For some people with sickle cell disease, blood and marrow transplant may offer the possibility of long-term disease control or potential cure.

Fred Hutch Cancer Center providers have extensive experience performing blood and marrow transplants and caring for people with complex blood disorders.

Sickle Cell Disease Care Tailored to You

You and your family are our top priority. At Fred Hutch Cancer Center, we offer comprehensive and compassionate care — personalized to you. You'll have access to the latest treatment options, clinical trials and supportive care services.

When Blood and Marrow Transplant May Be Recommended

Blood and marrow transplant (BMT) is not appropriate for every patient.

Your physician will evaluate your overall health, medical history and individual circumstances to determine whether transplantation should be considered as part of your treatment plan.

If you have a BMT, a team of Fred Hutch transplant experts will care for you. Your team will include a transplant oncologist, transplant nurse, radiation oncologist, advanced practice providers, pharmacist, registered dietitian, patient care coordinator and social worker.


What is a blood and marrow transplant?

A BMT resets your body’s ability to make healthy blood cells by replacing abnormally forming stem cells with healthy cells. Researchers at Fred Hutch pioneered this form of treatment.

It’s important to understand that when a BMT is used to treat your sickle cell disease it isn’t a one-time event. It is a process that involves several steps as well as meetings with your care team, and will take about four months. 

Stem Cell Mobilization

The first step is called stem cell mobilization, which is preparing your body so your healthy stem cells can be removed. This involves taking medications to help your stem cells move into your bloodstream so it is easier to collect them. 

Apheresis

Next is a process called apheresis. This is when healthy stem cells are removed from your own body or a donor. The blood is draw out from a vein and goes into a machine where the stem cells are separated and removed. Then, the rest of the blood is returned to the donor. Those collected stem cells are kept and frozen, to be used later.

Conditioning

The step that comes next is called conditioning and takes about one week. This involves using high doses of chemotherapy and/or radiation to destroy diseased cells. The final step is when the healthy cells are transplanted (infused into your bloodstream using an intravenous catheter, an IV) and travel to the bone marrow and begin producing new blood cells. 

Recovery

After this, you will go through a recovery phase that will last several weeks or months. You will have frequent follow-up appointments to monitor how you are doing and check your blood cell levels. 

Dr. Marco Mielcarek

“A misconception about BMT is that it is almost impossible to find a donor, particularly if you are from a certain race or ethnicity. This used to be true, but not now. Today, treatments and techniques have improved, too, which are making BMTs even more successful.”

— Marco Mielcarek, MD, PhD, Medical Director, Adult Blood and Marrow Transplant Program

Why Choose Fred Hutch for Blood and Marrow Transplant for Sickle Cell Disease

The world’s first bone marrow transplant took place in the 1970s, when one of our physician-researchers, E. Donnall Thomas, MD, and his team developed the clinical use of transplants — and won a Nobel Prize for this work.

Physicians at the Fred Hutch Blood and Marrow Transplant Program have done more than 18,500 transplants, including for people with sickle cell disease. This makes our program not only the first, but also one of the most respected and successful of its kind in the world.

E. Donnall Thomas in a white lab jacket next to a microscope
Dr. E. Donnall Thomas developed the clinical use of bone marrow transplants.