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9 Found open positions

CryoEM/Structural Biology Faculty Position

Basic Sciences Division
Category: Faculty: Associate, Assistant, and Full Member
Seattle, WA, US
Job ID: 64580

Fred Hutchinson Cancer Research Center invites applications for an open faculty position in the Division of Basic Sciences. Recruitment at an Assistant Member level is preferred but we will consider more senior applicants. We seek an exceptional structural biologist conducting fundamental research within areas of molecular and cellular biology that possess significant potential for novel biological insight and discovery. A particularly strong expertise and focus on the use of Cryo-electron microscopy (CryoEM) as their primary experimental approach is required.

Fred Hutch provides outstanding colleagues, a collegial atmosphere, and a wealth of resources to support junior faculty success. Graduate students are drawn from the outstanding ‘Molecular and Cellular Biology’ and ‘Biophysics, Structure and Design’ graduate programs at the University of Washington. Fred Hutch is located in a modern campus by Lake Union in Seattle, Washington, and is close to other non-profit research institutes and the University of Washington. See our website for further information (www.fredhutch.org/basic/).

For consideration, applicants must have a doctoral degree and a substantial record of achievement pre and post-doctoral. Applicants from underrepresented populations are particularly encouraged to apply. Application deadline for consideration for a fall interview: August 31, 2019. Applications will be considered on a rolling basis after the deadline if the position is not filled. Candidates should visit http://apply.interfolio.com/64580 for application instructions.

Lab Aide (Work Study)

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14510

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Off-Campus Work Study authorization is required for this position. All students must provide a Financial Aid Award Letter or an Authorization to work off-campus to verify their eligibility if selected for this position.

Responsibilities

This position is in a laboratory that uses in vivo and in vitro models to investigate the relationship between the immune system and the microbiota. The lab specifically focuses on the interaction between anti-commensal antibodies and its role in the protection and regulation of the naïve neonatal microbiome.

 

The individual in this position will be involved in projects exploring the specific mechanisms in which antibodies function in the context of the microbiome. Additionally, isolating microbes that play larger roles in models with dysregulated immune systems. They will also be responsible for general laboratory duties, such as preparation of lab stock solutions, lab maintenance, autoclaving, and/or emptying biohazard waste. Major duties include:

  • Handling and working with Mus musculus
  • Genotyping different strains of Mus musculus with varying dysregulated immune phenotypes
  • Conduct varying assays such as ELISA, gel electrophoresis, PCR
  • Stock lab supplies, prepare reagents, autoclave and/or empty biohazard waste
  • Follow safety/biohazard precautions and procedures

Qualifications

  • A high school diploma or GED and enrollment in a university-level science degree program (e.g. biology, immunology, chemistry, or biochemistry) are required.
  • Previous or current coursework in biology and/or chemistry and past laboratory experience are preferred
  • Experience with molecular biology techniques is highly desirable but not a requirement
  • Demonstrated accuracy, attention to detail, and ability to learn new skills quickly is essential
  • Off-Campus Work Study authorization is required for this position. All students must provide a Financial Aid Award Letter or an Authorization to work off-campus to verify their eligibility if selected for this position.

Post-Doctoral Research Fellow

FH Basic Sciences Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 14905

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

A person in this position will determine the molecular basis for cell quiescence using Saccharomyces cerevisiae as a model organism.  This person will use molecular biological, molecular genetic, biochemical and genomic approaches.  These experiments will require extensive experience in these approaches, and therefore Ph.D. is a prerequisite for the position.

Responsibilities

A post-doctoral research fellow is available in a lab that studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how its structure controls essential processes that take place on DNA. The responsibilities of this position will be to determine how cell quiescence is achieved using Saccharomyces cerevisiae as a model organism.

Qualifications

A Ph.D. in molecular biology, biochemistry or other related scientific discipline is required, as well as experience in studying DNA-dependent processes including transcription, DNA replication and DNA damage response.

Post-Doctoral Research Fellow

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14889

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Candidates will be encouraged to build on the lab’s ideas and develop new directions for their research projects. Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals.

 

The Rajan Lab investigates mechanisms that enable energy homeostasis, specifically how fat cells relay information to the brain.

 

Please apply with a letter summarizing previous work experience, future research interests, and contact information for three professional references.

Responsibilities

A postdoctoral position for a recent enthusiastic PhD graduate is available in the Rajan Lab at Fred Hutch. The Rajan lab uses multidisciplinary approaches to study how organisms sense and communicate nutrient state.  We are seeking a highly motivated postdoc candidate interested in one of the following two research areas – blood brain barrier access of adipokines or innate immune molecules that intersect with metabolism-- in the Drosophila model system, with subsequent validation in murine and/or human cell systems. The postdoc candidate will carry out independent research projects and participate in lab meetings/journal clubs, as well as contribute to the smooth running of the lab.

