Basic Sciences Job Openings

Overview

Howard Hughes Medical Institute (HHMI) is an independent, ever-evolving philanthropy that supports basic biomedical scientists and educators with the potential for transformative impact. We make long-term investments in people, not just projects, because we believe in the power of individuals to make breakthroughs over time. HHMI scientists have radically advanced the understanding of cells, the brain, the immune system, the development of organs, and how to treat many diseases. Founded in 1953 by aviator and industrialist Howard R. Hughes, HHMI is headquartered in Chevy Chase, Maryland, and employs more than 2,500 people across the U.S.

At HHMI, you are not just an employee – you are a part of a creative and talented team with colleagues whose expertise ranges from biomedical research to investment management, from information technology to law. We encourage collaborative and results-driven working styles and offer an adaptable environment where employees can do their best work. As HHMI scientists continue to push boundaries in laboratories and classrooms, you can be sure that your contributions while working at HHMI are making a difference.

We are currently looking for an enthusiastic Research Technician I to support the lab of Dr. Harmit Malik in the Basic Sciences Division of the Fred Hutchinson Cancer Research Center (also known as ‘Fred Hutch’ or ‘The Hutch’) in Seattle, WA. The Malik lab focuses on conducting evolutionary studies of genetic conflict to gain insight into their mechanisms and consequences. More information about Dr. Malik and the lab’s research can be found here.

The ideal candidate is an organized, detail-oriented, intellectually curious individual who will focus on developing Drosophila models for testing effects of evolutionary changes on proteins involved in reproduction. The ideal candidate would be someone who recently completed their undergraduate studies and would like to obtain additional research experience prior to attending graduate school in the biomedical sciences. Many former Malik lab research technicians have been accepted to top graduate school programs. In addition, depending on experience, the chosen individual may have the opportunity to carry out their own research projects under the supervision of senior researchers in the lab and will earn authorship on any scientific papers to which they contribute.

APPLY ON HHMI CAREERS PAGE TO BE CONSIDERED

Responsibilities

• Maintain various Drosophila species and strains, perform transgenic gene manipulation in Drosophila, and utilize extensive molecular biology techniques to develop and validate vectors and for subcloning and injection into transgenic Drosophila, followed by their validation.
• Serve as secondary person for lab management support including ordering and restocking scientific lab supplies and reagents and maintaining equipment.
• Prepare genomic and plasmid DNA and clone genes into vectors for transgenic purposes.
• Assist with various lab projects focusing on Drosophila and/or other model organisms as requested by Dr. Malik, postdoctoral fellows, graduate students, or other lab staff.
• Actively participate in weekly laboratory meetings and present data to the team on a regular basis.

Qualifications

Education

• A bachelor’s degree in biology or a related discipline is required.

Experience

• Previous hands-on laboratory experience is required. Laboratory experience (honors thesis, internship in a laboratory, etc.) obtained during undergraduate studies is acceptable and will be considered.
• Experience addressing a research question as part of a research environment beyond standard university coursework is preferred.
• Hands-on experience with DNA and RNA preparations, PCR, and subcloning is preferred.
• Experience with Drosophila maintenance, cell culture, cell transfections, in situ hybridization, and immunohistochemistry would be a plus, but is not essential.

Knowledge, Skills, and Abilities

• Superior verbal and written communication skills.
• Superior organizational skills, prioritization skills, time management skills, and meticulous attention to detail.
• Proficient computer skills (PC and/or Mac, Microsoft Office Suite, etc.)
• Ability to maintain accurate records of experiments and procedures.
• Ability to manage multiple priorities simultaneously.
• Ability to work well both independently and as part of a team of scientists working at the interface of evolutionary, cellular, and molecular biology.
• Ability to interact positively with all levels of staff.
• Ability to work efficiently, be adaptable, and be self-motivated.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through work at Fred Hutch is requested of all finalists.

HHMI is an Equal Opportunity Employer.

APPLY ON HHMI CAREERS PAGE TO BE CONSIDERED

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

This position is a part-time (~10-week commitment) opportunity specalizing in optical trapping. This person will assist ongoing biophysical projects in the lab that will involve optical trapping, expansion microscopy and TIRF microscopy.

