Kamen Simeonov, PhD

Metastasis and therapy resistance are the primary drivers of cancer mortality yet remain inherently challenging to study. Dr. Kamen Simeonov has pioneered molecular recording methods in cancer – engineered tools that enable cells to log aspects of their own biology directly into their DNA. By reading out molecular recordings with single-cell sequencing, his lab has decoded how pancreatic cancer evolves and identified rare cell states that drive metastasis. At Fred Hutch, the Simeonov Lab seeks to deploy existing and novel high-resolution methods at scale to uncover systems-level insights into the rules that govern cancer aggression.