pathways, or targeted translational therapeutics of neoplasms common in children. Physician faculty member would also participate in the care of patients with pediatric malignancies either in oncology or stem cell transplant service. Candidates must demonstrate a track-record of high-quality peer-reviewed publications, as well as independent research funding or competitive funding potential.
The primary appointment will be in the Clinical Research Division of Fred Hutch. Applicants must have an MD, MD/PhD, or PhD degree (or foreign equivalent) and US Board certification in Pediatric Hematology/Oncology (for physician candidates). Physician candidates, in order to be eligible for sponsorship for an H-1B visa, graduates of foreign (non-U.S.) medical schools must show successful completion of all three steps of the U.S. Medical Licensing Exam (USMLE), or equivalent as determined by the Secretary of Health and Human Services. Fred Hutch and University of Washington faculty engage in teaching, research and service.
Interested candidates should submit a curriculum vitae, and a letter summarizing research goals and career plans to Dr. Soheil Meshinchi at smeshinc@fredhutch.org.
The Fred Hutchinson Cancer Research Center and the University of Washington are affirmative action, equal opportunity employers. Both institutions are dedicated to building culturally diverse faculties and strongly encourage applications from women, minorities, individuals with disabilities and protected veterans.
The Fred Hutchinson Cancer Research Center invites applications from scientists working in the area of breast cancer research to lead a translational research program. Applicants will be considered at the rank of Associate or Full Faculty member, and we are seeking individuals who share our goals to advance an understanding of the biological basis of breast cancer, and to translate findings to the clinic.
We will consider PhD, MD/PhD, or MD scientists working in areas that include, but are not limited to: steroid receptors, signaling pathways, microenvironment, metastasis, systems biology, computational biology, and the biology of therapeutic response/resistance, genetics/genomics. A track record of relevant publication and funding commensurate with appointment level is highly desirable. Physician-scientists in any relevant medical discipline are encouraged to apply.
The successful candidate will enter a vibrant and dynamic research environment with opportunities to collaborate with basic and clinical researchers across diverse disciplines. The Breast and Ovary Cancer Program is one of 8 designated research programs in the Fred Hutch/University of Washington Cancer Consortium.
Opportunities exist for joint and/or affiliate appointment in the Fred Hutch Divisions of Human Biology, Clinical Research, Basic Sciences, Public Health Sciences, or Vaccine and Infectious Disease, as well as the University of Washington, depending on mutual interests. Applicants will also be eligible for membership in the Fred Hutch-based Seattle Translational Tumor Research (STTR) program, a multidisciplinary consortium of more than 500 faculty from Fred Hutch, the University of Washington, and Seattle Children’s, who work collaboratively on all aspects of solid tumor basic, translational, and clinical research.
Additional information about Fred Hutch and the Scientific Divisions can be found at:
http://www.fhcrc.org/science/
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are looking for a Clinical Research Coordinator to join our dynamic team of dedicated and skilled research staff working on clinical trials in the field of hematologic malignancies. The Clinical Research Coordinator will participate in the planning, coordination, and implementation of multiple industry- sponsored and investigator-initiated clinical trials involving human subjects. This individual will work under the supervision of the Clinical Program Operations Director and will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Clinical Resrearch Coordinator will coordinate day-to-day activities for clinical research protocols for the Pulmonary Critical Care Faculty at Fred Hutch for while demonstrating competence in clinical research skills, problem-solving, and priority setting. The Project Coordinator will participate in the planning, coordination and implementation of complex investigator-initiated clinical research studies involving human subjects, including a multi-year, multi-center observational study of lung disease in cancer patients. This individual will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines, and collaborate with a multi-disciplinary clinical and research team. This individual will report directly to the Investigator in the Pulmonary Section in the Clinical Research Division.
Study Conduct / Clinical Research Practice:
Protocol Development and Implementation:
Regulatory Compliance and Documentation:
Other Duties:
Required:
Preferred:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Clinical Research Coordinator will participate in the planning, coordination, and implementation of complex investigator-initiated and industry-sponsored clinical research studies involving human subjects. The position functions as a team member under the overall direction of the Principal Investigators. This individual will work under the supervision of the Clinical Program Operations Director and will be required to perform their responsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines.
Principal Investigator Support:
Enrollment
Education
Protocol Implementation
Budget & Billing
Other Duties
Required:
Preferred:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
This individual will work under the supervision of the Principal Investigator(s) and will be required to perform their esponsibilities with a high level of independence within the scope of study protocol(s) and institutional guidelines. The ability to work across Fred Hutchinson, University of Washington and Seattle Cancer Care Alliance will be critical.
The ideal candidate will be able to address the full set of responsibilities in this listing and commit to a 1.0 FTE position.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
This person will serve in a full-time role of data analyst/programmer, working under the direct mentorship of the group lead data analyst. The engineer will be focused on:
Required:
Preferred:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Data Coordinator (DC) is responsible for the documentation and monitoring of a biorepository and Phase 1-3 clinical trials, including the collection, coordination, processing and quality control of clinical trial data. The position will track clinical activity and subject visits, and abstract and report data. The DC will work on studies for at least two investigators, and regularly update those investigators on progress and activity. The DC will work closely with a Clinical Research Coordinator and will report directly to the Clinical Program Operations Director.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Hingorani Laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA), or more commonly, pancreas cancer, pathogenesis. We seek a part-time Lab Aide with an interest in cancer research and molecular biology to work 12-19 hours per week. Work schedules are flexible but require a minimum of 2 days per week (up to 4 days) and at least 3 hours per shift. The position is work-study eligible but this is not required.
