Efficacy and Safety Study of Tisotumab Vedotin for Patients With Solid Tumors (innovaTV 207)

Complete Title: Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors
Trial Phase: II
Investigator: Tina Rodriguez

This trial will study tisotumab vedotin to find out whether it is an effective treatment for certain solid tumors and what side effects (unwanted effects) may occur. There are four parts to this study. In Part A, the treatment will be given to participants every 3 weeks (3-week cycles). In Part B, participants will receive tisotumab vedotin on Days 1, 8, and 15 every 4-week cycle. In Part C, participants may receive tisotumab vedotin on Days 1 and 15 or Days 1, 8, and 15 on a 4-week cycle. In Part D, participants will be given treatment on Day 1 of every 3-week cycle. Participants in Part D will get tisotumab vedotin with either: Pembrolizumab or, Pembrolizumab and carboplatin, or Pembrolizumab and cisplatin

Keywords:
  • Pancreatic Cancer
  • Lung Carcinoma, Non-Small-Cell (NSCLC)
  • Carcinoma, Squamous Cell
  • Colorectal Neoplasms
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Adult
II
Tina Rodriguez
RG1122942
NCT03485209
Open Label Phase 2 Study of Tisotumab Vedotin for Locally Advanced or Metastatic Disease in Solid Tumors
Pancreatic Cancer
Lung Carcinoma, Non-Small-Cell (NSCLC)
Carcinoma, Squamous Cell
Colorectal Neoplasms