Barry Stoddard, PhD
Barry Stoddard, PhD
Professor
Basic Sciences Division, Fred Hutch
Dr. Barry Stoddard is an expert in protein structure and engineering. He uses cutting-edge laboratory and computational techniques to reveal proteins’ 3D forms at the atomic level, which is key to his ultimate goal: modifying natural proteins to treat or cure human diseases. In particular, his group has made major contributions to the understanding of gene-targeting proteins, from determining their structure to creating variants for use in gene therapy. Dr. Stoddard’s work could lead to engineered proteins that are capable of correcting mutations that underlie genetic diseases like cystic fibrosis, and he’s working on proteins that could cure HIV and other chronic infections.
Other Appointments & Affiliations
Affiliate Professor, Biochemistry
University of Washington School of Medicine
Director
NCI Interdisciplinary Training Program in Cancer
Education
PhD, Biophysical Chemistry, Massachusetts Institute of Technology, 1990
BS, Chemistry/Biology, Whitman College, 1985
Research Interests
The structure, mechanism, and engineering of proteins and enzymatic catalysts for basic research and biomedical applications
Current Projects
Research on gene-specific endonucleases, nucleic acid enzymes, structural enzymology and protein engineering
"Whether it’s my particular approach or not, there’s no question that [targeted gene correction] is going to happen before my career is over."
— Dr. Barry Stoddard
Dr. Stoddard in the News
For the Media
The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.
Email media@fredhutch.org or call 206.667.2210