Duties include, but are not limited to, general lab and equipment maintenance, DNA extraction, PCR amplification, gel analysis, interpretation of results, data management, inventory of supplies and experimental materials, preparation of reagents, data coordination and assisting technical staff. With interest and experience in our laboratory, may assist with experimental setup, mouse colony, histopathology or other areas.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Lab Aide performs routine work to support a fast-paced research lab with the Program in Immunology. This position is part-time, 10-15 hours per week. The incumbent works under the close supervision of the Lab Manager or other lab personnel. Responsibilities include:
Required:
Completion of a high school degree.
Preferred:
Some lab experience is preferred.
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch) is an independent, nonprofit research institution and home of three Nobel laureates. Fred Hutch is dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. Together with our clinical and research partners, the University of Washington and Seattle Children’s, we are the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
A highly qualified and self-motivated Research Associate/Senior Post-Doctoral Research Fellow is sought to join the laboratory of Dr. Sunil Hingorani at Fred Hutchinson Cancer Research Center.
Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based treatment strategies. Our ultimate aim is to take our discoveries and reduce them to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.
This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.
Process proteomic samples for LC-MS analysis (e.g., protein extraction, fractionation, immuno-depletion, trypsin digestion, alkylation, reduction, etc.)
Perform HPLC separations and maintain HPLC instruments
Work with antibodies (immunoaffinity purification, immobilization on solid supports, screening hybridomas for mass spectrometry)
Generate mass spectrometry (MS)-based proteomics data and maintain MS instruments
Contribute to the analysis of proteomic (mass spectrometry) datasets
Collaborate effectively with an interdisciplinary team spanning expertise in biology, analytical chemistry, and statistics
Collaborate with others to develop new methods and tools that support research objectives
Maintain research results files and databases
Assist with written progress reports and development of standard operating protocols (SOP)
Assist with writing scientific manuscripts for peer-reviewed journals
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Green laboratory is focused on research developing new immunotherapeutic approaches to treat and ultimately eradicate multiple myeloma and lymphoma.
The post-doctoral research fellow will work on projects in the Green Lab primarily involving laboratory based research related to the evaluation of the proliferation, function, and trafficking of chimeric antigen receptor (CAR)-T cells to treat multiple myeloma and other B-cell malignancies. In addition, studies will be conducted to determine mechanisms of tumor resistance in patients and to evaluate processes through which the efficacy of the CAR-T cell constructs can be enhanced through rational combination with agents designed to augment the immune response.
The successful applicant will employ strategies such as functional T cell assays, multi-parametric flow cytometry, flow sorting, DNA extraction, analysis of sequencing data, isolation of CAR-T cells from the peripheral blood and BM of treated patients, isolation of RNA for scRNA-seq studies, quantitative PCR and bioinformatics analysis. The successful applicant will work closely with members of the Riddell lab on this project.
The position will involve supervision of one Full-Time Research Technician and oversee the day-to-day operations of research sample activities for multiple clinical research protocols.
Applicants will have a PhD in a biological science and/or a MD. The ideal candidate will have a research background in immunology with robust skills in molecular and cellular biology, including significant experience with flow cytometry, and experience with T cell functional assays, DNA and RNA extraction, molecular cloning, PCR and quantitative PCR. Desirable skills include bioinformatics analysis, scientific writing and presentations.
To be successful in this position, the post-doctoral research fellow must be highly motivated with a track record of productive research, exemplified by first author publication(s) and presentations, and willing to work in a highly collaborative, fast paced environment. This position is suited to someone who enjoys mastering new skills, multitasking and working in a team environment.
This is a full-time position with a salary based on the NIH scale and excellent benefits.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Silberstein lab (https://research.fhcrc.org/silberstein/en.html) is seeking to recruit a post-doctoral fellow who is interested in pursuing laboratory-based research project.
The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote HSC function in bone marrow failure and to enhance post-transplant hematopoietic reconstitution. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and discovered several novel niche factors using proximity-based single cell analysis (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).
A successful candidate will be studying the effect of extrinsic HSC regulators on the bone marrow function and disease progression in preclinical models of myelodysplastic syndrome. In parallel, they will also be involved in a project which investigates the role of newly-defined niche factors in HSC aging and stress response.
They will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle). There will be ample opportunities for data presentation and informal discussions. They will be encouraged to develop research ideas and branch out into more independent projects. Mentorship and support for post-doctoral fellowship applications will be provided.
The candidate is expected to have a PhD and/or MD and a strong interest in stem cell research and commitment to basic/translational science in hematopoiesis. Applications from trainee hematologists who are willing to undertake a laboratory-based research project are welcome. Previous experience of working with murine models is not essential, but would be preferred. Excellent verbal and written communication skills are required.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
Postdoctoral Research Fellows in immuno-oncology – Novel cancer immunotherapies
Immunotherapies, such as checkpoint inhibition and adoptive T cell therapies, represent a paradigm shift in the treatment of cancer, inducing impressive responses in diverse malignancies. However, not all patients respond to current immunotherapies and novel therapeutic approaches are needed to circumvent these obstacles.
