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6 Found open positions

CryoEM/Structural Biology Faculty Position

Basic Sciences Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 64580

Fred Hutchinson Cancer Research Center invites applications for an open faculty position in the Division of Basic Sciences. Recruitment at an Assistant Member level is preferred but we will consider more senior applicants. We seek an exceptional structural biologist conducting fundamental research within areas of molecular and cellular biology that possess significant potential for novel biological insight and discovery. A particularly strong expertise and focus on the use of Cryo-electron microscopy (CryoEM) as their primary experimental approach is required.

Fred Hutch provides outstanding colleagues, a collegial atmosphere, and a wealth of resources to support junior faculty success. Graduate students are drawn from the outstanding ‘Molecular and Cellular Biology’ and ‘Biophysics, Structure and Design’ graduate programs at the University of Washington. Fred Hutch is located in a modern campus by Lake Union in Seattle, Washington, and is close to other non-profit research institutes and the University of Washington. See our website for further information (www.fredhutch.org/basic/).

For consideration, applicants must have a doctoral degree and a substantial record of achievement pre and post-doctoral. Applicants from underrepresented populations are particularly encouraged to apply. Application deadline for consideration for a fall interview: August 31, 2019. Applications will be considered on a rolling basis after the deadline if the position is not filled. Candidates should visit http://apply.interfolio.com/64580 for application instructions.

Lab Aide (Work Study)

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 17454

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Brent lab is seeking a one or more work study students from Bio-Engineering, Electrical Engineering, Computer Science or related fields, to help develop technology and content for procedural guidance in biomedical research, development, and production.


Ideal candidates will be available for up to 40 hours per week and be eligible for state or federal work study. In order to qualify for work-study position over this summer, candidates must not be taking summer courses for credit at their institutions. The position has the possibility of extending into the 2020-2021 academic year. The majority of work can be done remotely.

 

Off-Campus Work Study authorization is required for this position. All students must provide a Financial Aid Award Letter or an Authorization to work off-campus to verify their eligibility if selected for this position.

Responsibilities

  • Acquire, annotate, wrangle and curate image data for neural networks
  • Help train neural networks
  • Research and improve on existing workflow
  • Contribute to a larger project using Augmented Reality to provide procedural guidance for biomedical research and development, and applied work relevant to the pandemic response

Qualifications

Required qualifications:

  • Currently enrolled as undergraduate in a four-year university and eligible for a work-study program
  • Literate in Linux command line
  • Familiar with Python language and, ideally JSON file format
  • Flexible and able to work independently without supervision


Preferred qualifications:

  • Ideal candidates would be undergraduates pursuing a four-year degree in Bio-Engineering, Electrical Engineering, Computer Science or possibly in related fields (eg. experimental physics or biology) with a strong Computer Science Component
  • Ideal candidates would have extensive (4+ years) programming experience, as evidenced by vettable code
  • Ideal candidates would have experience in object oriented programming and interest in machine learning

Off-Campus Work Study authorization is required for this position. All students must provide a Financial Aid Award Letter or an Authorization to work off-campus to verify their eligibility if selected for this position.

Research Technician I

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 15192

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

You are invited to apply for a position at the Shou Lab in the Basic Sciences Division at Fred Hutch. We are interested in using experimental biology to quantitatively examine “cooperation,” because cooperation can be found virtually everywhere: between different cell types (e.g. our body), different individuals (e.g. ant colonies), or different species (e.g. flower-pollinator symbiosis). How can cooperation survive the invasion of cheaters that take but not give? How does cooperation evolve? We plan to study cooperation initially using an engineered system in which two complementary types of yeast cells can only survive when both types are present.

Responsibilities

The incumbent will perform a project related to evolution.  The incumbent will also be responsible for making common reagents for the lab and participating in daily activities and duties of the lab.  Finally, the incumbent will aid in the completion of other ongoing projects in the lab as needed.  The incumbent will have opportunities to present substantial research results at conferences and gain authorship in research articles.

 

The lab will start its move to University College London at the end of 2020 or early 2021. The incumbent will need to help with the move to London and work for one or more years in London.

 

This position is ideal for some one who wants to gain more research experience before going to graduate school and wants to explore the exciting cities of Seattle and London.

Qualifications

A bachelor's degree is required and at least one year of laboratory experience. Strong quantitative skills including basic (high school) mathematics knowledge are required as is the ability to learn new things and to be highly organized. Comfort with computer programming and the ability to quantitatively analyze datasets independently is a big plus.

 

Applicants must submit a cover letter (stating why you are interested in the position and your educational/career goals), resume, at least one reference letter from your primary research adviser and the contact information for two other professional references.

Research Technician II-III, Genomics of Mouse Gene Regulation

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14888

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Our laboratory focuses on how gene regulation, chromatin structure, and nuclear organization are linked, with a special emphasis on changes that occur with differentiation.  This is a part-time position where effort is negotiable depending on the candidates’ skills and needs. The person in this position will be the lead on a collaborative project to define all cis-acting regulatory sequences on a genome-wide basis. The focus of this work is the isolation of defined populations of hematopoietic cells at defined stages of development and differentiation with the goal of subjecting them to a variety of molecular analyses. Samples will be obtained from wildtype and mutant mice, at baseline, and while recovering from stress.  The candidate will prepare samples for analysis by Next Generation Sequencing (NGS).  This work will require managing a mouse colony as well as isolating and analyzing mouse tissues.

Responsibilities

The research technician will work under the direct supervision by the principal investigators and be working with outside collaborators. This individual will be the sole Fred Hutch person doing bench work on this project and will need to work semi-independently and be adept at balancing responsibilities. To be successful in this laboratory the technician will need to work fairly autonomously and take the lead on trouble-shooting.  Excellent communication, documentation and organization skills are essential.

