/content/dam/www/people-profile-photos/p/andrew-portuguese/provider-andrew-portuguese-directory-1x.jpg
/content/dam/www/people-profile-photos/p/andrew-portuguese/provider-andrew-portuguese-directory-2x.jpg
Portuguese
Andrew Jay Portuguese, MD

Andrew Jay Portuguese, MD

Hematology-Oncology

  • Physician, Fred Hutch
  • Assistant Professor, Clinical Research Division, Fred Hutch
  • Assistant Professor, Division of Hematology and Oncology, University of Washington School of Medicine
Request an Appointment

About

Dr. Andrew Jay Portuguese is a board-certified physician and researcher at Fred Hutch who specializes in blood and marrow transplantation and immunotherapy.

Background

Dr. Portuguese is board certified in medical oncology, hematology and internal medicine. His patient care work spans blood and marrow transplantation (BMT), immunotherapy and multiple myeloma. He cares for patients receiving a BMT and immune‑based therapies and focuses on treating multiple myeloma, a complex blood cancer where treatment decisions often depend on careful sequencing, timing, prior therapies and individual patient factors.

He values his role at the intersection of transplantation and multiple myeloma care, working closely with patients to help determine when and how different treatment options may offer the best possible outcomes. He emphasizes personalized guidance, recognizing that successful care is not only about meeting eligibility criteria but also about understanding the full clinical picture over time.

As a researcher, Dr. Portuguese has contributed to the field through multiple publications, particularly in statistical modeling of real‑world data and in conducting clinical trials focused on multiple myeloma. His work aims to improve how treatments are evaluated, sequenced and applied in everyday patient care.

Area of Clinical Practice
Blood and marrow transplant, immunotherapy, multiple myeloma

Follow Andrew Portuguese

“The mystery and uncertainty of cancer can be really harrowing. I want people to come away feeling like they know what their options are and understand possible paths forward.”

— Dr. Portuguese

What brought you to oncology?

My grandfather had multiple myeloma during a time when there really weren't a lot of treatments. Today, I like to think he would have done better. And, even though my uncle had smoldering multiple myeloma that he never needed treatment for, it was still a very scary diagnosis for him that affected everything, as well. From these experiences, I have an appreciation for the psychological impact of a major illness on a family.

What do you find interesting or motivating about your work?

I’m very data oriented, and a lot of what I do involves analyzing data – I was a physics major as an undergraduate student. I really believe in evidence-based medicine, so I want to make sure we’re making use of all the data we have to make the best decisions for our patients. I also want to present options that are going to have the highest likelihood of the outcome a patient wants to achieve.

Diseases Treated

Lymphoma

Multiple Myeloma

Research Interests

Statistical Modeling of Real-World Data

Clinical Trials in Multiple Myeloma

Languages

English

Education and Experience

Fellowship, Hematology and Oncology, University of Washington

Residency, Internal Medicine, University of Rochester

MD, University of Rochester School of Medicine

BA, Hamilton College

Board Certifications

Medical Oncology, 2023; Hematology, 2023; Internal Medicine, 2020; American Board of Internal Medicine

Clinical Trials

We make promising new treatments available to you through studies called clinical trials led by Fred Hutch physicians and researchers. Many of these trials at Fred Hutch have led to FDA-approved treatments and have improved standards of care globally. Together, you and your physician can decide if a study is right for you.

Find a Clinical Trial Led by Dr. Portuguese

Publications

Many of our Fred Hutch physicians and researchers conduct ongoing research to improve standards of patient care. Their work is evaluated by others in their field and selected for publication to the United States National Library of Medicine, the largest medical library in the world. See scientific papers this Fred Hutch physician has written.

View Dr. Portugues's Publications

Your Care Team

At Fred Hutch, you receive care from a team of providers with extensive experience in your disease. Your team includes physicians, a patient care coordinator, a registered nurse, an advanced practice provider and others, based on your needs. You also have access to experts like registered dietitians, social workers, acupuncturists, psychiatrists and more who specialize in supporting people with cancer or blood disorders.

Meet Other Providers

Insurance

Fred Hutch accepts most national private health insurance plans as well as Medicare. We also accept Medicaid for people from Washington, Alaska, Montana and Idaho. We are working to ensure that everyone, no matter what their financial situation, has access to the care they need.

More About Insurance

Contact Information

206.667.6656