Post-Doctoral Research Fellow positions are available in the Immunotherapy Integrated Research Center at the Fred Hutchinson Cancer Research Center. The successful applicants will join a collaborative team that combines clinical research, animal modeling, computational biology and multiplexed immuno-histochemistry to understand the basic mechanisms of antitumor immunity and apply them to the development of novel immunotherapies.
This research program includes the laboratories of: Dr. Aude Chapuis, a translational immuno-oncologist who specializes in adoptive T cell therapies; Dr. Anthony Rongvaux, an immunologist who develops innovative humanized murine models to study the tumor/immune interface; Dr. Raphael Gottardo, a biostatistician with expertise in high-dimensional single cell data analysis; and Dr. Robert Pierce, a pathologist and expert in tumor microenvironment analyses who previously developed tissue-based biomarkers for Merck’s anti-PD-1 pembrolizumab antibody.
Our research is focused on understanding the biology and improving clinical outcomes after immune-boosting treatments. Human adoptive immunotherapy trials are initiated and being conducted using the robust Fred Hutch clinical platform. We are performing detailed analysis of patient outcomes to inform next-generation trials. , and developing humanized murine models of checkpoint inhibition and adoptive T cell therapy against solid and liquid cancers. We are using single cell RNA sequencing, genome editing and genomic screens in humanized murine to understand how anti-tumoral immunity functions, why it fails in some patients, and how we can overcome current limitations. We use multiparametric immunohistochemistry to validate humanized mouse results in humans, using a large biorepository of annotated patient specimens.
The scientific questions being addressed include:
The overall objective of this interdisciplinary project is to provide the scientific basis for future clinical trials, leveraging Fred Hutch’s continuing leadership in the design, clinical testing and commercialization of successful anticancer drugs and immunotherapies.
Desired skills and experience of the applicants:
The successful candidates will be scientifically driven individuals who enjoy working in a highly collaborative environment, with a track record of productive research, demonstrated by at least one first author publication, and with excellent communication skills.
Please apply online with a letter summarizing previous work experience, personal strengths and future interests, a resume, and contact information for three professional references.
Related publications:
Chapuis lab:
Paulson KG, Voillet V, McAfee MS, Hunter DS, Wagener FD, Perdicchio M, Valente WJ, Koelle SJ, Church CD, Vandeven N, Thomas H, Colunga AG, Iyer JG, Yee C, Kulikauskas R, Koelle DM, Pierce RH, Bielas JH, Greenberg PD, Bhatia S, Gottardo R, Nghiem P, Chapuis AG.
Acquired cancer resistance to combination immunotherapy from transcriptional loss of class I HLA.
Nat Commun. 2018 Sep 24;9(1):3868. PMID: 30250229.
Chapuis AG, Desmarais C, Emerson R, Schmitt TM, Shibuya K, Lai I, Wagener F, Chou J, Roberts IM, Coffey DG, Warren E, Robbins H, Greenberg PD, Yee C.
Tracking the Fate and Origin of Clinically Relevant Adoptively Transferred CD8(+) T Cells In Vivo.
Sci Immunol. 2017 Feb;2(8). PMID: 28367538.
Chapuis AG, Lee SM, Thompson JA, Roberts IM, Margolin KA, Bhatia S, Sloan HL, Lai I, Wagener F, Shibuya K, Cao J, Wolchok JD, Greenberg PD, Yee C.
Combined IL-21-primed polyclonal CTL plus CTLA4 blockade controls refractory metastatic melanoma in a patient.
J Exp Med. 2016 Jun 27;213(7):1133-9. PMID: 27242164.
Rongvaux lab:
Rongvaux A, Willinger T, Martinek J, Strowig T, Gearty SV, Teichmann LL, Saito Y, Marches F, Halene S, Palucka AK, Manz MG, Flavell RA.
Development and function of human innate immune cells in a humanized mouse model.
Nat Biotechnol. 2014 Apr;32(4):364-72. PMID: 24633240.
Rongvaux A, Takizawa H, Strowig T, Willinger T, Eynon EE, Flavell RA, Manz MG.
Human hemato-lymphoid system mice: current use and future potential for medicine.
Annu Rev Immunol. 2013;31:635-674. PMID: 23330956.
Gottardo lab:
McDavid A, Finak G, Gottardo R.
The contribution of cell cycle to heterogeneity in single-cell RNA-seq data.
Nat Biotechnol. 2016 Jun 9;34(6):591-3. PMID: 27281413.
Finak G, McDavid A, Yajima M, Deng J, Gersuk V, Shalek AK, Slichter CK, Miller HW, McElrath MJ, Prlic M, Linsley PS, Gottardo R.
MAST: a flexible statistical framework for assessing transcriptional changes and characterizing heterogeneity in single-cell RNA sequencing data.
Genome Biol. 2015 Dec 10;16:278. PMID: 26653891.
Pierce lab:
Stromnes IM, Hulbert A, Pierce RH, Greenberg PD, Hingorani SR.
T-cell Localization, Activation, and Clonal Expansion in Human Pancreatic Ductal Adenocarcinoma.
Cancer Immunol Res. 2017 Nov;5(11):978-991. PMID: 29066497.
