"In this genetic conflict, either the host is winning or the virus is winning."
— Dr. Harmit Malik
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Malik
Harmit Malik, PhD
- Professor and Associate Director, Basic Sciences Division, Fred Hutch
- Member, Pathogen-Associated Malignancies Integrated Research Center (PAM IRC)
Background
Dr. Harmit Malik studies genetic conflict, the competition between genes and proteins with opposing functions that drives evolutionary change. His research could have implications for a range of diseases, from HIV to cancer. As part of this work, his team developed an approach for identifying genes that divide one species from another, which could help solve the riddle of how new species evolve. Dr. Malik also studies the evolutionary processes that drive our body’s interactions with viruses, including contemporary scourges like HIV as well as ancient viruses whose fossils litter our genome. With Hutch colleagues, he has characterized the rapidly evolving interface between proteins on human cells and viruses that make us sick. This work has highlighted surprising deviations from “textbook” models of these interactions, and it is revealing gene variants that could influence our susceptibility to infection.
Howard Hughes Medical Institute Investigator, Howard Hughes Medical Institute
Education
PhD, Biology, University of Rochester, 1999
BTech, Chemical Engineering, Indian Institute of Technology, Bombay, 1993