Keith Jerome, M.D., Ph.D.

faculty member

Keith Jerome, M.D., Ph.D.

Member
Vaccine and Infectious Disease Division, Fred Hutch

Fax: 206.667.6179
Mail Stop: E5-110

Dr. Keith Jerome is a renowned virologist whose research focuses on viruses such as herpes simplex, HIV and hepatitis B that persist in their hosts. He studies the ways in which these viruses evade the immune system and potential therapies for these infections. His work involves using specific enzymes or proteins as molecular scissors that can accurately target, remove or replace short sequences of DNA. Dr. Jerome and his colleagues are studying the uses of these precision “gene-editing” tools, including the protein known as CRISPR/Cas9, to remove damaging viral genes that have tucked themselves into our genetic code or to insert genes that can protect cells from invading viruses. He and his colleagues are exploring this approach in combination with blood stem cell transplants as a means of curing HIV. In ongoing clinical trials, a patient’s own immune cells are harvested, genetically modified to resist HIV infection, and then returned to the patient’s bloodstream in the hope of permanently blocking replication of the virus.

Other Appointments & Affiliations

Professor, Laboratory Medicine
University of Washington

Head, Virology Division
University of Washington

Director, Molecular Virology Laboratory, Laboratory Medicine
University of Washington

Education

M.D., Duke University, 1993

Ph.D., Immunology, Duke University, 1992

B.S., Chemistry, Georgetown College, 1985

Current Projects

Novel proteins (CRISPR/Cas9 and meganucleases) as potential treatments for HIV, hepatitis B, and herpes simplex infections

Diagnostics for viruses posing the greatest threat to human health

In vivo delivery of gene therapy for HIV and other persistent viral infections

Hepatitis B Research Network Central Lab

Find A Clinical Trial

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210