Qualifications

Required:

  • Bachelor’s degree in biology or related fields as well as two or five years of professional experience are required for the research technician II and III levels, respectively.
  • Hands on mouse handling experience.
  • The ability to master new techniques with limited supervision.
  • Basic media and reagent preparation.
  • The successful candidate must be highly motivated, reliable and take projects from conception to conclusion while working with intermittent supervision. 
  • Good organizational, time-management and documentation skills.

Preferred:

  • Comfort, and being facile with flow cytometry, including optimizing antibody staining and data analysis. Having job experience with this would be a major benefit.

  • Comfort with basic mouse husbandry, genotyping and isolation of organs. Having job experience with this would be a major benefit.

  • Tissue culture experience.

Research Technician III-IV, Molecular Biology

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 15206

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Brent lab is seeking a Research Technician IV. In this position, you will contribute to understanding how cell signaling systems carry information and the causes and consequences of non-genetic phenotypic variation in signal and response. Specifically, you will lead work on design and construction of "controllers", complex artificial systems allowing chemically tunable variation-suppressed expression of genes in mammalian cells induced by different small molecules.

 

You will also be involved in/ help alpha test our efforts to develop Augmented Reality (AR) methods to aid biological research. That work applies original engineering approaches and custom-built hardware/ software devices to increase the performance and add new capabilities to contemporary AR devices. Our approach has combined "analytical" approaches to computer vision and object sensing, as well as complementary application of trained deep neural networks (NNs) to provide the same functions and guidance. The work benefits from 25+ years of experience by PI and Current Protocols founders in providing procedural guidance.

 

Like the controller project, the explicit aim of this AR work is to assist experimentation. If these projects are successful, your work will have contributed to accelerating the pace of scientific discovery, and democratizing access to biomedical methods worldwide.

Responsibilities

For this position, we are hoping to find an extraordinary and dedicated individual. The lab is a multidisciplinary environment and offers a number of intellectual growth paths by which scientists willing to engage can continue to develop scientifically. This position will support research activities that include but are not limited to:

  • Generation of variation-suppressed expression constructs to control genes in mammalian cells
  • Generation and testing of large numbers of intermediate constructs carrying out subfunctions, en route to assembly and testing of the best expression controllers
  • Facility with contemporary DNA assembly methods including in vitro assembly and relevant construction methodologies in Saccharomyces cerevisiae
  • Use of software to plan DNA constructions and ability to quickly use lab and other image cytometric software to quantify gene expression in single mammalian cells
  • Use of flow cytometry and flow cytometric methods
  • Updating of standard molecular cell biology/genetic techniques, including retroviral and lentiviral gene transduction, CRISPR, and next generation sequencing analysis, as methods change, based on input from other scientists and literature
  • Engagement with rapidly developing AR and ancillary technologies to aid research projects, willingness to participate in developmental work that will enable others to benefit from this new medium, and possible help with translation to AR representations
  • Aid conventional training, supervision, and evaluation of laboratory staff and students
  • Development and updating of laboratory procedures, draft of reports and manuscripts, and presentation of data at lab meetings and scientific conferences
  • Collaboration with PI for the submission of research grants and the submission of progress reports to identify funding and manage projects and research studies

Qualifications

Required:

  • A bachelor's degree or higher in Biochemistry, Genetics, Cell Biology or related areas
  • At least four years of professional experience in a related area, or equivalent combination of education/experience, and a strong background in molecular biology, DNA work, mammalian cell culture, and demonstrated facility with contemporary DNA assembly methods


Preferred:

  • Previous experience with rigorous genetics in a prokaryotic system, or in the model systems S. cerevisiae, C. elegans, or D. melanogaster
  • At least 8 years of relevant research experience with some combination of genetics, molecular biology, single cell assays, DNA/genomic based analytical methods, and cell culture

Please apply by submitting a CV or resume, a cover letter describing your past research experiences and future goals as well as contact information for three references.

Staff Scientist, CryoEM Facility Manager

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 17628

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Fred Hutchinson Cancer Research Center in Seattle is seeking a highly communicative, organized, and motivated individual to oversee the day-to-day operation and maintenance of our new cryo-EM center. This brand new facility will include a Thermo Fisher Glacios Microscope with a Gatan K3 direct detector and a Thermo Fisher Talos 120C. The EM center will be used by a diverse group of researchers from Fred Hutch, Seattle Children's Hospital, and the University of Washington and is part of a vibrant and established structural biology community in Seattle.

Responsibilities

The primary responsibilities for this facility manager position include training and assisting users in EM sample preparation, data collection, and data processing and analysis; monitoring and troubleshooting instrumentation to maintain an efficient operating environment; and interfacing with vendors and field service engineers to coordinate repairs and maintenance as needed.

Qualifications

The successful candidate must have a PhD degree or equivalent and extensive experience in all aspects of single particle analysis. Outstanding technical, communication, and teaching skills are essential for this position. Fred Hutch offers great benefits and highly competitive salaries commensurate with experience.

 

Further qualifications:

  • Demonstrated experience in cryo-EM sample preparation, data collection, and image processing techniques
  • Experience with automated acquisition of high-resolution cryo-EM data
  • Deep knowledge of electron microscope instrumentation
  • Clear communication skills, and ability to organize and document research data
  • Experience training users
  • Ability to multi-task and demonstrate good time management skills
  • Demonstrated ability to work independently and as part of a research team
  • Demonstrated ability to rapidly incorporate new sample preparation, data acquisition, and image processing approaches
  • Ability to maintain a high level of professional expertise through familiarity with current scientific literature

 

Applicants should provide a brief statement of relevant research experience in cryoEM, a CV, and the names and contact information of three references.

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