At Fred Hutch Cancer Center, our experts offer the full range of soft tissue sarcoma treatment as well as bone cancer treatment. This includes advanced therapies and new options that are only available through clinical trials.

The most common treatments for sarcoma are surgery, chemotherapy and radiation therapy. Many people have a combination of treatments. But not everyone needs all of them. We’ll tailor your treatment to your diagnosis.

Sarcoma Care Tailored to You

You and your family are our top priority. At Fred Hutch Cancer Center, we offer comprehensive and compassionate care — personalized to you. You'll have access to the latest treatment options, clinical trials and supportive care services.

How We Treat Sarcoma at Fred Hutch

Sarcoma is often hard to treat, so it’s important to receive care at a specialized center like Fred Hutch with sarcoma expertise.

Different subtypes of sarcoma start, progress and respond to treatments in different ways. We choose, combine and schedule your treatments based on what works for your subtype. Your care team makes sure you understand each treatment option.

Surgery

Surgery is the most common treatment for sarcoma, and it may cure some people.

Learn More About Surgery for Sarcoma

Chemotherapy

Chemotherapy is an important part of sarcoma care. It may be given before or after surgery or when complete surgical removal of a sarcoma tumor would be difficult.

Learn More About Chemotherapy for Sarcoma

Radiation Therapy

Radiation therapy may be used before or after surgery to reduce the risk of sarcoma coming back. It may also be used to shrink a tumor and help with pain. In addition to conventional radiation, Fred Hutch offers proton therapy, EBRT, IORT and fast neutron therapy.

Learn More About Radiation for Sarcoma

Targeted Therapy and Immunotherapy for Sarcoma

Targeted therapies are a type of medicine that can be used in sarcoma treatment. These therapies look for a gene or protein that allow cancer to grow and damage any cancer cells they find. They can help your immune system attack particular cells, too (this is called immunotherapy).

Targeted therapy and immunotherapy for sarcoma can be used on soft tissue sarcoma and bone cancer. Often, two drugs, olaratumab and pazopanib, are used to treat soft tissue sarcoma. A different drug, denosumab, is used to treat bone cancer.

Because there are many subtypes of sarcoma, there are targeted therapies designed for different subtypes. For example, there is sorafenib for desmoid tumors and imatinib, sunitinib, regorafenib and pazopanib for gastrointestinal stromal tumors.

Learn More About Immunotherapy

CRS-HIPEC for Sarcoma

Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy (CRS-HIPEC) is sometimes used to help control advanced sarcoma while also supporting a good quality of life. The experienced CRS-HIPEC team at Fred Hutch performs two treatments during a single operation:

  • Surgery to remove all the cancer that is visible 
  • Warmed, liquid chemotherapy is put into the abdomen to kill any cancer cells that are left behind after surgery
Learn More About CRS-HIPEC

Why Choose Fred Hutch for Sarcoma Care

At Fred Hutch, we understand this may be one of the most intense and challenging experiences you and your family ever go through. We are here to provide the care you need.

Team-Based Care from Specialists

Fred Hutch has surgeons, medical oncologists and pathologists who specialize in sarcoma. We offer the most advanced diagnostic, treatment and recovery programs. Along with treating your cancer, we also offer a range of services to support you and your caregiver.

Treatment Tailored to You

We view treatment as a collaborative effort. Your Fred Hutch physicians will explain all your options. We’ll recommend a treatment plan to get you the best results based on the stage and size of your cancer, where it is and your overall health.

Clinical Trials to Improve Outcomes

Our physicians and researchers are always searching for new ways to make sarcoma treatments more effective and reduce side effects. This is why we do clinical trials. Through these trials, we can offer you therapies that aren’t offered everywhere.

Your First Appointment at Fred Hutch

Your first appointment at Fred Hutch is a time for you and your medical oncologist, surgical oncologist or orthopedic oncologist to meet. You might meet your advanced practice provider, too.

You will talk about your diagnosis, sarcoma type, grade, stage and likely treatment. This visit is also a time for us to start getting to know you as a person. This helps us fit our recommendations to you. Together, you and your care team will decide what needs to happen next.

We encourage you to bring a family member or friend to your first appointment (and any future visits).

What to Expect

Your first appointment usually takes one to two hours. You will spend about one hour with your physician. The rest of your visit may involve checking in, going to an exam room and getting settled in there, meeting other members of your team and setting up your next appointments.

Your first appointment will include:

  • Confirming your diagnosis
  • Staging your disease
  • Discussing your treatment
  • Answering your questions

How Treatment Plans Are Created

Your Fred Hutch physician works together with a group of other sarcoma specialists. They include medical oncologists, radiation oncologists, surgeons and researchers who are looking for better ways to treat this disease.

Every week, this team goes to a meeting called a tumor board. Together, these experts discuss their patients’ cases and treatment plans. This approach means each patient benefits from the experience of the whole group. With support from the larger team, your physician will:

  • Consider the standard therapy for your sarcoma subtype
  • Find out if any clinical trials match your needs, so you can think about joining them

Your physician will explain the treatment plan the tumor board has recommended for you. You will have a chance to share your personal preferences and options, and you will decide together what happens next.


Sarcoma Treatment FAQ

The treatment plan we recommend depends on many factors, including:

  • Your type of sarcoma (soft tissue sarcoma or bone cancer)
  • Your subtype of sarcoma
  • The grade of your tumor, either low-grade or high-grade
  • The stage of your disease
  • If you were treated for sarcoma in the past
  • Your age and overall health
  • Your needs and preferences, like what type of treatment schedule works in your life and if you want to join a clinical trial

While you are in active treatment, your sarcoma care team will check on you regularly to test and see:

  • How well your treatment is working
  • If there is any reason to adjust your treatment
  • If you need help with side effects or supportive care services, like nutrition care or mental health counseling

We update your treatment plan based on the best scientific evidence as well as how your disease responds and what you prefer.

Being a caregiver can mean many things, from lending a hand with daily living tasks to helping with medical decisions.

Caregivers are valuable members of a patient’s care team. We see every day that their presence and support make a difference. We know that what a patient is going through affects them, too, and caregivers experience their own emotions and stress.

Part of our mission is to help caregivers take care of themselves. Our social workers, Spiritual Health team and Patient and Family Resource Center staff are here to help support both patients and caregivers.

Get information and support for caregivers.

Just like we personalize your treatment plan for you, we personalize your follow-up schedule, too. Your provider will base your schedule on many things, including:

  • Your sarcoma type and subtype
  • Which treatments you had and how your disease responded
  • How the disease and treatments affected you
  • How long it has been since your treatment ended

Sometimes physicians use the word “cured” if you have been in complete remission for at least five years. After 10 years, cancer is less likely to come back (recur), but recurrence is still possible.