Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain (KALPAS)

Complete Title: Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
Trial Phase: III
Investigator: Michele Curatolo

The study utilizes a 3-arm placebo-controlled RCT to study the effectiveness of ketamine in reducing chronic post-mastectomy pain. Participants randomized to the first arm will receive a 0.35 mg/kg dose after induction, followed by a 0.3 mg/kg/hr infusion throughout surgery and continued for 2 hours postoperatively. Participants in the second arm will receive a single dose of 0.6 mg/kg of ketamine in the post-anesthesia care unit, and the final group will serve as the control group and receive saline (no ketamine).

Keywords:
  • Chronic Pain
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Adult
III
Michele Curatolo
RG1121718
NCT05037123
Optimizing the Use of Ketamine to Reduce Chronic Postsurgical Pain
Chronic Pain