Editor’s note: We will update this story as the situation progresses.
On Thursday, the World Health Organization designated the novel coronavirus known as 2019-nCoV a “public health emergency of international concern” as the U.S. confirmed its first in-country transmission of the virus that originated in Wuhan, China.
With thousands of confirmed cases in China and thousands more suspected, according to the WHO, the virus killed nearly two hundred people by the end of January, disrupted global travel and forced governments and other organizations to take extreme measures to limit its global spread, from evacuations to mass quarantines.
Scientists are racing to understand this new threat, including how the virus is evolving and passing from person to person, to inform ongoing public health efforts, including the possible development of a vaccine.
Among the scientists on the front lines of that research effort are infectious-disease experts at Fred Hutchinson Cancer Research Center, such as Dr. Trevor Bedford. Bedford, a computational biologist who studies how viruses evolve and spread, is gaining insights about 2019-nCoV that he hopes will help save lives from this new viral respiratory illness.
As he has been analyzing the spreading virus, Bedford has been sharing what he’s learned so far with the public via media interviews, his team’s open-source platform for real-time tracking of viral evolution — Nextstrain.org — and his Twitter feed (follow Bedford at @trvrb).
Here are highlights of what he and other experts have learned so far — and the critical questions they’re still pursuing:
2019-nCoV questions and answers
The U.S. Centers for Disease Control and Prevention and the World Health Organization have up-to-date information and resources on a variety of questions related to 2019-nCoV, including:
Analyses by Bedford and others of the genetic sequences of some of the first human cases showed that the virus had remarkable lack of genetic diversity from person to person after it first emerged.
At first, there was not enough data to clarify what this meant — was the virus jumping repeatedly to humans from animals or, more dangerously, spreading rapidly between people after an initial jump from animals? “The DNA can’t distinguish those two scenarios. Only epidemiological data or DNA from the reservoir animal can,” Bedford told WIRED on Jan. 22. Figuring this out “would be the big epidemiological goal for everyone at the moment,” he told the journal Nature the same week.
“If it’s not contained shortly, I think we are looking at a pandemic,” Bedford told STAT News on Jan. 27 — although he cautioned that it was impossible to say how serious a 2019-nCoV pandemic would be.
This research by Bedford and other virus-trackers is possible because of rapid genetic sequencing of infected people — unfeasible or even impossible not too many years ago — and a global commitment to sharing these genetic data freely with the worldwide research community.
“Basically, a week after registering that there’s this new thing, the amazing scientists in China have a genome for the novel virus that had never been seen before. Then, after the first genome was released on a Friday afternoon, we had five more Sunday morning. And now, nine days later, we’re up to 24,” Bedford explained on the public radio show Science Friday on Jan. 24. “That first genome has been amazing for people developing rapid tests to be able to actually confirm cases, and these subsequent genomes are being very useful to understand basic epidemiological questions.”
Because of the rapidly emerging nature of the disease, “adding a few key samples can change the story significantly,” Bedford told the journal Nature on Jan. 28.
That is, in fact, what happened. With access to additional genetic sequences from more infected people, Bedford and Nextstrain teammates wrote on a report on their site on Jan. 30 that the disease’s low mutation rate is the result of person-to-person spread since its initial jump, or jumps, from unknown animals to people in November or early December 2019.
In their Jan. 30 report, the team also wrote:
Meanwhile, a new analysis of the first 425 people with the virus, published on Jan. 29 in the New England Journal of Medicine by a China-based research team, concluded that it takes about five days for a person who is ultimately diagnosed with the illness to develop symptoms after their initial infection with the virus.
Bedford wrote on Twitter on Jan. 30 that the key question at this point for understanding the disease’s transmission is how many people get infected with the virus without getting diagnosable symptoms of the disease.
So far, people who have been coming down with the most severe cases of illness caused by 2019-nCoV are almost always older people and people with underlying health conditions, according to the CDC’s Jan. 30 media briefing.
There is no vaccine, but researchers are already developing candidates, the Washington Post reported on Jan. 30. It’s unclear whether one can be developed before the virus runs its course.
Although there are no drugs specifically for the 2019-nCoV virus, the WHO advises that patients who are hospitalized with confirmed cases of infection be treated with therapies to overcome particular symptoms of illness.
Susan Keown, a staff writer at Fred Hutchinson Cancer Research Center, has written about health and research topics for a variety of research institutions, including the National Institutes of Health and the Centers for Disease Control and Prevention. Reach her at skeown@fredhutch.org or on Twitter @sejkeown.
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