Qualifications

A high school diploma or equivalent and at least some college-level courses are required. The candidate must have experience in building custom microscopes including anti-Stokes Raman scattering microscopes.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The Brent Lab works on the causes and consequences of nongenetic phenotypic variation but also on means to accelerate the pace of scientific discovery during this century. Much of the work on the latter topic is directed toward support of applied activities directed against pandemic spread of SARS-CoV-2. Brent Lab is part of the Division of Basic Sciences at the Fred Hutchinson Cancer Research. Work in this Division spans a wide range of basic research projects, and DBS is an exceptionally active and interactive scientific environment that offers high quality scientific education to students immersed in its activities.

To qualify for this position, you must be eligible for state or federal work study.

Responsibilities

The Brent lab is seeking one or more work study students from Computer Science, Bio-Engineering, Electrical Engineering or related fields of study to help develop supporting software and content to enable Augmented Reality guidance for lab procedures.

Ideal candidates will be available for 19 hours per week and be eligible for state or federal work study. Schedule can vary depending on class or other work schedule. Majority of work can be done remotely.

Job duties:

• Help develop UI/UX and content for Augmented Reality guidance for lab procedures
• Help with acquisition, annotation and curation of image and other data to be used for machine learning
• Contribute to a larger project to use AR to aid biomedical research and development

Qualifications

Required:

• Currently enrolled as undergraduate in a four-year university and be eligible for a work-study program
• Literate in Linux command line
• Familiar with Python language and, ideally JSON file format
• Flexible and able to work independently without supervision

Preferred:

• The ideal candidate would be pursuing a degree in Bio-Engineering, Electrical Engineering, Computer Science or related field
• Ideal candidates would have extensive programming experience, as evidenced by vettable code
• Ideal candidates would have experience in object oriented programming and interest in machine learning

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The Brent lab is seeking two work study students from the School of Public Health, Biostatistics or a related field, to assist on a small-scale randomized control trial testing the use of Augmented Reality to aid diagnostic testing for SARS-CoV-2.

Ideal candidates will be available for 19 hours per week and be eligible for state or federal work study. Much of the work will need to be done in person at Fred Hutchinson starting Winter Quarter 2021.

Responsibilities

• Use epidemiological methods to carry out a small-scale randomized control trial using a cross-over design
• Aid in study recruitment and participant scheduling
• Instruct and observe study participants during in-person data collection sessions
• Analyze study results using R, STATA, or some alternative data analysis system

Qualifications

• The ideal candidate would be pursuing a degree in Public Health, Health Informatics, Biostatistics or a related field
• Currently enrolled an undergraduate or master program at a four-year university and be eligible for a work-study program
• Proficiency in basic research methods
• Flexibility and able to work independently without supervision
• Possess some basic laboratory skills and knowledge
• Hiring process will continue until ideal candidates are selected

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

• Develop an organizational system to catalog 45 years of scientific manuscripts, communications, and email and written correspondence
• Convert printed manuscripts and correspondence from hard copy to electronic

Qualifications

• High school diploma or equivalent required. Currently enrolled as undergraduate in a four-year university and be eligible for a work-study program
• Must be able to read and comprehend complex scientific articles and professional correspondence
• Strong proficiency in the English language
• Flexibility and able to work independently without supervision
• The ideal candidate would be pursuing a degree in History, English, Library & Information Science, Science and Technology Studies or Liberal Arts more broadly
• Possess strong organizational capabilities and works meticulously
• Computer skills using programs such as Excel and Microsoft Word

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The Subramaniam lab is part of the Basic Sciences Division and the Computational Biology Program at Fred Hutch in Seattle. Members of the lab come from a variety of scientific backgrounds including physics, biochemistry, and microbiology. The lab places a strong emphasis on one-on-one mentoring and on providing a supportive environment for learning and research. Trainees are prepared for a wide range of careers in academia and industry through learning of broadly applicable technical and organizational skills. We encourage applicants from historically underrepresented groups and from any disadvantaged socio-economic backgrounds. More information on the Subramaniam lab can be found by clicking this link.

The goal of this postdoc research project is to use functional genomic approaches to discover and characterize novel mechanisms of mRNA translation in human cells. Our longer-term goal is to identify how these mechanisms are dysregulated across different tissue types and disease states. Thanks to methods such as ribosome profiling and RNA-seq, we have unprecedented genome-wide snapshots of gene expression at single nucleotide resolution. However, our ability to interrogate and predict the functional effects of mRNA sequence motifs on gene expression and cell physiology has been limited. We aim to address this gap using:

• Pooled deep sequencing methods to measure in parallel the effects of thousands of mRNA sequence motifs on gene expression in human cells.
• Unbiased CRISPR screens to identify factors that act at specific motifs.
• Machine learning and kinetic models to quantitatively predict the effect of novel mRNA motifs on gene expression.
• Biochemical and genetic studies to test the resulting models of gene regulation.

