A Study to Investigate LYL797 in Adults With Solid Tumors

Complete Title: A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults with Relapsed and/or Refractory Solid-Tumor Malignancies
Trial Phase: I
Investigator: Jennifer Specht

This study will evaluate the safety and tolerability of LYL797, a ROR1-targeted CAR T-cell therapy, in patients with ROR1+ relapsed or refractory triple negative breast cancer (TNBC) or non-small cell lung cancer (NSCLC). The first part of the study will determine the safe dose for the next part of the study, and will enroll TNBC and NSCLC patients. The second part of the study will test that dose in additional TNBC and NSCLC patients.

Keywords:
  • Breast Cancer
  • Lung Cancer
  • Lung Carcinoma, Non-Small-Cell (NSCLC)
  • Triple Negative Breast Neoplasms
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Adult
I
Jennifer Specht
RG1122382
NCT05274451
A Phase 1 Study to Assess the Safety and Efficacy of LYL797, ROR1-Targeting CAR T Cells, in Adults with Relapsed and/or Refractory Solid-Tumor Malignancies
Breast Cancer
Lung Cancer
Lung Carcinoma, Non-Small-Cell (NSCLC)
Triple Negative Breast Neoplasms