Tumeh PC, Harview CL, Yearley JH, Shintaku IP, Taylor EJ, Robert L, Chmielowski B, Spasic M, Henry G, Ciobanu V, West AN, Carmona M, Kivork C, Seja E, Cherry G, Gutierrez AJ, Grogan TR, Mateus C, Tomasic G, Glaspy JA, Emerson RO, Robins H, Pierce RH, Elashoff DA, Robert C, Ribas A.
PD-1 blockade induces responses by inhibiting adaptive immune resistance.
Nature. 2014 Nov 27;515(7528):568-71. PMID: 25428505.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A Postdoctoral Research Fellow position is available immediately in the Clinical Research Division of Fred Hutch. The successful applicant will work with Dr. Matthias Stephan to create off-the-shelf nanoreagents that genetically reprogram the body’s ability to fight tumors and infectious disease (Nature Outlook December 21, 2017).
Suitable applicants should have a recent PhD in immunology or a related field. The ideal candidate will work well in an interactive scientific environment, be intellectually curious, and have experience in all aspects of cellular immunology. Critical skills include extensive animal science knowledge and extensive experience with animal handling, direct, hands-on experience with, and extensive knowledge of, cellular immunology, oncology, cell-based immune functional assays, flow cytometric analysis and isolation of transformed and primary cells, modulation of tumor microenvironments, and relevant statistical analysis
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The post-doctoral research fellow will work on independent and collaborative projects in Dr. Chapuis laboratory developing adoptive T cell immunotherapy for viral driven malignancies within the Program in Immunology and Clinical Research Division at Fred Hutchinson Cancer Research Center. The successful applicant will employ strategies for cloning T cell receptors (TCRs) and genetic modification of human T cells with TCRs specific for antigens expressed by malignancies. In vitro studies using human T cells and in vivo murine models will be used to develop and test novel T cell therapies. The research fellow will perform correlative studies to evaluate the transfer, persistence and function of antigen-specific T cells in human clinical trials of adoptive T cell immunotherapy.
The Program in Immunology is a leader in the development and clinical application of adoptive immunotherapy using genetically modified T cells and is committed to the advancement of this approach. The post-doctoral research fellow may also participate in the laboratory evaluation of ongoing clinical trials involving engineering of peripheral blood stem cell grafts for improved allogeneic hematopoietic stem cell transplantation outcomes, and in the development of future immunotherapy strategies. This is a full-time position with a salary based on the NIH scale and excellent benefits.
To be successful in this position, the post-doctoral research fellow must be highly motivated and driven to establish a career as a future independent investigator, will need to be able to work independently and play well with others.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer with minimal side effects. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Turtle Lab is looking for a post-doctoral research fellow who will work on independent and collaborative projects developing adoptive T cell immunotherapy for hematologic malignancies within the Program in Immunology and Clinical Research Division at Fred Hutch. The successful applicant will employ strategies for genetic modification of human T cells to enable their expression of chimeric antigen receptors (CARs) and redirection of specificity to antigens expressed by hematologic malignancies. In vitro studies using human T cells and in vivo xenogeneic models will be used to develop and test novel T cell therapies that can be studied in future human clinical trials.
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
A highly qualified and motivated post-doctoral research fellow is sought to join the laboratory of Dr. Sunil Hingorani (https://research.fhcrc.org/hingorani/en.html) at Fred Hutchinson Cancer Research Center in Seattle, WA.
Our laboratory investigates molecular and cellular mechanisms of pancreatic ductal adenocarcinoma (PDA) pathogenesis. The murine models of distinct genetic subtypes of pancreas cancer that we have developed form the basis of our integrated, systematic, and multidisciplinary research program. Our efforts are directed at identifying and overcoming stromal barriers to treatment (including elevated interstitial pressures, activated fibroblasts, and multiple mechanisms of immune suppression); identifying and disrupting molecular drivers of metastasis; and developing immune-based strategies. Our ultimate aim is to reduce our discoveries to practice in the clinic in order to radically transform the approach and prognosis for patients with this devastating disease.
Successful applicants will have:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Hadland Lab (http://research.fhcrc.org/hadland/en.html) is seeking a talented postdoctoral fellow interested in studying the mechanisms regulating hematopoietic stem cell (HSC) emergence. The focus of our lab is to unravel the dynamic intercellular interactions and signal pathways governing the generation of blood and immune cells during embryonic development, and in turn apply this knowledge toward engineering novel approaches for the study and treatment of blood and immune disorders.
This is a basic science position that focuses on utilizing emerging single cell technologies and computational approaches for the functional and molecular analysis of the dynamics of HSC development. The position will also provide opportunities to develop novel translational applications in the areas of gene and cellular therapies, disease modeling, and/or drug discovery, and for collaborations with colleagues in Genome Sciences, Bioengineering, and other departments. This position is ideally suited for a candidate who is an independent thinker but who also enjoys working collaboratively across disciplines.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A Stem Cell and Gene Therapy Program laboratory that studies hematopoietic stem cell biology and develops novel gene therapy and gene editing strategies is recruiting a postdoctoral fellow to develop novel in vivo gene therapy approaches for the modification of primary hematopoietic stem cells using preclinical animal models. The position involves responsibilities, such as the development and optimization of viral vectors, follow up analyses for tracking of modified cells after delivery of the vector or formulation, processing of primary tissue samples, and culture/analysis of cells modified with nanoparticles and/or viruses. The candidate will be expected to publish and present their work in both internal and external events.
