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Shadman
Mazyar Shadman, MD, MPH

Mazyar Shadman, MD, MPH

Medical Oncology

  • Deputy Chief Medical Officer, Fred Hutch
  • Medical Director, Cellular Immunotherapy; Bezos Family Immunotherapy Clinic, Fred Hutch
  • Professor, Clinical Research Division, Fred Hutch
  • Innovators Network Endowed Chair, Fred Hutch
  • Member, Immunotherapy Integrated Research Center (IIRC), Fred Hutch
  • Affiliate Investigator, Translational Science and Therapeutics Division, Fred Hutch
  • Professor, Division of Hematology and Oncology, University of Washington School of Medicine

About

Dr. Mazyar Shadman is a board-certified hematologist-oncologist and stem-cell transplant expert who specializes in treating patients with lymphomas and other blood disorders at Fred Hutch. 


Background

Dr. Shadman serves as deputy chief medical officer for classical hematology, hematologic malignancies, transplant and immunotherapy at Fred Hutch. His clinical research focuses on testing novel agents for leukemia and lymphoma, particularly chronic lymphocytic leukemia (CLL), and on studying outcomes in patients who have already received treatment. His goal is to identify patient  or disease specific factors that help predict how a cancer behaves and responds to different therapies.

Dr. Shadman also studies the epidemiology of hematologic neoplasms, meaning patterns and causes of abnormal growth in blood forming tissue. In 2013, he co authored a study that identified a correlation between certain allergies and blood cancers. In additional research, he focuses on lymphoid malignancies using new therapeutic agents, immunotherapy such as CAR T-cell therapy (a treatment that uses a patient’s own immune cells to target cancer) and blood stem cell transplantation. His goal is to identify the best treatment sequence or combination for patients with high-risk lymphoma and CLL.

Area of Clinical Practice
Adult blood and marrow transplantation, cellular immunotherapy, hematologic malignancies


“Your positive attitude and willingness to fight have always inspired me.”

— Dr. Shadman


What do you enjoy about being an academic physician?

Every day, I get to integrate science with the art of human interaction. Seeing patients benefit from medical advances, and being active in pushing the science forward, is extremely rewarding. It’s an exciting time for both cancer care and research. We now have access to a variety of novel therapies that enable us to target cancer cells more specifically without causing major side effects. In my field, we’re always looking for a “cure,” but in the meantime, I’m hopeful that we can relegate cancer to a chronic disease and help patients maintain their desired quality of life.

What is your role in cancer treatment?

A diagnosis of cancer kicks off a torrent of life changes, and in the middle of all this disruption are many important decisions to make about your care. My role is to help you thoroughly understand and weigh your options. At Fred Hutch, you have access to a variety of standard and experimental treatments, from chemotherapy to more novel, targeted approaches that may have fewer side effects. We’ll discuss each option in detail — the potential benefits, the risks and the overall impact on your life and family — so that you can make the best choices for your unique situation.

Diseases Treated

Chronic Lymphocytic Leukemia

Cutaneous Lymphoma

Diffuse Large B-cell Lymphoma

Follicular Lymphoma

Hodgkin Lymphoma

Low Grade Lymphoma

Lymphoma

MALT Lymphoma

Mantle Cell Lymphoma

Marginal Zone Lymphoma

Non-Hodgkin Lymphoma

Waldenström Macroglobulinemia

Research Interests

Therapeutic clinical trials in lymphoid malignancies with a focus on chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)

Clinical outcome research in hematopoietic cell transplantation

Epidemiology of hematologic malignancies

Languages

English
Persian

Education and Experience

Fellowship, Hematology and Medical Oncology, Fred Hutch/University of Washington

Residency, Internal Medicine, Cleveland Clinic

MPH, Cancer Epidemiology, University of Washington School of Medicine

MD, Tehran University of Medical Sciences

Board Certifications

Medical Oncology, 2014; Hematology, 2014; Internal Medicine, 2011; American Board of Internal Medicine

Clinical Trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch physicians and researchers. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your physician can decide if a study is right for you. 

Find a Clinical Trial Led by Dr. Shadman

Publications

Many of our Fred Hutch physicians and researchers conduct ongoing research to improve standards of patient care. Their work is evaluated by other physicians and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch physician has written. 

View Dr. Shadman's Publications

Your Care Team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes physicians, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like registered dietitians, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders. 

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

Stories

All news
Oncology Insights with Dr. Petros Grivas - Episode 10 Inside the world of immunotherapy: innovations and access strategies with Dr. Mazyar Shadman March 24, 2026
New long-term analysis suggests follicular lymphoma can be cured The findings could change patient and provider expectations and influence how patients are followed after treatment February 26, 2026
For many blood cancer patients, CAR T-cell therapy is game-changing In this episode of From Bench to Bedside and Beyond, Dr. Mazyar Shadman explains why CAR T-cell therapy should be considered for patients who relapse December 2, 2025

Contact Information

206.667.5467

206.667.1874