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Study of the CHK1 Inhibitor BBI-355, an EcDNA-directed Therapy (ecDTx), in Subjects with Tumors with Oncogene Amplifications (POTENTIATE)
Complete Title: An Open-Label, Multicenter, First-in-Human, Dose-Escalation and Dose-Expansion, Phase 1/2 Study of BBI-355 and BBI-355 in Combination with Select Targeted Therapies in Subjects with Locally Advanced or Metastatic Solid Tumors with Oncogene Amplifications
Trial Phase: I/II
Investigator: Andrew Coveler
BBI-355 is an oral, potent, selective checkpoint kinase 1 (or CHK1) small molecule inhibitor in development as an ecDNA (extrachromosomal DNA) directed therapy (ecDTx). This is a first-in-human, open-label, 3-part, Phase 1/2 study to determine the safety profile and identify the maximum tolerated dose and recommended Phase 2 dose of BBI-355 administered as a single agent or in combination with select therapies.
Keywords:
- Bladder Cancer; Breast Cancer; Endometrial Cancer; Carcinoma, Squamous Cell; Esophageal Cancer; Gastric Cancer; Head and Neck Cancer; Ovarian Cancer; Lung Carcinoma, Non-Small-Cell (NSCLC); Liposarcoma
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