Human Biology Division, Fred Hutch
Dr. Patrick Paddison uses cutting-edge genetic techniques to understand stem cells, which can develop into many different types of cells. He studies the gene networks and DNA modifications that contribute to stem cells’ choice to remain stem cells or to begin the process of developing into a new type of cell, as well as which cell type to become. Tumors can hijack these normal processes to generate cancer stem cells that fuel tumors. Dr. Paddison is an expert in the use of genome editing and other innovative genetic technologies that allow researchers to tease out the function of specific genes throughout the genome. His insights may contribute to the search for new therapeutics aimed at thwarting cancer stem cells.
Ph.D., Biological Sciences, Cold Spring Harbor Laboratory, 2004
B.A., Psychology, The Evergreen State College, 1996
B.S., Molecular Biology and Genetics, The Evergreen State College, 1996
The Paddison Lab uses functional genomics to probe the underlying biology of normal and cancerous stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of CRISPR-Cas9 and RNAi technologies. For our cancer studies we create novel models of precision functional genomics directly in patient tumor isolates.
—Dr. Patrick Paddison