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Golimumab and Apalutamide for the Treatment of Castration-Resistant Prostate Cancer, TRAMP Study
Complete Title: TRAMP: Tumor Necrosis Factor- α Blockade Enhances AR Inhibition in Men with CRPC
Trial Phase: II
Investigator: Ruben Raychaudhuri
This phase II trial tests how well golimumab and apalutamide work in treating patients with castration resistant prostate cancer. Golimumab is in a class of medications called tumor necrosis factor (TNF) inhibitors. It works by blocking the action of TNF, a substance in the body that causes inflammation. Apalutamide is in a class of medications called androgen receptor inhibitors. It works by blocking the effects of androgen (a male reproductive hormone) to stop the growth and spread of cancer cells. Giving golimumab and apalutamide may work better in treating patients with castration-resistant prostate cancer.
Keywords:
- Prostate Cancer; Prostate Cancer, Castration-resistant (CRPC)
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