Exploring Human T cells and TCRαβ repertoire at the single-cell level
T cell function is defined by both T cell receptors (TCR) and T cell gene expression (GEX). While single-cell technologies now enable the simultaneous capture of both modalities, the field lacks a comprehensive reference atlas and the computational framework necessary to decode fundamental TCR usage rules. In this talk, I will present our work in bridging this gap through the development of a single-cell T cell immune profiling database and novel tools for the integrative analysis of T cell states and TCR sequences. Together, these methods and resources provide a robust foundation for the characterization of disease-associated TCRs and serve as a vital resource for the T cell research community.
Dr. Wanlu Liu is an Associate Professor/Vice Dean at ZJU-UoE Institute in Zhejiang University. She is currently a Visiting Scholar at Dr. Mark M. Davis lab in Stanford University School of Medicine.
Hybrid, but in-person attendance is encouraged.