Multiple Myeloma Research and Clinical Trials

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Fred Hutch Cancer Center is at the forefront of research and developing new treatments for multiple myeloma. Our researchers pioneered blood and marrow transplant (BMT), which is one of the most significant advances in treating multiple myeloma, lymphoma and other blood cancers.

Fred Hutch researchers continue to study and improve BMT for multiple myeloma, too, making it safer and more effective. We also pioneered the mini-transplant, a gentler version of transplant that is appropriate for some patients and reduces radiation exposure.

Multiple Myeloma Clinical Trials 

Fred Hutch typically has over 750 active cancer clinical trials enrolling participants. 

Clinical trials may allow some patients access to a promising new treatment, and help physicians and researchers learn more about a disease. 

Search for Multiple Myeloma Clinical Trials

Multiple Myeloma Research 

Our multiple myeloma research begins in the laboratory, where we study the biology of myeloma cells and test and develop potential new drugs and immunotherapies. It also includes clinical research in which our scientists test new methods for treating and caring for myeloma patients. This work spans years and decades as we track survivors’ quality of life after treatment.

Blood and Marrow Transplantation

Fred Hutch researchers continue to learn more about immune genetics in order to find better-matched donors for each patient and to develop even better transplant treatment plans that are less toxic. Our researchers are also developing new forms of blood and marrow transplant that can offer a patient a good chance of success even without a fully matched donor.  All of these advances are informed by our research on the fundamental biology of blood-forming cells, the immune system and myeloma itself.

Immunotherapy Research

Fred Hutch researchers are contributing landmark discoveries about how to engineer immune cells called T cells to target multiple myeloma. Our scientists are developing new myeloma drugs based on antibodies, which are disease-targeting immune proteins. We are also leaders in the study of radioimmunotherapy, in which antibodies deliver powerful radioactive isotopes (a type of atom that gives off radiation) straight to myeloma cells to destroy them. Read news on multiple myeloma immunotherapy research.

Survivorship and Treatment Research

During and after treatment for multiple myeloma, patients can experience numerous side effects. Fred Hutch scientists are developing new supportive care approaches to help patients manage them and improve their quality of life. They are also studying the long-term and late effects of treatment to help improve quality of life after treatment as well.

  

Multiple Myeloma News

All news
For many blood cancer patients, CAR T-cell therapy is game-changing
For many blood cancer patients, CAR T-cell therapy is game-changing In this episode of From Bench to Bedside and Beyond, Dr. Mazyar Shadman explains why CAR T-cell therapy should be considered for patients who relapse December 2, 2025
Gratitude for life-saving care at Fred Hutch leads to endowed chair
Gratitude for life-saving care at Fred Hutch leads to endowed chair Dr. Madhav Dhodapkar is the recipient of the Milton B. Rubin Family Endowed Chair August 19, 2025
Giving that feels ‘beyond meaningful’
Giving that feels ‘beyond meaningful’ The Steinberg family honors the memory of loved ones by celebrating and supporting a profession that takes caring to another level May 19, 2025

Our Multiple Myeloma Researchers and Faculty

Our interdisciplinary researchers and clinicians work together to prevent, diagnose and treat multiple myeloma as well as other cancers and diseases.

Fred Hutch scientists are world experts on the complications of blood and marrow transplants, including infections and graft-versus-host disease. They are learning how these complications occur and developing better methods to prevent and treat them.