A PhD or MD in a scientific field is required. The individual must possess knowledge of hematopoietic stem cell biology. Experience in animal models, transduction of primary cells with viral vectors and gene therapy and editing tools are required. Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, viral vector platforms, flow cytometry/flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR. Previous experience in basic bioinformatics, and/or GLP/GMP techniques is desired, but not required.
To be successful in this position, the candidate must be highly motivated and able to work independently to design and execute experiments, possess a high level of initiative and attention to detail, and must also be able to multi-task and prioritize work at short notice. They must also be capable of working independently in a team environment. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Project Coordinator, Center for Accelerated Translation in Pancreas Cancer (CATPAC) is responsible for day-to-day coordination of clinical and preclinical studies under the direction of the PI and the Hingorani Translational Research Program Manager. This part-time position represents an excellent opportunity for an experienced, highly motivated individual with a passion for research to work and learn in a dynamic scientific environment while addressing important problems relevant for the successful treatment of cancer.
The Project Coordinator will be primarily responsible for the operations of our pancreas cancer biorepository program and other pancreas cancer research team studies. This will involve implementing study processes, assisting with protocol development, coordinating collections and shipments, assuring adherence to regulatory guidelines and maintaining study records. This position will define and implement best practices for data and materials management and will also conduct literature reviews to assist in determining most suitable methods to be used in team projects.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
Join the Bleakley clinical research team and be at the forefront of stem cell transplantation and immunotherapy research. Under the supervision of Principal Investigator Marie Bleakley, MD/PhD, this position is responsible for coordinating research activities and managing data for leukemia patients undergoing transplantation on clinical trials. This role involves primarily responsibilities of a regulatory coordinator and also elements of research coordination, data entry and clinical trial implementation. The successful candidate will perform their responsibilities with a high level of independence and collaboratively within the scope of study protocols and institutional guidelines.
This position works in collaboration with the clinical research nurse and other members of the clinical research team on a set of transplantation protocols studying naïve T cell depletion of peripheral blood stem cell grafts. The patient population includes both pediatrics and adults from around the globe that come to Fred Hutch, SCCA, UWMC and Seattle Children’s Hospital for cutting edge research and treatment. The position includes interaction with the clinical care teams, researchers, and other support staff within and outside of the Fred Hutch/SCCA/UW/SCH system.
The regulatory and research coordinator position will be approximately 60% regulatory, 20% data, 10% implementation and 10% clinical research coordination.
The incumbent works both independently and within a highly collaborative team while performing work assignments, and uses judgment in data monitoring and collection, quality control, co-ordination and liaison activities. Demonstrates initiative and sound judgment in problem solving, providing regulatory guidance and in developing policies and procedures. Has significant interaction with the PI(s), other team members, internal departments and external organizations and agencies.
60% Regulatory:
• Prepare, track and maintain all correspondence and regulatory documentation required by the IRB, FDA and other institutional and federal oversight committees, including drafting and reviewing content as appropriate
• Submit all regulatory documents to the IRB and other governing bodies to maintain study compliance with GCP, institutional and federal regulations
• Maintain study regulatory binders and files
• Perform internal audit and quality assurance checks on regulatory documents
• With input from PI(s), draft initial clinical research trial informed consent forms
• Assist study start-up: prepare and submit all required regulatory documents for new study applications; successfully open new studies from inception to accrual
• Assist in preparing and presenting materials for monitoring visits
• Assist with follow-up and resolve all issues related to regulatory concerns identified during monitoring visits
• Prepare and submit modifications/amendments and continuing renewals for ongoing study maintenance
• Conduct study close-out
• Process IND external safety reports; maintain documentation of PI review and submit/escalate safety reports as appropriate
• Report non-compliance and unanticipated problems to IRB as applicable
• Serve as liaison for internal regulatory bodies (IRB, Clinical Research Support, Regulatory Affairs, etc.)
• Stay abreast of new impacts/areas of knowledge and regulatory changes and disseminate this knowledge to the study/operations team
20% Data, 10% Implementation, 10% Clinical Research Coordinator
• Review and monitor patient clinical trial data
• Maintain protocol databases and ensure timely electronic data capture and review
• Review patient medical records and other related documentation to assist with protocol eligibility determination
• Thorough understanding of all protocol-required monitoring, data collection and reporting requirements
• Monitor patient response to therapy and review for adverse events
• Collaborate with the Clinical Research Nurse to investigate possible protocol deviations and promptly resolve potential clinical concerns
• Monitor adherence to protocol, investigating any violation
• Coordinate research and clinical operations activities to ensure protocol compliance
• Oversee biospecimen tracking and collection of protocol-specific data after patients return to their outside provider
• Organize, coordinate and oversee specimen shipments from outside institutions to the research laboratories
• Assist in the planning and content of reports to the DSMB, IRB, FDA and publications
• Coordinate special projects
• Perform other duties as assigned
• Bachelor's Degree in a related field; relevant experience in lieu of degree acceptable
• 1-2 years' experience in clinical research and/or regulatory, human research protection or related experience
• Demonstrated knowledge of regulatory guidelines (IRB, IACUC, MUA, etc.)
