Treatment Research

HIV Prevention and Cure

Fred Hutch researchers have spent more than two decades unraveling how HIV/AIDS works and conducting groundbreaking prevention and treatment research to end its deadly march.  Research ranges from identifying a safe and effective vaccine to understanding to the role of the immune system in resisting HIV infection to transplantation-related clinical trials.

HIV Vaccine Trials Network

Cornerstone of prevention efforts

A cornerstone of the prevention efforts is the HIV Vaccine Trials Network (HVTN), the world’s largest publicly funded multi-disciplinary international collaboration facilitating the development of vaccines to prevent HIV/AIDS. Based at Fred Hutch, the HVTN includes over 30 sites on five continents.

The HVTN is partnership of research scientists, clinical trial sites, laboratories, funders, regulators and ethicists, participants, volunteers and community representatives working with industry, academia, and governments in the global search for a preventive HIV vaccine.

Its researchers conduct all phases of clinical trials, from evaluating experimental vaccines for safety and immunogenicity to testing vaccine efficacy.  The networks efforts have advanced the HIV vaccinology field and advance the knowledge in fields as varied as social and behavioral sciences, statistics, and immunology.

The Seattle Vaccine Trials Unit (SVTU), a local site for the HVTN, is one of the first sites to conduct an HIV vaccine trial. 

Support Fred Hutch's Cure Agenda

Contribution support HIV/AIDS research at Fred Hutch and the Timothy Ray Brown Foundation

In pursuit of a cure

In pursuit of a cure for HIV, Fred Hutch researchers are conducting research to develop cell and gene therapies for making an HIV-infected person's own immune cells resistant to HIV infection. In 2011, Drs. Keith Jerome and Hans-Peter Kiem received a $20 million grant to investigate whether stem cell transplants can accomplish this lifesaving goal.

This research builds on the remarkable success of Timothy Ray Brown – also known as the “Berlin patient” – who is the first person ever cured of HIV. Brown was diagnosed with the virus in 1995 and used antiretroviral therapy to control it. The Fred Hutch-led team uses this breakthrough as a possible blueprint for new curative therapies that could reach patients worldwide.

Fred Hutch researchers are also exploring stem-cell transplantation as an option as a cure for people have cancer or do not have cancer and who are HIV positive. These clinical trials combine low-dose chemotherapy with or without radiation.

Interested in participating in study?

Study participants are key to the success of prevention studies.  The HVTU has studies for people who are HIV negative and HIV positive. To learn more HIV vaccine study near you, vist the HVTN.


Looking for an HIV clinical trial?

Fred Hutch has clinical trials involving stem-cell transplantation for people who are HIV positive with or without cancer.  Search for a trial >