Université d’Orleans, France, BA, 1982, Biochemistry
Université de Paris XI, France, M.Sc 1983, Organic Chemistry
McGill University, Canada, Ph.D. 1988, Biochemistry
We investigate the B cell responses to infection or vaccination. We are particularly interested in understanding the activation, survival and maturation of B cell clonal lineages that produce protective antibodies against infectious agents. New immunogens and immunization regiments are developed to target these B cell lineages and are tested in vivo. We employ diverse experimental approaches, including structure-based immunogen-design, X-ray crystallography, next generation deep sequencing, and immunological, molecular and cellular techniques. Our work encompasses the entire space between pre-clinical and clinical evaluation of candidate vaccines.