• Knowledge of FDA, GCP, and NIH requirements
• Strong computer skills and experience working with databases
• Strong verbal and written communication skills essential
• Experience in protocol implementation is desirable
• Knowledge of medical terminology preferred
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Stem Cell and Gene Therapy (SCGT) program at Fred Hutch is recruiting a Research Technician I, with a focus on bench research duties. Bench research experiments will support multiple projects within the laboratory, under the supervision of senior laboratory staff and the PI. Duties may include processing and analysis of primary blood and tissue samples for flow cytometry, PCR-based analysis of cell populations, sterile cell culture work with cell lines and primary cells including hematopoietic stem cells, and ELISA assays. The candidate must also be comfortable working with potentially infectious material and biosafety level 2+ techniques.
A BS degree in molecular/cellular biology or other related scientific fields is required. The individual must possess knowledge of basic biological and molecular assays and experience with performing these techniques. Experience is preferred in one or more of the following areas: hematopoietic stem cell cultures/model systems, in vivo gene therapy studies, flow cytometry/flow-assisted cell sorting, and/or molecular biology techniques e.g. quantitative PCR. Knowledge or experience maintaining and ordering materials is preferred in addition to excellent record keeping skills. The ideal candidate would be familiar with computer programs including Microsoft Office, FlowJo, Graphpad Prism, online spreadsheet sharing documentation, and/or similar products.
To be successful in this position, the candidate must be highly motivated, execute experiments, possess a great attention to detail, and must also be able to multi-task and prioritize work at short notice. They must also be capable of working independently in a team environment. Candidates with excellent organizational skills and communication skills (written and oral) are encouraged to apply.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Silberstein lab is seeking to recruit a Research Technician I-II.
The main goal of the laboratory is to combine basic stem cell biology and clinically relevant murine models in order to develop new therapeutic approaches to promote hematopoietic stem cell function in bone marrow failure and to enhance hematopoietic reconstitution after bone marrow transplantation. We are particularly interested in using microenvironment-derived molecules as drugs or therapeutic targets, and have identified several novel niche factors using proximity-based single cell analysis as a discovery strategy (for details, please see Silberstein et al, Cell Stem Cell 2016, Goncalves, Silberstein et al, Cell 2016).
A successful candidate will be responsible for maintaining the murine colony and conducting animal experiments which involve stem cell transplantation, fluorescently-activated cell sorting/analysis and molecular studies of stem cells/progenitors.
The incumbent will be part of a Stem Cell and Gene Therapy Program at the Fred Hutch and interact closely with other laboratories within the Program (Kiem, Adair, Bernstein, Hadland, Doulatov) and those within Integrated Immunotherapy Research Center (Dudakov, Turtle).
Research Technician I required qualifications: Bachelor's degree in a related scientific discipline and prior research laboratory experience.
Research Technician II required qualifications: Bachelor's degree in a related scientific discipline and 2 or more years of relevant professional research experience. A Master's degree in a relevant scientific discipline can substitute for 2 years of professional research experience.
The candidate must have an interest in stem cell research. Applications from candidates considering medical/graduate schools are encouraged. Previous experience of working with murine models is not essential, but the position requires that a candidate handle the animals on a daily basis and perform standard animal procedures (appropriate training will be provided). Excellent written and verbal communication skills are required.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
We are looking for a highly motivated individual to support the development of immunotherapy for cancer. The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity to cancer. The technician will be closely involved in the preclinical development of new TCR-based therapies and their translation into clinical trials. The candidate should be capable of maintaining detailed laboratory records, analyzing data, and reporting experimental results.
The technician will assist in the design, implementation and interpretation of experiments involving human T lymphocytes engineered to target tumor cells. These studies are specifically aimed at identifying ways to increase the therapeutic activity of tumor-reactive T lymphocytes.
Minimum qualifications:
Preferred qualifications:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
A highly motivated candidate is sought to join the laboratory of James M. Olson in the Clinical Research Division at the Fred Hutchinson Cancer Research Center. The focus of research conducted in our group is the discovery and advancement of novel therapeutics. The candidate will join a highly innovative program as a Technician II in the protein sciences group to produce, purify, and characterize novel peptides.
The responsibilities and duties expected of this position are to support all aspects of the production, purification, and characterization of novel proteins using mammalian expression platforms. The main responsibilities will include mammalian cell culture, lentivirus generation, protein purification using affinity and size exclusion chromatography under endotoxin-free conditions, and analytical protein biochemistry. Experience with standard molecular biology techniques, mammalian protein expression systems, and protein chromatography are required for this position. Applicants must thrive in a team environment.
Research Technician I - A Bachelor's degree in Biology, Chemistry, Biochemistry or a related scientific discipline and prior research lab experience are required.
Research Technician II - A Bachelor's degree in Biology, Chemistry, Biochemistry or a related scientific discipline and two years of professional lab research experience are required.
