Phase 1a/?1b Study of IGM-8444 Alone and in Combination in Subjects With Relapsed, Refractory, or Newly Diagnosed Cancers

Complete Title: An Open-Label, Multicenter, Phase 1a/1b Study of Igm-8444 as a Single Agent And In Combination in Subjects with Relapsed, Refractory, or Newly Diagnosed Cancers
Trial Phase: I
Investigator: Vivian Oehler

This study is a first-in-human, Phase 1a/1b, multicenter, open-label study to determine the safety, tolerability, and pharmacokinetics of IGM-8444 as a single agent and in combination in subjects with relapsed and/or refractory solid or hematologic cancers, as well as newly diagnosed cancers, and an open-label, randomized study of IGM-8444+FOLFIRI (± bevacizumab).

Keywords:
  • Leukemia, Acute Myeloid (AML)
  • Leukemia, Chronic Lymphocytic (CLL)
  • Lymphoma, Non-Hodgkin (NHL)
  • Sarcoma
  • Solid Tumors
  • Colorectal Neoplasms
  • Lymphoma, Small Lymphocytic (SLL)
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Adult
I
Vivian Oehler
RG1123124
NCT04553692
An Open-Label, Multicenter, Phase 1a/1b Study of Igm-8444 as a Single Agent And In Combination in Subjects with Relapsed, Refractory, or Newly Diagnosed Cancers
Leukemia, Acute Myeloid (AML)
Leukemia, Chronic Lymphocytic (CLL)
Lymphoma, Non-Hodgkin (NHL)
Sarcoma
Solid Tumors
Colorectal Neoplasms
Lymphoma, Small Lymphocytic (SLL)