Responsibilities

The postdoctoral fellow will learn and apply cutting-edge deep sequencing approaches to identify novel sequence motifs and protein factors regulating mRNA translation in human cells. They will use targeted biochemical and genetic approaches to characterize the identified motifs and factors. They will learn and use computational methods to analyze large-scale sequencing data and formulate quantitative models.

The fellow will have the opportunity to explore and bring novel approaches and ideas to their project by collaborating with other labs at Fred Hutch, including:

• Melody Campbell (Structural Biology using cryo-EM)
• Andrew Hsieh (Cancer Biology)
• Adam Geballe (Virology)

The fellow will present their work at group meetings and conferences, and write up their work for publication.

Qualifications

• A PhD is required, preferrably in biochemistry, molecular biology or related field 
• The ideal candidate for this project will have PhD-level expertise in applying biochemical and structural approaches to study RNAs and proteins or in mammalian RNA biology.
• Candidates with strong expertise in cell biological approaches or cutting edge microscopy are also welcome to apply.
• The candidate will be highly motivated to learn deep sequencing methods and computational approaches for studying gene regulation.
• The candidate should be able to work independently and must have strong communication skills.

Application instructions:

To apply, please submit the following materials

• Your CV including contact information for 2 references.
• A statement of your research interests. This should specifically address why your background and interests are a good fit for this project.

Graduate students getting ready to complete their PhD are encouraged to apply.

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

A fully-funded post-doctoral research fellow position is available in the Hatch Lab in the Basic Sciences Division. We study the structure and dynamics of the mammalian nuclear envelope, and our primary interests are to understand why and how nuclear membranes rupture and repair, and how defects in nuclear membrane stability impact cancer development (Hatch et al., Cell, 2013; Maciejowski and Hatch, Ann Rev Cell Dev Biol, 2020; Young, Gunn, and Hatch, MBoC, 2020). The Hatch lab uses a variety of techniques to achieve these goals with a focus on microscopy and cell-based tool development.

Responsibilities

The fellow will be responsible for developing, in discussion with Dr. Hatch, and executing a project related to the core interests of the lab with the goal of developing a new line of inquiry that the fellow could start their own research program with, if desired.

Current areas of interest are: identifying proteins that drive membrane repair and how membrane gap size influences repair pathway choice, determining why chromatin state regulates nuclear lamina organization and membrane stability in micronuclei, developing new tools to track and isolate micronucleated chromatin and cells, and designing new experimental models to investigate how chromosome missegregation into micronuclei impacts cell transformation and tumor progression. The development of collaborative projects with other labs at Fred Hutch or elsewhere is of substantial interest.

Strong candidates will have demonstrated excellent abilities to independently design and execute a project, identify and communicate with scientists outside their lab to learn new techniques or topics, and effectively communicate the significance of their research in both oral and written presentations.

Qualifications

• A PhD in biology is required.
• First authorship on a published manuscript, or one close to submission, is required.
• The ability to clearly and efficiently communicate data, both in writing and verbally, is required.
• The ability to work independently is required.
• Experience with microscopy and quantitative image analysis is strongly preferred.
• Experience with immunological labeling techniques, including western blotting, flow cytometry, and immunofluorescence, is preferred.

To apply to this position please provide the following:

• Cover letter summarizing previous work experience and research interests,
• CV
• Contact information for three professional references.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

A postdoctoral position is available in the Lehrbach Lab at the Fred Hutchinson Cancer Research Center. The long-term aim of research in the Lehrbach Lab is to better understand proteostasis mechanisms and their roles in aging, neurodegenerative diseases and cancer. The fellow will work on individual and collaborative projects that use genetic, genomic, and cell and molecular biology approaches to discover new proteostasis mechanisms and reveal their physiological roles.  The primary model organism for this work will be C. elegans, however previous experience with C. elegans is not essential.

