Hutch News

Recent Stories

Good news at Fred Hutch: Celebrating our achievements

March 27, 2015 | By Fred Hutch staff

Dr. Anne McTiernan

Dr. Anne McTiernan, Fred Hutch

Photo by Robert Hood / Fred Hutch News Service

We want to recognize the excellent work and achievements of our staff and faculty and highlight them each week in this space.

Dr. Anne McTiernan on expert panel that reports strong link between alcohol consumption and liver cancer

Three or more drinks a day significantly increase risk, but coffee can decrease risk

Consuming three or more alcoholic drinks a day is linked to a significant increase in the risk of developing liver cancer, according to a report released this week by World Cancer Research Fund International. Fred Hutch cancer prevention researcher Dr. Anne McTiernan was on the international expert panel that has provided the clearest indication to date of how many drinks may actually cause liver cancer.

The 10-member panel, which analyzed 34 studies from around the world involving more than 8 million men and women and more than 24,000 cases of liver cancer – also found strong evidence that:

  • Being overweight/obese can cause liver cancer.
  • Foods contaminated by aflatoxins, which are produced by a fungus found in inappropriately stored food, can cause liver cancer. Foods commonly contaminated by the fungus, called Aspergillus, include cereals, spices, nuts, dried fruit and figs from warmer regions of the world.

Other established causes of liver cancer include cirrhosis of the liver, long-term use of oral contraceptives containing high doses of estrogen and progesterone, chronic viral hepatitis and smoking.

The panel also found:

  • Drinking coffee decreases the risk of liver cancer, but further research is needed to determine how much and what type of coffee may confer a protective effect. 
  • There is limited evidence that eating a diet rich in fish and engaging in physical activity may confer protection against liver cancer.

The bottom line, McTiernan said, is to maintain a healthy weight and avoid alcohol or drink only in moderation, which amounts to no more than two drinks a day for men and one for women.

Liver cancer, which is the second most common cause of cancer death worldwide, accounted for 746,000 deaths in 2012.

The report was part of the WCRF’s Continuous Update Project, or CUP, which analyzes global cancer prevention and survival research linked to diet, nutrition, physical activity and weight.


‘The successes kept you going’: 40 years of bone marrow transplantation

On the eve of ‘Emperor’ cancer documentary, Dr. Fred Appelbaum recounts 40 years of difficult and exhilarating advances in bone marrow transplantation

March 27, 2015 | By Mary Engel / Fred Hutch News Service

In this video extra, Dr. Fred Appelbaum shares a story about how he came to work on bone marrow transplantation at Fred Hutch and of patients who “stick with you” forever.

Dr. Fred Appelbaum was a medical student in 1970 when he stumbled upon Dr. E. Donnall Thomas’ initial description of bone-marrow transplantation in a medical journal and was transfixed.

“I thought it was so cool that this was even possible,” said Appelbaum, now deputy director and executive vice president of Fred Hutchinson Cancer Research Center. In 1978, he leapt at the chance to work alongside Thomas at Fred Hutch, helping to refine the pioneering technique that transformed leukemia and related cancers, once thought incurable, into highly treatable diseases.

Today more than 1 million people around the globe have received blood stem cell transplants to treat dozens of different diseases, and researchers at Fred Hutch continue to build on that work to find innovative new treatments.  Transplants are one of the most significant advances in the history of cancer treatment, which is chronicled in the Pulitzer Prize-winning book “The Emperor of All Maladies: A Biography of Cancer” by Dr. Siddhartha Mukherjee. The book has been made into the six-hour documentary, “Cancer,” by Ken Burns and Barak Goodman and will air on PBS Monday, Tuesday and Wednesday. 

Recently, Appelbaum sat down to talk about 40 years of transplants at Fred Hutch, from the early, heart-wrenching challenges to the latest innovations in immunotherapy, which harnesses the body’s own immune system to fight cancer. 

Continue reading >


Understanding Angelina Jolie Pitt’s medical choices

Actress, filmmaker lauded for raising awareness and saving lives, but her actions also bring up questions

March 25, 2015 | By Diane Mapes / Fred Hutch News Service

Angelina Jolie Pitt

Angelina Jolie Pitt's disclosure that she had her ovaries and fallopian tubes removed has raised awareness about cancer related to the BRCA mutations — and also some questions.

File photo by Matt Sayles / AP

In late 2009 at the age of 40, Amy Byer Shainman, a mother of two from Jupiter, Florida, found out that she carried a BRCA1 genetic mutation, which put her at high risk for both breast and ovarian cancer. Tests showed that she inherited the gene from her father.

After sifting through her options with a genetic counselor and high-risk oncologist, she decided to go ahead with two preventive surgeries. In March of 2010, she had a complete hysterectomy, removing her healthy uterus, fallopian tubes and ovaries. Then in September of that year, she had a preventive nipple-sparing mastectomy followed by immediate reconstruction with implants.

At the time, her daughter was 8 and her son was 5, both far too young to understand why anyone would intentionally remove a healthy body part. Or to grapple with the realities of what it means to carry a genetic mutation that puts you at high risk for certain cancers.

