Experts in Gynecologic Cancer Care

If you have gynecologic cancer, your outcomes are likely to be better if a gynecologic oncologist treats you from the beginning. Fred Hutch Cancer Center has more gynecologic oncologists than any other medical center or clinic in the Pacific Northwest. We treat all types of gynecologic cancer — including cervical, endometrial, ovarian and vulvar cancers; uterine sarcoma; and gestational trophoblastic disease.

Your Fred Hutch gynecologic oncologist and pathologist specialize in finding out the stage and specific features of your disease. They will design a custom treatment plan to get the best possible outcome for you. We integrate supportive care services into your cancer treatment.

Gynecologic Cancer Care Tailored to Your Stage

You and your family are our top priority. At Fred Hutch Cancer Center, we offer comprehensive and compassionate care — personalized to you. You'll have access to the latest treatment options, clinical trials and supportive care services.  Referrals are required for new patients. Please request your primary care provider or specialist fax all relevant medical information to the fax number listed below.

Phone: 206.598.8300
Fax: 206.598.3590

What is gynecologic cancer?

Gynecologic cancers are those that affect female genital or reproductive organs. Usually, these are internal organs, like the uterus or ovaries. Less often, cancer can affect the external genitals, or vulva.


Types of Gynecologic Cancer

At Fred Hutch, our physicians treat all types of gynecologic cancer as well as gestational trophoblastic disease.

Cervical Cancer

Cervical cancer starts on the surface of the cervix, the narrow lower end of the uterus that extends into the vagina. Physicians think a common virus called human papillomavirus (HPV) causes 95% of cervical cancer cases. The HPV vaccine along with treatment for dysplasia (precancerous changes in cervical cells) can prevent nearly all cases.

Learn More About Cervical Cancer

Endometrial Cancer

The endometrium is the inner lining of the uterus. Most cancer in the uterus — more than 95% — starts in the endometrium. Many of the symptoms, like abnormal bleeding, can also be caused by other conditions that aren’t cancer. If you have any symptoms that concern you, your primary care provider can help figure out the cause.

Learn More About Endometrial Cancer

Ovarian Cancer

Ovarian cancer affects the ovaries, which make eggs and female hormones. Because the symptoms can be vague and easy to miss, most people are not diagnosed until the disease is advanced. Treatment usually involves surgery and chemotherapy and sometimes targeted therapies or immunotherapy.

Learn More About Ovarian Cancer

Vulvar Cancer

Most vulvar cancers are a type of skin cancer. But sometimes a tumor in the vulva starts from glandular structures. If detected early, before it has spread to the lymph nodes, the chances of a cure are high. HPV infection increases risk for vulvar cancer as well as cervical cancer. Treating abnormal cells early can help prevent precancers from turning into cancer.

Learn More About Vulvar Cancer

Uterine Sarcoma

Only about 3% of uterine cancers are uterine sarcomas. (Most are endometrial cancers.) The most common type is uterine leiomyosarcoma, which starts in the thick layer of muscle. Treatment usually begins with surgery to remove the uterus, ovaries, fallopian tubes and sometimes other tissues if the cancer has spread.

Learn More About Uterine Sarcoma

Gestational Trophoblastic Disease 

Gestational trophoblastic disease (GTD) includes several types of tumors that can form during or shortly after pregnancy. Most of these tumors are not cancer, but some are. These rare tumors develop in the cells (trophoblasts) that form part of the placenta. GTD is highly treatable, and most women with the disease will be cured.

GTD can happen from a full-term pregnancy or from a miscarriage, abortion or tubal ectopic pregnancy (a fertilized egg implants outside the uterus in the fallopian tube). If you are of reproductive age (typically defined as age 15 to your mid-to-late 40s) and you have metastatic cancer of unknown primary origin (there’s no clear answer about where it started), it’s important to have a pregnancy test. The test will check your level of human chorionic gonadotropin (hCG). This hormone increases during pregnancy or when a person has GTD.

There are several types of GTD.

Molar Pregnancy

A sperm fertilizes an egg, but a normal fetus does not develop. Instead, the placental tissue grows very fast, forming a tumor. This condition is also called hydatidiform mole. In complete mole, no fetus is formed. In partial mole, a fetus forms but is abnormal and will not survive. This type of GTD does not spread outside the uterus to other parts of the body.

Choriocarcinoma

Choriocarcinoma may start from a molar pregnancy or from tissue that remains in the uterus after an abortion, an ectopic pregnancy or the delivery of a baby. This type of GTD can spread from the uterus to other parts of the body.

Placenta-Site Trophoblastic Tumor

This is a very rare type of GTD that starts in the uterus where the placenta was attached. It grows slowly. Signs and symptoms may show up months to years after a pregnancy. It usually stays within the uterus but can spread to other parts of the body.

