Patrick Paddison, PhD

faculty member

Patrick Paddison, PhD

Human Biology Division, Fred Hutch

Fax: 206.667.4023
Mail Stop: C3-168

Dr. Patrick Paddison uses cutting-edge genetic techniques to understand stem cells, which can develop into many different types of cells. He studies the gene networks and DNA modifications that contribute to stem cells’ choice to remain stem cells or to begin the process of developing into a new type of cell, as well as which cell type to become. Tumors can hijack these normal processes to generate cancer stem cells that fuel tumors. Dr. Paddison is an expert in the use of genome editing and other innovative genetic technologies that allow researchers to tease out the function of specific genes throughout the genome. His insights may contribute to the search for new therapeutics aimed at thwarting cancer stem cells.


PhD, Biological Sciences, Cold Spring Harbor Laboratory, 2004

BA, Psychology, The Evergreen State College, 1996

BS, Molecular Biology and Genetics, The Evergreen State College, 1996

Research Interests

The Paddison Lab uses functional genomics to probe the underlying biology of normal and cancerous stem/progenitor cells. We identify and characterize gene products affecting stem cell self-renewal, differentiation, proliferation, or survival through the use of CRISPR-Cas9 and RNAi technologies. For our cancer studies we create novel models of precision functional genomics directly in patient tumor isolates.

"[RNAi technology] has sort of been a revolution. It has allowed us to address questions we wouldn't otherwise be able to address."

— Dr. Patrick Paddison

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For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210