“At that point, we discussed it in an age-appropriate manner,” she said. “I told them, ‘Mommy’s going into the hospital for a Mommy check-up.’”

Shainman knew she would eventually explain the decision to her children but wanted to wait for the right moment. That moment came when Angelina Jolie Pitt revealed in May 2013 that she had undergone a preventive double mastectomy in order to hip check a BRCA1-driven breast cancer, a drastic but effective way to beat the devil at his own game.

“My daughter had seen a story online and turned to me and said, ‘Oh my god, Mom. What is up with that Jolie lady? She, like, cut off her boobs or something,’” said Shainman. “In that exact teenage tone. I took that as my cue to explain to her what she’d done — and what I’d done.”

Continue reading >


'On the threshold of extraordinary advances'

In speech to Rotary Club of Seattle, Fred Hutch President and Director Dr. D. Gary Gilliland looks toward the future

March 25, 2015 | By Linda Dahlstrom / Fred Hutch News Service

Dr. D. Gary Gilliland

Fred Hutch's President and Director Dr. D. Gary Gilliland speaks to the Rotary Club of Seattle on Wednesday, March 25.

Bo Jungmayer / Fred Hutch News Service

Jann Curley had one question for Dr. D. Gary Gilliland. Her husband, Bob, died eight years ago of metastatic melanoma, only three months after being diagnosed.

Now, she wanted to know, are there new advances that would save other families from going through what hers did?

“It’s a terrible, terrible disease as you know. Eight years ago there were really only two treatments,” Gilliland, president and director of Fred Hutchinson Cancer Research Center, told her.

Today, he said, “we are on the threshold of a tsunami of approaches that harness our own immune systems to benefit patients who have cancer. It’s stunning to see. I’ve never seen anything like it. I’ve seen patients go home to hospice and then come back three months later (doing well).”

Gilliland spoke to a crowd of about 300 on Wednesday when he gave the keynote speech to the Rotary Club of Seattle, one of the largest chapters in the world. One of the most dramatic advances in recent years for treating cancer has been in the area of immunotherapy, he said. It’s showing incredible promise for treating melanoma and other cancers.

“As an oncologist, it takes my breath away,” he said.

Continue reading >


Angelina Jolie Pitt reveals she had ovaries removed

The actress has the BRCA1 mutation, which puts her at high risk for breast and ovarian cancer

March 24, 2015 | By Diane Mapes / Fred Hutch News Service

Angelina Jolie Pitt

Angelina Jolie Pitt announced Tuesday that she's had her ovaries and Fallopian tubes removed to combat her risk of cancer.

File photo by Matt Sayles / AP

After actress and filmmaker Angelina Jolie Pitt went public two years ago with her choice to have a preventive double mastectomy to combat the risk of breast cancer, she hinted that another surgery awaited her.

Jolie, who lost her mother, grandmother and aunt to cancer, has the BRCA1 genetic mutation, which puts her at high risk for breast and ovarian cancer.

Now, in an opinion piece published in The New York Times, she has announced that last week she also had surgery to remove her ovaries and fallopian tubes. 

Continue reading >


When the doctor is the patient

A kidney transplant and a cancer diagnosis helped shape the career of infection-control expert Steve Pergam

March 23, 2015 | By Mary Engel / Fred Hutch News Service

Dr. Steve Pergam, right, chats with a colleague.

As director of infection control at Seattle Cancer Care Alliance and an infectious disease researcher at Fred Hutchinson Cancer Research Center, Dr. Steve Pergam works to protect a subset of people who are particularly vulnerable to infectious diseases: cancer patients. Here he is shown with graduate research assistant Arianna Miles-Jay.

Photo by Bo Jungmayer / Fred Hutch News Service

As a first-year medical student at University of Nebraska Medical Center, Dr. Steve Pergam volunteered for a vaccine campaign in Nicaragua, bringing basic childhood immunizations to squatters living in cardboard shacks. When he returned to Nicaragua the following spring to deliver a second round of immunizations, he found that local health care workers had already done so. His earlier efforts had helped put the impoverished community on the government’s radar.

“One of the things I really liked about infectious diseases was I actually felt I could make a tangible difference,” he said, reflecting recently on the experience that sparked his interest in what would become his life’s work.

Having seen firsthand the toll that such diseases take on developing countries, Pergam assumed that like many others in the field he would go on to work internationally.

Instead, as director of infection prevention at the Seattle Cancer Care Alliance and an infectious disease researcher at Fred Hutchinson Cancer Research Center, Pergam today works to protect a subset of people who are particularly vulnerable to infectious diseases, even in developed countries: cancer patients.

Continue reading >


GIVE NOW &
SAVE LIVES

Support our quest for cures

For the Media

News releases >
Media coverage >
Contact us >


Story Archive


Publications

Quest
Our quarterly magazine

Annual Report
Fiscal year highlights

Science Spotlight
Monthly review of Center-authored papers


Fred Hutch News

Get updates via email.