Qualifications

• PhD degree in molecular biology, genetics, cell biology, developmental biology, biochemistry or related field
• Research experience in a genetic model system would be ideal
• Experience in molecular biology and cell biology
• Independent, self-motivated and able to work as part of a collaborative team
• Experience in writing and submitting manuscripts and meeting abstracts
• Excellent verbal and written communication skills

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

A postdoctoral fellow position in Molecular Neuroscience is available in the lab of Dr. Linda Buck at Fred Hutch Cancer Research Center. The lab is part of the Basic Sciences Division, which investigates diverse areas of molecular and cellular biology, including neuroscience, virology, and evolutionary biology.

The Buck Lab is investigating fundamental mechanisms underlying brain function. Current projects focus on molecular mechanisms involved in stress and fear and the control of appetite. These include elucidation of genes and neural circuits that regulate these functions and how they are modulated by the olfactory system. Methods used include cutting edge tools for genetic, chemical and optical control of neuronal function, imaging of gene expression and neuronal activation, gene editing to analyze specific gene functions, and single cell genomics.

Responsibilities

The fellow will be responsible for developing and executing a project related to current and future interests of the lab, as determined by discussions with Dr. Buck. The successful candidate will be an individual who is enthusiastic about science and is capable of independent research.

Qualifications

Required

• PhD in molecular/cell biology, molecular neuroscience, computational biology, or related field
• Excellent knowledge of fundamental molecular and cell biology
• Experience using molecular techniques for cloning and for analysis of nucleic acids and proteins
• Experience using immunohistochemistry and/or in situ hybridization for analyses of gene expression

Preferred

• Experience with RNA sequencing and bioinformatics
• Experience in mouse breeding and genotyping
• Knowledge of neuroscience

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The Research Technician works under the direction of the Principal Investigator, Dr. Singhvi or higher-level laboratory personnel. The technician uses limited discretion and judgement in carrying out experiments. Job duties include:

• Perform experiments at the bench level to support investigative work
• Prepare and maintain laboratory reagents, stocks, cultures or cell lines
• Perform and modify documented protocols and assays
• Maintain laboratory records and compile data on experiments and assays
• Interpret and report on experimental results
• Perform statistical analysis of test results and prepare written reports on work performed
• Operate and carry out basic maintenance of laboratory equipment
• Order and maintain appropriate levels of supplies
• May supervise work-study students
• Perform other duties as required

Qualifications

• BA/BS in a scientific field required
• Must have scientific knowledge in the area of study and basic laboratory skills
• Independent research experience in addition to school lab experience is usually necessary
• A two-year commitment is preferred

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The Priess Lab is looking to hire a Research Technician II. The work will involve cell and biochemical studies on cell differentiation and germ cell development using the model system C. elegans. 

Qualifications

• Research Technician I - Requires a BA/BS, preferably in biological sciences, and independent research experience outside of laboratory course work. Undergraduate thesis preferred.
• Research Technician II - Intermediate level position requires a BA/BS and 2+ years’ experience working in a laboratory. Independent research experience outside of laboratory course work is required.
• The applicant must have proven laboratory expertise in standard DNA and protein biochemical techniques such as plasmid construction, PCR, Western analysis, and immunoprecipitation.
• Experience working with C. elegans desired but not essential

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

Responsibilities

The technician will contribute to research projects in the Lehrbach Lab involving C. elegans genetics, cell biology and molecular biology. This is an ideal position for a recent graduate looking to gain research experience before pursuing graduate and/or medical school. Tasks include:

• DNA extraction
• DNA sequencing and analysis
• Preparation of next generation sequencing libraries
• Carry out and interpret PCR genotyping assays
• C.elegans husbandry and microinjection
• General lab maintenance and organization
• Participation in lab meetings and journal clubs

Qualifications

• Research Technician I - Requires a BA/BS, preferably in biological sciences, and independent research experience outside of laboratory course work.
• Research Technician II - Intermediate level position requires a BA/BS and 2+ years’ experience working in a laboratory. Independent research experience outside of laboratory course work is required.
• Experience with genetics, molecular biology, cell biology or with genetic model organisms is preferred
• Good verbal and written communication skills
• Good interpersonal skills

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

A full-time Research Technician II/III position is available in the Hatch Lab in the Basic Sciences Division. We study the structure and dynamics of the mammalian nuclear envelope, and our primary interests are to understand why and how nuclear membranes rupture and repair, and how defects in nuclear membrane stability impact cancer development (Hatch et al., Cell, 2013; Maciejowski and Hatch, Ann Rev Cell Dev Biol, 2020; Young, Gunn, and Hatch, MBoC, 2020). The Hatch lab uses a variety of techniques to achieve these goals with a focus on microscopy and cell-based tool development.

