Associate Professor, Immunology and Vaccine Development Program
Vaccine and Infectious Disease Division, Fred Hutch
Dr. Andrew McGuire is a molecular and cellular biologist who works on the design of HIV vaccines. His research is focused on developing immunogens — molecules that would cause the immune system to generate protective proteins, or neutralizing antibodies, to block the virus. Because HIV mutates so rapidly, conventional antibodies do not provide lasting protection. So, Dr. McGuire is working on coaxing the immune system to generate so-called broadly neutralizing antibodies, which are difficult for HIV to evade and more effective at protecting against different strains. His lab also works on the design of vaccines against Epstein-Barr virus, which can cause mononucleosis and certain cancers.
Ph.D., Molecular and Cellular Biology, University of Guelph, Ontario, 2011
B.Sc., Molecular Biology and Genetics, University of Guelph, 2004
HIV-1 Immunogen Design
Development of Broadly Neutralizing Antibodies in HIV-1 Infection
Antigen-B cell interactions
Developing, producing, and assessing novel immunogens to elicit broadly neutralizing antibodies against HIV-1
Developing and testing vaccines against Epstein-Barr virus
— Dr. Andrew McGuire
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