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Henikoff
Steven Henikoff, PhD

Steven Henikoff, PhD

  • Professor, Basic Sciences Division, Fred Hutch
  • Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch
  • Affiliate Faculty, Genome Sciences, University of Washington
206.667.4515
206.667.5889

Background

Dr. Steven Henikoff is a molecular biologist who studies the structure, function and evolution of our DNA molecules, or chromosomes. He also develops tools for comparing gene sequences, determining the arrangement of genes in living cells and understanding the biological functions of genes. Credited with helping build the infrastructure for analyzing the human genome, Dr. Henikoff was among the first to realize that computing and the internet could revolutionize biological research. In 1992, he and his wife, Jorja Henikoff, developed a computational method that researchers have used to compare the relatedness among all living things, making it possible to uncover the roots of human diseases through the study of simpler organisms. Dr. Henikoff and his colleagues have also developed techniques that allow scientists to map features of chromosomes that are altered when genes are switched on or off. These methods have already offered new insight into how gene activity patterns may persist for many cell generations. It also may eventually help scientists determine how an embryo develops into an adult animal or how healthy cells become cancerous.

Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute

Education

Postdoctoral, University of Washington, Zoology, 1980

PhD, Harvard University, Biochemistry and Molecular Biology, 1977

"Science is always changing. You can't just sit back and relax and say, 'I'll do this over and over again.' That's what makes it so much fun."

— Dr. Steven Henikoff

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Stories

All news
Brandeis University honors Fred Hutch molecular biologist Dr. Steven Henikoff receives 55th Lewis S. Rosenstiel Award for Distinguished Work in Basic Medical Research October 30, 2025
Rewriting the story about the molecules that turn genes on and off Fred Hutch researchers discover that most transcription factors in budding yeast don’t follow the textbook example of binding close to the genes they regulate April 16, 2025
New methods reveal cancer mechanism in ancient genes Fred Hutch researchers discover that overproduction of DNA packaging material predicts aggressive brain and breast tumors, which could lead to cheaper diagnostic tests and new drug therapies March 3, 2025