Holly Janes, PhD

Affiliate Associate Professor, Biostatistics
University of Washington
Graduate Faculty, Biostatistics
University of Washington


University of Washington, 2005, PhD (Biostatistics)
University of Massachusetts, 2000, MS (Mathematics)
Skidmore College, 1998, BA (Philosophy of Physical Science and Mathematical Modeling)

Research Interests

  • Analysis of vaccine-induced immune responses
  • Design and analysis efficacy trials
  • Evaluation of biomarkers for disease diagnosis/screening, risk prediction and treatment selection

Current Studies

  • Biological markers that predict an individual’s response to a given treatment
  • Statistical analyses of vaccine trial data

Awards and Honors

2008, Travel Award, Global HIV Vaccine Enterprise, AIDS Vaccine Conference
2006, Young Investigator Award, Section on Statistics in Epidemiology, American Statistical Association
2005, Gilbert S. Omenn Graduate Student Award for Academic Excellence, School of Public Health, University of Washington
2005, Student Conference Award, International Society for Clinical Biostatistics
2005, Senior Student Award, Department of Biostatistics, University of Washington
2004, Student Paper Award, Section on Statistics and the Environment, American Statistical Association
2000, Cardiovascular Biostatistics Training Grant, National Institutes of Health

Selected Publications

Janes H, Pepe MS. Matching in studies of classification accuracy: Implications for analysis, efficiency, and assessment of incremental value. Biometrics. 2008;64(1):1-9.

Janes H, Pepe MS, Bossuyt PM, Barlow WE. Measuring the performance of markers for guiding treatment decisions. Ann Intern Med. 2011;154(4):253-9. PMCID: 3085402.

Haynes BF, Gilbert PB, McElrath MJ, Zolla-Pazner S, Tomaras GD, Alam SM, Evans DT, Montefiori DC, Karnasuta C, Sutthent R, Liao HX, DeVico AL, Lewis GK, Williams C, Pinter A, Fong Y, Janes H, DeCamp A, Huang Y, Rao M, Billings E, Karasavvas N, Robb ML, Ngauy V, de Souza MS, Paris R, Ferrari G, Bailer RT, Soderberg KA, Andrews C, Berman PW, Frahm N, De Rosa SC, Alpert MD, Yates NL, Shen X, Koup RA, Pitisuttithum P, Kaewkungwal J, Nitayaphan S, Rerks-Ngarm S, Michael NL, Kim JH. Immune-correlates analysis of an HIV-1 vaccine efficacy trial. The N Engl J Med. 2012;366(14):1275-86. PMCID: 3371689.

Hammer SM, Sobieszczyk ME, Janes H, Karuna ST, Mulligan MJ, Grove D, Koblin BA, Buchbinder SP, Keefer MC, Tomaras GD, Frahm N, Hural J, Anude C, Graham BS, Enama ME, Adams E, DeJesus E, Novak RM, Frank I, Bentley C, Ramirez S, Fu R, Koup RA, Mascola JR, Nabel GJ, Montefiori DC, Kublin J, McElrath MJ, Corey L, Gilbert PB, HVTN 505 Study Team. Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine. N Engl J Med. 2013;369(22):2083-92. PMCID: 4030634.

Janes H, Gilbert P, Buchbinder S, Kublin J, Sobieszczyk ME, Hammer SM. In Pursuit of an HIV Vaccine: Designing Efficacy Trials in the Context of Partially Effective Non-Vaccine Prevention Modalities. AIDS research and human retroviruses. 2013;29(11):1513-23. PMCID: 3809388.

Kang C, Janes H, Huang Y. Combining biomarkers to optimize patient treatment recommendations. Biometrics. 2014;70(3):695-707. PMCID: 4248022.

Holly Janes, PhD

Contact Information

(206) 667-6353
(206) 667-4378
Additional contact

Mail Stop M2-C200