Basic Sciences Division

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How to preserve genetic information

Tsukiyama and colleagues investigate how chromatin, a macromolecular structure for genetic information storage, is accurately propagated and maintained. Misregulation of chromatin is one of the major drivers of cancer.

Photo by Jeremy Mseitif / Fred Hutch

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The machinery for cell movement

Jon Cooper looks at blots showing proteins that regulate cell migration.

Photo by Jeremy Mseitif / Fred Hutch

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DNA break-repair and genetic recombination

Cells must repair broken DNA or they die. DNA break repair is a basis for genetic recombination, which generates new combinations of genetic alleles and diversity to propel evolution.

Photo by Jeremy Mseitif / Fred Hutch

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Dissecting the cellular aging process

Dan Gottschling and colleague review the growth of yeast, Saccharomyces cerevisiae, which is used as a model system for studying the aging process in eukaryotic cells.

Photo by Fred Hutch

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The complex traits of human disease

Katie Peichel inspects tanks of stickleback fish. Many diseases in stickleback result from a combination of genetic and environmental factors just as in human diseases.

Photo by Fred Hutch

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Molecular evolution of proteins and viruses

Rapid evolution is a defining factor of most viral diseases, including influenza. Studying the evolution of diseases answers important biologic questions.

Photo by Robert Hood / Fred Hutch

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Centromere paradox

Centromeres are indispensable for chromosome segregation in most eukaryotes yet the underlying DNA sequences are fastest evolving regions in their genomes.

Photo by Jeremy Mseitif / Fred Hutch

Making Foundational Discoveries

Our Faculty

Basic scientists answer fundamental biological questions and produces new insights on the basic biology of life processes and cancer development.  Our faculty include structural, genetic, molecular, cellular, developmental and evolutionary biology investigators working in diverse areas related to all aspects of biology.  

News / Publications

Current News

Read Fred Hutch News articles, news releases and scientific publications involving basic sciences researchers and their accomplishments.

Weintraub Award

Award Recipients

Given annually, the Harold M. Weintraub Graduate Student Award recognizes outstanding achievement during graduate studies in the biological sciences.

Scientific Exchange

Meetings / Clubs

Friday Evening and Seattle Fly Club meetings are on hold for the summer.  Upcoming meetings:

  • Sept 3    Seattle Mitosis

Scheduled Seminars

Current Biology Series

Features weekly seminars with presentations by Hutch and outside scientists to share the latest developments and recent research.

  • June 23 D. Allan Drummond

Scientific Excellence

About Our Division

Basic science discoveries are the foundation for understanding the causes of and developing the treatments for human disease.  Our varied research interests have led to a number of significant discoveries.

Groundbreaking Work

Our Research Focus

We have 29 laboratories working in diverse areas related to all aspects of biology aimed at understanding how the many systems of cells interact and are regulated.    

Career Opportunities

Find A Position

We are seeking outstanding scientists interested in conducting cutting-edge research into fundamental biological questions.  We also sponsor postdoctoral fellows, talented graduate students or recent graduates.