Responsibilities

• Work closely with Dr. Hatch and other senior lab members to design and execute experiments related to scientific goals defined by them.
• Analyzing, interpreting, and reporting experimental results on a shared lab database as well as in group meetings and at local conferences.
• Consulting and working with experts outside of the lab
• Independent learning about how different techniques work to identify optimization parameters.
• General lab maintenance duties, including checking and maintaining lab stocks, checking and replenishing supplies
• Maintaining lab records
• Maintain laboratory records and compile data on experiments and assays
• Perform other duties as required

Qualifications

• Proven ability to independently develop protocols for new techniques, including a motivation to read and synthesize current literature in the field, constant assessment of conditions while executing an experiment
• Excellent record keeping, a basic understanding of experimental design, and an ability to define the next steps in an experiment.
• Interest or ability in discussing data, asking questions in a group setting, and asking for help or training are key skills for success. 

Research Technician II

• Bachelor's degree required
• 2 years previous experience working in a laboratory. 
• Independent research experience outside of laboratory course work is usually necessary.

Research Technician III

• Extensive experience in a laboratory.  Generally, the incumbent will possess a Masters’ degree in a related scientific field.
• Minimum of 3-5 years previous experience working in a laboratory
• Excellent written and verbal communication skills are required
• Experience with tissue culture and microscopy is strongly preferred
• Familiarity with basic statistical tests, including chi-square analysis, and one-way anova’s, is preferred
• Experience with immunological labeling techniques, including western blotting, flow cytometry, and immunofluorescence, is preferred

Application instructions:

To apply to this position please provide the following:

• CV, including summaries of previous work experiences
• Contact information for three professional references

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

A hallmark of many diseases and cancers is a dysfunctional cytoskeleton. A properly functioning cytoskeleton is needed for a wide variety of cellular events ranging from cell shape to cell signaling and migration/metastasis. The Parkhurst laboratory in the Basic Sciences Division at Fred Hutch uses multidisciplinary approaches to study these dynamic structural elements in various processes including wound repair and nuclear architecture/organization. Our goal is to understand the role of these elements in regulating normal developmental events and how this regulation goes awry in diseases/cancers, thereby providing new avenues for possible therapeutic targets or to enhance the effectiveness of existing treatment modalities.

Our current research efforts are divided among studies of: (1) Molecular and cellular mechanisms of cell wound repair and (2) Nuclear architecture and organization.

Click here for information about the research in the Parkhurst lab.

Responsibilities

• The research technician will primarily carry out an independent research project that involves cell biology, developmental genetics, and molecular biology

• The technician will participate in lab meetings and journal clubs

• Other responsibilities include general lab maintenance (ordering, caring for Drosophila flies, fly media preparation), and other duties as needed

• This is an ideal position for a recent graduate who wants to gain an intense research experience before pursuing graduate and/or medical school

Qualifications

• A bachelor’s degree in a biological science and bench research experience are required
• 2+ years' experience working in a research laboratory required
• Reliability is essential
• Good verbal and written communication skills
• Good interpersonal skills
• To be successful in this position, the technician must have scientific curiosity, a high level of self-motivation, the ability to take instruction and correction and to follow directions, good organizational skills, the ability to work and think independently, and wants to stay at least two years
• Must be able to distinguish different intensities and hues of red color

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and antiracism in your career or that will be made through work at Fred Hutch is requested of all finalists.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization.  We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.   

Our laboratory focuses on how gene regulation, chromatin structure, and nuclear organization are linked, with a special emphasis on changes that occur with differentiation.  This is a part-time position where effort is negotiable depending on the candidates’ skills and needs. The person in this position will be the lead on a collaborative project to define all cis-acting regulatory sequences on a genome-wide basis. The focus of this work is the isolation of defined populations of hematopoietic cells at defined stages of development and differentiation with the goal of subjecting them to a variety of molecular analyses. Samples will be obtained from wildtype and mutant mice, at baseline, and while recovering from stress.  The candidate will prepare samples for analysis by Next Generation Sequencing (NGS).  This work will require managing a mouse colony as well as isolating and analyzing mouse tissues.

Responsibilities

The research technician will work under the direct supervision by the principal investigators and be working with outside collaborators. This individual will be the sole Fred Hutch person doing bench work on this project and will need to work semi-independently and be adept at balancing responsibilities. To be successful in this laboratory the technician will need to work fairly autonomously and take the lead on trouble-shooting.  Excellent communication, documentation and organization skills are essential.