Qualifications

Required:

  • A recent PhD degree in biology or related field
  • A strong foundation in molecular and cell biology
  • Candidates need to be highly motivated and well-organized individuals who think independently, but enjoy working as part of a dynamic and collaborative team
  • Excellent verbal and written communication skills

 

Preferred:

  • Background and familiarity with Drosophila genetics and/or mammalian cell culture desirable

Post-Doctoral Research Fellow, Neuro-immune Control of Metabolism

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14425

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first and largest cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Candidates will be encouraged to build on the lab’s ideas and develop new directions for their research projects. Fred Hutch has more than 200 postdoctoral fellows working in labs across all five research divisions. We provide postdocs with the opportunity to work on the cutting edge of biomedical research in a supportive, collaborative environment with faculty and staff who are dedicated to helping their trainees achieve their career goals.

 

The Rajan Lab investigates mechanisms that enable energy homeostasis, specifically how fat cells relay information to the brain.

Responsibilities

A postdoctoral position for a recent enthusiastic PhD graduate is available in the Rajan Lab at Fred Hutch. The Rajan lab uses multidisciplinary approaches to study how organisms sense and communicate nutrient state.  We are seeking a highly motivated postdoc candidate interested in one of the following two research areas – blood brain barrier access of adipokines or innate immune molecules that intersect with metabolism-- in the Drosophila model system, with subsequent validation in murine and/or human cell systems. The postdoc candidate will carry out independent research projects and participate in lab meetings/journal clubs, as well as contribute to the smooth running of the lab.

Qualifications

Required:

  • A recent PhD degree in biology or related field.
  • A strong foundation in molecular and cell biology.
  • Candidates need to be highly motivated and well-organized individuals who think independently, but enjoy working as part of a dynamic and collaborative team.
  • Excellent verbal and written communication skills.

Preferred:

  • Background and familiarity with Drosophila genetics and/or mammalian cell culture desirable

Please apply with a letter summarizing previous work experience, future research interests, and contact information for three professional references.

Post-Doctoral Research Fellow, Shou Laboratory

FH Basic Sciences Division
Category: Post-Doctoral Research Fellows and Associates
Seattle, WA, US
Job ID: 14871

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

A quantitative biology laboratory in the Division of Basic Sciences is seeking a highly motivated postdoctoral fellow with PhD in mathematics or physics.

Responsibilities

Our lab uses experimental biology, quantitative measurements, and mathematics to examine microbial communities.  For example, how might different microbial species interact with each other to allow the community to carry out a function that would have otherwise been impossible?  How might we effectively manipulate or evolve community functions? How might we extract information from time series data? Our lab provides excellent opportunities to combine theory with biology.

 

We are interested in recruiting an accomplished mathematician and/or physicist to tackle biological problems from the theory side.

 

More information about the group may be found at honeycomb.fhcrc.org.

Qualifications

A Ph.D. in physics, mathematics or engineering is required.

 

Ideally, the candidate is familiar with out-of-equilibrium stochastic processes or time series analysis.

 

The successful candidate should have a strong background in physics, mathematics, and/or engineering.

 

To apply, please submit a CV, a cover letter stating your long-term goal, and a list of professional references.

Research Technician II, Cell Biology

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14147

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


A hallmark of many diseases and cancers is a dysfunctional cytoskeleton. A properly functioning cytoskeleton is needed for a wide variety of cellular events ranging from cell shape to cell signaling and migration/metastasis. The Parkhurst laboratory in the Basic Sciences Division at Fred Hutch uses multidisciplinary approaches to study these dynamic structural elements in various processes including wound repair and nuclear architecture/organization. Our goal is to understand the role of these elements in regulating normal developmental events and how this regulation goes awry in diseases/cancers, thereby providing new avenues for possible therapeutic targets or to enhance the effectiveness of existing treatment modalities.


Our current research efforts are divided among studies of: (1) Molecular and cellular mechanisms of single cell wound repair, and (2) Actin and microtubule cytoskeleton dynamics mediated by the Rho1 small GTPase and its effectors; and (3) Nuclear architecture and organization.

Responsibilities

  • The research technician will primarily carry out an independent research project that involves cell biology, developmental genetics, and molecular biology.
  • The technician will participate in lab meetings and journal clubs.
  • Other responsibilities include general lab maintenance (ordering, caring for Drosophila flies, fly media preparation), and other duties as needed.

This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate and/or medical school.

Qualifications

  • A bachelor’s degree in a biological science and bench research experience are required.
  • Reliability is essential.
  • Good verbal and written communication skills.
  • Good interpersonal skills.
  • To be successful in this position, the technician must have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills, the ability to work and think independently, and wants to stay at least two years.
  • Must be able to distinguish different intensities and hues of red color.

