CCRC Clinical Studies

Potential study participants talking with nurse

Advancing COVID-19 Clinical Research

The CCRC researchers are focused on the advancement of effective therapeutics and interventions for COVID-19 and hope to further the develop treatment and prevention that could be accessible for community members locally and globally, outside of a hospital setting.

The CCRC research teams have conducted a wide range COVID-related clinical studies, including treatment and prophylaxis use of monoclonal antibody infusions/injections and oral antiviral medications. The research participation opportunities that are open for enrollment and that have previously taken place at the CCRC are detailed below for reference. Study sponsors cover all clinical study-related costs. The CCRC is not a hospital and will only have participation from volunteers that fit the study criteria and fully consent to participation.

 Interested in volunteering for one of our studies? Contact us to see if you qualify.

Your Health is Our Priority

The COVID-19 Clinical Research Center has been designed with safety top of mind with separate entrances and exits for study volunteers, optimized medical-grade air flow, private clinic rooms, extensive cleaning & disinfecting protocols and more. If you are chosen to join a study, your health will be closely monitored and care adjusted if our team determines that it is in your best interest. You may also end the study at any time without having to provide a reason.

Qualifying for Our Studies

Our studies are inclusive of adult participants of all races, ethnicities, and backgrounds to help Researchers understand the best treatment medicines and methods across diverse populations. The facility plans to support COVID-positive study participants as well as those that have recently recovered from COVID infection. Each study has different criteria for participation. Review each study listed below for more information on the eligibility criteria.

About Informed Consent

Before you participate in a study, our researchers will make sure you understand the details of the study and all of the possible known benefits, risks and alternatives to the trial in a process known as informed consent. This time will help you learn the facts about the study before deciding to take part in the trial. Informed consent is not a contract and you always have a right to ask our team questions or end your involvement at any time during the trial. 

Current Studies — There are No Studies Currently Open for Enrollment

Fred Hutch is also seeking volunteers for observational and vaccine trials for COVID-19.

Past Studies — No Longer Enrolling

Study Understanding Pre-Exposure Prophylaxis of Novel Antibodies (SUPERNOVA) – AstraZeneca

A Phase III randomized, double-blind study to evaluate the safety, efficacy, and neutralizing activity of AZD5156/AZD3152 for pre-exposure prophylaxis of COVID-19 in participants with conditions causing immune impairment.

The goal of this clinical study was to evaluate the safety and neutralizing activity for pre-exposure prophylaxis of COVID-19 in adults who are negative for COVID-19 infection and have a condition causing immune impairment, who are less likely to mount an adequate protective immune response after vaccination and thus are at high risk of developing severe COVID-19.

Nirmatrelvir/Ritonavir (Paxlovid) — Pfizer

An interventional efficacy and safety, phase 2, randomized, double-blind, 3-arm study to investigate Nirmatrelvir/Ritonavir in non-hospitalized participants at least 18 years of age with symptomatic COVID-19 who are immunocompromised.

The purpose of this study was to assess the efficacy, safety, and tolerability of Paxlovid (Nirmatrelvir/Ritonavir) taken for different durations — 5 days (standard of care), 10 days, or 15 days - for adults who had recently tested positive for COVID-19, were actively symptomatic, with a compromised immune system. In addition, the study evaluated the efficacy and safety of a second treatment course of Paxlovid (Nirmatrelvir/Ritonavir) for adults with a compromised immune system who experience that their COVID-19 is flaring-up (rebounding) within 14 days of having taken a 5-day treatment course of Paxlovid (Nirmatrelvir/Ritonavir)

molnupiravir MK-4482-013 — Merck Sharp & Dohme Corp.

A Phase 3, Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate the Efficacy and Safety of MK-4482 for the Prevention of COVID-19 (Laboratory-confirmed SARS-CoV-2 Infection With Symptoms) in Adults Residing With a Person With COVID-19.

The primary objective of this phase 3, multicenter, randomized, double-blind, placebo-controlled study was to determine the efficacy, and safety/tolerability, of molnupiravir (MK-4482) in preventing COVID-19 infection in adults who were residing with a person recently infected with COVID-19. 

Resolve RSLV-132 - Resolved Therapeutics

A phase 2, double-blind, placebo-controlled study of RSLV-132 in subjects with post-acute COVID-19 (long COVID). 

This study’s objective, as a Phase 1 study, was to determine the highest tolerated dose of an investigational cell therapy called DVX201 in patients hospitalized with COVID-19.

DVX201 - Deverra Therapeutics, Inc.

