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Feng
Ziding Feng, PhD
- Professor, Biostatistics Program, Public Health Sciences Division, Fred Hutch
- Member, Pathogen-Associated Malignancies Integrated Research Center (PAM IRC)
- Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch
Background
Dr. Ziding Feng is an expert in biostatistics who applies statistical analysis to biological data. Much of his research is focused on biomarker evaluation for cancer risk assessment, early detection, diagnosis and prognosis. He is the principal investigator of the Data Management and Coordinating Center for the National Cancer Institute-funded Early Detection Research Network, or EDRN, a multicenter research collaboration that focuses on biomarker discovery and validation. In that role, he is responsible for coordinating all of EDRN’s network collaborative research activities, providing logistical support and conducting statistical and computational research for data analysis. In addition, he is the principal investigator for the Translational Liver Cancer (TLC) Consortium Data Management and Coordinating Center funded by NCI, the principal investigator for the New Onset Diabetes Coordinating Center funded by NIDDK/NCI and the principal investigator for the Early Detection Initiative Coordinating Center funded by PanCAN. He is on the Scientific Board of Directors for the Comprehensive Center for the Advancement of Scientific Strategies (COMPASS) and a co-PI for the Statistics and Data Management Center (SDMC) for the NCI Cancer Screening Research Network (CSRN). Dr. Feng has also acted as lead biostatistician on a number of large, multicenter biomarker trials for cancers of the prostate, liver, lung, colon and esophagus.
Education
Cornell University, Ithaca, NY, PhD, 1990, Biometry
Cornell University, Ithaca, NY, MS, 1985, Entomology
Nanjing Agricultural University, Nanjing, Jiangsu, China, BS, 1982, Plant Protection
Awards & Honors
2007 - Elected, Fellow, American Statistical Association, American Statistical Association
Current Projects
The Early Detection Research Network: Data Management and Coordination Center
Cologuard Impact in Clinical Practice: A Real-World Evidence Survey Study
Liquid Biopsy of the Lung to Profile Lung Cancer
Clinical Validation Center for Lung Cancer Early Detection
Accelerating biomarker development through novel statistical methods for analyzing phase III/IV studies
Consortium on Translational Research in Early Detection of Liver Cancer: Data Management and Coordinating Center (DMCC)
Statistics and Data Management Center (SDMC) for the NCI Cancer Screening Research Network (CSRN)
Evaluating Galad Model for HCC Early Detection
Early Detection Initiative for Pancreatic Cancer (EDI)
Selected Scientific Publications
Chari S, Wu B, Lopez C, Lustigova E, Chen Q, Vandeneeden S, Leimpeter A, Fisher, Wood A, Alexander A, Valenta J, Vege S, Rabe K, Carlson E, Hart P, Qian L, Zhao Y, Matrisian L, Kenner B, Rinaudo J, Maitra A, Feng Z. Risk of pancreatic cancer in glycemically defined new-onset diabetes: A prospective cohort study. Gastroenterology, in press.
Zheng Y, Wagner PD, Singal AG, Hanash SM, Srivastava S, Huang Y, Zhao YQ, Chari ST, Marquez G, Etizioni R, Marsh TL, Feng Z. Designing Rigorous and Efficient Clinical Utility Studies for Early Detection Biomarkers. Cancer Epidemiol Biomarkers Prev. 2024 Sep 3;33(9):1150-1157. doi: 10.1158/1055-9965.EPI-23-1594. PMID: 39223980; PMCID: PMC11534000.
Etzioni R, Gulati R, Patriotis C, Rutter C, Zheng Y, Srivastava S, Feng Z. Revisiting the Standard Blueprint for Biomarker Development to Address Emerging Cancer Early Detection Technologies. J Natl Cancer Inst. 2024 Feb 8;116(2):189-193. doi: 10.1093/jnci/djad227. PMID: 37941446; PMCID: PMC10852609.
Huang Y, Feng Z. Assessing Screening Efficacy in the Presence of Cancer Overdiagnosis. Ann Appl Stat. 2024 Jun;18(2):1543-1564. doi: 10.1214/23-aoas1848. Epub 2024 Apr 5. PMID: 39555026; PMCID: PMC11566264.
Tayob N, Stingo F, Do KA, Lok ASF, Feng Z. A Bayesian Screening Approach for Hepatocellular Carcinoma using Multiple Longitudinal Biomarkers. Biometrics. 2018 Mar;74(1):249-259. doi: 10.1111/biom.12717. Epub 2017 May 8. PMID: 28482112; PMCID: PMC5677596.