Research Technician II-III, Genomics of Mouse Gene Regulation

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14888

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

 

Our laboratory focuses on how gene regulation, chromatin structure, and nuclear organization are linked, with a special emphasis on changes that occur with differentiation.  This is a part-time position where effort is negotiable depending on the candidates’ skills and needs. The person in this position will be the lead on a collaborative project to define all cis-acting regulatory sequences on a genome-wide basis. The focus of this work is the isolation of defined populations of hematopoietic cells at defined stages of development and differentiation with the goal of subjecting them to a variety of molecular analyses. Samples will be obtained from wildtype and mutant mice, at baseline, and while recovering from stress.  The candidate will prepare samples for analysis by Next Generation Sequencing (NGS).  This work will require managing a mouse colony as well as isolating and analyzing mouse tissues.

Responsibilities

The research technician will work under the direct supervision by the principal investigators and be working with outside collaborators. This individual will be the sole Fred Hutch person doing bench work on this project and will need to work semi-independently and be adept at balancing responsibilities. To be successful in this laboratory the technician will need to work fairly autonomously and take the lead on trouble-shooting.  Excellent communication, documentation and organization skills are essential.

Qualifications

Required:

  • Bachelor’s degree in biology or related fields as well as two or five years of professional experience are required for the research technician II and III levels, respectively.
  • Hands on mouse handling experience.
  • The ability to master new techniques with limited supervision.
  • Basic media and reagent preparation.
  • The successful candidate must be highly motivated, reliable and take projects from conception to conclusion while working with intermittent supervision. 
  • Good organizational, time-management and documentation skills.

Preferred:

  • Comfort, and being facile with flow cytometry, including optimizing antibody staining and data analysis. Having job experience with this would be a major benefit.

  • Comfort with basic mouse husbandry, genotyping and isolation of organs. Having job experience with this would be a major benefit.

  • Tissue culture experience.

Research Technician IV, Brent Lab

FH Basic Sciences Division
Category: Laboratory Research Sciences
Seattle, WA, US
Job ID: 14848

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.


The Brent lab is seeking a Research Technician IV to support our research in the causes and consequences of non-genetic phenotypic variation.

 

The project specifically includes design and construction of "controllers", complex artificial systems allowing tunable variation-suppressed expression of genes in mammalian cells. The Research Technician IV will also be involved in efforts to develop Augmented Reality (AR) methods and protocols to aid the controller project, and to in work to learn how to use AR to enable other researchers to better carry out a variety of fundamental experimental manipulations.

Responsibilities

For this position, we are hoping to find an extraordinary and dedicated individual. The lab is a multidisciplinary environment and offers a number of intellectual growth paths by which scientists willing to engage can continue to develop scientifically. This position will support research activities that include but are not limited to:

  • Generation of variation-suppressed expression constructs to control genes in mammalian cells
  • Generation and testing of large numbers of intermediate constructs carrying out subfunctions, en route to assembly and testing of the best expression controllers
  • Facility with contemporary DNA assembly methods including in vitro assembly and relevant construction methodologies in Saccharomyces cerevisiae
  • Use of software to plan DNA constructions and ability to quickly use lab and other image cytometric software to quantify gene expression in single mammalian cells
  • Use of flow cytometry and flow cytometric methods
  • Updating of standard molecular cell biology/genetic techniques, including retroviral and lentiviral gene transduction, CRISPR, and next generation sequencing analysis, as methods change, based on input from other scientists, literature
  • Engagement with rapidly developing AR and ancillary technologies to aid research projects, willingness to participate in developmental work that will enable others to benefit from this new medium, and possible help with translation to AR representations
  • Aid conventional training, supervision and evaluation of laboratory staff and students
  • Development and updating of laboratory procedures, drafts of reports and manuscripts and the presentation of data at lab meetings develop and establish published
  • Participation in local and national scientific meetings.
  • Collaboration with PI for the submission of research grants and the submission of progress reports to identify funding and manage projects and research studies

Qualifications

Required:

  • Master's degree or higher in Biochemistry, Genetics, Cell Biology or related areas
  • At least eight years of experience in a related area, or equivalent combination of education/experience, and a strong background in molecular biology, DNA work, and mammalian cell culture, demonstrated facility with contemporary DNA assembly methods

 

Preferred:

  • Experience with rigorous genetics in a prokaryotic system, or in the model systems S. cerevisiae, C. elegans, or D. melanogaster
  • At least 10 years of relevant research experience with some combination of genetics, molecular biology, single cell assays, DNA/genomic based analytical methods, and cell culture

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