Metastatic GTD 

Despite treatment, GTD sometimes comes back in the uterus or another part of the body. In some cases, the cancer has already metastasized (spread) by the time a person discovers that she has GTD. Metastatic GTD can be put into remission with chemotherapy about 85% to 90% of the time. Fred Hutch can offer you new procedures and treatments for GTD, as well as access to clinical trials, that your community provider may not be able to offer.

Where You Are Treated Matters

Coming to Fred Hutch after a gynecologic cancer diagnosis means you are now at the center of one of the most experienced, research-driven, comprehensive cancer care centers in the country.

Our gynecologic cancer experts provide all standard therapies for these diseases. We know how to choose the right ones for you and how to deliver them to give you the best chance at a full recovery. Our physicians and researchers also do clinical trials (also called clinical studies). Through these trials, we are able to offer you therapies that aren’t offered everywhere.

Gynecologic Cancer Specialists

Meet your gynecologic cancer care team at Fred Hutch, from gynecologic oncologists to supportive care specialists, all dedicated to your treatment.

Gynecologic Cancer Research and Clinical Trials

Explore new breakthroughs from Fred Hutch researchers who are pioneering gynecologic cancer treatments, clinical trials, early detection methods and more.

Locations For Gynecologic Cancer Care

Find expert gynecologic cancer care at Fred Hutch locations. Explore treatment backed by compassionate, world-class oncology teams.

Screening and Diagnosis

There are two tests used to screen for cervical cancer: the Pap test (also called a Pap smear) and the human papillomavirus (HPV) test. There is currently no screening tests for other gynecologic cancers to identify precancerous symptoms or early-stage cancer but researchers are always studying new ways to help with cancer prevention and screening, including early detection methods.

Why Choose Fred Hutch for Gynecologic Cancer Care

At Fred Hutch we combine compassionate care with innovative research to address the impact of cancer and infectious disease. We’re driven by the urgency of our patients, the hope of our community and our passion for discovery to pursue scientific breakthroughs and healthier lives for every person.

Gynecologic Cancer FAQ

If you have any signs or symptoms that you worry might be from cancer, talk with your primary care provider. The same symptoms may happen for reasons other than cancer. Whatever the cause, it’s important to find out so you can get treatment to help. If it is cancer, finding it earlier may mean it’s easier to treat.

Your gynecologist or primary care provider is a good place to start if you have questions or concerns about your risk for getting cancer. They can tell you about screening tests and help with any symptoms that might be from cancer or another condition. Before you visit your provider, write down your questions. Bring the list to your appointment.

If you’re concerned about risk, here are some questions you may want to ask:

  • Do I have any risk factors for cancer?
  • Is there any reason to think I’m at higher risk than the average person?
  • If I am at higher risk, what does this mean for me?
  • Do I need any tests or procedures to check for cancer even if I feel fine?
  • Is there anything I can do to lower my risk?

Ask your gynecologist or primary care provider to help you understand the best cancer screening plan for you.

  • Are any cancer screening tests recommended for me? 
  • Do I have more than one screening option?
  • If so, which type of screening should I have?  
  • How often should I have the test? 
  • At what age should I stop having it?
  • What is the purpose of the test? What will the results tell us?

If you have symptoms that concern you, here are some questions to ask:

  • What could be causing my symptoms?
  • Do these symptoms mean I might have a serious condition?
  • How can we find out the cause?
  • Do I need any tests?
  • What should I do if my symptoms don’t get better or if I get new symptoms?

Gynecologic cancer starts when cells in one of the genital or reproductive organs grow out of control. Normally, cells in the body grow and multiply to form new cells as the body needs them. When cells get old or damaged, they die and are replaced. Sometimes, this normal process breaks down. Abnormal or damaged cells grow and multiply when they shouldn’t, forming tumors. Some tumors are cancer, and others are benign (noncancerous).

Cancer spreads by growing into, or invading, nearby tissues. If the cancer cells invade nearby lymph nodes or blood vessels, they can travel through the lymph or blood to distant parts in the body. Then they can form new tumors in these places. 

The Fred Hutch patient and family education team works with other Fred Hutch experts to create reliable resources and select materials from trusted cancer organizations. Find a resource.

Gynecologic Cancer News

All news
What’s the psychology behind using dietary supplements? In this episode of From Bench to Bedside and Beyond, Dr. Jonathan Bricker explains why we choose the ‘quick fix’ over tried-and-true cancer prevention methods March 5, 2026
Dr. Holly Harris awarded the inaugural Bus Family Endowed Chair for research on women’s health Fred Hutch endowed chair to focus on gynecologic cancers and related conditions February 25, 2026
Endometrial cancer patient advocate reinforces the importance of normalizing conversations about symptoms In this episode of From Bench to Bedside and Beyond, Margie Wilson shares how community support helped power her recovery December 16, 2025
Lack of insurance, follow-ups undercut cancer screening wins Large multi-institution PROSPR II study finds big gaps in access, timely care in cervical, colorectal and lung cancers across U.S. November 4, 2025