Acute myeloid leukemia (AML) is not a single disease. There are many types and subtypes of AML based on the type of blood cell affected and the genetic changes found in the leukemia cells.
This information helps predict how the leukemia may behave and whether certain targeted therapies or other treatments may be appropriate. Fred Hutch Cancer Center hematologist-oncologists have expertise in caring for patients with all AML subtypes.
Acute Myeloid Leukemia Care Tailored to You
You and your family are our top priority. At Fred Hutch Cancer Center, we offer comprehensive and compassionate care — personalized to you. You'll have access to the latest treatment options, clinical trials and supportive care services.
Factors in Determining AML Subtype
Your physician uses information from blood tests, bone marrow testing and specialized laboratory studies to determine the type of AML you have.
Your subtype is based mainly on three factors:
- How mature your cancer cells are
- How similar they are to normal cells
- If they have certain changes in chromosomes or genes
AML Subtypes
- AML with recurrent genetic abnormalities: This subtype has many subgroups. It includes acute promyelocytic leukemia (APL).
- AML with myelodysplasia-related changes
- Therapy-related myeloid neoplasms
- Myeloid sarcoma
- Myeloid proliferation related to Down syndrome
- AML, not otherwise specified: This subtype has many subgroups.
Acute Promyelocytic Leukemia (APL)
Acute promyelocytic leukemia (APL) is a rare subtype of AML that requires prompt diagnosis and treatment. Although APL is a type of AML, it is treated differently from other forms of the disease.