Leonidas Stamatatos, Ph.D.

faculty member

Leonidas Stamatatos, Ph.D.

Vaccine and Infectious Disease Division, Fred Hutch

Fax: 206.667.7767
Mail Stop: E5-110

Dr. Leonidas “Leo” Stamatatos and his team of researchers explore how antibody-producing B cells respond to infection and vaccination. Using diverse experimental approaches, the researchers also design and test ways to stimulate B cells into producing the antibodies deemed most likely to succeed against a chosen virus. Much of the work focuses on getting B cells to make antibodies that can provide sustained protection against HIV, which is adept at evading conventional vaccines through rapid genetic mutation. The group’s work encompasses the many stages in the development of candidate vaccines. These range from early, basic research on the structure of antibodies and their targets to detailed evaluation of the level of protection they provide to human volunteers in clinical trials.

Other Appointments & Affiliations

Affiliate Professor, Department of Global Health
University of Washington


Ph.D., Biochemistry, McGill University, Canada, 1988

M.Sc., Organic Chemistry, Université de Paris XI, France, 1983

B.A., Biochemistry, Université d’Orleans, France, 1982

Current Projects

Development of methodologies that improve the activation and survival of B cells producing protective antibodies against human viruses

Comparing B cell responses elicited by mRNA and non-mRNA coronavirus vaccines

Phase I clinical testing of a novel HIV vaccine

Find A Clinical Trial

Dr. Stamatatos in the News

Latest Fred Hutch research on COVID-19

Hutch News - July 29, 2021

AIDS@40: Stories of hope and heroes

Hutch News - May 27, 2021

A year of research dominated by the coronavirus

Hutch News - December 21, 2020

Fearless Science is ...

Hutch News - November 30, 2020

All immunogens are not created equal

Science Spotlight - November 16, 2020

COVID-19 Research at the Hutch

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210