Clinical Trial Detail

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Complete title: Hematopoietic Stem Cell Transplantation from Haploidentical Donors in Patients with Hematological Malignancies Using a Treosulfan-Based Preparative Regimen

Research Study Number RG1005742
Principal Investigator Filippo Milano
Phase II

Look up trial at NIH

Research Study Description

This phase II trial studies how well a donor stem cell transplant, treosulfan, fludarabine, and total-body irradiation work in treating patients with blood cancers (hematological malignancies). Giving chemotherapy and total-body irradiation before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. It may also stop the patient`s immune system from rejecting the donor`s

stem cells. When the healthy stem cells from a donor are infused into the patient, they may help the patient`s

bone marrow make stem cells, red blood cells, white blood cells, and platelets. The donated stem cells may also replace the patient`s immune cells and help destroy any remaining cancer cells.

Eligibility Criteria (must meet the following to participate in this study)

** For Eligibility information, please click on the "Look up trial at NIH" link above **

Other eligibility criteria may apply.

Research Study Number RG1005742

Keywords: Leukemia, Acute Lymphoblastic (ALL); Leukemia, Acute Myeloid (AML); Lymphoma, Burkitt; Lymphoma, Hodgkin; Myelodysplastic Syndromes (MDS); Leukemia, Lymphoid; Lymphoma, Mantle-Cell; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Follicular; Lymphoma, Small Lymphocytic (SLL); Leukemia, Prolymphocytic; Lymphoma, Lymphoblastic (LBL); Lymphoma, Marginal Zone

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Last Modified, June 25, 2019