Edus Houston Warren, MD, PhD

faculty member

Edus Houston Warren, MD, PhD

Program Head
Global Oncology Program, Fred Hutch

Translational Science and Therapeutics Division, Fred Hutch

Vaccine and Infectious Disease Division, Fred Hutch

Immunotherapy Integrated Research Center (IIRC), Fred Hutch

Pathogen-Associated Malignancies Integrated Research Center (PAM IRC), Fred Hutch

Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

Fax: 206.667.2917
Mail Stop: S3-204

Edus "Hootie" Warren, MD, PhD, is an oncologist and cancer immunologist with expertise in cellular and molecular dissection of antitumor immune responses. Dr. Warren is the program head for Global Oncology at Fred Hutchinson Cancer Center. His laboratory has a long-standing interest in harnessing the exceptional specificity and potency of T cells for cancer recognition and elimination. Currently, his lab's primary focus is on the development of T-cell therapy for advanced kidney cancer.

In his role as program head for Global Oncology, Dr. Warren leads an international team consisting of over 50 individuals, primarily based at the Hutchinson Centre Research Institute in Kampala, Uganda. This team is dedicated to conducting research aimed at enhancing the prevention, diagnosis and treatment of cancer in low- and middle-income countries, focusing on studying Kaposi sarcoma, non-Hodgkin lymphoma, breast cancer and lung cancer.

Throughout his career, Dr. Warren has exhibited a passionate commitment to the training of future biomedical scientists and investigators. He has served or is currently serving as the primary mentor for numerous high school and undergraduate students as well as many doctorate students, postdoctoral fellows and medical fellows.  Dr. Warren is deeply dedicated to fostering the development of future clinicians and investigators in all health-related fields, with a particular emphasis on cancer.

Other Appointments & Affiliations

Attending Physician
Fred Hutchinson Cancer Center

Professor of Medicine
University of Washington School of Medicine


Fellow, Medical Oncology; University of Washington 1993-1996

Intern and Resident, Internal Medicine; Massachusetts General Hospital; 1991-1993

MD, Harvard Medical School, 1991

PhD, Neurobiology; Harvard University, 1988

AB, Applied Mathematics; Harvard College, 1982

Research Interests

High-throughput Sequencing of T- and B-Cell Antigen Receptor Repertoires

Mechanisms of Cancer Regression After Immune Checkpoint Inhibition

Immunology and Immunotherapy of Kidney Cancer

Pathogenesis, Treatment and Prevention of Pediatric and Adult Lymphomas in Sub-Saharan Africa

Immunobiology of Graft-versus-Host Disease and the Graft-versus-Tumor Effect

Clinical Expertise

Dr. Warren is an oncologist specializing in the treatment of patients with blood cancers such as leukemia, lymphoma, and multiple myeloma. He is an Attending Physician at Fred Hutchinson Cancer Center, University of Washington, and Seattle Children’s Hospital, where he serves on both the Medical Oncology/Hematologic Malignancy and the Hematopoietic Cell Transplant Services. He has considerable experience as an investigator on clinical trials of novel agents for the treatment of blood cancers, and served as the Principal Investigator on a Phase I clinical trial of T cell immunotherapy for patients with relapse of acute leukemia or high-grade myelodysplasia after HLA-identical allogeneic hematopoietic cell transplantation (HCT).

Research Focus

The overall focus of Dr. Warren’s laboratory is cancer immunology. His particular interest is the mechanisms and molecules that mediate graft-versus-host disease (GVHD) and graft-versus-tumor (GVT) activity after allogeneic HCT, as well as the mechanisms that mediate tumor regression after treatment with other modes of immunotherapy such as immune-checkpoint inhibition. His lab has extensive experience with characterization and manipulation of human T and B lymphocytes, identification of antigens recognized by T and B lymphocytes, comprehensive analysis of T- and B-lymphocyte repertoires with the aid of high-throughput DNA sequencing, and assessment of adoptive cellular therapy in murine models. Dr. Warren’s laboratory also has a strong research focus on lymphomas that affect children and adults in sub-Saharan Africa, particularly Burkitt lymphoma (BL).

"One of our major goals is to figure out how we can adapt the incredibly exciting work that’s done here so that it can benefit people around the world."

— Dr. Hootie Warren

Find A Clinical Trial

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210