Fred Hutch, Seattle Cancer Care Alliance, and UW Medicine Complete Restructure of Partnership

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Frontiers: Intro to Cancer Unit

Explore cell growth/development, cancer, and cancer treatments through the story of Hina Marsey who is diagnosed with leukemia. This whole unit has opportunities for collaborative model building, discussions about health inequities in cancer, and evidence based argumentation.
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Intro to Cancer: Leukemia & Hina's Story

A Cellular Look at Cancer and Treatments

Overview

This is a cancer unit, intended for high school biology classes, focused on cell growth, cell cycle, and mutations. Over ten lessons, students investigate the case of Hina Marsey, an eleven-year old girl, who is diagnosed with a rare form of leukemia. As the unit unfolds, students develop conceptual models on cell growth, cancer, and treatments for leukemia. The unit builds toward a wet lab in which students conduct a gel electrophoresis lab to understand what it means to look for a "match" for transplantation.

The unit is organized into two conceptual bends:

Bend #1: How is Hina's illness affecting her body? unfolds over six lessons that are focused on understanding Hina’s story and how her doctors are able to diagnose her blood cancer. Students develop an understanding of cell growth, the cell cycle, and differentiation of blood cells. In the five lessons that make up

Bend #2: How can Hina’s cancer be cured?, students are introduced to different forms of cancer treatments, before diving deeper into how chemotherapy and bone marrow transplants (including the process of matching donors with recipients) help patients, like Hina, who have leukemia. 

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FUNDING SOURCES:

This project was made possible by a Science Education Partnership Award (SEPA), Grant Number R25 GM129842, from the National Institute of General Medical Sciences (NIGMS), National Institutes of Health (NIH).  Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIGMS or NIH.

NIGMS, part of the National Institutes of Health, supports basic research that increases the understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. Its Science Education Partnership Award program funds innovative pre-kindergarten to grade 12 science, technology, engineering and mathematics, or STEM, and informal science education projects.

DETAILS:

10 Lesson plans

Step 1: Complete Short Survey

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Step 2: Review Unit and Teacher Prep Materials

Unit Overview

An overview of the unit with lesson summaries, unit calendar/timeline, and more information for the teacher before teaching this unit. 

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Unit Preface

Information on our approach to science teaching & learning, background reading on race and racism for teachers, and credits & acknowledgments.

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Unit Storyline Table

The Unit Storyline Table featured in this document communicates the storyline that drives the unit.

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Learning Standards Connections Table

This table summarizes how each lesson was designed for three-dimensional science learning and the NGSS learning standards.

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Step 3: Download Lessons

Bend 1: How is Hina's illness affecting her body? (Lessons 1-5)

Intro to Hina's Story

To launch the unit, students draw on their own experiences and prior knowledge. They document ideas and experiences that they have around cancer and are introduced to Hina’s story. To track progress and record questions, the students create an initial conceptual model to help them understand Hina’s symptoms. They also fill out an incremental model tracking worksheet.

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Cancer in the Blood

In this activity, students engage with productive uncertainty as they examine data, develop claims, and engage in scientific argumentation using a data-based seminar discussion format. Students examine two types of data from blood samples: complete blood count test results and blood smear microscope slide images. Students then participate in a seminar. Through collaborative discourse, they discuss the data, their interpretations, and how it applies to Hina’s story.

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Cell Division & Cell Cycle

In this lesson, students learn about cell division and the process of mitosis as a way of understanding what caused Hina to have blast cells in her blood. In Part I, students explore why cells divide and learn that different cells divide at different rates based on what the body needs. Students watch several videos that show the process of mitosis. They then sequence the order of images in a cell cycle cartoon that shows the steps in cell division.

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Cell Differentiation

In this lesson, students explore the process of cell differentiation. Students will work through a hands-on model using modeling clay that shows normal cell differentiation in the bone marrow beginning with undifferentiated stem cells and ending with mature blood cells of various types. This process, called hematopoiesis, is driven by the activation of specific genes triggered by environmental cues.

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Cell Cycle Activity & Model of Hina's Disease

In this lesson, the classroom is transformed into a “board game” and the students into “game pieces” to model the cell cycle. In this role-playing game, students act as cells (healthy and cancerous) and go through the cell cycle, while some students play the roles of checkpoint proteins. This experience deepens their learning of the cell cycle, checkpoints, genetic mutations, and the effects of cancer on the cell cycle. Students complete the lesson by returning to their initial model’s of Hina’s disease.

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Bend 2: How can Hina's cancer be cured? (Lessons 6-10)

Cancer Treatment & Patient Stories

After receiving an update on Hina's case, students explore the different treatments for cancer, with a focus on chemotherapy and bone marrow transplants. Students explore different patient stories from the Fred Hutch Cancer Center to learn more about cancer treatments to better understand Hina’s treatments. Students also have an opportunity to research different cancer-related careers.

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Hina's Treatment

Students learn about human leukocyte antigens (HLAs) and the science behind finding bone marrow donor matches. Students also explore the diversity of the HLA genes and why matching bone marrow donors and cancer patients can be so difficult. This lesson also contains an optional lab activity in which students use DNA technology to find Hina a match.

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Disparities in Leukemia

This series of two activities helps students explain why finding a bone marrow transplant match might be difficult for Hina. In the first activity, students explore the insufficient diversity of HLA alleles in the bone marrow database to support patients of non-European descent. Students read about the experiences of individuals with cancer who identify as Black as well as the work of Community Health Educators and researchers and share their ideas in a seminar discussion.

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Cord Blood Donation & Model for Hina's Treatment

Students explore three sources of stem cells (bone marrow, peripheral blood, and cord blood) for those that need transplantation. They learn about the pros/cons, process, and obstacles for each source of stem cells before moving on to discussing the bioethics of one source: cord blood donation. Finally, students build on their previous conceptual models to show how Hina’s chemotherapy treatment affects her body and how the new donor stem cells replace her cancerous cells. 

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Conclusion

This lesson provides two ways for students to conclude their learning around Hina and her cancer treatment. The first activity is a public service announcement (PSA) project that allows students to apply their understanding of leukemia, stem cell transplantation, and HLA matching. Through this activity, students can take action against this problem. In the second activity, students create luminaria to honor those who are struggling with cancer or have struggled with cancer in the past. This is an opportunity to bring emotional closure to the unit. 

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Career Profiles

The Frontiers in Cancer Research - Career Profiles Website has been developed as a tool for high school students to accompany the Frontiers in Cancer Research curriculum units. The site features profiles of real professionals working in fields related to cancer research, cancer treatment, and patient care. These people work across many disciplines of science, social sciences, medicine, and healthcare. Their stories represent a variety of career and educational pathways, diverse backgrounds, and various career stages. The featured professionals work for Fred Hutchinson Cancer Center, the University of Washington, Seattle Children's Hospital, and other organizations based in Washington State. Some work with adult patients, others work with pediatric patients and their families. For many of the featured professionals, their work is related to leukemia and other blood cancers and the topics featured in these curriculum units. Students can explore the profiles on the site, read a variety of career stories, and access links to external resources. In addition, a Becoming the Next Cancer Researcher or Clinician section provides college and career information for students planning for a career in STEM, healthcare, or medicine. Teachers can use the Supplementary Info: College & Career Connections document to plan how to incorporate the study of careers in the science classroom. (Note that this site is currently in development; more profiles are being added each month).