The candidate should be motivated and have a demonstrated willingness to learn. The position requires a high level of organizational skill, the ability to manage multiple projects at once, and excellent communication skills.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Geraghty Lab seeks an exceptionally skilled, experienced molecular and or sequencing technician to join their team. A summary of Dr. Geraghty's research can be found here: https://www.fredhutch.org/en/faculty-lab-directory/geraghty-daniel.html
The Research Technician II will work in a molecular genotyping laboratory that performs state of the art genotyping for disease association studies. The laboratory collaborates with local and international labs to carry out anthropological, clinical, and basic disease studies that are aimed at a better understanding and development of data and tools for diagnosis and treatment of a variety of human diseases.
To be successful in this position, you must have the ability to communicate effectively with coworkers, working together in executing tasks that engage multiple complementary activities in parallel. In addition to benchwork, these activities include data analysis and effective interaction with the laboratory’s software and data analysis group. The ability and willingness to take initiative in problem solving and suggestions for workflow improvements will be a key to advancement and associated benefits.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Stem Cell and Gene Therapy (SCGT) program is recruiting a Research Technician II with a focus on bench research. Duties may include processing and analysis of primary blood and tissue samples for flow cytometry, PCR, sterile cell culture work with cell lines and primary cells, ELISA assays.
The position involves additional responsibilities, such as culture/analysis of cells infected with HIV and related viruses. The candidate should be motivated to participate in sample processing and analysis from preclinical modeling experiments. This position affords the motivated technician an opportunity to develop/utilize both tissue culture and molecular biology skills. The candidate must also be comfortable working with potentially infectious material and biosafety level 2+ techniques.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Immunopathology Lab in the Clinical Research Division is seeking a well-organized and highly motivated Research Technician II to join the Multiplex Immunohistochemistry (mIHC) Team with a focus on image acquisition and analysis. The Lab utilizes cutting-edge technologies in a Team Science approach to interrogate the tumor microenvironment through tissue-based analyses of immunotherapy clinical and pre-clinical trials.
Minimum qualifications:
Additional Preferred Experience:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Hill Lab within the Transplantation Program of the Clinical Research Division is looking for a highly motivated individual to support preclinical and translational research on the use of stem cell transplantation for the treatment of serious blood diseases. The successful candidate will be involved in a variety of cutting edge cellular and molecular techniques to study murine and human immune responses.
The successful applicant will assist in the day to day running of the laboratory in liaison with senior laboratory members. The candidate will also contribute to multiple projects studying stem cell transplantation, with the ultimate aim to generate testable therapeutic interventions that attenuate graft-versus-host disease and improve graft versus leukemia effects after transplantation. The technician will be closely involved in research projects using both in vivo murine models of transplantation and handling/preparation of clinical samples for analysis.
Key duties include:
A Bachelor's degree in a scientific discipline with at least two years of professional lab experience in a related field with relevant techniques is required. A Master’s degree in a related field can substitute for two years of professional lab experience. Experience with murine models is also required and flow cytometry experience is preferred.
The successful applicant should have an excellent knowledge of immunology, previous research experience including murine handling, genotyping, cell culture, basic flow cytometry and be capable of maintaining detailed laboratory records. Ability to analyze and report primary data would be highly advantageous.
Cures Start Here. Fred Hutchinson Cancer Research Center (Fred Hutch), home of three Nobel laureates, is an independent, nonprofit research institution dedicated to the development and advancement of biomedical research to eliminate cancer and other potentially fatal diseases. Recognized internationally for its pioneering work in bone-marrow transplantation, Fred Hutch’s five scientific divisions collaborate to form a unique environment for conducting basic and applied science. The Fred Hutch, in collaboration with its clinical and research partners, the University of Washington and Seattle Children’s, is the only National Cancer Institute-designated comprehensive cancer center in the Pacific Northwest. Careers Start Here.
The Rongvaux Lab in the Program in Immunology in the Clinical Research Division is looking for a highly motivated individual to support fundamental research on the mechanisms of immune responses to infection and cancer. The technician will be closely involved in the development of research projects using in vivo murine models. They should be capable of maintaining a large murine colony and perform diverse in vivo experimental procedures. This position requires a high level of organization, capacity to coordinate experiments with diverse researchers and collaborators, maintenance of detailed records, and excellent communication skills. Additional laboratory skills (tissue culture, molecular biology) are highly desirable.
Research Technician II - A bachelor’s degree in biological science and animal research experience beyond course work are absolutely essential. The candidate should have at least two years of full-time, post-bachelor's laboratory experience.
Research Technician III - As Research Technician II but with five or more years of full-time post-bachelor's laboratory experience.
Experience working with murine models is required. Experience with mammalian cell culture and flow cytometry are preferred.
Please include a resume and a brief (1-2 paragraphs) cover letter summarizing your interests and experience.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Riddell Laboratory is seeking an enthusiastic and highly motivated technician to join a team of scientists working in a multi-disciplinary environment on the forefront of immunotherapy research.
The successful candidate will utilize a variety of cutting-edge cellular and molecular techniques to analyze T cell immunity and support the preclinical development of novel T cell immunotherapies and their translation into clinical trials. This position will be under the direction of higher-level laboratory personnel to provide support to their research, with an opportunity to advance independent research projects. The technician will be responsible for performing bench-level experiments, operating analytical instruments, and compiling and verifying the accuracy of experimental data. The technician will also maintain detailed laboratory records, analyze data, and report on experimental results.
