"I’m working to find the Achilles heel of certain cancers that have genomic instabilities to discover how we can exploit their weaknesses to eliminate the cancer cells."
— Dr. Richard Adeyemi
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Adeyemi
Richard Adeyemi, DVM, PhD
- Assistant Professor, Basic Sciences Division, Fred Hutch
- Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch
Background
Dr. Richard Adeyemi studies how our cells maintain the integrity of their DNA. Unstable DNA, leading to rearrangements, extra copies and even loss of genetic information, is a hallmark of cancer. In particular, Adeyemi focuses on how cells protect their genetic information by coordinating and deploying their DNA repair machinery, both during normal replication and in response to events that could damage DNA, including viral infection and chemotherapy. A deeper understanding of the molecular mechanisms underlying these processes will support his work toward novel therapies for cancer, infections, aging and genetic diseases.
Education
Harvard Medical School, 2020, Postdoctoral Fellowship (Genetics)
University of Missouri, 2012, PhD (Microbiology)
University of Ibadan, 2005, DVM
Research Interests
DNA repair and the replication stress response
CRISPR and ORFeome library screens
DNA virus-host interactions
RNA polymerase, lncRNAs and RNA-DNA hybrid roles in DNA repair
BRCA and other tumor suppressor gene roles in cancer
Ubiquitin ligases and the regulation of protein stability