A Phase 1 Study of DVX201, an Allogeneic Natural Killer (NK) Cell Therapy in Subjects Hospitalized for COVID-19

This study’s objective, as a Phase 1 study, was to determine the highest tolerated dose of an investigational cell therapy called DVX201 in patients hospitalized with COVID-19.

casirivimab+imdevimab REGN-2176 - Regeneron Pharmaceuticals, Inc

A phase 3, randomized, double-blind, placebo-controlled study to evaluate the efficacy and safety of anti-spike SARS-CoV-2 monoclonal antibodies as pre-exposure prophylaxis to prevent COVID-19 in immunocompromised participants.

This study’s primary objective was to evaluate the effect of casirivimab + imdevimab, compared with placebo, in preventing symptomatic SARS-CoV-2 infection in immunocompromised participants. .

molnupiravir MK-4482-002 — Merck Sharp & Dohme Corp.

A Phase 2/3, Randomized, Placebo-Controlled, Double-Blind Clinical Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of MK-4482 in Non-Hospitalized Adults with COVID-19.

This study aimed to evaluate the safety, tolerability and efficacy of molnupiravir (MK-4482) compared to placebo. This study enrolled adults who had recently tested positive for SARS-COV-2 and had experienced at least one related mild or moderate symptom. Patients between the ages of 18-59 were required to have at least one pre-existing risk factor to be eligible.


sotrovimab VIR COMET TAIL — Vir Biotechnology Inc

A Phase 3 randomized, multi-center, open label study to assess the efficacy, safety, and tolerability of monoclonal antibody VIR-7831 (sotrovimab) given intramuscularly versus intravenously for the treatment of mild/moderate coronavirus disease 2019 (COVID-19) in high-risk non-hospitalized patients

This was a phase 3 study that compared the administration route of an intramuscular shot to IV infusion of sotrovimab, a monoclonal antibody with FDA emergency use authorization, for the early treatment of non-hospitalized patients with COVID-19.

REGN 2067 — Regeneron Pharmaceuticals

A Master Protocol Assessing the Safety, Tolerability, and Efficacy of Anti-Spike (S) SARS-CoV-2 Monoclonal Antibodies for the Treatment of Ambulatory Patients With COVID-19

The REGN 2067 study tested an infusion of REGN-COV2, a combination of two antibodies against SARS-CoV-2, the virus that causes COVID-19, to see whether they could: decrease the amount of virus in the body; decrease the length of time the virus is in the body; and decrease the length and severity of COVID-19 illness.

Remdesivir — Gilead Sciences, Inc

A Phase 3 Randomized, Double-Blind Placebo-Controlled Trial to Evaluate the Efficacy and Safety of Remdesivir (GS-5734™) Treatment of COVID-19 in an Outpatient Setting

The primary objectives of this study were to evaluate the efficacy of remdesivir (RDV) in reducing the rate of coronavirus disease 2019 (COVID-19) related hospitalization or all-cause death in non-hospitalized participants with early stage COVID-19 and to evaluate the safety of RDV administered in an outpatient setting.

StopCOVID2 — Washington University School of Medicine, St Louis

Fluvoxamine for Early Treatment of COVID-19: A Fully-remote, Randomized Placebo Controlled Trial

The purpose of this research study was to determine if a drug called fluvoxamine could be used early in the course of the COVID-19 infection to prevent more serious complications like shortness of breath. Fluvoxamine is an anti-depressant drug approved by the FDA for the treatment of obsessive-compulsive disorder. The use of fluvoxamine for the treatment of COVID-19 was considered investigational, which means the US Food and Drug Administration has not approved it for this use. This study was fully-remote, which means that there is no face-to-face contact; study materials including study drug were shipped to participants' houses. People around the United States and Canada could participate.

EIDD 2801 — Ridgeback Therapeutics

This is a phase IIa, double-blind, placebo-controlled, randomized trial, designed to compare the safety, tolerability, and antiviral activity of EIDD-2801 versus placebo as measured by infectious virus detection in symptomatic adult outpatients with COVID-19.

This study was Phase 2 of Merck’s MK-4482-002 study, under Ridgeback Therapeutics. Preliminary results show a reduction in infection time with no adverse events reported that were study drug related.

Fred Hutchinson Cancer Center campus, COVID-19 Clinical Research Center

COVID-19 Clinical Research Center

Entrance A:
820 Minor Ave N.
Seattle, WA 98109

Entrance B:
1205 Aloha St.
Seattle, WA 98109

Phone: 206.667.7100
Work Location: 820 Minor Ave N. Seattle, WA 98109