The position requires a high level of organization, a keen eye for detail, persistence, and accurate and thorough record keeping. We seek a candidate who is consistent in executing lab protocols and can swiftly adapt and troubleshoot new ones when necessary. This position will be extended to a candidate who is creative, passionate, patient, and critical, with a strong sense of independence, initiative, and drive to propel work forward. We seek a committed candidate who is an effective communicator of science; who is confident, and proactive, with excellent interpersonal skills, discipline, readiness to learn and contribute, and eagerness to take on new challenges.
Required:
Preferred:
Experience in molecular genetics, viral vector production, multi-color flow cytometry, FACS, and T cell functional assays is highly desirable. The ideal candidate is interested in 2+ years in the Riddell Lab.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.
This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Fred Hutch core center for excellence in hematology vector production and development facility assists researchers in the production of viral vector preparations for use in research experiments in their laboratories. The position involves managing the research viral vector core facility, driving vector development and application of new viral manufacturing processes as well as training and supervision of core technicians to ensure the facilities performance standards are met.
The manager is responsible for keeping the facility equipment operational and ensuring safety during production in accordance to Fred Hutch and NIH guidelines. The position involves ensuring all consumables and other supplies needed for vector production are available and that orders of such products by the core are billed correctly. Another responsibility is organizing and overseeing storage of cell lines and plasmids used by the facility as well as storage of final viral products.
The position requires the manager to maintain and archive production records of the viral products generated and tested. This includes documentation of client work-orders filed with the vector core as well as creating and passing on billing information to Fred Hutch Shared Resources Billing to ensure proper charge of services provided by the core.
The manager is responsible for assembling and providing data on vector production volume and development progress for reports to the funding agency. The position also includes performing client consulting services in terms of viral vector design and choice of preparation possibilities offered by the core in order to plan and develop transfer vectors fitting individual project requirements.
The position requires a PhD degree in an appropriate and laboratory intensive scientific field with a minimum of at least 2 years additional productive work experience in a research laboratory that includes specific experience in constructing new recombinant DNA molecules. Required educational expertise is strong background in the fields of genetics, virology as well as cell- and microbiology.
Detailed understanding of viral gene delivery systems and experience in design and testing of DNA vectors is required. Furthermore a qualified researcher should have technical expertise in mammalian tissue culture, recombinant DNA technology, molecular cloning, viral vector production, flow cytometry, DNA gel electrophoresis and PCR methods including real time PCR.
A statement of research interests and/or a cover letter are required.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Program of Immunology and Clinical Research Division are seeking an experienced Staff Scientist to work in a collaborative environment to help develop and optimize novel TCR gene therapy products for clinical translation, and to support current and future TCR gene therapy clinical trials.
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
Lead Immunotherapy Bioinformatician - Staff Scientist
Fred Hutch is a leading force in cancer immunotherapy research, a field dedicated to understanding how we can harness the immune system to treat cancer. This research arena spans an incredibly diverse spectrum of scientific questions ranging from understanding the form and function of the tumor immune microenvironment, augmenting the endogenous immune response to tumors, to crafting custom immune responses through gene editing approaches. The Adair, Bleakley, Dudakov, Headley, and Rongvaux labs, a core group of Junior Faculty within the Fred Hutch Immunotherapy and Translational Data Science Integrated Research Centers (IIRC and TDS-IRC), are seeking a PhD level bioinformatician to fill a Staff Scientist position working within and across the five groups.
The Staff Scientist will implement existing analysis platforms and help drive the development of cutting-edge new tools and technologies targeted at understanding the cellular and molecular underpinnings of immune responses to cancer. This position provides the opportunity to work on a diverse range of datatypes from transcriptomic and epigenomic analysis (both bulk and single cell), trajectory analysis of immune cell differentiation, high dimensional protein analysis through flow cytometry and CITEseq, and mutational analysis in gene-edited cells. The incumbent will participate in grant and manuscript preparation, experimental design and execution, and presentation of results in local and national meetings. They will also have the opportunity to participate in multidisciplinary collaborations involving laboratory-based scientists (immunologists, cancer researchers), clinical investigators, biostatisticians, data scientists, programmers and computational biologists through associations with the Fred Hutch IIRC and TDS-IRCs. We are looking for an individual who is truly passionate about applying data science to big questions in cancer immunotherapy.
We as a group value inclusion and a diversity of backgrounds and perspectives to inform our work. We believe in supporting each other through mentorship and providing resources for professional development. Given these values, we strive to make our recruitment and promotion processes fair and transparent. Therefore, we strongly encourage all individuals with an interest in the position to apply. To learn more about our groups please visit our lab websites and those of the Immunotherapy and Translational Data Sciences IRCs.
Minimum qualifications:
Preferred qualifications:
Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.
The Paulovich Lab at Fred Hutch is an interdisciplinary team whose mission is to develop and implement tools for protein quantification to enable precision medicine (patient selection and identification of novel therapeutic targets). The lab has a major focus on mass spectrometry, especially multiple reaction monitoring. Our group is highly collaborative, participating in national and international consortia in which teams of scientists, statisticians, and clinicians work together to solve clinical or biological problems to impact human health.
This is a terrific opportunity for a highly motivated, interactive, Protein or Analytical Chemist to join our translational proteomics team to help drive translational projects forward towards clinical applications by performing proteomic experiments and participating in the analysis and interpretation of results.
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