Keith Loeb, MD, PhD

Dr. Keith Loeb MD, PhD
faculty member

Keith Loeb, MD, PhD

Associate Professor
Translational Science and Therapeutics Division, Fred Hutch

Associate Professor
Public Health Sciences Division, Fred Hutch

Fax: 206.606.1345
Mail Stop: G7-910

Dr. Keith Loeb is an experimental hematopathologist. His basic science studies have focused on molecular processes leading to genetic instability and cancer. Using preclinical models, Dr. Loeb explores how abnormal cell cycle regulation impacts cell growth, differentiation and stem cell maintenance. His work has shown that misregulation of cyclin E, a key factor in driving DNA synthesis, can lead to chromosomal abnormalities and cancer. The loss of regulatory pathways that normally inhibit excess cyclin E function promotes more aggressive cancer development. Dr. Loeb is currently studying mutations that arise in super-enhancers and their relationship to chromosomal instability and gene expression. Dr. Loeb’s clinical work focuses on the pathologic complications of blood stem cell transplantation and hematopathology. He is an expert in the diagnosis and evaluation of graft-vs.-host disease and infectious complications associated with blood stem cell transplant. Dr. Loeb is currently studying the impact of donor-derived microglial cells in the brain following transplant.

Other Appointments & Affiliations

Associate Professor, Pathology
University of Washington

Adjunct Associate Professor, Laboratory Medicine
University of Washington


MD, Medical College of Wisconsin, 1995

PhD, Biochemistry, Medical College of Wisconsin, 1994

Current Projects

Characterization of super-enhancer mutations in normal and malignant myeloid cells

Donor cell engraftment in the microglial compartment in stem cell transplant patients

Effect of ETS transcriptional factors in promoting acute myeloid leukemia

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For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210