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Sylvia Lee, M.D.

Sylvia Lee M.D.
faculty member

Sylvia Lee, M.D.

Associate Professor, Program in Immunology
Clinical Research Division, Fred Hutch

Fax: 206.606.1435
Mail Stop: K2-231

Dr. Sylvia Lee is interested in developing T-cell therapies for solid tumors. She collaborates with lab-based investigators to help bring novel T-cell constructs to clinical trials in patients. One type of this cancer immunotherapy that she studies is called tumor infiltrating lymphocyte, or TIL, therapy. TILs are T cells that can attack cancer but get shut off by tumors before they can eradicate the disease. To harness TILs’ power, researchers extract these dormant cells from a piece of tumor and reactivate them in the lab. They then select those cells best able to recognize and attack the tumor and multiply those cells to the billions in the laboratory before reinfusing them into patients. This experimental strategy may hold particular promise for treating patients with highly mutated cancers like melanoma. Dr. Lee started Fred Hutch’s TIL program and works with industry to help expand TIL therapy to other types of cancer. An oncologist, Dr. Lee also treats patients with melanoma and lung cancers at Seattle Cancer Care Alliance, Fred Hutch’s clinical-care partner.

Other Appointments & Affiliations

Assistant Professor
University of Washington School of Medicine


M.D., University of North Carolina School of Medicine

Internship, University of Washington School of Medicine, Division of General Internal Medicine

Residency, University of Washington School of Medicine, Division of General Internal Medicine

Fellowship, University of Washington School of Medicine, Division of Oncology and Fred Hutchinson Cancer Research Center

Find an Active Clinical Trial Led by Dr. Lee

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210