Rahul Banerjee, MD, FACP

Rahul Banerjee, MD, FACP

Rahul Banerjee, MD, FACP

Assistant Professor, Clinical Research Division, Fred Hutch

3 more appointments

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Christopher D. Blosser, MD

Christopher D. Blosser, MD

Christopher D. Blosser, MD

Professor, Clinical Research Division, Fred Hutch

Director, Cancer and Organ Transplant Clinic, Fred Hutch

4 more appointments

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Delphine Chen, MD

Delphine Chen, MD

Delphine Chen, MD

Professor, Clinical Research Division, Fred Hutch

Director, Molecular Imaging and Therapy, Fred Hutch

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Kara Cicero, MD, MPH

Kara Cicero, MD, MPH

Kara Cicero, MD, MPH

Assistant Professor, Clinical Research Division, Fred Hutch

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Ann Dahlberg, MD

Ann Dahlberg, MD

Ann Dahlberg, MD

Associate Professor, Clinical Research Division, Fred Hutch

4 more appointments

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Madhav Dhodapkar, MBBS

Madhav Dhodapkar, MBBS

Madhav Dhodapkar, MBBS

Professor, Translational Science and Therapeutics Division, Fred Hutch

Scientific Director, Multiple Myeloma Program, Fred Hutch

4 more appointments

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Danai Dima, MD

Danai Dima, MD

Danai Dima, MD

Assistant Professor, Clinical Research Division, Fred Hutch

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Lawrence Fong, MD

Lawrence Fong, MD

Lawrence Fong, MD

Scientific Director, Immunotherapy Integrated Research Center (IIRC), Fred Hutch

Professor, Translational Science and Therapeutics Division, Fred Hutch

5 more appointments

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Geoffrey Hill, MD, FRACP, FRCPA

Geoffrey Hill, MD, FRACP, FRCPA

Geoffrey Hill, MD, FRACP, FRCPA

Senior Vice President and Director, Translational Science and Therapeutics Division, Fred Hutch

Professor, Translational Science and Therapeutics Division, Fred Hutch

5 more appointments

Phone: 206.667.3324
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Leona Holmberg, MD, PhD

Leona Holmberg, MD, PhD

Leona Holmberg, MD, PhD

Professor, Clinical Research Division, Fred Hutch

1 more appointment

Phone: 206.667.6447
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Fax: 206.667.4937
Mail Stop: D5-390
Lorenzo Iovino, MD, PhD

Lorenzo Iovino, MD, PhD

Lorenzo Iovino, MD, PhD

Assistant Professor, Clinical Research Division, Fred Hutch

Member, Translational Data Science Integrated Research Center (TDS IRC), Fred Hutch

3 more appointments

Phone: 206.667.4475
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Noam E. Kopmar, MD

Noam E. Kopmar, MD

Noam E. Kopmar, MD

Assistant Professor, Clinical Research Division, Fred Hutch

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David G. Maloney, MD, PhD

David G. Maloney, MD, PhD

David G. Maloney, MD, PhD

Professor Emeritus, Translational Science and Therapeutics Division, Fred Hutch

Member, Immunotherapy Integrated Research Center (IIRC), Fred Hutch

1 more appointment

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Marco Mielcarek, MD

Marco Mielcarek, MD

Marco Mielcarek, MD

Professor, Clinical Research Division, Fred Hutch

Medical Director, Adult Blood and Marrow Transplantation, Fred Hutch

2 more appointments

Phone: 206.667.2827
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Fax: 206.667.6124
Mail Stop: D1-100
Johnnie José Orozco, MD, PhD

Johnnie José Orozco, MD, PhD

Johnnie José Orozco, MD, PhD

Associate Professor, Translational Science and Therapeutics Division, Fred Hutch

Member, Immunotherapy Integrated Research Center (IIRC), Fred Hutch

2 more appointments

Phone: 206.667.4102
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Fax: 206.667.1854
Mail Stop: D3-190
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Andrew Jay Portuguese, MD

Andrew Jay Portuguese, MD

Andrew Jay Portuguese, MD

Assistant Professor, Clinical Research Division, Fred Hutch

Phone: 206.667.6656
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Brenda Sandmaier, MD

Brenda Sandmaier, MD

Brenda Sandmaier, MD

Deputy Director, Translational Science and Therapeutics Division, Fred Hutch

Professor, Translational Science and Therapeutics Division, Fred Hutch

3 more appointments

Phone: 206.667.4961
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Rainer Storb, MD

Rainer Storb, MD

Rainer Storb, MD

Professor Emeritus, Clinical Research Division, Fred Hutch

Phone: 206.667.4407
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Fax: 206.667.6124
Mail Stop: D1-100
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Masumi Ueda Oshima, MD, MA

Masumi Ueda Oshima, MD, MA

Masumi Ueda Oshima, MD, MA

Associate Professor, Clinical Research Division, Fred Hutch

2 more appointments

Phone: 206.667.4546
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Edus Houston Warren, MD, PhD

Edus Houston Warren, MD, PhD

Edus Houston Warren, MD, PhD

Professor, Translational Science and Therapeutics Division, Fred Hutch

Professor, Vaccine and Infectious Disease Division, Fred Hutch

6 more appointments

Phone: 206.667.6441
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Mail Stop: S3-204
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