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Patient Guide to Clinical TrialsTegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Complete Title: A Phase 1/2 Study of Tegavivint (IND#156033, NSC#826393) in Children, Adolescents, and Young Adults with Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Trial Phase: I/II
Investigator: Katherine Tarlock
This phase I/II trial evaluates the highest safe dose, side effects, and possible benefits of tegavivint in treating patients with solid tumors that has come back (recurrent) or does not respond to treatment (refractory). Tegavivint interferes with the binding of beta-catenin to TBL1, which may help stop the growth of tumor cells by blocking the signals passed from one molecule to another inside a cell that tell a cell to grow.
Keywords:
- Endometrial Cancer; Melanoma; Neuroblastoma; Lymphoma, Non-Hodgkin (NHL); Ovarian Cancer; Sarcoma; Colorectal Neoplasms; Carcinoma, Hepatocellular; Fibromatosis, Aggressive; Hepatoblastoma; Solid Tumors; Wilms' Tumor; Neoplasms; Sarcoma, Ewing; Osteosarcoma; Adenocarcinoma
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