Adam Geballe, MD


Adam Geballe, MD

Professor and Associate Director
Human Biology Division, Fred Hutch

Clinical Research Division, Fred Hutch

Fax: 206.667.6523
Mail Stop: C2-023

Dr. Adam Geballe studies the ongoing tug of war between virus and host. In particular, he focuses on cytomegalovirus, or CMV, a common, usually benign, infection. It can cause problems in people with suppressed immune function, such as bone marrow transplant recipients. As we have evolved molecular strategies to prevent infection, CMV has evolved ways to evade them. Dr. Geballe and his team pinpointed the two proteins that human CMV uses to evade the body’s defenses. Various types of CMV infect different organisms, from humans to guinea pigs to certain monkeys. Each has related proteins that allow it to sidestep our defensive strategies. Dr. Geballe aims to understand how these different proteins work and how they evolve. Ultimately, he hopes to better understand the viruses’ ability to counteract our defenses. His long-term goal is to be able to control the pathway to improve human health.

Other Appointments & Affiliations

Professor, Department of Medicine
University of Washington

Adjunct Professor, Department of Microbiology
University of Washington


Duke University, 1978, MD

Research Interests

The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.

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Dr. Geballe in the News

Switching from KSHV latency to lytic replication

Science Spotlight - March 20, 2023

Nipping poxviruses in the bud with nitazoxanide

Science Spotlight - July 16, 2018

Counteracting the mighty PKR

Science Spotlight - February 19, 2018

Adam Geballe elected AAAS Fellow

Hutch News - November 20, 2017

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email or call 206.667.2210