David Fredricks, MD


David Fredricks, MD

Vaccine and Infectious Disease Division, Fred Hutch

Clinical Research Division, Fred Hutch

Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

Fax: 206.667.4411
Mail Stop: E4-100

Dr. David Fredricks studies the human microbiome — which includes the trillions of tiny organisms that live in and on us — to determine how changes in these microbial communities affect our health. His research has focused on organisms associated with bacterial vaginosis, a common but little-understood condition that increases the risk of preterm birth, pelvic inflammatory disease, HIV and other sexually transmitted diseases. Dr. Fredricks’ team also studies the impact of microbial communities on the outcomes of patients who receive blood stem cell transplants. His research shows that the makeup of gut bacterial populations can vary significantly among patients after antibiotic treatment, and analysis of these patterns might help predict the risk of graft-vs.-host disease, a potentially deadly transplant complication. He leads the Microbiome Research Initiative, a cross-disciplinary effort at Fred Hutch to deepen understanding of the effects of microbial communities on human health.

Other Appointments & Affiliations

Professor, Medicine
University of Washington

Adjunct Professor, Microbiology
University of Washington

Graduate Faculty
Microbiology, University of Washington

Attending Physician
Infectious Disease Consulting Service, Fred Hutchinson Cancer Center


Case Western Reserve University, MD, 1990

Stanford University, 1984, MS (Biology)

Stanford University, 1983, BS (Biology)

American Board of Internal Medicine (Infectious Diseases), Washington State Medical License

Research Interests

Determining how changes in microbial communities impact human health

Identifying, characterizing, and culturing microbes found in the human genital tract

Associating the reproductive tract microbiome with human disease

Developing molecular diagnostic tests to detect and identify pathogens in immunocompromised hosts such as cancer patients

Studying antifungal and antibacterial therapies for cancer patients

Understanding changes in the microbiome in patients undergoing cancer therapy

Current Projects

Ecology of human microbial communities

Nucleic acid sequence-based methods for discovering novel pathogens

Developing diagnostic tests based on microbial nucleic acid sequences to detect human pathogens

Find a Clinical Trial Led by Dr. Fredricks

For the Media

The Media Relations team at Fred Hutch is available to assist members of the news media who would like to arrange interviews with faculty.

Email media@fredhutch.org or call 206.667.2210