Qualifications

Required:

• Bachelor’s degree in biology or related fields as well as two or five years of professional experience are required for the research technician II and III levels, respectively.
• Hands on mouse handling experience.
• The ability to master new techniques with limited supervision.
• Basic media and reagent preparation.
• The successful candidate must be highly motivated, reliable and take projects from conception to conclusion while working with intermittent supervision. 
• Good organizational, time-management and documentation skills.

Preferred:

• Comfort, and being facile with flow cytometry, including optimizing antibody staining and data analysis. Having job experience with this would be a major benefit.

• Comfort with basic mouse husbandry, genotyping and isolation of organs. Having job experience with this would be a major benefit.

• Tissue culture experience.

Overview

Cures Start Here. At Fred Hutchinson Cancer Research Center, home to three Nobel laureates, interdisciplinary teams of world-renowned scientists seek new and innovative ways to prevent, diagnose and treat cancer, HIV/AIDS and other life-threatening diseases. Fred Hutch’s pioneering work in bone marrow transplantation led to the development of immunotherapy, which harnesses the power of the immune system to treat cancer. An independent, nonprofit research institute based in Seattle, Fred Hutch houses the nation’s first cancer prevention research program, as well as the clinical coordinating center of the Women’s Health Initiative and the international headquarters of the HIV Vaccine Trials Network. Careers Start Here.

At Fred Hutch, we believe that the innovation, collaboration, and rigor that result from diversity and inclusion are critical to our mission of eliminating cancer and related diseases. We seek employees who bring different and innovative ways of seeing the world and solving problems. Fred Hutch is in pursuit of becoming an antiracist organization. We are committed to ensuring that all candidates hired share our commitment to diversity, antiracism, and inclusion.

The Bloom lab at the Fred Hutch Cancer Research Center has an opening for a research technician to assist with studies of how mutations to viral proteins affect recognition by antibodies and immunity. In the near-term, the scientist will focus on the impact of mutations to SARS-CoV-2. This is an exciting project that will shed light on basic principles of viral evolution and immunity and will also having immediate impacts on antibody therapeutics or vaccines.

We will consider applicants with a wide range of experience provided that your application clearly explains why you are suited for this position, and why you think you could work well on this project with other members of our lab. Therefore, when preparing your application, please keep in mind that our evaluation will be based heavily on how well the cover letter fully and lucidly explains your interest, motivation, and ideas for this position in relation to the ongoing research described in the two publications below - that is as important as past experience listed on your CV.

Specifically, interested applicants should read the following two publications and include in their cover letter an explanation of why they find this research interesting and any ideas they have about how it could be extended to address new questions relevant to viral evolution, antibodies, and vaccines:

• Greaney et al, Cell Host & Microbe, DOI 10.1016/j.chom.2020.11.007
• Starr et al, bioRxiv, DOI 10.1101/2020.11.30.405472
   

Please include a cover letter that fully explains your interest, motivation, and ideas for this position as relevant to the publications above.

Responsibilities

• Work with graduate students and post-docs to perform deep mutational scanning experiments.
• Flow cytometry/FACS, deep sequencing library preparation, and possibly generation of mutant libraries.
• Virology experiments and computational analyses.
• Is independently responsible and accountable for design and implementation of a major project related to the research goals of the lab.
• Maintains communication with others in the scientific community regarding issues related to both the general project area and the specific research project
• Utilizes literature reviews, protocols, networking and prior laboratory experience to determine the most suitable methods and resources to be used in research.
• Summarize and write for publication or presentation the results of research projects, often as co-author or author.  Write and edit reports of research.
• Responsible for the daily operation of the laboratory; may lead or supervise other laboratory personnel.

Qualifications

• Ability to work collaboratively with other scientists in the lab and beyond

• Exceptional organization and time management skills

Research Technician III

• Bachelor's degree in biology or a related field
• At least three to five years prior experience in scientific research
   

Research Technician IV

• Bachelor's degree in relevant field, Master's or PhD preferred
• Minimum of eight years prior experience in scientific research
• Experience in one or more of the following areas preferred: flow cytometry/FACS, deep sequencing library preparation, generation of mutant libraries

A statement describing your commitment and contributions toward greater diversity, equity, inclusion, and anti-racism in your career or that will be made through work at Fred Hutch is requested of all finalists.