HIV Vaccine Trials Network

global map of HVTN sites

The HIV Vaccine Trials Network (HVTN) is the world’s largest publicly funded multi-disciplinary international collaboration facilitating the development of vaccines to prevent HIV/AIDS. The Network conducts all phases of clinical trials, from evaluating experimental vaccines for safety and immunogenicity to testing vaccine efficacy.

Over the past decade, the HVTN has aimed to improve the process of designing, implementing, and analyzing vaccine trials. Several major achievements include streamlining protocol development while maintaining input from diverse stakeholders, establishing a laboratory program with standardized assays and systems allowing for reliable assessments across trials, setting statistical standards for the field, and actively engaging with site communities. These achievements have allowed the Network to conduct over 50 clinical trials as well as numerous scientific contributions to the field.

An international partnership

The 10,000-square foot HVTN Immunology Laboratory serves as a base for upcoming HIV vaccine trials in South Africa and throughout the region.

Robert Hood/Fred Hutch

Headquartered at Fred Hutch, the HVTN is an international partnership of research scientists, clinical trial sites, laboratories, funders, regulators and ethicists, participants, volunteers and community representatives working with industry, academia, and governments in the global search for a preventive HIV vaccine. There are more than 30 sites on five continents.

Supported through a cooperative agreement with the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health (NIH), researchers conduct all phases of clinical trials, from evaluating candidate vaccines for safety and the ability to stimulate immune responses, to testing vaccine efficacy.