"Whether it’s my particular approach or not, there’s no question that [targeted gene correction] is going to happen before my career is over."
— Dr. Barry Stoddard
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Stoddard
Barry Stoddard, PhD
- Professor, Basic Sciences Division, Fred Hutch
- Member, Immunotherapy Integrated Research Center (IIRC), Fred Hutch
- Affiliate Professor, Biochemistry, University of Washington School of Medicine
Background
Dr. Barry Stoddard is an expert in protein structure and engineering. He uses cutting-edge laboratory and computational techniques to reveal proteins’ 3D forms at the atomic level, which is key to his ultimate goal: modifying natural proteins to treat or cure human diseases. In particular, his group has made major contributions to the understanding of gene-targeting proteins, from determining their structure to creating variants for use in gene therapy. Dr. Stoddard’s work could lead to engineered proteins that are capable of correcting mutations that underlie genetic diseases like cystic fibrosis, and he’s working on proteins that could cure HIV and other chronic infections.
Director, NCI Interdisciplinary Training Program in Cancer
Education
PhD, Biophysical Chemistry, Massachusetts Institute of Technology, 1990
BS, Chemistry/Biology, Whitman College, 1985
Research Interests
The structure, mechanism, and engineering of proteins and enzymatic catalysts for basic research and biomedical applications
Current Projects
Research on gene-specific endonucleases, nucleic acid enzymes, structural enzymology and protein engineering