A Study to Determine Dose, Safety, Tolerability, Drug Levels, and Efficacy of CC-220 Monotherapy, and in Combination With Other Treatments in Participants With Multiple Myeloma

Complete Title: A phase 1b/2a multicenter, open-label, dose escalation study to determine the maximum tolerated dose, assess the safety, tolerability, pharmacokinetics and efficacy of CC-220 as monotherapy and in combinations with other treatments in subjects with multiple myeloma

Trial Phase: I/II

Investigator: Andrew Cowan, MD

This is a multicenter, multi-country, open-label, Phase 1b/2a dose-escalation study consisting of two parts: dose escalation (Part 1) for CC-220 monotherapy, CC-220 in combination with DEX, CC-220 in combination with DEX and DARA, CC-220 in combination with DEX and BTZ and CC-220 in combination with DEX and CFZ; and the expansion of the RP2D (Part 2) for CC-220 in combination with DEX for Relapsed Refractory Multiple Myeloma and CC-220 in combination with DEX and BTZ for Newly Diagnosed Multiple Myeloma.

Keywords:

Multiple Myeloma (MM)

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